Effects of BMI, Fat Mass, and Lean Mass on Asthma in Childhood: A Mendelian Randomization Study

PLoS Medicine

Volumn 11, Issue 7, 2014, Pages

  Granell, Raquel ^a   Henderson, A John ^a   Evans, David M ^a,b   Smith, George Davey ^a   Ness, Andrew R ^a,c   Lewis, Sarah ^a   Palmer, Tom M ^a,d   Sterne, Jonathan A C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ALLELE; ALLERGIC ASTHMA; ARTICLE; ASTHMA; BIRTH WEIGHT; BODY HEIGHT; BODY MASS; CHILD; COHORT ANALYSIS; FAT MASS; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; GENOTYPING TECHNIQUE; HUMAN; LEAN BODY WEIGHT; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MATERNAL SMOKING; MENDELIAN RANDOMIZATION ANALYSIS; OBESITY; PHENOTYPE; PLEIOTROPY; PRICK TEST; QUESTIONNAIRE; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; BODY WEIGHT; GENETICS; RANDOMIZATION; UNITED KINGDOM;

ADIPOSITY; ALLELES; ASTHMA; BODY MASS INDEX; BODY WEIGHT; CHILD; ENGLAND; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RANDOM ALLOCATION;

EID: 84905401194     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1001669     Document Type: Article

References (50)

