Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice

Journal of Clinical Investigation

Volumn 122, Issue 5, 2012, Pages 1758-1763

  Quinton, Lee J ^a   Blahna, Matthew T ^a   Jones, Matthew R ^a   Allen, Eri ^a   Ferrari, Joseph D ^a   Hilliard, Kristie L ^a   Zhang, Xiaoling ^a   Sabharwal, Vishakha ^b   Algül, Hana ^c   Akira, Shizuo ^d   Schmid, Roland M ^c   Pelton, Stephen I ^a,b   Spira, Avrum ^a   Mizgerd, Joseph P ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON MEDICAL CENTER   (United States)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR RELA;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE TRANSMISSION; GENE MUTATION; INFECTION; INFLAMMATION; LIVER; LIVER CELL; MACROPHAGE; MOUSE; NONHUMAN; OPSONOPHAGOCYTOSIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOCOCCUS PNEUMONIA;

ACUTE-PHASE REACTION; ANIMALS; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; HEPATOCYTES; IMMUNITY, INNATE; LIVER; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PNEUMONIA, PNEUMOCOCCAL; SERUM AMYLOID A PROTEIN; SERUM AMYLOID P-COMPONENT; STAT3 TRANSCRIPTION FACTOR; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION FACTOR RELA; TRANSCRIPTOME;

EID: 84860587432     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI59408     Document Type: Article

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