Global role of the protein kinase Gcn2 in the human pathogen Candida albicans

Eukaryotic Cell

Volumn 4, Issue 10, 2005, Pages 1687-1696

  Tournu, Hélène ^a,b   Tripathi, Gyanendra ^a,c   Bertram, Gwyneth ^a   Macaskill, Susan ^a   Mavor, Abigail ^a   Walker, Louise ^a   Odds, Frank C ^a   Gow, Neil A R ^a   Brown, Alistair J P ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMITROLE; DNA BINDING PROTEIN; ENZYME INHIBITOR; FUNGAL PROTEIN; GCN2 PROTEIN, S CEREVISIAE; GCN4 PROTEIN, S CEREVISIAE; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SACCHAROMYCES CEREVISIAE PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; CANDIDA ALBICANS; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROMOTER REGION; REGULON; SACCHAROMYCES CEREVISIAE;

AMINO ACIDS; AMITROLE; ANIMALS; CANDIDA ALBICANS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME INHIBITORS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; REGULON; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

CANDIDA ALBICANS; SACCHAROMYCES CEREVISIAE;

EID: 26944450499     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.4.10.1687-1696.2005     Document Type: Article

References (49)

1. Alarco, A. M., and M. Raymond. 1999. The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans. J. Bacteriol. 181:700-708.
2. Albrecht, G., H.-U. Mosch, B. Hoffman, U. Reusser, and G. H. Braus. 1998. Monitoring the Gcn4 protein-mediated response in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 273:12696-12702.
3. Barelle, C. J., C. Manson, D. MacCallum, F. C. Odds, N. A. R. Gow, and A. J. P. Brown. 2004. GFP as a quantitative reporter of gene regulation in Candida albicans. Yeast 21:333-340.
4. Brand, A., D. M. MacCallum, A. J. P. Brown, N. A. R. Gow, and F. C. Odds. 2004. Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus. Eukaryot. Cell 3:900-909.
5. Braun, B. R., and A. D. Johnson. 1997. Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science 277:105-109.
6. Braun, B. R., D. Kadosh, and A. D. Johnson. 2001. NRG1, a repressor of filamentous growth in Candida albicans, is down-regulated during filament induction. EMBO J. 20:4753-4761.
7. Brega, E., R. Zufferey, and C. B. Mamoun. 2004. Candida albicans Csy1 is a nutrient sensor important for activation of amino acid uptake and hyphal morphogenesis. Eukaryot. Cell 3:135-143.
8. Brown, A. J. P. 2001. Morphogenetic signalling pathways in Candida albicans, p. 95-106. In R. Calderone (ed.), Candida and candidiasis. ASM Press, Washington, D.C.
9. Brown, A. J. P., R. J. Planta, F. Restuhadi, D. A. Bailey, P. R. Butler, J. L. Cadahia, M. E. Cerdan, M. De Jonge, D. C. J. Gardner, M. E. Gent, A. Hayes, C. P. A. M. Kolen, L. J. Lombardia, A. M. A. Murad, R. A. Oliver, M. Sefton, J. Thevelein, H. Tournu, Y. J. van Delft, D. J. Verbart, J. Winderick, and S. G. Oliver. 2001. Transcript analysis of 1003 novel yeast genes using high-throughput Northern hybridisations. EMBO J. 20:3177-3186.
10. Calderone, R. A. 2002. Candida and candidiasis. ASM Press, Washington, D.C.
11. Chi, Y., M. J. Huddleston, X. Zhang, R. A. Young, R. S. Annan, S. A. Carr, and R. J. Deshaies. 2001. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev. 15:1078-1092.
12. Cormack, B., G. Bertram, M. Egerton, N. A. R. Gow, S. Falkow, and A. J. P. Brown. 1997. Yeast enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans. Microbiology 143:303-311.
