Combining information on multiple instrumental variables in Mendelian randomization: Comparison of allele score and summarized data methods

Statistics in Medicine

Volumn 35, Issue 11, 2016, Pages 1880-1906

  Burgess, Stephen ^a   Dudbridge, Frank ^b   Thompson, Simon G ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Aggregated data; Allele score; Causal inference; Genetic risk score; Genetic variants; Instrumental variables; Mendelian randomization; Summarized data; Weak instruments

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; GENETIC ASSOCIATION; INDIVIDUAL LEVEL DATA ALLELE SCORE METHOD; INSTRUMENTAL VARIABLE ANALYSIS; INTERMETHOD COMPARISON; ISCHEMIC HEART DISEASE; LIKELIHOOD BASED METHOD; MENDELIAN RANDOMIZATION ANALYSIS; MULTIPLE INSTRUMENTAL VARIABLE; NULL HYPOTHESIS; RISK FACTOR; SIMULATION; STATISTICAL ANALYSIS; SUMMARIZED DATA ALLELE SCORE METHOD; SUMMARIZED DATA METHOD; ALLELE; BIOLOGICAL MODEL; BLOOD; CAUSALITY; COMPARATIVE STUDY; CORONARY ARTERY DISEASE; GENETICS; HUMAN; PROCEDURES; STATISTICAL MODEL;

ALLELES; CAUSALITY; CHOLESTEROL, LDL; CORONARY DISEASE; HUMANS; MENDELIAN RANDOMIZATION ANALYSIS; MODELS, GENETIC; MODELS, STATISTICAL; RISK FACTORS;

EID: 84949998712     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.6835     Document Type: Article

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