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Volumn 10, Issue , 2018, Pages

New progress on the role of glia in iron metabolism and iron-induced degeneration of dopamine neurons in Parkinson’s disease

Author keywords

Dopamine neurons; Glia; Iron; Iron transporters; Parkinson s disease

Indexed keywords

ALPHA SYNUCLEIN; APOTRANSFERRIN; CD200 ANTIGEN; CD71 ANTIGEN; CERULOPLASMIN; FERRITIN; FERROPORTIN 1; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLYCOSYLPHOSPHATIDYLINOSITOL; HEME OXYGENASE 1; HEPCIDIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTOFERRIN; LIPOPOLYSACCHARIDE; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NERVE GROWTH FACTOR; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OXIDOPAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; STAT3 PROTEIN; TRANSFERRIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TUMOR NECROSIS FACTOR;

EID: 85041293979     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2017.00455     Document Type: Review
Times cited : (52)

References (106)
  • 1
    • 57049113728 scopus 로고    scopus 로고
    • Effect of transferrin on hypomyelination induced by iron deficiency
    • Badaracco, M. E., Ortiz, E. H., Soto, E. F., Connor, J., and Pasquini, J. M. (2008). Effect of transferrin on hypomyelination induced by iron deficiency. J. Neurosci. Res. 86, 2663-2673. doi: 10.1002/jnr.21709
    • (2008) J. Neurosci. Res , vol.86 , pp. 2663-2673
    • Badaracco, M.E.1    Ortiz, E.H.2    Soto, E.F.3    Connor, J.4    Pasquini, J.M.5
  • 2
    • 0028641617 scopus 로고
    • Three-dimensional structure of lactoferrin in various functional states
    • Baker, E. N., Anderson, B. F., Baker, H. M., Day, C. L., Haridas, M., Norris, G. E., et al. (1994). Three-dimensional structure of lactoferrin in various functional states. Adv. Exp. Med. Biol. 357, 1-12. doi: 10.1007/978-1-4615-2548-6_1
    • (1994) Adv. Exp. Med. Biol , vol.357 , pp. 1-12
    • Baker, E.N.1    Anderson, B.F.2    Baker, H.M.3    Day, C.L.4    Haridas, M.5    Norris, G.E.6
  • 3
    • 0031930771 scopus 로고    scopus 로고
    • Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson’s disease
    • Banati, R. B., Daniel, S. E., and Blunt, S. B. (1998). Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson’s disease. Mov. Disord. 13, 221-227. doi: 10.1002/mds.870130205
    • (1998) Mov. Disord , vol.13 , pp. 221-227
    • Banati, R.B.1    Daniel, S.E.2    Blunt, S.B.3
  • 4
    • 34848846081 scopus 로고    scopus 로고
    • Marked microglial reaction in normal aging human substantia nigra: Correlation with extraneuronal neuromelanin pigment deposits
    • Beach, T. G., Sue, L. I., Walker, D. G., Lue, L. F., Connor, D. J., Caviness, J. N., et al. (2007). Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits. Acta Neuropathol. 114, 419-424. doi: 10.1007/s00401-007-0250-5
    • (2007) Acta Neuropathol , vol.114 , pp. 419-424
    • Beach, T.G.1    Sue, L.I.2    Walker, D.G.3    Lue, L.F.4    Connor, D.J.5    Caviness, J.N.6
  • 5
    • 84871664204 scopus 로고    scopus 로고
    • EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson’s disease
    • Berardelli, A., Wenning, G. K., Antonini, A., Berg, D., Bloem, B. R., Bonifati, V., et al. (2013). EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson’s disease. Eur. J. Neurol. 20, 16-34. doi: 10.1111/ene. 12022
    • (2013) Eur. J. Neurol , vol.20 , pp. 16-34
    • Berardelli, A.1    Wenning, G.K.2    Antonini, A.3    Berg, D.4    Bloem, B.R.5    Bonifati, V.6
  • 6
    • 33744901442 scopus 로고    scopus 로고
    • In vivo detection of iron and neuromelanin by transcranial sonography-a new approach for early detection of substantia nigra damage
    • Berg, D. (2006). In vivo detection of iron and neuromelanin by transcranial sonography-a new approach for early detection of substantia nigra damage. J. Neural Transm. 113, 775-780. doi: 10.1007/s00702-005-0447-5
    • (2006) J. Neural Transm , vol.113 , pp. 775-780
    • Berg, D.1
  • 7
    • 35748939409 scopus 로고    scopus 로고
    • Neuronal ‘On’ and ‘Off’ signals control microglia
    • Biber, K., Neumann, H., Inoue, K., and Boddeke, H. W. (2007). Neuronal ‘On’ and ‘Off’ signals control microglia. Trends Neurosci. 30, 596-602. doi: 10.1016/j.tins. 2007.08.007
    • (2007) Trends Neurosci , vol.30 , pp. 596-602
    • Biber, K.1    Neumann, H.2    Inoue, K.3    Boddeke, H.W.4
  • 8
    • 79951960174 scopus 로고    scopus 로고
    • Accumulation of non-transferrin-bound iron by neurons, astrocytes, and microglia
    • Bishop, G. M., Dang, T. N., Dringen, R., and Robinson, S. R. (2011). Accumulation of non-transferrin-bound iron by neurons, astrocytes, and microglia. Neurotox. Res. 19, 443-451. doi: 10.1007/s12640-010-9195-x
    • (2011) Neurotox. Res , vol.19 , pp. 443-451
    • Bishop, G.M.1    Dang, T.N.2    Dringen, R.3    Robinson, S.R.4
  • 9
    • 77954534911 scopus 로고    scopus 로고
    • Synergistic accumulation of iron and zinc by cultured astrocytes
    • Bishop, G. M., Scheiber, I. F., Dringen, R., and Robinson, S. R. (2010). Synergistic accumulation of iron and zinc by cultured astrocytes. J. Neural Transm. 117, 809-817. doi: 10.1007/s00702-010-0420-9
    • (2010) J. Neural Transm , vol.117 , pp. 809-817
    • Bishop, G.M.1    Scheiber, I.F.2    Dringen, R.3    Robinson, S.R.4
  • 10
    • 36749051047 scopus 로고    scopus 로고
    • Chronic microglial activation and progressive dopaminergic neurotoxicity
    • Block, M. L., and Hong, J. S. (2007). Chronic microglial activation and progressive dopaminergic neurotoxicity. Biochem. Soc. Trans. 35, 1127-1132. doi: 10.1042/BST0351127
    • (2007) Biochem. Soc. Trans , vol.35 , pp. 1127-1132
    • Block, M.L.1    Hong, J.S.2
  • 11
    • 84877707641 scopus 로고    scopus 로고
    • Specificity and sensitivity of transcranial sonography of the substantia nigra in the diagnosis of Parkinson’s disease: Prospective cohort study in 196 patients
    • Bouwmans, A. E., Vlaar, A. M., Mess, W. H., Kessels, A., and Weber, W. E. (2013). Specificity and sensitivity of transcranial sonography of the substantia nigra in the diagnosis of Parkinson’s disease: prospective cohort study in 196 patients. BMJ Open 3:e002613. doi: 10.1136/bmjopen-2013-00 2613
    • (2013) BMJ Open , vol.3
    • Bouwmans, A.E.1    Vlaar, A.M.2    Mess, W.H.3    Kessels, A.4    Weber, W.E.5
  • 12
    • 84949725441 scopus 로고    scopus 로고
    • Glia and alpha-synuclein in neurodegeneration: A complex interaction
    • Bruck, D., Wenning, G. K., Stefanova, N., and Fellner, L. (2016). Glia and alpha-synuclein in neurodegeneration: a complex interaction. Neurobiol. Dis. 85, 262-274. doi: 10.1016/j.nbd.2015.03.003
    • (2016) Neurobiol. Dis , vol.85 , pp. 262-274
    • Bruck, D.1    Wenning, G.K.2    Stefanova, N.3    Fellner, L.4
  • 13
    • 0035892632 scopus 로고    scopus 로고
    • Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat
