USP18 lack in microglia causes destructive interferonopathy of the mouse brain

EMBO Journal

Volumn 34, Issue 12, 2015, Pages 1612-1629

  Goldmann, Tobias ^a   Zeller, Nicolas ^a   Raasch, Jenni ^a   Kierdorf, Katrin ^a   Frenzel, Kathrin ^a   Ketscher, Lars ^a   Basters, Anja ^a   Staszewski, Ori ^a   Brendecke, Stefanie M ^a   Spiess, Alena ^a   Tay, Tuan Leng ^a   Kreutz, Clemens ^a   Timmer, Jens ^a   Mancini, Grazia M S ^b   Blank, Thomas ^a   Fritz, Günter ^a   Biber, Knut ^a,c   Lang, Roland ^d   Malo, Danielle ^e   Merkler, Doron ^f   Heikenwälder, Mathias ^g   Knobeloch, Klaus Peter ^a   Prinz, Marco ^a   more..

^a UNIVERSITY OF FREIBURG   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^e MCGILL UNIVERSITY   (Canada)

^f UNIVERSITY OF GENEVA   (Switzerland)

^g TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

EAE; Microglia; Multiple sclerosis; Type I interferon; Usp18

Indexed keywords

DEUBIQUITINASE; INTERFERON RECEPTOR; INTERFERON RECEPTOR 2; STAT1 PROTEIN; UBIQUITIN SPECIFIC PROTEASE 18; UNCLASSIFIED DRUG; INTERFERON; PRIMER DNA; PROTEINASE; USP18 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; FEMALE; MICROGLIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WHITE MATTER; ANIMAL; BIOLOGICAL MODEL; BRAIN; DEFICIENCY; FLUORESCENCE MICROSCOPY; GENETICS; HISTOLOGY; KNOCKOUT MOUSE; METABOLISM; MICROARRAY ANALYSIS; MOLECULAR CLONING; NONPARAMETRIC TEST; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN; CLONING, MOLECULAR; DNA PRIMERS; ENDOPEPTIDASES; HISTOLOGICAL TECHNIQUES; INTERFERONS; MICE; MICE, KNOCKOUT; MICROARRAY ANALYSIS; MICROGLIA; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MODELS, NEUROLOGICAL; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC;

EID: 84930864391     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201490791     Document Type: Article

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