Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice

Blood

Volumn 121, Issue 8, 2013, Pages 1335-1344

  Dovey, Oliver M ^a,b   Foster, Charles T ^c   Conte, Nathalie ^d   Edwards, Sally A ^e   Edwards, Jennifer M ^a   Singh, Rajinder ^f   Vassiliou, George ^b   Bradley, Allan ^b   Cowley, Shaun M ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d EUROPEAN BIOINFORMATICS INSTITUTE   (United Kingdom)

^e QUEEN S MEDICAL CENTRE   (United Kingdom)

^f UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA H2AX PROTEIN; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE H2AX; LAT PROTEIN; MYC PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ALLELE; ANEUPLOIDY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CELL MATURATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE EXPRESSION REGULATION; GENOMIC INSTABILITY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T CELL DEPLETION; T LYMPHOCYTE; THYMOCYTE;

EID: 84874399937     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-07-441949     Document Type: Article

References (50)

1. Haberland M, Johnson A, Mokalled MH, Montgomery RL, Olson EN. Genetic dissection of histone deacetylase requirement in tumor cells. Proc Natl Acad Sci U S A. 2009;106(19):7751-7755.
2. Montgomery RL, Davis CA, Potthoff MJ, et al. Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev. 2007;21(14):1790-1802. (Pubitemid 47076478)
3. Montgomery RL, Hsieh J, Barbosa AC, Richardson JA, Olson EN. Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc Natl Acad Sci U S A. 2009;106(19):7876-7881.
4. Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell. 1997;89(3):349-356. (Pubitemid 27220879)
5. Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature. 1998;395(6705):917-921. (Pubitemid 28503435)
6. Xue Y, Wong J, Moreno GT, Young MK, Cote J, Wang W. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell. 1998;2(6):851-861. (Pubitemid 128378992)
7. You A, Tong JK, Grozinger CM, Schreiber SL. CoREST is an integral component of the CoREST-human histone deacetylase complex. Proc Natl Acad Sci U S A. 2001;98(4):1454-1458. (Pubitemid 32165520)
8. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R. Acore-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A. 2002;99(11):7420-7425. (Pubitemid 34568706)
9. Luger K, Richmond TJ. The histone tails of the nucleosome. Curr Opin Genet Dev. 1998;8(2):140-146. (Pubitemid 28206276)
10. Robinson PJ, An W, Routh A, et al. 30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction. J Mol Biol. 2008;381(4):816-825.
11. Wang Z, Zang C, Cui K, et al. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell. 2009;138(5):1019-1031.
12. Kurdistani SK, Robyr D, Tavazoie S, Grunstein M. Genome-wide binding map of the histone deacetylase Rpd3 in yeast. Nat Genet. 2002;31(3):248-254.
13. Dovey OM, Foster CT, Cowley SM. Emphasizing the positive: A role for histone deacetylases in transcriptional activation. Cell Cycle. 2010;9(14):2700-2701.
14. Marks PA, Xu WS. Histone deacetylase inhibitors: Potential in cancer therapy. J Cell Biochem. 2009;107(4):600-608.
15. Godfrey DI, Zlotnik A. Control points in early T-cell development. Immunol Today. 1993;14(11):547-553. (Pubitemid 23316714)
16. Starr TK, Jameson SC, Hogquist KA. Positive and negative selection of T cells. Annu Rev Immunol. 2003;21:139-176. (Pubitemid 37174529)
17. Taniuchi I, Ellmeier W, Littman DR. The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development. Adv Immunol. 2004;83:55-89. (Pubitemid 38657637)
18. Taniuchi I, Osato M, Egawa T, et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell. 2002;111(5):621-633. (Pubitemid 35441245)
19. Sato T, Ohno S, Hayashi T, et al. Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes. Immunity. 2005;22(3):317-328. (Pubitemid 40387474)
20. Hendriks RW, Nawijn MC, Engel JD, van Doorninck H, Grosveld F, Karis A. Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus. Eur J Immunol. 1999;29(6):1912-1918. (Pubitemid 29265546)
21. He X, Dave VP, Zhang Y, et al. The zinc finger transcription factor Th-POK regulates CD4 versus CD8T-cell lineage commitment. Nature. 2005;433(7028):826-833. (Pubitemid 40314886)
22. Kasler HG, Young BD, Mottet D, et al. Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double-positive thymocytes. J Immunol. 2011;186(8):4782-4793.
