메뉴 건너뛰기




Volumn 8, Issue 1, 2017, Pages

Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; STAT3 PROTEIN; TRANSCRIPTION FACTOR; RNA POLYMERASE II; STAT3 PROTEIN, MOUSE;

EID: 85036580400     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-02055-5     Document Type: Article
Times cited : (64)

References (71)
  • 1
    • 0033545342 scopus 로고    scopus 로고
    • Acute-phase proteins and other systemic responses to inflammation
    • Gabay, C. & Kushner, I. Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 340, 448-54 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 448-454
    • Gabay, C.1    Kushner, I.2
  • 2
    • 84860250390 scopus 로고    scopus 로고
    • Hepatic acute phase proteins-Regulation by IL-6-and IL-1-Type cytokines involving STAT3 and its crosstalk with NF-kappaB-dependent signaling
    • Bode, J. G., Albrecht, U., Haussinger, D., Heinrich, P. C. & Schaper, F. Hepatic acute phase proteins-regulation by IL-6-and IL-1-Type cytokines involving STAT3 and its crosstalk with NF-kappaB-dependent signaling. Eur. J. Cell Biol. 91, 496-505 (2012).
    • (2012) Eur. J. Cell Biol. , vol.91 , pp. 496-505
    • Bode, J.G.1    Albrecht, U.2    Haussinger, D.3    Heinrich, P.C.4    Schaper, F.5
  • 3
    • 84966431031 scopus 로고    scopus 로고
    • Hepatocytes: A key cell type for innate immunity
    • Zhou, Z., Xu, M. J. & Gao, B. Hepatocytes: A key cell type for innate immunity. Cell Mol. Immunol. 13, 301-15 (2016).
    • (2016) Cell Mol. Immunol. , vol.13 , pp. 301-315
    • Zhou, Z.1    Xu, M.J.2    Gao, B.3
  • 4
    • 84953314438 scopus 로고    scopus 로고
    • Hepatocytes as immunological agents
    • Crispe, I. N. Hepatocytes as immunological agents. J. Immunol. 196, 17-21 (2016).
    • (2016) J. Immunol. , vol.196 , pp. 17-21
    • Crispe, I.N.1
  • 5
    • 84901820722 scopus 로고    scopus 로고
    • Role of interleukins in obesity: Implications for metabolic disease
    • Febbraio, M. A. Role of interleukins in obesity: implications for metabolic disease. Trends Endocrinol. Metab. 25, 312-9 (2014).
    • (2014) Trends Endocrinol. Metab. , vol.25 , pp. 312-319
    • Febbraio, M.A.1
  • 6
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath, M. Y. & Shoelson, S. E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 11, 98-107 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 7
    • 79751492851 scopus 로고    scopus 로고
    • NF-kappaB in the liver-Linking injury, fibrosis and hepatocellular carcinoma
    • Luedde, T. & Schwabe, R. F. NF-kappaB in the liver-linking injury, fibrosis and hepatocellular carcinoma. Nat. Rev. Gastroenterol Hepatol. 8, 108-18 (2011).
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 108-118
    • Luedde, T.1    Schwabe, R.F.2
  • 8
    • 84963541541 scopus 로고    scopus 로고
    • IL-6 pathway in the liver: From physiopathology to therapy
    • Schmidt-Arras, D. & Rose-John, S. IL-6 pathway in the liver: From physiopathology to therapy. J. Hepatol. 64, 1403-15 (2016).
    • (2016) J. Hepatol. , vol.64 , pp. 1403-1415
    • Schmidt-Arras, D.1    Rose-John, S.2
  • 9
    • 84860587432 scopus 로고    scopus 로고
    • Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice
    • Quinton, L. J. et al. Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice. J. Clin. Invest. 122, 1758-63 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 1758-1763
    • Quinton, L.J.1
  • 10
    • 0035131190 scopus 로고    scopus 로고
    • Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver
    • Alonzi, T. et al. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver. Mol. Cell. Biol. 21, 1621-32 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1621-1632
    • Alonzi, T.1
  • 11
    • 77954399377 scopus 로고    scopus 로고
    • Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
    • Sander, L. E. et al. Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J. Exp. Med. 207, 1453-64 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1453-1464
    • Sander, L.E.1
  • 12
    • 66549093853 scopus 로고    scopus 로고
    • Mechanisms of the hepatic acute-phase response during bacterial pneumonia
    • Quinton, L. J., Jones, M. R., Robson, B. E. & Mizgerd, J. P. Mechanisms of the hepatic acute-phase response during bacterial pneumonia. Infect. Immun. 77, 2417-26 (2009).
