The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1–mediated tissue injury

Kidney International

Volumn 93, Issue 3, 2018, Pages 656-669

  Anders, Hans Joachim ^a,d   Suarez Alvarez, Beatriz ^a,d   Grigorescu, Melissa ^a,d   Foresto Neto, Orestes ^a,d   Steiger, Stefanie ^a   Desai, Jyaysi ^a   Marschner, Julian A ^a   Honarpisheh, Mohsen ^a   Shi, Chongxu ^a   Jordan, Jutta ^b   Müller, Lisa ^c   Burzlaff, Nicolai ^c   Bäuerle, Tobias ^b   Mulay, Shrikant R ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d NONE

Author keywords

beta hydroxybutyrate; crystal nephropathy; fibrosis; NALP3; necroinflammation

Indexed keywords

ADAPTOR PROTEIN; CD11B ANTIGEN; CHEMOKINE RECEPTOR CX3CR1; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1; RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASE C; TRANSFORMING GROWTH FACTOR BETA; 1,3-BUTYLENE GLYCOL; BUTANEDIOL; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; NLRP3 PROTEIN, MOUSE; PYCARD PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CHRONIC KIDNEY FAILURE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; FEMALE; FIBROBLAST; HYPEROXALURIA; KIDNEY CALCIFICATION; KIDNEY FIBROSIS; MACROPHAGE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TISSUE INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CELL PLASTICITY; DISEASE MODEL; DRUG EFFECT; GENETICS; IMMUNOLOGY; KIDNEY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; BUTYLENE GLYCOLS; CARD SIGNALING ADAPTOR PROTEINS; CELL PLASTICITY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLASTS; HYPEROXALURIA; INFLAMMASOMES; INTERLEUKIN-1; KIDNEY; MACROPHAGES; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEPHROCALCINOSIS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PHENOTYPE; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION;

EID: 85037728814     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2017.09.022     Document Type: Article

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