    • Burdo, J. R., Menzies, S. L., Simpson, I. A., Garrick, L. M., Garrick, M. D., Dolan, K. G., et al. (2001). Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J. Neurosci. Res. 66, 1198-1207. doi: 10.1002/jnr.1256
    • (2001) J. Neurosci. Res , vol.66 , pp. 1198-1207
    • Burdo, J.R.1    Menzies, S.L.2    Simpson, I.A.3    Garrick, L.M.4    Garrick, M.D.5    Dolan, K.G.6
  • 14
    • 17844406433 scopus 로고    scopus 로고
    • Intra-parenchymal injection of tumor necrosis factor-alpha and interleukin 1-beta produces dopamine neuron loss in the rat
    • Carvey, P. M., Chen, E. Y., Lipton, J. W., Tong, C. W., Chang, Q. A., and Ling, Z. D. (2005). Intra-parenchymal injection of tumor necrosis factor-alpha and interleukin 1-beta produces dopamine neuron loss in the rat. J. Neural Transm. 112, 601-612. doi: 10.1007/s00702-004-0222-z
    • (2005) J. Neural Transm , vol.112 , pp. 601-612
    • Carvey, P.M.1    Chen, E.Y.2    Lipton, J.W.3    Tong, C.W.4    Chang, Q.A.5    Ling, Z.D.6
  • 15
    • 25844475970 scopus 로고    scopus 로고
    • TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis
    • Chen, T. T., Li, L., Chung, D. H., Allen, C. D., Torti, S. V., Torti, F. M., et al. (2005). TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J. Exp. Med. 202, 955-965. doi: 10.1084/jem.20042433
    • (2005) J. Exp. Med , vol.202 , pp. 955-965
    • Chen, T.T.1    Li, L.2    Chung, D.H.3    Allen, C.D.4    Torti, S.V.5    Torti, F.M.6
  • 16
    • 84902549638 scopus 로고    scopus 로고
    • Neuroinflammation and M2 microglia: The good, the bad, and the inflamed
    • Cherry, J. D., Olschowka, J. A., and O’Banion, M. K. (2014). Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J. Neuroinflammation 11:98. doi: 10.1186/1742-2094-11-98
    • (2014) J. Neuroinflammation , vol.11 , pp. 98
    • Cherry, J.D.1    Olschowka, J.A.2    O’Banion, M.K.3
  • 17
    • 70449526190 scopus 로고    scopus 로고
    • Heterogeneity of microglial activation in the innate immune response in the brain
    • Colton, C. A. (2009). Heterogeneity of microglial activation in the innate immune response in the brain. J. Neuroimmune Pharmacol. 4, 399-418. doi: 10.1007/s11481-009-9164-4
    • (2009) J. Neuroimmune Pharmacol , vol.4 , pp. 399-418
    • Colton, C.A.1
  • 18
    • 0025821265 scopus 로고
    • Alterations in the levels of iron, ferritin and other trace metals in Parkinson’s disease and other neurodegenerative diseases affecting the basal ganglia
    • Dexter, D. T., Carayon, A., Javoy-Agid, F., Agid, Y., Wells, F. R., Daniel, S. E., et al. (1991). Alterations in the levels of iron, ferritin and other trace metals in Parkinson’s disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114, 1953-1975. doi: 10.1093/brain/114.4.1953
    • (1991) Brain , vol.114 , pp. 1953-1975
    • Dexter, D.T.1    Carayon, A.2    Javoy-Agid, F.3    Agid, Y.4    Wells, F.R.5    Daniel, S.E.6
  • 19
    • 0024356620 scopus 로고
    • Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson’s disease
    • Dexter, D. T., Wells, F. R., Lees, A. J., Agid, F., Agid, Y., Jenner, P., et al. (1989). Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson’s disease. J. Neurochem. 52, 1830-1836. doi: 10.1111/j.1471-4159.1989.tb07264.x
    • (1989) J. Neurochem , vol.52 , pp. 1830-1836
    • Dexter, D.T.1    Wells, F.R.2    Lees, A.J.3    Agid, F.4    Agid, Y.5    Jenner, P.6
  • 20
    • 34848815312 scopus 로고    scopus 로고
    • The pivotal role of astrocytes in the metabolism of iron in the brain
    • Dringen, R., Bishop, G. M., Koeppe, M., Dang, T. N., and Robinson, S. R. (2007). The pivotal role of astrocytes in the metabolism of iron in the brain. Neurochem. Res. 32, 1884-1890. doi: 10.1007/s11064-007-9375-0
    • (2007) Neurochem. Res , vol.32 , pp. 1884-1890
    • Dringen, R.1    Bishop, G.M.2    Koeppe, M.3    Dang, T.N.4    Robinson, S.R.5
  • 21
    • 28544449476 scopus 로고    scopus 로고
    • Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter
    • Erikson, K. M., and Aschner, M. (2006). Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter. Neurotoxicology 27, 125-130. doi: 10.1016/j.neuro.2005. 07.003
    • (2006) Neurotoxicology , vol.27 , pp. 125-130
    • Erikson, K.M.1    Aschner, M.2
  • 22
    • 0028662387 scopus 로고
    • Single intracerebral injection of apotransferrin in young rats induces increased myelination
    • Escobar Cabrera, O. E., Bongarzone, E. R., Soto, E. F., and Pasquini, J. M. (1994). Single intracerebral injection of apotransferrin in young rats induces increased myelination. Dev. Neurosci. 16, 248-254. doi: 10.1159/000112116
    • (1994) Dev. Neurosci , vol.16 , pp. 248-254
    • Escobar Cabrera, O.E.1    Bongarzone, E.R.2    Soto, E.F.3    Pasquini, J.M.4
  • 23
    • 0030968309 scopus 로고    scopus 로고
    • Single intracranial injection of apotransferrin in young rats increases the expression of specific myelin protein mRNA
    • Escobar Cabrera, O. E., Zakin, M. M., Soto, E. F., and Pasquini, J. M. (1997). Single intracranial injection of apotransferrin in young rats increases the expression of specific myelin protein mRNA. J. Neurosci. Res. 47, 603-608. doi: 10.1002/(SICI)1097-4547(19970315)47:6<603::AID-JNR5>3.0.CO;2-H
    • (1997) J. Neurosci. Res , vol.47 , pp. 603-608
    • Escobar Cabrera, O.E.1    Zakin, M.M.2    Soto, E.F.3    Pasquini, J.M.4
  • 24
    • 0028786932 scopus 로고
    • Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease
    • Faucheux, B. A., Nillesse, N., Damier, P., Spik, G., Mouatt-Prigent, A., Pierce, A., et al. (1995). Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease. Proc. Natl. Acad. Sci. U.S.A. 92, 9603-9607. doi: 10.1073/pnas.92.21.9603
    • (1995) Proc. Natl. Acad. Sci. U.S.A , vol.92 , pp. 9603-9607
    • Faucheux, B.A.1    Nillesse, N.2    Damier, P.3    Spik, G.4    Mouatt-Prigent, A.5    Pierce, A.6
  • 26
    • 0035976727 scopus 로고    scopus 로고
    • Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment
    • Fillebeen, C., Ruchoux, M. M., Mitchell, V., Vincent, S., Benaissa, M., and Pierce, A. (2001). Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment. Brain Res. Mol. Brain Res. 96, 103-113. doi: 10.1016/S0169-328X(01) 00216-9
    • (2001) Brain Res. Mol. Brain Res , vol.96 , pp. 103-113
    • Fillebeen, C.1    Ruchoux, M.M.2    Mitchell, V.3    Vincent, S.4    Benaissa, M.5    Pierce, A.6
  • 27
  • 28
    • 84946493245 scopus 로고    scopus 로고
    • Paving the way for adequate myelination: The contribution of galectin-3, transferrin and iron
    • Franco, P. G., Pasquini, L. A., Perez, M. J., Rosato-Siri, M. V., Silvestroff, L., and Pasquini, J. M. (2015). Paving the way for adequate myelination: the contribution of galectin-3, transferrin and iron. FEBS Lett. 589, 3388-3395. doi: 10.1016/j.febslet.2015.08.001
    • (2015) FEBS Lett , vol.589 , pp. 3388-3395
    • Franco, P.G.1    Pasquini, L.A.2    Perez, M.J.3    Rosato-Siri, M.V.4    Silvestroff, L.5    Pasquini, J.M.6
  • 29
    • 0024324152 scopus 로고
    • Do oligodendrocytes mediate iron regulation in the human brain?