13. Davis, D., R. B. Wilson, and A. P. Mitchell. 2000. RIM101-dependent and -independent pathways govern pH responses in Candida albicans. Mol. Cell. Biol. 20:971-978.
14. d'Enfert, C., S. Goyard, S. Rodriguez-Arnaveilhe, L. Frangeul, L. Jones, F. Tekaia, O. Bader, L. Castillo, A. Dominguez, J. Ernst, C. Fradin, C. Gaillardin, S. Garcia-Sanchez, P. de Groot, B. Hube, F. Klis, S. Krishnamurthy, D. Kunze, M.-C. Lopez, A. Mavor, N. Martin, I. Moszer, D. Onésime, J. Perez Martin, R. Sentandreu, and A. J. P. Brown. 2005. CandidaDB: a genome database for Candida albicans pathogenomics. Nucleic Acids Res. 33:D353-D357.
15. El Barkani, A., O. Kurzai, W. A. Fonzi, A. Ramon, A. Porta, M. Frosch, and F. A. Muhlschlegel. 2000. Dominant active alleles of RIM101 (PRR2) bypass the pH restriction on filamentation of Candida albicans. Mol. Cell. Biol. 20:4635-4647.
16. Enjalbert, B., A. Nantel, and M. Whiteway. 2003. Stress induced gene expression in Candida albicans: absence of a general stress response. Mol. Biol. Cell 14:1460-1467.
17. Feng, Q., E. Summers, B. Guo, and G. R. Fink. 1999. Ras signaling is required for serum-induced hyphal differentiation in Candida albicans. J. Bacteriol. 181:6339-6346.
18. Fonzi, W. A., and M. Y. Irwin. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728.
19. Garcia-Sanchez, S., S. Aubert, I. Iraqui, G. Janbon, J.-M. Ghigo, and C. d'Enfert. 2004. Candida albicans biofilms: a developmental state associated with specific and stable gene expression patterns. Eukaryot. Cell 3:536-545.
20. Gerami-Nejad, M., J. Berman, and C. A. Gale. 2001. Cassettes for PCR-mediated construction of green, yellow and cyan fluorescent protein fusions in Candida albicans. Yeast 18:859-864.
21. Gildor, T., R. Shemer, A. Atir-Lande, and D. Kornitzer. 2005. Co-evolution of the cyclin Pcl5 and its substrate Gcn4. Eukaryot. Cell 4:310-318.
22. Gillum, A. M., E. Y. Tsay, and D. R. Kirsch. 1984. Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol. Gen. Genet. 198:179-182.
23. Gow, N. A. R., A. J. P. Brown, and F. C. Odds. 2002. Fungal morphogenesis and host invasion. Curr. Opin. Microbiol. 5:366-371.
24. Hauser, N. C., M. Vingron, M. Scheideler, B. Krems, K. Hellmuth, K.-D. Entian, and J. D. Hoheisel. 1998. Transcriptional profiling on all open reading frames of Saccharomyces cerevisiae. Yeast 14:1209-1221.
25. Hinnebusch, A. G. 1988. Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae. Microbiol. Rev. 52:248-273.
26. Hinnebusch, A. G., and K. Natarajan. 2002. Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot. Cell 1:22-32.
27. Hoffmann, B., O. Valerius, M. Andermann, and G. H. Braus. 2001. Transcriptional autoregulation and inhibition of mRNA translation of amino acid regulator gene cpcA of filamentous fungus Aspergillus nidulans. Mol. Biol. Cell 12:2846-2857.
28. Kadosh, D., and A. D. Johnson. 2001. Rfg1, a protein related to the S. cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in C. albicans. Mol. Cell. Biol. 21:2496-2505.
29. Kornitzer, D., B. Raboy, R. G. Kulka, and G. R. Fink. 1994. Regulated degradation of the transcription factor Gcn4. EMBO J. 13:6021-6030.
30. Krappmann, S., E. M. Bignell, U. Reichard, T. Rogers, K. Haynes, and G. H. Braus. 2004. The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen. Mol. Microbiol. 52:785-799.
31. Kumamoto, C. A. 2002. Candida biofilms. Curr. Opin. Microbiol. 5:608-611.