    • (2009) Infect. Immun. , vol.77 , pp. 2417-2426
    • Quinton, L.J.1    Jones, M.R.2    Robson, B.E.3    Mizgerd, J.P.4
  • 13
    • 0030589152 scopus 로고    scopus 로고
    • Initiation of acute phase response and synthesis of cytokines
    • Koj, A. Initiation of acute phase response and synthesis of cytokines. Biochim. Biophys. Acta 1317, 84-94 (1996).
    • (1996) Biochim. Biophys. Acta , vol.1317 , pp. 84-94
    • Koj, A.1
  • 14
  • 15
    • 0034887798 scopus 로고    scopus 로고
    • Gene transcription in hepatocytes during the acute phase of a systemic inflammation: From transcription factors to target genes
    • Ruminy, P. et al. Gene transcription in hepatocytes during the acute phase of a systemic inflammation: from transcription factors to target genes. Inflamm. Res. 50, 383-90 (2001).
    • (2001) Inflamm. Res. , vol.50 , pp. 383-390
    • Ruminy, P.1
  • 16
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu, H., Pardoll, D. & Jove, R. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat. Rev. Cancer 9, 798-809 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 17
    • 79151473780 scopus 로고    scopus 로고
    • NF-kappaB and STAT3 signaling hubs for lung innate immunity
    • Quinton, L. J. & Mizgerd, J. P. NF-kappaB and STAT3 signaling hubs for lung innate immunity. Cell Tissue Res. 343, 153-65 (2011).
    • (2011) Cell Tissue Res. , vol.343 , pp. 153-165
    • Quinton, L.J.1    Mizgerd, J.P.2
  • 18
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
    • Yang, J. et al. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev. 21, 1396-408 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 1396-1408
    • Yang, J.1
  • 19
    • 0036797750 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB
    • Yu, Z., Zhang, W. & Kone, B. C. Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB. Biochem. J. 367, 97-105 (2002).
    • (2002) Biochem. J. , vol.367 , pp. 97-105
    • Yu, Z.1    Zhang, W.2    Kone, B.C.3
  • 20
    • 63249092765 scopus 로고    scopus 로고
    • Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
    • Lee, H. et al. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15, 283-93 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 283-293
    • Lee, H.1
  • 21
    • 85009841534 scopus 로고    scopus 로고
    • Nuclear translocation of STAT3 and NF-kappaB are independent of each other but NF-kappaB supports expression and activation of STAT3
    • Martincuks, A. et al. Nuclear translocation of STAT3 and NF-kappaB are independent of each other but NF-kappaB supports expression and activation of STAT3. Cell Signal. 32, 36-47 (2017).
    • (2017) Cell Signal. , vol.32 , pp. 36-47
    • Martincuks, A.1
  • 22
    • 84899450857 scopus 로고    scopus 로고
    • Transcriptional enhancers: From properties to genome-wide predictions
    • Shlyueva, D., Stampfel, G. & Stark, A. Transcriptional enhancers: from properties to genome-wide predictions. Nat. Rev. Genet. 15, 272-286 (2014).
    • (2014) Nat. Rev.Genet. , vol.15 , pp. 272-286
    • Shlyueva, D.1    Stampfel, G.2    Stark, A.3
  • 23
    • 77949971595 scopus 로고    scopus 로고
    • Selective transcription in response to an inflammatory stimulus
    • Smale, S. T. Selective transcription in response to an inflammatory stimulus. Cell 140, 833-844 (2010).