    • Gerber, M. R., and Connor, J. R. (1989). Do oligodendrocytes mediate iron regulation in the human brain? Ann. Neurol. 26, 95-98. doi: 10.1002/ana. 410260115
    • (1989) Ann. Neurol , vol.26 , pp. 95-98
    • Gerber, M.R.1    Connor, J.R.2
  • 30
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., and Gage, F. H. (2010). Mechanisms underlying inflammation in neurodegeneration. Cell 140, 918- 934. doi: 10.1016/j.cell.2010.02.016
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 31
    • 77951077317 scopus 로고    scopus 로고
    • Astrocytic expression of Parkinson’s disease-related A53T alpha-synuclein causes neurodegeneration in mice
    • Gu, X. L., Long, C. X., Sun, L., Xie, C., Lin, X., and Cai, H. (2010). Astrocytic expression of Parkinson’s disease-related A53T alpha-synuclein causes neurodegeneration in mice. Mol. Brain 3:12. doi: 10.1186/1756-66 06-3-12
    • (2010) Mol. Brain , vol.3 , pp. 12
    • Gu, X.L.1    Long, C.X.2    Sun, L.3    Xie, C.4    Lin, X.5    Cai, H.6
  • 32
    • 84975702009 scopus 로고    scopus 로고
    • Regionally progressive accumulation of iron in Parkinson’s disease as measured by quantitative susceptibility mapping
    • Guan, X., Xuan, M., Gu, Q., Huang, P., Liu, C., Wang, N., et al. (2017). Regionally progressive accumulation of iron in Parkinson’s disease as measured by quantitative susceptibility mapping. NMR Biomed. 30:e3489. doi: 10.1002/nbm.3489
    • (2017) NMR Biomed , vol.30
    • Guan, X.1    Xuan, M.2    Gu, Q.3    Huang, P.4    Liu, C.5    Wang, N.6
  • 33
    • 79951499176 scopus 로고    scopus 로고
    • Glia: Initiators and progressors of pathology in Parkinson’s disease
    • Halliday, G. M., and Stevens, C. H. (2011). Glia: initiators and progressors of pathology in Parkinson’s disease. Mov. Disord. 26, 6-17. doi: 10.1002/mds. 23455
    • (2011) Mov. Disord , vol.26 , pp. 6-17
    • Halliday, G.M.1    Stevens, C.H.2
  • 34
    • 1442323987 scopus 로고    scopus 로고
    • Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate
    • Hoepken, H. H., Korten, T., Robinson, S. R., and Dringen, R. (2004). Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate. J. Neurochem. 88, 1194-1202. doi: 10.1046/j.1471-4159. 2003.02236.x
    • (2004) J. Neurochem , vol.88 , pp. 1194-1202
    • Hoepken, H.H.1    Korten, T.2    Robinson, S.R.3    Dringen, R.4
  • 35
    • 85013883035 scopus 로고    scopus 로고
    • In vivo detection of lateral-ventral tier nigral degeneration in Parkinson’s disease
    • Huddleston, D. E., Langley, J., Sedlacik, J., Boelmans, K., Factor, S. A., and Hu, X. P. (2017). In vivo detection of lateral-ventral tier nigral degeneration in Parkinson’s disease. Hum. Brain Mapp. 38, 2627-2634. doi: 10.1002/hbm. 23547
    • (2017) Hum. Brain Mapp , vol.38 , pp. 2627-2634
    • Huddleston, D.E.1    Langley, J.2    Sedlacik, J.3    Boelmans, K.4    Factor, S.A.5    Hu, X.P.6
  • 36
    • 0032956629 scopus 로고    scopus 로고
    • Characterization and distribution of ferritin binding sites in the adult mouse brain
    • Hulet, S. W., Hess, E. J., Debinski, W., Arosio, P., Bruce, K., Powers, S., et al. (1999). Characterization and distribution of ferritin binding sites in the adult mouse brain. J. Neurochem. 72, 868-874. doi: 10.1046/j.1471-4159.1999.720868.x
    • (1999) J. Neurochem , vol.72 , pp. 868-874
    • Hulet, S.W.1    Hess, E.J.2    Debinski, W.3    Arosio, P.4    Bruce, K.5    Powers, S.6
  • 37
    • 84887445769 scopus 로고    scopus 로고
    • Phenotypic polarization of activated astrocytes: The critical role of lipocalin-2 in the classical inflammatory activation of astrocytes
    • Jang, E., Kim, J. H., Lee, S., Kim, J. H., Seo, J. W., Jin, M., et al. (2013a). Phenotypic polarization of activated astrocytes: the critical role of lipocalin-2 in the classical inflammatory activation of astrocytes. J. Immunol. 191, 5204-5219. doi: 10. 4049/jimmunol.1301637
    • (2013) J. Immunol , vol.191 , pp. 5204-5219
    • Jang, E.1    Kim, J.H.2    Lee, S.3    Kim, J.H.4    Seo, J.W.5    Jin, M.6
  • 38
    • 84874615861 scopus 로고    scopus 로고
    • Secreted protein lipocalin-2 promotes microglial M1 polarization
    • Jang, E., Lee, S., Kim, J. H., Kim, J. H., Seo, J. W., Lee, W. H., et al. (2013b). Secreted protein lipocalin-2 promotes microglial M1 polarization. FASEB J. 27, 1176-1190. doi: 10.1096/fj.12-222257
    • (2013) FASEB J , vol.27 , pp. 1176-1190
    • Jang, E.1    Lee, S.2    Kim, J.H.3    Kim, J.H.4    Seo, J.W.5    Lee, W.H.6
  • 39
    • 0038711587 scopus 로고    scopus 로고
    • Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system
    • Jeong, S. Y., and David, S. (2003). Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system. J. Biol. Chem. 278, 27144-27148. doi: 10.1074/jbc.M301988200
    • (2003) J. Biol. Chem , vol.278 , pp. 27144-27148
    • Jeong, S.Y.1    David, S.2
  • 40
    • 84920158533 scopus 로고    scopus 로고
    • Diverse functional roles of lipocalin-2 in the central nervous system
    • Jha, M. K., Lee, S., Park, D. H., Kook, H., Park, K. G., Lee, I. K., et al. (2015). Diverse functional roles of lipocalin-2 in the central nervous system. Neurosci. Biobehav. Rev. 49, 135-156. doi: 10.1016/j.neubiorev.2014.12.006
    • (2015) Neurosci. Biobehav. Rev , vol.49 , pp. 135-156
    • Jha, M.K.1    Lee, S.2    Park, D.H.3    Kook, H.4    Park, K.G.5    Lee, I.K.6
  • 41
    • 77949261597 scopus 로고    scopus 로고
    • Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent
    • Jiang, H., Song, N., Xu, H., Zhang, S., Wang, J., and Xie, J. (2010). Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent. Cell Res. 20, 345-356. doi: 10.1038/cr.2010.20
    • (2010) Cell Res , vol.20 , pp. 345-356
    • Jiang, H.1    Song, N.2    Xu, H.3    Zhang, S.4    Wang, J.5    Xie, J.6
  • 42
    • 84962197452 scopus 로고    scopus 로고
    • Brain iron metabolism dysfunction in Parkinson’s disease
    • Jiang, H., Wang, J., Rogers, J., and Xie, J. (2017). Brain iron metabolism dysfunction in Parkinson’s disease. Mol. Neurobiol. 54, 3078-3101. doi: 10.1007/s12035-016-9879-1
