X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket

Biochemistry

Volumn 57, Issue 6, 2018, Pages 925-934

  Dahms, Sven O ^a,b   Hardes, Kornelia ^c   Steinmetzer, Torsten ^c   Than, Manuel E ^b  

^a UNIVERSITY OF SALZBURG   (Austria)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ARGININE; CHAINS; PEPTIDES; SUBSTRATES; VIRUSES; X RAYS;

LYSINE SIDE CHAINS; PROPROTEIN CONVERTASE FURIN; PROTEIN X-RAY CRYSTALLOGRAPHY; PROTEOLYTIC CLEAVAGE; SECRETORY PATHWAYS; STERIC PROPERTIES; SUBSTRATE SPECIFICITY; SUBSTRATE-BINDING SITES;

X RAY CRYSTALLOGRAPHY;

ARGININE; CITRULLINE; FURIN; GLUTAMINE; LYSINE; TYROSINE; PEPTIDE; PROTEINASE INHIBITOR;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; HYDROGEN BOND; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; STATIC ELECTRICITY; THERMOSTABILITY; TRANS ISOMER; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR DOCKING;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FURIN; HEK293 CELLS; HUMANS; HYDROGEN BONDING; MOLECULAR DOCKING SIMULATION; PEPTIDES; PROTEASE INHIBITORS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 85042030902     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.7b01124     Document Type: Article

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