    • (2010) Cell , vol.140 , pp. 833-844
    • Smale, S.T.1
  • 24
    • 84959346645 scopus 로고    scopus 로고
    • Inducible chromatin priming is associated with the establishment of immunological memory in T cells
    • Bevington, S. L. et al. Inducible chromatin priming is associated with the establishment of immunological memory in T cells. EMBO. J. 35, 515-535 (2016).
    • (2016) EMBO. J. , vol.35 , pp. 515-535
    • Bevington, S.L.1
  • 25
    • 84908425487 scopus 로고    scopus 로고
    • Transcriptional control of inflammatory responses
    • Smale, S. T. & Natoli, G. Transcriptional control of inflammatory responses. Cold Spring Harb. Perspect Biol. 6, a016261 (2014).
    • (2014) Cold Spring Harb. Perspect Biol , vol.6 , pp. a016261
    • Smale, S.T.1    Natoli, G.2
  • 26
    • 84892800329 scopus 로고    scopus 로고
    • Dynamic regulation of transcriptional states by chromatin and transcription factors
    • Voss, T. C. & Hager, G. L. Dynamic regulation of transcriptional states by chromatin and transcription factors. Nat. Rev. Genet. 15, 69-81 (2014).
    • (2014) Nat. Rev.Genet. , vol.15 , pp. 69-81
    • Voss, T.C.1    Hager, G.L.2
  • 27
    • 84964555664 scopus 로고    scopus 로고
    • Chromatin structure and gene regulation: A dynamic view of enhancer function
    • Stavreva, D. A. & Hager, G. L. Chromatin structure and gene regulation: A dynamic view of enhancer function. Nucleus 6, 442-448 (2015).
    • (2015) Nucleus , vol.6 , pp. 442-448
    • Stavreva, D.A.1    Hager, G.L.2
  • 28
    • 80052000538 scopus 로고    scopus 로고
    • Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism
    • Voss, T. C. et al. Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. Cell 146, 544-554 (2011).
    • (2011) Cell , vol.146 , pp. 544-554
    • Voss, T.C.1
  • 29
    • 84992446138 scopus 로고    scopus 로고
    • Pioneer factors and ATP-dependent chromatin remodeling factors interact dynamically: A new perspective: Multiple transcription factors can effect chromatin pioneer functions through dynamic interactions with ATP-dependent chromatin remodeling factors
    • Swinstead, E. E., Paakinaho, V., Presman, D. M. & Hager, G. L. Pioneer factors and ATP-dependent chromatin remodeling factors interact dynamically: A new perspective: Multiple transcription factors can effect chromatin pioneer functions through dynamic interactions with ATP-dependent chromatin remodeling factors. Bioessays 38, 1150-1157 (2016).
    • (2016) Bioessays , vol.38 , pp. 1150-1157
    • Swinstead, E.E.1    Paakinaho, V.2    Presman, D.M.3    Hager, G.L.4
  • 30
    • 79959911826 scopus 로고    scopus 로고
    • Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding
    • Biddie, S. C. et al. Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding. Mol. Cell 43, 145-155 (2011).
    • (2011) Mol. Cell , vol.43 , pp. 145-155
    • Biddie, S.C.1
  • 31
    • 84878547373 scopus 로고    scopus 로고
    • C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements
    • Grontved, L. et al. C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements. EMBO J 32, 1568-1583 (2013).
    • (2013) EMBO J , vol.32 , pp. 1568-1583
    • Grontved, L.1
  • 32
    • 84882600977 scopus 로고    scopus 로고
    • Reprogramming of the chromatin landscape: Interplay of the estrogen and glucocorticoid receptors at the genomic level
    • Miranda, T. B. et al. Reprogramming of the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level. Cancer Res. 73, 5130-5139 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 5130-5139
    • Miranda, T.B.1
  • 33
    • 84894235553 scopus 로고    scopus 로고
    • Peroxisome proliferator-Activated receptor gamma and C/EBPalpha synergistically activate key metabolic adipocyte genes by assisted loading
    • Madsen, M. S., Siersbaek, R., Boergesen, M., Nielsen, R. & Mandrup, S. Peroxisome proliferator-Activated receptor gamma and C/EBPalpha synergistically activate key metabolic adipocyte genes by assisted loading. Mol. Cell. Biol. 34, 939-954 (2014).