    • (2017) Mol. Neurobiol , vol.54 , pp. 3078-3101
    • Jiang, H.1    Wang, J.2    Rogers, J.3    Xie, J.4
  • 43
    • 80051937861 scopus 로고    scopus 로고
    • Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells
    • Jiang, R., Lopez, V., Kelleher, S. L., and Lonnerdal, B. (2011). Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells. J. Cell Physiol. 226, 3022-3031. doi: 10.1002/jcp.22650
    • (2011) J. Cell Physiol , vol.226 , pp. 3022-3031
    • Jiang, R.1    Lopez, V.2    Kelleher, S.L.3    Lonnerdal, B.4
  • 44
    • 84969262473 scopus 로고    scopus 로고
    • Pathogenic upregulation of glial lipocalin-2 in the parkinsonian dopaminergic system
    • Kim, B. W., Jeong, K. H., Kim, J. H., Jin, M., Kim, J. H., Lee, M. G., et al. (2016). Pathogenic upregulation of glial lipocalin-2 in the parkinsonian dopaminergic system. J. Neurosci. 36, 5608-5622. doi: 10.1523/JNEUROSCI.4261-15.2016
    • (2016) J. Neurosci , vol.36 , pp. 5608-5622
    • Kim, B.W.1    Jeong, K.H.2    Kim, J.H.3    Jin, M.4    Kim, J.H.5    Lee, M.G.6
  • 46
    • 84910058865 scopus 로고    scopus 로고
    • Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microglia
    • Lazzaro, M., Bettegazzi, B., Barbariga, M., Codazzi, F., Zacchetti, D., and Alessio, M. (2014). Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microglia. J. Neuroinflammation 11:164. doi: 10.1186/s12974-014-0164-9
    • (2014) J. Neuroinflammation , vol.11 , pp. 164
    • Lazzaro, M.1    Bettegazzi, B.2    Barbariga, M.3    Codazzi, F.4    Zacchetti, D.5    Alessio, M.6
  • 47
    • 84989844583 scopus 로고    scopus 로고
    • Protective microglia and their regulation in Parkinson’s disease
    • Le, W., Wu, J., and Tang, Y. (2016). Protective microglia and their regulation in Parkinson’s disease. Front. Mol. Neurosci. 9:89. doi: 10.3389/fnmol.2016.00089
    • (2016) Front. Mol. Neurosci , vol.9 , pp. 89
    • Le, W.1    Wu, J.2    Tang, Y.3
  • 48
    • 77950571596 scopus 로고    scopus 로고
    • Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies
    • Lee, H. J., Suk, J. E., Patrick, C., Bae, E. J., Cho, J. H., Rho, S., et al. (2010). Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J. Biol. Chem. 285, 9262-9272. doi: 10.1074/jbc. M109.081125
    • (2010) J. Biol. Chem , vol.285 , pp. 9262-9272
    • Lee, H.J.1    Suk, J.E.2    Patrick, C.3    Bae, E.J.4    Cho, J.H.5    Rho, S.6
  • 49
    • 84934989276 scopus 로고    scopus 로고
    • Lipocalin-2 in the inflammatory activation of brain astrocytes
    • Lee, S., Jha, M. K., and Suk, K. (2015). Lipocalin-2 in the inflammatory activation of brain astrocytes. Crit. Rev. Immunol. 35, 77-84. doi: 10.1615/CritRevImmunol. 2015012127
    • (2015) Crit. Rev. Immunol , vol.35 , pp. 77-84
    • Lee, S.1    Jha, M.K.2    Suk, K.3
  • 50
    • 84855907566 scopus 로고    scopus 로고
    • Regulation by lipocalin-2 of neuronal cell death, migration, and morphology
    • Lee, S., Lee, W. H., Lee, M. S., Mori, K., and Suk, K. (2012). Regulation by lipocalin-2 of neuronal cell death, migration, and morphology. J. Neurosci. Res. 90, 540-550. doi: 10.1002/jnr.22779
    • (2012) J. Neurosci. Res , vol.90 , pp. 540-550
    • Lee, S.1    Lee, W.H.2    Lee, M.S.3    Mori, K.4    Suk, K.5
  • 51
    • 58149477863 scopus 로고    scopus 로고
    • Scara5 is a ferritin receptor mediating non-transferrin iron delivery
    • Li, J. Y., Paragas, N., Ned, R. M., Qiu, A., Viltard, M., Leete, T., et al. (2009). Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev. Cell 16, 35-46. doi: 10.1016/j.devcel.2008.12.002
    • (2009) Dev. Cell , vol.16 , pp. 35-46
    • Li, J.Y.1    Paragas, N.2    Ned, R.M.3    Qiu, A.4    Viltard, M.5    Leete, T.6
  • 52
  • 53
    • 85019915133 scopus 로고    scopus 로고
    • Extensive uptake of alpha-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
    • Lindstrom, V., Gustafsson, G., Sanders, L. H., Howlett, E. H., Sigvardson, J., Kasrayan, A., et al. (2017). Extensive uptake of alpha-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage. Mol. Cell. Neurosci. 82, 143-156. doi: 10.1016/j.mcn.2017.04.009
    • (2017) Mol. Cell. Neurosci , vol.82 , pp. 143-156
    • Lindstrom, V.1    Gustafsson, G.2    Sanders, L.H.3    Howlett, E.H.4    Sigvardson, J.5    Kasrayan, A.6
  • 54
    • 84871225910 scopus 로고    scopus 로고
    • Endogenous repair by the activation of cell survival signalling cascades during the early stages of rat Parkinsonism
    • Lui, N. P., Chen, L. W., Yung, W. H., Chan, Y. S., and Yung, K. K. (2012). Endogenous repair by the activation of cell survival signalling cascades during the early stages of rat Parkinsonism. PLOS ONE 7:e51294. doi: 10.1371/journal. pone.0051294
    • (2012) PLOS ONE , vol.7
    • Lui, N.P.1    Chen, L.W.2    Yung, W.H.3    Chan, Y.S.4    Yung, K.K.5
  • 55
    • 34547680192 scopus 로고    scopus 로고
    • CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: A role for IL-4
    • Lyons, A., Downer, E. J., Crotty, S., Nolan, Y. M., Mills, K. H., and Lynch, M. A. (2007). CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4. J. Neurosci. 27, 8309-8313. doi: 10.1523/JNEUROSCI.1781-07.2007
    • (2007) J. Neurosci , vol.27 , pp. 8309-8313
    • Lyons, A.1    Downer, E.J.2    Crotty, S.3    Nolan, Y.M.4    Mills, K.H.5    Lynch, M.A.6
  • 56
    • 0037266963 scopus 로고    scopus 로고
    • Morphological changes of myelin sheaths in rats intracranially injected with apotransferrin
    • Marta, C. B., Paez, P., Lopez, M., Pellegrino de Iraldi, A., Soto, E. F., and Pasquini, J. M. (2003). Morphological changes of myelin sheaths in rats intracranially injected with apotransferrin. Neurochem. Res. 28, 101-110. doi: 10.1023/A: 1021604413737
    • (2003) Neurochem. Res , vol.28 , pp. 101-110
    • Marta, C.B.1    Paez, P.2    Lopez, M.3    Pellegrino De Iraldi, A.4    Soto, E.F.5    Pasquini, J.M.6
  • 57
    • 42049123661 scopus 로고    scopus 로고
    • Midbrain iron content in early Parkinson disease: A potential biomarker of disease status
    • Martin, W. R., Wieler, M., and Gee, M. (2008). Midbrain iron content in early Parkinson disease: a potential biomarker of disease status. Neurology 70, 1411- 1417. doi: 10.1212/01.wnl.0000286384.31050.b5
