Bama miniature pigs (sus scrofa domestica) as a model for drug evaluation for humans: comparison of in vitro metabolism and in vivo pharmacokinetics of lovastatin

Comparative Medicine

Volumn 58, Issue 6, 2008, Pages 580-587

  Liu, Yu ^a   Zeng, Ben Hua ^a   Shang, Hai Tao ^a   Cen, Yan Yan ^a   Wei, Hong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; DRUG METABOLITE; HYDROXYACID; MEVINOLIN; TROLEANDOMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOMESTIC PIG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG HYDROLYSIS; DRUG INHIBITION; DRUG METABOLISM; DRUG SCREENING; DRUG URINE LEVEL; ENZYME KINETICS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; PLASMA PROTEIN BINDING; SINGLE DRUG DOSE; STOMACH ABSORPTION;

ANIMALS; CYTOCHROME P-450 CYP3A; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; HYDROLYSIS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MALE; MICROSOMES, LIVER; MODELS, ANIMAL; SPECIES SPECIFICITY; SWINE; SWINE, MINIATURE; TROLEANDOMYCIN;

EID: 59049083549     PISSN: 15320820     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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