32. Liu, H., J. R. Kohler, and G. R. Fink. 1994. Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266:1723-1726.
33. CDC4 ubiquitin ligase complex. Mol. Biol. Cell 11:915-927.
34. Murad, A. M. A., P. R. Lee, I. D. Broadbent, C. J. Barelle, and A. J. P. Brown. 2000. CIp10, an efficient and convenient integrating vector for Candida albicans. Yeast 16:325-327.
35. Murad, A. M. A., P. Leng, M. Straffon, J. Wishart, S. Macaskill, D. MacCallum, N. Schnell, D. Talibi, D. Marechal, F. Tekaia, C. d'Enfert, C. Gaillardin, F. C. Odds, and A. J. P. Brown. 2001. NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO J. 20:4742-4752.
36. Nantel, A., D. Dignard, C. Bachewich, D. Harcus, A. Marcil, A.-P. Bouin, C. W. Sensen, H. Hogues, M. van het Hoog, P. Gordon, T. Rigby, F. Benoit, D. C. Tessier, D. Y. Thomas, and M. Whiteway. 2002. Transcript profiling of Candida albicans cells undergoing the yeast-to-hyphal transition. Mol. Biol. Cell 13:3452-3465.
37. Natarajan, K., M. R. Meyer, B. M. Jackson, D. Slade, C. Roberts, A. G. Hinnebusch, and M. J. Marton. 2001. Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol. Cell. Biol. 21:4347-4368.
38. Nicholls, S., M. Straffon, B. Enjalbert, A. Nantel, S. Macaskill, M. Whiteway, and A. J. P. Brown. 2004. Msn2- and Msn4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen Candida albicans. Eukaryot. Cell 3:1111-1123.
39. Odds, F. C. 1988. Candida and candidosis, 2nd ed. Bailliere Tindall, London, United Kingdom.
40. Paluh, J. L., M. J. Orbach, T. L. Legerton, and C. Yanofsky. 1988. The cross-pathway control gene of Neurospora crassa, cpc-1, encodes a protein similar to GCN4 of yeast and the DNA-binding domain of the oncogene v-jun-encoded protein. Proc. Natl. Acad. Sci. USA 85:3728-3732.
41. Rocha, C. R. C., K. Schroppel, D. Harcus, A. Marcil, D. Dignard, B. N. Taylor, D. Y. Thomas, M. Whiteway, and E. Leberer. 2001. Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans. Mol. Biol. Cell 12:3631-3643.
42. Rubin-Bejerano, I., I. Fraser, P. Grisafil, and G. R. Fink. 2003. Phagocytosis by neutrophils induces an amino acid deprivation response in Saccharomyces cerevisiae and Candida albicans. Proc. Natl. Acad. Sci. USA 100:11007-11012.
43. San Jose, C., R. A. Monge, R. Perez-Diaz, J. Pla, and C. Nombela. 1996. The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans. J. Bacteriol. 178:5850-5952.
44. Schaller, M., W. Schafer, H. C. Korting, and B. Hube. 1998. Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity. Mol. Microbiol. 29:605-615.
45. Sherman, F. 1991. Getting started with yeast. Methods Enzymol. 194:3-21.
46. Tripathi, G., C. Wiltshire, S. Macaskill, H. Tournu, S. Budge, and A. J. P. Brown. 2002. CaGcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans. EMBO J. 21:5448-5456.
47. Tusher, V. G., R. Tibshirani, and G. Chu. 2001. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 98:5116-5121.
48. Wanke, C., S. Eckert, G. Albrecht, W. van Hartingsveldt, P. J. Punt, C. A. van den Hondel, and G. H. Braus. 1997. The Aspergillus niger GCN4 homologue, cpcA, is transcriptionally regulated and encodes an unusual leucine zipper. Mol. Microbiol. 23:23-33.
49. Yin, Z., D. Stead, L. Selway, J. Walker, I. Riba-Garcia, T. McInerney, S. Gaskell, S. G. Oliver, P. Cash, and A. J. P. Brown. 2004. Proteomic response to amino acid starvation in Candida albicans and Saccharomyces cerevisiae. Proteomics 4:2425-2436.