    • (2008) Neurology , vol.70 , pp. 1411-1417
    • Martin, W.R.1    Wieler, M.2    Gee, M.3
  • 58
    • 0028171374 scopus 로고
    • Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients
    • Mogi, M., Harada, M., Kondo, T., Riederer, P., Inagaki, H., Minami, M., et al. (1994). Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci. Lett. 180, 147-150. doi: 10.1016/0304-3940(94) 90508-8
    • (1994) Neurosci. Lett , vol.180 , pp. 147-150
    • Mogi, M.1    Harada, M.2    Kondo, T.3    Riederer, P.4    Inagaki, H.5    Minami, M.6
  • 59
    • 0030582991 scopus 로고    scopus 로고
    • Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson’s disease
    • Mogi, M., Harada, M., Narabayashi, H., Inagaki, H., Minami, M., and Nagatsu, T. (1996). Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson’s disease. Neurosci. Lett. 211, 13-16. doi: 10.1016/0304-3940(96)12706-3
    • (1996) Neurosci. Lett , vol.211 , pp. 13-16
    • Mogi, M.1    Harada, M.2    Narabayashi, H.3    Inagaki, H.4    Minami, M.5    Nagatsu, T.6
  • 60
    • 0029976834 scopus 로고    scopus 로고
    • Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system
    • Moos, T. (1996). Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system. J. Comp. Neurol. 375, 675-692. doi: 10.1002/(SICI)1096-9861(19961125)375:4<675:: AID-CNE8>3.0.CO;2-Z
    • (1996) J. Comp. Neurol , vol.375 , pp. 675-692
    • Moos, T.1
  • 61
    • 79955008182 scopus 로고    scopus 로고
    • Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death
    • Neher, J. J., Neniskyte, U., Zhao, J. W., Bal-Price, A., Tolkovsky, A. M., and Brown, G. C. (2011). Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. J. Immunol. 186, 4973-4983. doi: 10. 4049/jimmunol.1003600
    • (2011) J. Immunol , vol.186 , pp. 4973-4983
    • Neher, J.J.1    Neniskyte, U.2    Zhao, J.W.3    Bal-Price, A.4    Tolkovsky, A.M.5    Brown, G.C.6
  • 62
    • 0032149229 scopus 로고    scopus 로고
    • Characterization of a transferrin-independent iron uptake system in rat primary cultured cortical cells
    • Oshiro, S., Nozawa, K., Cai, Y., Hori, M., and Kitajima, S. (1998). Characterization of a transferrin-independent iron uptake system in rat primary cultured cortical cells. J. Med. Dent. Sci. 45, 171-176.
    • (1998) J. Med. Dent. Sci , vol.45 , pp. 171-176
    • Oshiro, S.1    Nozawa, K.2    Cai, Y.3    Hori, M.4    Kitajima, S.5
  • 63
    • 0030856558 scopus 로고    scopus 로고
    • A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes
    • Patel, B. N., and David, S. (1997). A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes. J. Biol. Chem. 272, 20185-20190. doi: 10.1074/jbc.272.32.20185
    • (1997) J. Biol. Chem , vol.272 , pp. 20185-20190
    • Patel, B.N.1    David, S.2
  • 64
    • 68649126827 scopus 로고    scopus 로고
    • Imaging neurodegeneration in Parkinson’s disease
    • Pavese, N., and Brooks, D. J. (2009). Imaging neurodegeneration in Parkinson’s disease. Biochim. Biophys. Acta 1792, 722-729. doi: 10.1016/j.bbadis.2008. 10.003
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 722-729
    • Pavese, N.1    Brooks, D.J.2
  • 65
    • 84877340972 scopus 로고    scopus 로고
    • Iron uptake in quiescent and inflammation-activated astrocytes: A potentially neuroprotective control of iron burden
    • Pelizzoni, I., Zacchetti, D., Campanella, A., Grohovaz, F., and Codazzi, F. (2013). Iron uptake in quiescent and inflammation-activated astrocytes: a potentially neuroprotective control of iron burden. Biochim. Biophys. Acta 1832, 1326- 1333. doi: 10.1016/j.bbadis.2013.04.007
    • (2013) Biochim. Biophys. Acta , vol.1832 , pp. 1326-1333
    • Pelizzoni, I.1    Zacchetti, D.2    Campanella, A.3    Grohovaz, F.4    Codazzi, F.5
  • 67
    • 84896413655 scopus 로고    scopus 로고
    • Lipopolysaccharides upregulate hepcidin in neuron via microglia and the IL-6/STAT3 signaling pathway
    • Qian, Z. M., He, X., Liang, T., Wu, K. C., Yan, Y. C., Lu, L. N., et al. (2014). Lipopolysaccharides upregulate hepcidin in neuron via microglia and the IL-6/STAT3 signaling pathway. Mol. Neurobiol. 50, 811-820. doi: 10.1007/s12035-014-8671-3
    • (2014) Mol. Neurobiol , vol.50 , pp. 811-820
    • Qian, Z.M.1    He, X.2    Liang, T.3    Wu, K.C.4    Yan, Y.C.5    Lu, L.N.6
  • 68
    • 84983071295 scopus 로고    scopus 로고
    • How neuroinflammation contributes to neurodegeneration
    • Ransohoff, R. M. (2016). How neuroinflammation contributes to neurodegeneration. Science 353, 777-783. doi: 10.1126/science.aag2590
    • (2016) Science , vol.353 , pp. 777-783
    • Ransohoff, R.M.1
  • 69
    • 77957048035 scopus 로고    scopus 로고
    • Astrocytes and therapeutics for Parkinson’s disease
    • Rappold, P. M., and Tieu, K. (2010). Astrocytes and therapeutics for Parkinson’s disease. Neurotherapeutics 7, 413-423. doi: 10.1016/j.nurt.2010.07.001
    • (2010) Neurotherapeutics , vol.7 , pp. 413-423
    • Rappold, P.M.1    Tieu, K.2
  • 70
    • 84858078783 scopus 로고    scopus 로고
    • Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-alpha and TGF-beta1
    • Rathore, K. I., Redensek, A., and David, S. (2012). Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-alpha and TGF-beta1. Glia 60, 738-750. doi: 10.1002/glia.22303
    • (2012) Glia , vol.60 , pp. 738-750
    • Rathore, K.I.1    Redensek, A.2    David, S.3
  • 71
    • 3242657100 scopus 로고    scopus 로고
    • Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells
    • Riemer, J., Hoepken, H. H., Czerwinska, H., Robinson, S. R., and Dringen, R. (2004). Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells. Anal. Biochem. 331, 370-375. doi: 10.1016/j.ab.2004.03.049
    • (2004) Anal. Biochem , vol.331 , pp. 370-375
    • Riemer, J.1    Hoepken, H.H.2    Czerwinska, H.3    Robinson, S.R.4    Dringen, R.5
  • 72
    • 84863442753 scopus 로고    scopus 로고
    • Astrocyte-derived GDNF is a potent inhibitor of microglial activation
