Adaptive mistranslation accelerates the evolution of fluconazole resistance and induces major genomic and gene expression alterations in Candida albicans

mSphere

Volumn 2, Issue 4, 2017, Pages

  Weil, Tobias ^a,b   Santamaría, Rodrigo ^c   Lee, Wanseon ^d,e   Rung, Johan ^d,f   Tocci, Noemi ^b   Abbey, Darren ^g   Bezerra, Ana R ^a   Carreto, Laura ^a   Moura, Gabriela R ^a   Bayés, Mónica ^h   Gut, Ivo G ^h   Csikasz Nagy, Attila ^b,i   Cavalieri, Duccio ^b   Berman, Judith ^j   Santos, Manuel A S ^a  

^a UNIVERSITY OF AVEIRO   (Portugal)

^b RESEARCH AND INNOVATION CENTRE   (Italy)

^c UNIVERSITY OF SALAMANCA   (Spain)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UPPSALA UNIVERSITY   (Sweden)

^g UNIVERSITY OF MINNESOTA   (United States)

^h Currently Centro Nacional de Analisis Genomico   (Spain)

ⁱ KING'S COLLEGE LONDON   (United Kingdom)

^j TEL AVIV UNIVERSITY   (Israel)

more..

Author keywords

Aneuploidy; Candida albicans; Codon ambiguity; Drug resistance evolution; Fluconazole; LOH; Phenotypic variability; Protein mistranslation

Indexed keywords

EID: 85040978047     PISSN: None     EISSN: 23795042     Source Type: Journal    
DOI: 10.1128/mSphere.00167-17     Document Type: Article

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