1. Ford ES, (2005) The epidemiology of obesity and asthma. J Allergy Clin Immunol 115: 897-909.
2. Figueroa-Munoz JI, Chinn S, Rona RJ, (2001) Association between obesity and asthma in 4-11 year old children in the UK. Thorax 56: 133-137.
3. Wickens K, Barry D, Friezema A, Rhodius R, Bone N, et al. (2005) Obesity and asthma in 11-12 year old New Zealand children in 1989 and 2000. Thorax 60: 7-12.
4. Rzehak P, Wijga AH, Keil T, Eller E, Bindslev-Jensen C, et al. (2013) Body mass index trajectory classes and incident asthma in childhood: results from 8 European Birth Cohorts-a Global Allergy and Asthma European Network initiative. J Allergy Clin Immunol 131: 1528-1536.
5. Gilliland FD, Berhane K, Islam T, McConnell R, Gauderman WJ, et al. (2003) Obesity and the risk of newly diagnosed asthma in school-age children. Am J Epidemiol 158: 406-415.
6. Bedogni G, Iughetti L, Ferrari M, Malavolti M, Poli M, et al. (2003) Sensitivity and specificity of body mass index and skinfold thicknesses in detecting excess adiposity in children aged 8-12 years. Ann Hum Biol 30: 132-139.
7. Cole TJ, Freeman JV, Preece MA, (1995) Body mass index reference curves for the UK, 1990. Arch Dis Child 73: 25-29.
8. Daniels SR, Khoury PR, Morrison JA, (1997) The utility of body mass index as a measure of body fatness in children and adolescents: differences by race and gender. Pediatrics 99: 804-807.
9. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42: 937-948.
10. Davey Smith G, Ebrahim S, (2003) 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32: 1-22.
11. Davey Smith G, Lawlor DA, Harbord R, Timpson N, Day I, et al. (2008) Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med 4: e352.
12. Boyd A, Golding J, Macleod J, Lawlor DA, Fraser A, et al. (2013) Cohort profile: the 'children of the 90s'-the index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol 42: 111-127.
13. Rogers IS, Ness AR, Steer CD, Wells JC, Emmett PM, et al. (2006) Associations of size at birth and dual-energy X-ray absorptiometry measures of lean and fat mass at 9 to 10 y of age. Am J Clin Nutr 84: 739-747.
14. Leary SD, Smith GD, Rogers IS, Reilly JJ, Wells JC, et al. (2006) Smoking during pregnancy and offspring fat and lean mass in childhood. Obesity 14: 2284-2293.
15. Riddoch CJ, Leary SD, Ness AR, Blair SN, Deere K, et al. (2009) Prospective associations between objective measures of physical activity and fat mass in 12-14 year old children: the Avon Longitudinal Study of Parents and Children (ALSPAC). BMJ 339: b4544.
16. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH, (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320: 1240-1243.
17. Burgess S, Thompson SG, (2013) Use of allele scores as instrumental variables for Mendelian randomization. Int J Epidemiol 42: 1134-1144.
18. Howe LD, Parmar P, Paternoster L, Warrington NM, Kemp JP, et al. (2013) genetic influences on trajectories of systolic blood pressure across childhood and adolescence. Circ Cardiovasc Genet 6: 608-614.
19. Lawlor DA, Timpson N, Harbord RM, Leary S, Ness A, et al. (2008) Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable. PLoS Med 5: e33.
20. Timpson NJ, Sayers A, Davey-Smith G, Tobias JH, (2009) How does body fat influence bone mass in childhood? A Mendelian randomization approach. J Bone Miner Res 24: 522-533.
21. Fatemifar G, Hoggart CJ, Paternoster L, Kemp JP, Prokopenko I, et al. (2013) Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. Hum Mol Genet 22: 3807-3817.
22. Palmer TM, Sterne JA, Harbord RM, Lawlor DA, Sheehan NA, et al. (2011) Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses. Am J Epidemiol 173: 1392-1403.
23. Hernan MA, Robins JM, (2006) Instruments for causal inference: an epidemiologist's dream? Epidemiology 17: 360-372.
24. Anderson HR, Gupta R, Strachan DP, Limb ES, (2007) 50 years of asthma: UK trends from 1955 to 2004. Thorax 62: 85-90.
25. Fletcher ES, Rugg-Gunn AJ, Matthews JN, Hackett A, Moynihan PJ, et al. (2004) Changes over 20 years in macronutrient intake and body mass index in 11- to 12-year-old adolescents living in Northumberland. Br J Nutr 92: 321-333.
26. Egan KB, Ettinger AS, Bracken MB, (2013) Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies. BMC Pediatr 13: 121.
27. Beuther DA, Sutherland ER, (2007) Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 175: 661-666.
28. Fantuzzi G, (2005) Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115: 911-919.
29. Sideleva O, Suratt BT, Black KE, Tharp WG, Pratley RE, et al. (2012) Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med 186: 598-605.
30. Fenger RV, Gonzalez-Quintela A, Vidal C, Gude F, Husemoen LL, et al. (2012) Exploring the obesity-asthma link: do all types of adiposity increase the risk of asthma? Clin Exp Allergy 42: 1237-1245.
31. Black MH, Zhou H, Takayanagi M, Jacobsen SJ, Koebnick C, (2013) Increased asthma risk and asthma-related health care complications associated with childhood obesity. Am J Epidemiol 178: 1120-1128.
32. Borrell LN, Nguyen EA, Roth LA, Oh SS, Tcheurekdjian H, et al. (2013) Childhood obesity and asthma control in the GALA II and SAGE II studies. Am J Respir Crit Care Med 187: 697-702.
33. Telenga ED, Tideman SW, Kerstjens HA, Hacken NH, Timens W, et al. (2012) Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response. Allergy 67: 1060-1068.
34. Chen YC, Dong GH, Lin KC, Lee YL, (2013) Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta-analysis. Obes Rev 14: 222-231.
35. Gnatiuc L, Kato B, Matheson MC, Newson RB, Jarvis DL, (2013) The association of asthma with BMI and menarche in the 1958 British Birth Cohort. J Asthma 50: 751-758.
36. Guerra S, Wright AL, Morgan WJ, Sherrill DL, Holberg CJ, et al. (2004) Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty. Am J Respir Crit Care Med 170: 78-85.
37. Parks EP, Zemel B, Moore RH, Berkowitz RI, (2014) Change in body composition during a weight loss trial in obese adolescents. Pediatr Obes 9: 26-35.
38. Knöpfli BH, Radtke T, Lehmann M, Schätzle B, Eisenblätter J, et al. (2008) Effects of a multidisciplinary inpatient intervention on body composition, aerobic fitness, and quality of life in severely obese girls and boys. J Adolesc Health 42: 119-127.
39. Sood A, Qualls C, Li R, Schuyler M, Beckett WS, et al. (2011) Lean mass predicts asthma better than fat mass among females. Eur Respir J 37: 65-71.
40. Björntorp P, (1990) "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 10: 493-496.
41. Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, et al. (2012) Relationship between body composition, inflammation and lung function in overweight and obese asthma. Respir Res 13: 10.
42. Thomsen SF, Ulrik CS, Kyvik KO, Sorensen TI, Posthuma D, et al. (2007) Association between obesity and asthma in a twin cohort. Allergy 62: 1199-1204.
43. Hallstrand TS, Fischer M, Wurfel MM, Afari N, Buchwald D, et al. (2005) Genetic pleiotropy between asthma and obesity in a community-based sample of twins. J Allergy Clin Immunol 116: 1235-1241.
44. Tantisira KG, Weiss ST, (2001) Complex interactions in complex traits: obesity and asthma. Thorax 56 (Suppl 2) (): ii64-ii73.
45. Melén E, Himes BE, Brehm JM, Boutaoui N, Klanderman BJ, et al. (2010) Analyses of shared genetic factors between asthma and obesity in children. J Allergy Clin Immunol 126: 631-637.
46. Melén E, Granell R, Kogevinas M, Strachan D, Gonzalez JR, et al. (2013) Genome-wide association study of body mass index in 23 000 individuals with and without asthma. Clin Exp Allergy 43: 463-474.
47. Xu X, Su S, Barnes VA, De Miguel C, Pollock J, et al. (2013) A genome-wide methylation study on obesity: differential variability and differential methylation. Epigenetics 8: 522-533.
48. Maynard LM, Wisemandle W, Roche AF, Chumlea WC, Guo SS, et al. (2001) Childhood body composition in relation to body mass index. Pediatrics 107: 344-350.
49. Henderson J, Granell R, Heron J, Sherriff A, Simpson A, et al. (2008) Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood. Thorax 63: 974-980.
50. Spratt M, Carpenter J, Sterne JA, Carlin JB, Heron J, et al. (2010) Strategies for multiple imputation in longitudinal studies. Am J Epidemiol 172: 478-487.