Marine Mammal Microbiota Yields Novel Antibiotic with Potent Activity Against Clostridium difficile

ACS Infectious Diseases

Volumn 4, Issue 1, 2018, Pages 59-67

  Ochoa, Jessica L ^a   Sanchez, Laura M ^a,b   Koo, Byoung Mo ^c   Doherty, Jennifer S ^c   Rajendram, Manohary ^d   Huang, Kerwyn Casey ^d,e   Gross, Carol A ^c   Linington, Roger G ^a,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Stanford University   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f SIMON FRASER UNIVERSITY   (Canada)

Author keywords

cytological profiling; drug discovery; microbiome; natural products; porpoise

Indexed keywords

ANTIBIOTIC AGENT; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CHLOROTHRICIN; DECATROMICIN B; FIDAXOMICIN; IONOPHORE; MAKLAMICIN; NATURAL PRODUCT; PHOCOENAMICIN; POLYKETIDE; RNA 16S; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; BIOLOGICAL PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATION; CLINICAL EVALUATION; CLOSTRIDIUM INFECTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; FISH; FLOW CYTOMETRY; FLUORESCENCE IMAGING; HOSPITAL CARE; HUMAN; INTESTINE FLORA; MEMBRANE DAMAGE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROMONOSPORA; MINING; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; PHOCA VITULINA; PRIORITY JOURNAL; TOOTHED WHALE; ZALOPHUS CALIFORNIANUS; ANIMAL; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECT; GRAM POSITIVE BACTERIUM; ISOLATION AND PURIFICATION; MAMMAL; METABOLISM; PROCEDURES; STRUCTURE ACTIVITY RELATION; WORKFLOW;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL PRODUCTS; CLOSTRIDIUM DIFFICILE; DRUG DISCOVERY; GASTROINTESTINAL MICROBIOME; GRAM-POSITIVE BACTERIA; MAMMALS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; WORKFLOW;

EID: 85040567891     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.7b00105     Document Type: Article

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