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 939-954
    • Madsen, M.S.1    Siersbaek, R.2    Boergesen, M.3    Nielsen, R.4    Mandrup, S.5
  • 34
    • 84934325147 scopus 로고    scopus 로고
    • Genetic variation determines PPARgamma function and anti-diabetic drug response in vivo
    • Soccio, R. E. et al. Genetic variation determines PPARgamma function and anti-diabetic drug response in vivo. Cell 162, 33-44 (2015).
    • (2015) Cell , vol.162 , pp. 33-44
    • Soccio, R.E.1
  • 35
    • 84962630625 scopus 로고    scopus 로고
    • Steroid receptors reprogram FoxA1 occupancy through dynamic chromatin transitions
    • Swinstead, E. E. et al. Steroid receptors reprogram FoxA1 occupancy through dynamic chromatin transitions. Cell 165, 593-605 (2016).
    • (2016) Cell , vol.165 , pp. 593-605
    • Swinstead, E.E.1
  • 36
    • 84952871218 scopus 로고    scopus 로고
    • Coactivator-dependent oscillation of chromatin accessibility dictates circadian gene amplitude via REV-ERB loading
    • Zhu, B. et al. Coactivator-dependent oscillation of chromatin accessibility dictates circadian gene amplitude via REV-ERB loading. Mol. Cell 60, 769-83 (2015).
    • (2015) Mol. Cell , vol.60 , pp. 769-783
    • Zhu, B.1
  • 37
    • 85016485849 scopus 로고    scopus 로고
    • Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response
    • Goldstein, I. et al. Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response. Genome Res. 27, 427-439 (2017).
    • (2017) Genome Res. , vol.27 , pp. 427-439
    • Goldstein, I.1
  • 38
    • 84884829249 scopus 로고    scopus 로고
    • Mapping human epigenomes
    • Rivera, C. M. & Ren, B. Mapping human epigenomes. Cell 155, 39-55 (2013).
    • (2013) Cell , vol.155 , pp. 39-55
    • Rivera, C.M.1    Ren, B.2
  • 39
    • 78650758676 scopus 로고    scopus 로고
    • Histone H3K27ac separates active from poised enhancers and predicts developmental state
    • Creyghton, M. P. et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc. Natl Acad. Sci. USA 107, 21931-21936 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 21931-21936
    • Creyghton, M.P.1
  • 40
    • 84865755978 scopus 로고    scopus 로고
    • The accessible chromatin landscape of the human genome
    • Thurman, R. E. et al. The accessible chromatin landscape of the human genome. Nature 489, 75-82 (2012).
    • (2012) Nature , vol.489 , pp. 75-82
    • Thurman, R.E.1
  • 41
    • 84904395679 scopus 로고    scopus 로고
    • Proteomic and genomic studies of non-Alcoholic fatty liver disease-Clues in the pathogenesis
    • Lim, J. W., Dillon, J. & Miller, M. Proteomic and genomic studies of non-Alcoholic fatty liver disease-clues in the pathogenesis. World J. Gastroenterol. 20, 8325-40 (2014).
    • (2014) World J. Gastroenterol. , vol.20 , pp. 8325-8340
    • Lim, J.W.1    Dillon, J.2    Miller, M.3
  • 42
    • 73249130002 scopus 로고    scopus 로고
    • Serum levels of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor alpha in mixed cryoglobulinemia
    • Antonelli, A. et al. Serum levels of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor alpha in mixed cryoglobulinemia. Arthritis Rheum. 60, 3841-7 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 3841-3847
    • Antonelli, A.1
  • 43
    • 77952367798 scopus 로고    scopus 로고
    • Widespread transcription at neuronal activity-regulated enhancers
    • Kim, T. K. et al. Widespread transcription at neuronal activity-regulated enhancers. Nature 465, 182-187 (2010).
    • (2010) Nature , vol.465 , pp. 182-187
    • Kim, T.K.1
  • 44
    • 77952908743 scopus 로고    scopus 로고
    • A large fraction of extragenic RNA pol II transcription sites overlap enhancers
    • De Santa, F. et al. A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol. 8, e1000384 (2010).
