Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 3, 2014, Pages 1132-1137

  Javid, Babak ^a,b,c   Sorrentino, Flavia ^b   Toosky, Melody ^a   Zheng, Wen ^b   Pinkham, Jessica T ^b   Jain, Nina ^b   Pan, Miaomiao ^a   Deighan, Padraig ^d   Rubin, Eric J ^b  

^a Tsinghua University   (China)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Drug tolerance; Persisters

Indexed keywords

ALANINE; ALANINE TRANSFER RNA; AMINO ACID TRANSFER RNA LIGASE; ASPARAGINE; ASPARTIC ACID; CIPROFLOXACIN; GLUTAMIC ACID; GLUTAMINE; RIFAMPICIN; RNA POLYMERASE; TRANSFER RNA; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTICODON; ARTICLE; BACTERIAL GROWTH; BACTERIAL MUTATION; ESCHERICHIA COLI; GENETIC RESISTANCE; GROWTH RATE; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PH; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS; UPREGULATION;

DRUG TOLERANCE; PERSISTERS;

AMINO ACID SEQUENCE; ANTIBIOTICS, ANTITUBERCULAR; ASPARAGINE; ASPARTIC ACID; DNA-DIRECTED RNA POLYMERASES; DRUG RESISTANCE, BACTERIAL; GLUTAMIC ACID; GLUTAMINE; MOLECULAR SEQUENCE DATA; MUTATION; MYCOBACTERIUM SMEGMATIS; PHENOTYPE; PROTEIN BIOSYNTHESIS; PROTEOMICS; RECOMBINATION, GENETIC; RIFAMPIN;

EID: 84892928454     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1317580111     Document Type: Article

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