Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

Immunity

Volumn 48, Issue 3, 2018, Pages 514-529.e6

  Datta, Moumita ^a,f   Staszewski, Ori ^a   Raschi, Elena ^b   Frosch, Maximilian ^a   Hagemeyer, Nora ^a   Tay, Tuan Leng ^a   Blank, Thomas ^a   Kreutzfeldt, Mario ^c   Merkler, Doron ^c   Ziegler Waldkirch, Stephanie ^a   Matthias, Patrick ^d   Meyer Luehmann, Melanie ^a   Prinz, Marco ^a,e  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^e UNIVERSITY OF FREIBURG   (Germany)

^f UNIVERSITY OF ULM   (Germany)

Author keywords

Alzheimer's disease; epigenetics; HDACs; microglia

Indexed keywords

ALPHA3 INTEGRIN; AMYLOID; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIN D2; CYCLIN D3; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2C; EPHRIN RECEPTOR A1; EPHRIN RECEPTOR A8; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 9; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 16; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; NETRIN 1; PROTEIN; PROTEIN KINASE C THETA; PROTEIN P90; RAC1 PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; SMAD3 PROTEIN; TRANSCRIPTION FACTOR E2F6; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6; WNT4 PROTEIN; HISTONE; TRANSCRIPTOME;

ADULT; ALZHEIMER DISEASE; AMNESIA; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE; CELL FUNCTION; CELL MATURATION; CELL SURVIVAL; COGNITIVE DEFECT; CONTROLLED STUDY; DEGENERATIVE DISEASE; EMBRYO; EPIGENETICS; FEMALE; GENE DELETION; GENE EXPRESSION; HISTONE ACETYLATION; HOMEOSTASIS; LEARNING DISORDER; MICROGLIA; MOUSE; MRNA EXPRESSION LEVEL; MUTAGENESIS; NEUROECTODERM; NEUROPATHOLOGY; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOCYTOSIS; PRENATAL DEVELOPMENT; PROMOTER REGION; PROTEIN EXPRESSION LEVEL; REGULATORY MECHANISM; SPATIAL LEARNING; SPATIAL MEMORY; STEADY STATE; TRANSCRIPTOMICS; ANIMAL; CELL PROLIFERATION; DISEASE MODEL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MEMORY DISORDER; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; PATHOLOGY; PSYCHOLOGY; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; EPIGENESIS, GENETIC; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONES; HOMEOSTASIS; MEMORY DISORDERS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROGLIA; NEURODEGENERATIVE DISEASES; NEUROGENESIS; PHAGOCYTOSIS; PLAQUE, AMYLOID; SPATIAL LEARNING; TRANSCRIPTOME;

EID: 85042868778     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.02.016     Document Type: Article

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