    • (2010) PLoS Biol. , vol.8 , pp. e1000384
    • De Santa, F.1
  • 45
    • 33646547951 scopus 로고    scopus 로고
    • Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
    • Gilchrist, M. et al. Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature 441, 173-8 (2006).
    • (2006) Nature , vol.441 , pp. 173-178
    • Gilchrist, M.1
  • 46
    • 84905970514 scopus 로고    scopus 로고
    • Metformin suppresses lipopolysaccharide (LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3 (ATF-3) induction
    • Kim, J. et al. Metformin suppresses lipopolysaccharide (LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3 (ATF-3) induction. J. Biol. Chem. 289, 23246-55 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 23246-23255
    • Kim, J.1
  • 47
    • 36348995922 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice
    • Sakamori, R. et al. Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice. Hepatology 46, 1564-73 (2007).
    • (2007) Hepatology , vol.46 , pp. 1564-1573
    • Sakamori, R.1
  • 48
    • 84922480037 scopus 로고    scopus 로고
    • Regulation of RNA polymerase II activation by histone acetylation in single living cells
    • Stasevich, T. J. et al. Regulation of RNA polymerase II activation by histone acetylation in single living cells. Nature 516, 272-275(2014).
    • (2014) Nature , vol.516 , pp. 272-275
    • Stasevich, T.J.1
  • 49
    • 65549104157 scopus 로고    scopus 로고
    • Histone modifications at human enhancers reflect global cell-Type-specific gene expression
    • Heintzman, N. D. et al. Histone modifications at human enhancers reflect global cell-Type-specific gene expression. Nature 459, 108-112 (2009).
    • (2009) Nature , vol.459 , pp. 108-112
    • Heintzman, N.D.1
  • 50
    • 79951516056 scopus 로고    scopus 로고
    • A unique chromatin signature uncovers early developmental enhancers in humans
    • Rada-Iglesias, A. et al. A unique chromatin signature uncovers early developmental enhancers in humans. Nature 470, 279-283 (2011).
    • (2011) Nature , vol.470 , pp. 279-283
    • Rada-Iglesias, A.1
  • 51
    • 84958191207 scopus 로고    scopus 로고
    • Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells
    • Soucie, E. L. et al. Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells. Science 351, aad5510 (2016).
    • (2016) Science , vol.351 , pp. aad5510
    • Soucie, E.L.1
  • 52
    • 84929135130 scopus 로고    scopus 로고
    • Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
    • Hilton, I. B. et al. Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat. Biotechnol. 33, 510-7 (2015).
    • (2015) Nat. Biotechnol. , vol.33 , pp. 510-517
    • Hilton, I.B.1
  • 53
    • 0032039076 scopus 로고    scopus 로고
    • Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
    • Zhong, H., Voll, R. E. & Ghosh, S. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1, 661-71 (1998).
    • (1998) Mol. Cell , vol.1 , pp. 661-671
    • Zhong, H.1    Voll, R.E.2    Ghosh, S.3
  • 54
    • 84923349602 scopus 로고    scopus 로고
    • The activation of IL-1-induced enhancers depends on TAK1 kinase activity and NF-kappaB p65
    • S2211-1247(15)00002-9
    • Jurida, L. et al. The activation of IL-1-induced enhancers depends on TAK1 kinase activity and NF-kappaB p65. Cell Rep. pii: S2211-1247(15)00002-9. doi: 10.1016/j.celrep.2015.01.001 (2015).
    • (2015) Cell Rep
    • Jurida, L.1
  • 55
    • 84908602740 scopus 로고    scopus 로고
    • NF-kappaB directs dynamic super enhancer formation in inflammation and atherogenesis
    • Brown, J. D. et al. NF-kappaB directs dynamic super enhancer formation in inflammation and atherogenesis. Mol. Cell 56, 219-31 (2014).
    • (2014) Mol. Cell , vol.56 , pp. 219-231
    • Brown, J.D.1
  • 56
    • 84872522528 scopus 로고    scopus 로고
    • Latent enhancers activated by stimulation in differentiated cells
    • Ostuni, R. et al. Latent enhancers activated by stimulation in differentiated cells. Cell 152, 157-71 (2013).
