Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

Diabetologia

Volumn 61, Issue 3, 2018, Pages 641-657

  Solimena, Michele ^a,b,c   Schulte, Anke M ^d   Marselli, Lorella ^e   Ehehalt, Florian ^a,b,f   Richter, Daniela ^a,b   Kleeberg, Manuela ^a,b,f   Mziaut, Hassan ^a,b   Knoch, Klaus Peter ^a,b   Parnis, Julia ^g   Bugliani, Marco ^e   Siddiq, Afshan ^h,i   Jörns, Anne ^j   Burdet, Frédéric ^k   Liechti, Robin ^k   Suleiman, Mara ^e   Margerie, Daniel ^d   Syed, Farooq ^e   Distler, Marius ^f   Grützmann, Robert ^l   Petretto, Enrico ^g,m   Moreno Moral, Aida ^g,m   Wegbrod, Carolin ^a,b   Sönmez, Anke ^a,b   Pfriem, Katja ^a,b   Friedrich, Anne ^a,b   Meinel, Jörn ^f   Wollheim, Claes B ⁿ   Baretton, Gustavo B ^f   Scharfmann, Raphael ^o   Nogoceke, Everson ^p   Bonifacio, Ezio ^a,b,q   Sturm, Dorothée ^a,b,f   Meyer Puttlitz, Birgit ^d   Boggi, Ugo ^e   Saeger, Hans Detlev ^a,b,f   Filipponi, Franco ^e   Lesche, Mathias ^r   Meda, Paolo ⁿ   Dahl, Andreas ^r   Wigger, Leonore ^k   Xenarios, Ioannis ^k   Falchi, Mario ⁱ   Thorens, Bernard ^s   Weitz, Jürgen ^a,b,f   Bokvist, Krister ^t   Lenzen, Sigurd ^j   Rutter, Guy A ^g   Froguel, Philippe ^i,u,v,w   von Bülow, Manon ^d   Ibberson, Mark ^k   Marchetti, Piero ^e   more..

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^c MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^d SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^e UNIVERSITY OF PISA   (Italy)

^f UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^g IMPERIAL COLLEGE LONDON   (United Kingdom)

^h QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

ⁱ HAMMERSMITH HOSPITAL   (United Kingdom)

^j HANNOVER MEDICAL SCHOOL   (Germany)

^k SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^l UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^m DUKE NUS MEDICAL SCHOOL   (Singapore)

ⁿ UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^o INSERM   (France)

^p F HOFFMANN LA ROCHE LTD   (Switzerland)

^q CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^r DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^s UNIVERSITY OF LAUSANNE   (Switzerland)

^t ELI LILLY AND COMPANY   (United States)

^u INSTITUT PASTEUR DE LILLE   (France)

^v LILLE UNIVERSITY HOSPITAL   (France)

^w EGID FR3508 European Genomics Institute of Diabetes   (France)

more..

Author keywords

Beta cell; Biobank; Diabetes; Gene expression; Insulin secretion; Islet; Laser capture microdissection; Organ donor; Pancreatectomy; Systems biology

Indexed keywords

CALCIUM ION; INSULIN; TRANSCRIPTOME;

ADULT; ARG2 GENE; ARTICLE; BIOBANK; BIOINFORMATICS; CALCIUM TRANSPORT; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; DIABETES MELLITUS TYPE 3; DIABETIC PATIENT; EX VIVO STUDY; FEMALE; GENE; GENE EXPRESSION; GENE FUNCTION; GENETIC CORRELATION; GLUCOSE TOLERANCE; HNF1A GENE; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN RELEASE; LASER CAPTURE MICRODISSECTION; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; ORGAN DONOR; PANCREAS DISEASE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREATECTOMY; PDX1 GENE; PPP1R1A GENE; PRIORITY JOURNAL; REST GENE; RNA PROCESSING; RNA SEQUENCE; SYSTEMS BIOLOGY; TMEM37 GENE; TRANSCRIPTOMICS; AGED; BIOLOGY; DONOR; GENETICS; METABOLISM; PROCEDURES; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BIOLOGICAL SPECIMEN BANKS; COMPUTATIONAL BIOLOGY; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; PANCREATECTOMY; SYSTEMS BIOLOGY; TISSUE DONORS; TRANSCRIPTOME;

EID: 85035086913     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-017-4500-3     Document Type: Article

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