    • Rocha, S. M., Cristovao, A. C., Campos, F. L., Fonseca, C. P., and Baltazar, G. (2012). Astrocyte-derived GDNF is a potent inhibitor of microglial activation. Neurobiol. Dis. 47, 407-415. doi: 10.1016/j.nbd.2012.04.014
    • (2012) Neurobiol. Dis , vol.47 , pp. 407-415
    • Rocha, S.M.1    Cristovao, A.C.2    Campos, F.L.3    Fonseca, C.P.4    Baltazar, G.5
  • 73
    • 85009513538 scopus 로고    scopus 로고
    • Iron availability compromises not only oligodendrocytes but also astrocytes and microglial cells
    • Rosato-Siri, M. V., Marziali, L., Guitart, M. E., Badaracco, M. E., Puntel, M., Pitossi, F., et al. (2017). Iron availability compromises not only oligodendrocytes but also astrocytes and microglial cells. Mol. Neurobiol. doi: 10.1007/s12035-016-0369-2 [Epub ahead of print].
    • (2017) Mol. Neurobiol
    • Rosato-Siri, M.V.1    Marziali, L.2    Guitart, M.E.3    Badaracco, M.E.4    Puntel, M.5    Pitossi, F.6
  • 74
    • 63049083734 scopus 로고    scopus 로고
    • A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    • Saijo, K., Winner, B., Carson, C. T., Collier, J. G., Boyer, L., Rosenfeld, M. G., et al. (2009). A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137, 47-59. doi: 10.1016/j.cell.2009.01.038
    • (2009) Cell , vol.137 , pp. 47-59
    • Saijo, K.1    Winner, B.2    Carson, C.T.3    Collier, J.G.4    Boyer, L.5    Rosenfeld, M.G.6
  • 75
    • 57449092273 scopus 로고    scopus 로고
    • Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson’s disease
    • Salazar, J., Mena, N., Hunot, S., Prigent, A., Alvarez-Fischer, D., Arredondo, M., et al. (2008). Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson’s disease. Proc. Natl. Acad. Sci. U.S.A. 105, 18578-18583. doi: 10.1073/pnas.0804373105
    • (2008) Proc. Natl. Acad. Sci. U.S.A , vol.105 , pp. 18578-18583
    • Salazar, J.1    Mena, N.2    Hunot, S.3    Prigent, A.4    Alvarez-Fischer, D.5    Arredondo, M.6
  • 77
    • 0038335842 scopus 로고    scopus 로고
    • Intranigral infusion of interleukin-1beta activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity
    • Saura, J., Pares, M., Bove, J., Pezzi, S., Alberch, J., Marin, C., et al. (2003). Intranigral infusion of interleukin-1beta activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity. J. Neurochem. 85, 651-661. doi: 10.1046/j. 1471-4159.2003.01676.x
    • (2003) J. Neurochem , vol.85 , pp. 651-661
    • Saura, J.1    Pares, M.2    Bove, J.3    Pezzi, S.4    Alberch, J.5    Marin, C.6
  • 78
    • 84859739036 scopus 로고    scopus 로고
    • Ferritin stimulates oligodendrocyte genesis in the adult spinal cord and can be transferred from macrophages to NG2 cells in vivo
    • Schonberg, D. L., Goldstein, E. Z., Sahinkaya, F. R., Wei, P., Popovich, P. G., and McTigue, D. M. (2012). Ferritin stimulates oligodendrocyte genesis in the adult spinal cord and can be transferred from macrophages to NG2 cells in vivo. J. Neurosci. 32, 5374-5384. doi: 10.1523/JNEUROSCI.3517-11.2012
    • (2012) J. Neurosci , vol.32 , pp. 5374-5384
    • Schonberg, D.L.1    Goldstein, E.Z.2    Sahinkaya, F.R.3    Wei, P.4    Popovich, P.G.5    McTigue, D.M.6
  • 79
    • 84859361252 scopus 로고    scopus 로고
    • Iron efflux from astrocytes plays a role in remyelination
    • Schulz, K., Kroner, A., and David, S. (2012). Iron efflux from astrocytes plays a role in remyelination. J. Neurosci. 32, 4841-4847. doi: 10.1523/JNEUROSCI.5328-11.2012
    • (2012) J. Neurosci , vol.32 , pp. 4841-4847
    • Schulz, K.1    Kroner, A.2    David, S.3
  • 80
    • 84943279504 scopus 로고    scopus 로고
    • Induction of microglial toll-like receptor 4 by prothrombin kringle-2: A potential pathogenic mechanism in Parkinson’s disease
    • Shin, W. H., Jeon, M. T., Leem, E., Won, S. Y., Jeong, K. H., Park, S. J., et al. (2015). Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson’s disease. Sci. Rep. 5:14764. doi: 10.1038/srep14764
    • (2015) Sci. Rep , vol.5
    • Shin, W.H.1    Jeon, M.T.2    Leem, E.3    Won, S.Y.4    Jeong, K.H.5    Park, S.J.6
  • 81
    • 0025963530 scopus 로고
    • Selective increase of iron in substantia nigra zona compacta of parkinsonian brains
    • Sofic, E., Paulus, W., Jellinger, K., Riederer, P., and Youdim, M. B. (1991). Selective increase of iron in substantia nigra zona compacta of parkinsonian brains. J. Neurochem. 56, 978-982. doi: 10.1111/j.1471-4159.1991.tb02017.x
    • (1991) J. Neurochem , vol.56 , pp. 978-982
    • Sofic, E.1    Paulus, W.2    Jellinger, K.3    Riederer, P.4    Youdim, M.B.5
  • 82
    • 72649090521 scopus 로고    scopus 로고
    • Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson’s disease
    • Song, N., Wang, J., Jiang, H., and Xie, J. (2010). Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson’s disease. Free Radic. Biol. Med. 48, 332-341. doi: 10.1016/j.freeradbiomed.2009.11.004
    • (2010) Free Radic. Biol. Med , vol.48 , pp. 332-341
    • Song, N.1    Wang, J.2    Jiang, H.3    Xie, J.4
  • 83
    • 70349917814 scopus 로고    scopus 로고
    • Mutant alpha-synuclein overexpression mediates early proinflammatory activity
    • Su, X., Federoff, H. J., and Maguire-Zeiss, K. A. (2009). Mutant alpha-synuclein overexpression mediates early proinflammatory activity. Neurotox. Res. 16, 238-254. doi: 10.1007/s12640-009-9053-x
    • (2009) Neurotox. Res , vol.16 , pp. 238-254
    • Su, X.1    Federoff, H.J.2    Maguire-Zeiss, K.A.3
  • 84
    • 0022339518 scopus 로고
    • Iron uptake by glial cells
    • Swaiman, K. F., and Machen, V. L. (1985). Iron uptake by glial cells. Neurochem. Res. 10, 1635-1644. doi: 10.1007/BF00988605
    • (1985) Neurochem. Res , vol.10 , pp. 1635-1644
    • Swaiman, K.F.1    Machen, V.L.2
  • 85
    • 0032519436 scopus 로고    scopus 로고
    • Evidence for non-transferrin-mediated uptake and release of iron and manganese in glial cell cultures from hypotransferrinemic mice
    • Takeda, A., Devenyi, A., and Connor, J. R. (1998). Evidence for non-transferrin-mediated uptake and release of iron and manganese in glial cell cultures from hypotransferrinemic mice. J. Neurosci. Res. 51, 454-462. doi: 10.1002/(SICI) 1097-4547(19980215)51:4<454::AID-JNR5>3.0.CO;2-B
