Deciphering azole resistance mechanisms with a focus on transcription factor-encoding genes TAC1, MRR1 and UPC2 in a set of fluconazole-resistant clinical isolates of Candida albicans

International Journal of Antimicrobial Agents

Volumn 42, Issue 5, 2013, Pages 410-415

  Morio, Florent ^a,b   Pagniez, Fabrice ^a   Besse, Myriam ^b   Gay Andrieu, Françoise ^a,b   Miegeville, Michel ^a,b   Le Pape, Patrice ^a,b  

^a UNIVERSITÉ DE NANTES   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

Author keywords

Azole antifungals; Candida albicans; Efflux pumps; Molecular mechanisms; Resistance; Transcription factors

Indexed keywords

FLUCONAZOLE; MRR1 PROTEIN; TAC1 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UPC2 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL RESISTANCE; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CDR1 GENE; CONTROLLED STUDY; ERG11 GENE; FEMALE; FUNGAL GENE; GAIN OF FUNCTION MUTATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE SEQUENCE; HUMAN; MDR1 GENE; MOUSE; MRR1 GENE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TAC1 GENE; TREATMENT FAILURE; UPC2 GENE;

AZOLE ANTIFUNGALS; CANDIDA ALBICANS; EFFLUX PUMPS; MOLECULAR MECHANISMS; RESISTANCE; TRANSCRIPTION FACTORS;

ADULT; ANIMALS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CANDIDIASIS; DRUG RESISTANCE, FUNGAL; FEMALE; FLUCONAZOLE; GENE EXPRESSION PROFILING; HUMANS; MALE; MICE; MIDDLE AGED; MUTATION, MISSENSE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS;

EID: 84885423640     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2013.07.013     Document Type: Article

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