Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

Science

Volumn 359, Issue 6376, 2018, Pages 693-697

  Gandal, Michael J ^a,b   Haney, Jillian R ^a,b   Parikshak, Neelroop N ^a,b   Leppa, Virpi ^a,b   Ramaswami, Gokul ^a,b   Hartl, Chris ^a,b   Schork, Andrew J ^c   Appadurai, Vivek ^c   Buil, Alfonso ^c   Werge, Thomas M ^c,d,e   Liu, Chunyu ^f,g   White, Kevin P ^h,i   Horvath, Steve ^b   Geschwind, Daniel H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Institute of Biological Psychiatry   (Denmark)

^d Aarhus   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^g CENTRAL SOUTH UNIVERSITY   (China)

^h UNIVERSITY OF CHICAGO   (United States)

ⁱ Tempus Labs Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROLEPTIC AGENT;

BRAIN; DISABILITY; GENE EXPRESSION; MOLECULAR ANALYSIS; NERVOUS SYSTEM DISORDER; PATHOLOGY;

ALCOHOLISM; ARTICLE; AUTISM; BIPOLAR DISORDER; BRAIN DYSFUNCTION; DEPRESSION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; GENE EXPRESSION; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HUMAN; MENTAL DISEASE; MOLECULAR GENETICS; MOLECULAR PATHOLOGY; MULTIFACTORIAL INHERITANCE; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS; BRAIN CORTEX; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; NEUROLOGIC DISEASE;

CEREBRAL CORTEX; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MENTAL DISORDERS; MULTIFACTORIAL INHERITANCE; NERVOUS SYSTEM DISEASES; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSCRIPTION, GENETIC;

EID: 85041925301     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad6469     Document Type: Article

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