    • (1998) J. Neurosci. Res , vol.51 , pp. 454-462
    • Takeda, A.1    Devenyi, A.2    Connor, J.R.3
  • 86
    • 65549095185 scopus 로고    scopus 로고
    • Oligodendrocytes and myelination: The role of iron
    • Todorich, B., Pasquini, J. M., Garcia, C. I., Paez, P. M., and Connor, J. R. (2009). Oligodendrocytes and myelination: the role of iron. Glia 57, 467-478. doi: 10.1002/glia.20784
    • (2009) Glia , vol.57 , pp. 467-478
    • Todorich, B.1    Pasquini, J.M.2    Garcia, C.I.3    Paez, P.M.4    Connor, J.R.5
  • 87
    • 56749156761 scopus 로고    scopus 로고
    • Tim-2 is the receptor for H-ferritin on oligodendrocytes
    • Todorich, B., Zhang, X., Slagle-Webb, B., Seaman, W. E., and Connor, J. R. (2008). Tim-2 is the receptor for H-ferritin on oligodendrocytes. J. Neurochem. 107, 1495-1505. doi: 10.1111/j.1471-4159.2008.05678.x
    • (2008) J. Neurochem , vol.107 , pp. 1495-1505
    • Todorich, B.1    Zhang, X.2    Slagle-Webb, B.3    Seaman, W.E.4    Connor, J.R.5
  • 88
    • 73949111296 scopus 로고    scopus 로고
    • Uptake of ferrous iron by cultured rat astrocytes
    • Tulpule, K., Robinson, S. R., Bishop, G. M., and Dringen, R. (2010). Uptake of ferrous iron by cultured rat astrocytes. J. Neurosci. Res. 88, 563-571. doi: 10. 1002/jnr.22217
    • (2010) J. Neurosci. Res , vol.88 , pp. 563-571
    • Tulpule, K.1    Robinson, S.R.2    Bishop, G.M.3    Dringen, R.4
  • 89
    • 0033973421 scopus 로고    scopus 로고
    • NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson’s disease brains
    • Wakabayashi, K., Hayashi, S., Yoshimoto, M., Kudo, H., and Takahashi, H. (2000). NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson’s disease brains. Acta Neuropathol. 99, 14-20. doi: 10.1007/PL00007400
    • (2000) Acta Neuropathol , vol.99 , pp. 14-20
    • Wakabayashi, K.1    Hayashi, S.2    Yoshimoto, M.3    Kudo, H.4    Takahashi, H.5
  • 91
    • 84880707773 scopus 로고    scopus 로고
    • Quantitative assessment of iron deposition in the midbrain using 3D-enhanced T2 star weighted angiography (ESWAN): A preliminary cross-sectional study of 20 Parkinson’s disease patients
    • Wang, C., Fan, G., Xu, K., and Wang, S. (2013). Quantitative assessment of iron deposition in the midbrain using 3D-enhanced T2 star weighted angiography (ESWAN): a preliminary cross-sectional study of 20 Parkinson’s disease patients. Magn. Reson. Imaging 31, 1068-1073. doi: 10.1016/j.mri.2013. 04.015
    • (2013) Magn. Reson. Imaging , vol.31 , pp. 1068-1073
    • Wang, C.1    Fan, G.2    Xu, K.3    Wang, S.4
  • 92
    • 84934880850 scopus 로고    scopus 로고
    • The protective effect of lactoferrin on ventral mesencephalon neurons against MPP + is not connected with its iron binding ability
    • Wang, J., Bi, M., Liu, H., Song, N., and Xie, J. (2015). The protective effect of lactoferrin on ventral mesencephalon neurons against MPP + is not connected with its iron binding ability. Sci. Rep. 5:10729. doi: 10.1038/srep 10729
    • (2015) Sci. Rep , vol.5
    • Wang, J.1    Bi, M.2    Liu, H.3    Song, N.4    Xie, J.5
  • 93
    • 34250014148 scopus 로고    scopus 로고
    • Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats
    • Wang, J., Jiang, H., and Xie, J. X. (2007). Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats. Eur. J. Neurosci. 25, 2766-2772. doi: 10.1111/j.1460-9568.2007.05515.x
    • (2007) Eur. J. Neurosci , vol.25 , pp. 2766-2772
    • Wang, J.1    Jiang, H.2    Xie, J.X.3
  • 94
    • 84874436258 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines modulate iron regulatory protein 1 expression and iron transportation through reactive oxygen/nitrogen species production in ventral mesencephalic neurons
    • Wang, J., Song, N., Jiang, H., Wang, J., and Xie, J. (2013). Pro-inflammatory cytokines modulate iron regulatory protein 1 expression and iron transportation through reactive oxygen/nitrogen species production in ventral mesencephalic neurons. Biochim. Biophys. Acta 1832, 618-625. doi: 10.1016/j.bbadis.2013.01.021
    • (2013) Biochim. Biophys. Acta , vol.1832 , pp. 618-625
    • Wang, J.1    Song, N.2    Jiang, H.3    Wang, J.4    Xie, J.5
  • 95
    • 59049094805 scopus 로고    scopus 로고
    • Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins
    • Wang, J., Xu, H. M., Yang, H. D., Du, X. X., Jiang, H., and Xie, J. X. (2009). Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins. Neurochem. Int. 54, 43-48. doi: 10.1016/j.neuint.2008. 10.003
    • (2009) Neurochem. Int , vol.54 , pp. 43-48
    • Wang, J.1    Xu, H.M.2    Yang, H.D.3    Du, X.X.4    Jiang, H.5    Xie, J.X.6
  • 96
    • 79953247926 scopus 로고    scopus 로고
    • Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: Roles of aging, superoxide, NADPH oxidase, and p38 MAPK
    • Wang, X. J., Zhang, S., Yan, Z. Q., Zhao, Y. X., Zhou, H. Y., Wang, Y., et al. (2011). Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK. Free Radic. Biol. Med. 50, 1094-1106. doi: 10.1016/j. freeradbiomed.2011.01.032
    • (2011) Free Radic. Biol. Med , vol.50 , pp. 1094-1106
    • Wang, X.J.1    Zhang, S.2    Yan, Z.Q.3    Zhao, Y.X.4    Zhou, H.Y.5    Wang, Y.6
  • 97
    • 0035732296 scopus 로고    scopus 로고
    • A light and electron microscopic study of the iron transporter protein DMT-1 in the monkey cerebral neocortex and hippocampus
    • Wang, X. S., Ong, W. Y., and Connor, J. R. (2001). A light and electron microscopic study of the iron transporter protein DMT-1 in the monkey cerebral neocortex and hippocampus. J. Neurocytol. 30, 353-360. doi: 10.1023/A:101446 4514793
    • (2001) J. Neurocytol , vol.30 , pp. 353-360
    • Wang, X.S.1    Ong, W.Y.2    Connor, J.R.3
  • 98
    • 84940656942 scopus 로고    scopus 로고
    • Assessment of cerebral iron content in patients with Parkinson’s disease by the susceptibility-weighted MRI
    • Wu, S. F., Zhu, Z. F., Kong, Y., Zhang, H. P., Zhou, G. Q., Jiang, Q. T., et al. (2014). Assessment of cerebral iron content in patients with Parkinson’s disease by the susceptibility-weighted MRI. Eur. Rev. Med. Pharmacol. Sci. 18, 2605-2608.