    • (2013) Cell , vol.152 , pp. 157-171
    • Ostuni, R.1
  • 57
    • 84884355522 scopus 로고    scopus 로고
    • Synergistic activation of inflammatory cytokine genes by interferon-gamma-induced chromatin remodeling and toll-like receptor signaling
    • Qiao, Y. et al. Synergistic activation of inflammatory cytokine genes by interferon-gamma-induced chromatin remodeling and toll-like receptor signaling. Immunity 39, 454-69 (2013).
    • (2013) Immunity , vol.39 , pp. 454-469
    • Qiao, Y.1
  • 58
    • 80455144479 scopus 로고    scopus 로고
    • Pioneer transcription factors: Establishing competence for gene expression
    • Zaret, K. S. & Carroll, J. S. Pioneer transcription factors: establishing competence for gene expression. Genes Dev. 25, 2227-2241 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 2227-2241
    • Zaret, K.S.1    Carroll, J.S.2
  • 60
    • 85018462823 scopus 로고    scopus 로고
    • The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells
    • King, H. W. & Klose, R. J. The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells. Elife 6, pii: e22631 (2017).
    • (2017) Elife , vol.6 , pp. e22631
    • King, H.W.1    Klose, R.J.2
  • 61
    • 77952972412 scopus 로고    scopus 로고
    • Isolation and culture of adult mouse hepatocytes
    • Li, W. C., Ralphs, K. L. & Tosh, D. Isolation and culture of adult mouse hepatocytes. Methods Mol. Biol. 633, 185-96 (2010).
    • (2010) Methods Mol. Biol. , vol.633 , pp. 185-196
    • Li, W.C.1    Ralphs, K.L.2    Tosh, D.3
  • 62
    • 84872198346 scopus 로고    scopus 로고
    • Differential analysis of gene regulation at transcript resolution with RNA-seq
    • Trapnell, C. et al. Differential analysis of gene regulation at transcript resolution with RNA-seq. Nat. Biotechnol. 31, 46-53 (2013).
    • (2013) Nat. Biotechnol. , vol.31 , pp. 46-53
    • Trapnell, C.1
  • 63
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
    • Trapnell, C. et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28, 511-5 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 511-515
    • Trapnell, C.1
  • 64
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-50 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 65
    • 77958471357 scopus 로고    scopus 로고
    • Differential expression analysis for sequence count data
    • R106 1:CAS:528:DC%2BC3cXhsVahs7bI 20979621 3218662
    • Anders, S. & Huber, W. Differential expression analysis for sequence count data. Genome Biol. 11, R106 (2010).
    • (2010) Genome Biol. , vol.11
    • Anders, S.1    Huber, W.2
  • 66
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576-589 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 576-589
    • Heinz, S.1
  • 67
    • 84962921733 scopus 로고    scopus 로고
    • Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration
    • Sun, X. et al. Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration. Cell Stem Cell 18, 456-66 (2016).
    • (2016) Cell Stem Cell , vol.18 , pp. 456-466
    • Sun, X.1
  • 68
    • 84868325694 scopus 로고    scopus 로고
    • Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules
    • Faure, A. J. et al. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 22, 2163-75 (2012).
    • (2012) Genome Res. , vol.22 , pp. 2163-2175
    • Faure, A.J.1
  • 69
    • 46249131371 scopus 로고    scopus 로고
    • Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-CoA dehydrogenase (MCAD)-deficient mice
    • Herrema, H. et al. Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-CoA dehydrogenase (MCAD)-deficient mice. Hepatology 47, 1894-904 (2008).
    • (2008) Hepatology , vol.47 , pp. 1894-1904
    • Herrema, H.1
  • 70
    • 84930666013 scopus 로고    scopus 로고
    • Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic Fatty liver disease
    • Frades, I. et al. Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic Fatty liver disease. PLoS ONE 10, e0124544 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0124544
    • Frades, I.1
  • 71
    • 84905492815 scopus 로고    scopus 로고
    • Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome
    • Meissner, E. G. et al. Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome. J. Clin. Invest. 124, 3352-63 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 3352-3363
    • Meissner, E.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.