23. de Zoeten EF, Wang L, Sai H, Dillmann WH, Hancock WW. Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology. 2010;138(2):583-594.
24. de Zoeten EF, Wang L, Butler K, et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3 (+) T-regulatory cells. Mol Cell Biol. 2011;31(10):2066-2078.
25. Villagra A, Cheng F, Wang HW, et al. The histone deacetylase HDAC11 regulates the expression of interleukin 10and immune tolerance. Nat Immunol. 2009;10(1):92-100.
26. Cowley SM, Iritani BM, Mendrysa SM, et al. The mSin3Achromatin-modifying complex is essential for embryogenesis and T-cell development. Mol Cell Biol. 2005;25(16):6990-7004. (Pubitemid 41105899)
27. Williams CJ, Naito T, Arco PG, et al. The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development. Immunity. 2004;20(6):719-733. (Pubitemid 38757442)
28. Grausenburger R, Bilic I, Boucheron N, et al. Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol. 2010;185(6):3489-3497.
29. Dovey OM, Foster CT, Cowley SM. Histone deacetylase 1(HDAC1), but not HDAC2, controls embryonic stem cell differentiation. Proc Natl AcadSciUSA. 2010;107(18):8242-8247.
30. Lee PP, Fitzpatrick DR, Beard C, et al. A critical role for Dnmt1 and DNAmethylation in T cell development, function, and survival. Immunity. 2001;15(5):763-774. (Pubitemid 34008504)
31. Barnden MJ, Allison J, Heath WR, Carbone FR. Defective TCR expression in transgenic mice constructed using cDNA-based alpha-and betachain genes under the control of heterologous regulatory elements. Immunol Cell Biol. 1998;76(1):34-40. (Pubitemid 28194695)
32. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44-57.
33. Wilting RH, Yanover E, Heideman MR, et al. Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. EMBOJ. 2010;29(15):2586-2597.
34. Yamaguchi T, Cubizolles F, Zhang Y, et al. Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev. 2010;24(5):455-469.
35. Lagger G, O'Carroll D, Rembold M, et al. Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. 2002;21(11):2672-2681. (Pubitemid 34619383)
36. Reichert N, Choukrallah MA, Matthias P. Multiple roles of class I HDACs in proliferation, differentiation, and development. Cell Mol Life Sci. 2012;69(13):2173-2187.
37. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674.
38. Nowicki MO, Pawlowski P, Fischer T, Hess G, Pawlowski T, Skorski T. Chronic myelogenous leukemia molecular signature. Oncogene. 2003;22(25):3952- 3963. (Pubitemid 36819669)
39. Maser RS, Choudhury B, Campbell PJ, et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature. 2007;447(7147):966-971. (Pubitemid 46975753)
40. Gaudet F, Hodgson JG, Eden A, et al. Induction of tumors in mice by genomic hypomethylation. Science. 2003;300(5618):489-492. (Pubitemid 36444330)
41. Du Z, Song J, Wang Y, et al. DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci Signal. 2010;3(146):ra80.
42. Miller KM, Tjeertes JV, Coates J, et al. Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous endjoining. Nat Struct Mol Biol. 2010;17(9):1144-1151.
43. Tjeertes JV, Miller KM, Jackson SP. Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J. 2009;28(13):1878-1889.
44. Zupkovitz G, Grausenburger R, Brunmeir R, et al. The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. Mol Cell Biol. 2010;30(5):1171-1181.
45. Naito T, Gomez-Del Arco P, Williams CJ, Georgopoulos K. Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression. Immunity. 2007;27(5):723-734. (Pubitemid 350102255)
46. Qiu Y, Zhao Y, Becker M, et al. HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol Cell. 2006;22(5):669-679. (Pubitemid 43817601)
47. David G, Turner GM, Yao Y, Protopopov A, DePinho RA. mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. Genes Dev. 2003;17(19):2396-2405. (Pubitemid 37214788)
48. Ekwall K, Olsson T, Turner BM, Cranston G, Allshire RC. Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres. Cell. 1997;91(7):1021-1032. (Pubitemid 28027834)
49. Grewal SI, Bonaduce MJ, Klar AJ. Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast. Genetics. 1998;150(2):563-576. (Pubitemid 28463036)
50. Senese S, Zaragoza K, Minardi S, et al. Role for histone deacetylase 1 in human tumor cell proliferation. Mol Cell Biol. 2007;27(13):4784-4795. (Pubitemid 47016131)