    • (2014) Eur. Rev. Med. Pharmacol. Sci , vol.18 , pp. 2605-2608
    • Wu, S.F.1    Zhu, Z.F.2    Kong, Y.3    Zhang, H.P.4    Zhou, G.Q.5    Jiang, Q.T.6
  • 99
    • 84942010842 scopus 로고    scopus 로고
    • Preferential heme oxygenase-1 activation in striatal astrocytes antagonizes dopaminergic neuron degeneration in MPTP-intoxicated mice
    • Xu, X., Song, N., Wang, R., Jiang, H., and Xie, J. (2016). Preferential heme oxygenase-1 activation in striatal astrocytes antagonizes dopaminergic neuron degeneration in MPTP-intoxicated mice. Mol. Neurobiol. 53, 5056-5065. doi: 10.1007/s12035-015-9437-2
    • (2016) Mol. Neurobiol , vol.53 , pp. 5056-5065
    • Xu, X.1    Song, N.2    Wang, R.3    Jiang, H.4    Xie, J.5
  • 100
    • 85024120954 scopus 로고    scopus 로고
    • Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis
    • You, L. H., Yan, C. Z., Zheng, B. J., Ci, Y. Z., Chang, S. Y., Yu, P., et al. (2017). Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis. Cell Death Dis. 8:e2676. doi: 10.1038/cddis.2017.93
    • (2017) Cell Death Dis , vol.8
    • You, L.H.1    Yan, C.Z.2    Zheng, B.J.3    Ci, Y.Z.4    Chang, S.Y.5    Yu, P.6
  • 101
    • 84860322835 scopus 로고    scopus 로고
    • Genomic analysis of reactive astrogliosis
    • Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., et al. (2012). Genomic analysis of reactive astrogliosis. J. Neurosci. 32, 6391-6410. doi: 10.1523/JNEUROSCI.6221-11.2012
    • (2012) J. Neurosci , vol.32 , pp. 6391-6410
    • Zamanian, J.L.1    Xu, L.2    Foo, L.C.3    Nouri, N.4    Zhou, L.5    Giffard, R.G.6
  • 102
    • 27844547163 scopus 로고    scopus 로고
    • In vivo detection of iron and neuromelanin by transcranial sonography: A new approach for early detection of substantia nigra damage
    • Zecca, L., Berg, D., Arzberger, T., Ruprecht, P., Rausch, W. D., Musicco, M., et al. (2005). In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage. Mov. Disord. 20, 1278-1285. doi: 10.1002/mds.20550
    • (2005) Mov. Disord , vol.20 , pp. 1278-1285
    • Zecca, L.1    Berg, D.2    Arzberger, T.3    Ruprecht, P.4    Rausch, W.D.5    Musicco, M.6
  • 103
    • 84907554716 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor inhibit ferrous iron influx via divalent metal transporter 1 and iron regulatory protein 1 regulation in ventral mesencephalic neurons
    • Zhang, H. Y., Song, N., Jiang, H., Bi, M. X., and Xie, J. X. (2014). Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor inhibit ferrous iron influx via divalent metal transporter 1 and iron regulatory protein 1 regulation in ventral mesencephalic neurons. Biochim. Biophys. Acta 1843, 2967-2975. doi: 10.1016/j.bbamcr.2014.09.010
    • (2014) Biochim. Biophys. Acta , vol.1843 , pp. 2967-2975
    • Zhang, H.Y.1    Song, N.2    Jiang, H.3    Bi, M.X.4    Xie, J.X.5
  • 104
    • 84885476383 scopus 로고    scopus 로고
    • 6-Hydroxydopamine promotes iron traffic in primary cultured astrocytes
    • Zhang, H. Y., Wang, N. D., Song, N., Xu, H. M., Shi, L. M., Jiang, H., et al. (2013). 6-Hydroxydopamine promotes iron traffic in primary cultured astrocytes. Biometals 26, 705-714. doi: 10.1007/s10534-013-9647-x
    • (2013) Biometals , vol.26 , pp. 705-714
    • Zhang, H.Y.1    Wang, N.D.2    Song, N.3    Xu, H.M.4    Shi, L.M.5    Jiang, H.6
  • 105
    • 84902548750 scopus 로고    scopus 로고
    • Role and mechanism of microglial activation in iron-induced selective and progressive dopaminergic neurodegeneration
    • Zhang, W., Yan, Z. F., Gao, J. H., Sun, L., Huang, X. Y., Liu, Z., et al. (2014). Role and mechanism of microglial activation in iron-induced selective and progressive dopaminergic neurodegeneration. Mol. Neurobiol. 49, 1153-1165. doi: 10.1007/s12035-013-8586-4
    • (2014) Mol. Neurobiol , vol.49 , pp. 1153-1165
    • Zhang, W.1    Yan, Z.F.2    Gao, J.H.3    Sun, L.4    Huang, X.Y.5    Liu, Z.6
  • 106
    • 33750535445 scopus 로고    scopus 로고
    • Cellular iron status influences the functional relationship between microglia and oligodendrocytes
    • Zhang, X., Surguladze, N., Slagle-Webb, B., Cozzi, A., and Connor, J. R. (2006). Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Glia 54, 795-804. doi: 10.1002/glia.20416
    • (2006) Glia , vol.54 , pp. 795-804
    • Zhang, X.1    Surguladze, N.2    Slagle-Webb, B.3    Cozzi, A.4    Connor, J.R.5


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