Activation of macrophage-associated molecules after brain death in islets

Cell Transplantation

Volumn 12, Issue 1, 2003, Pages 27-32

  Toyama, Hirochika ^a   Takada, Moriatsu ^a   Suzuki, Yasuyuki ^a   Kuroda, Yoshikazu ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

Brain death; Immunogenicity; Intraislet cytokines; Islet of Langerhans; Islet infiltrating immunocyte

Indexed keywords

CD11B ANTIGEN; GLYCOPROTEIN P 15095; INTERLEUKIN 1; INTERLEUKIN 6; ISOPROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEATH; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOMODULATION; MACROPHAGE MIGRATION; MALE; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALIA; RODENTIA;

EID: 0037241577     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000003783985205     Document Type: Article

References (19)

1. Amado, J. A.; Lopez-Espadas, F.; Vazquez-Barquero, A.; Salas, E.; Riancho, J. A.; Lopez-Cordovilla, J. J.; GarciaUnzueta, M. T. Blood levels of cytokines in brain-dead patients: Relationship with circulating hormones and acute-phase reactants. Metabolism 44:812-816; 1995.
2. Arnush, M.; Heitmeier, M. R.; Scarim, A. L.; Marino, M. H.; Manning, P. T.; Corbett, J. A. IL-1 produced and released endogenously within human islets inhibits beta cell function. J. Clin. Invest. 102:516-526; 1998.
3. Benhamou, P. Y.; Moriscot, C.; Badet, L.; Halimi, S. Strategies for graft immunomodulation in islet transplantation. Diabetes Metab. 24:215-224; 1998.
4. Berney, T.; Molano, R. D.; Cattan, P.; Pileggi, A.; Vizzardelli, C.; Oliver, R.; Ricordi, C.; Inverardi, L. Endotoxinmediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis. Transplantation 71:125-132; 2001.
5. Delaney, C. A.; Pavlovic, D.; Hoorens, A.; Pipeleers, D. G.; Eizirik, D. L. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 138:2610-2614; 1997.
6. Ghosh, S.; Bethune, D. W.; Hardy, I.; Kneeshaw, J.; Latimer, R. D.; Oduro, A. Management of donors for heart and heart-lung transplantation. Anaesthesia 45:672-675; 1990.
7. Gotoh, M.; Maki, T.; Satomi, S.; Porter, J.; Bonner-Weir, S.; O'Hara, C. J.; Monaco, A. P. Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation 43:725-730; 1987.
8. Mandrup-Poulsen, T.; Bendtzen, K.; Dinarello, C. A.; Nerup, J. Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity. J. Immunol. 139:4077-4082; 1987.
9. Mayhan, W. G. Regulation of blood-brain barrier permeability. Microcirculation 8:89-104; 2001.
10. Nicolls, M. R.; Coulombe, M.; Gill, R. G. The basis of immunogenicity of endocrine allografts. Crit. Rev. Immunol. 21:87-101; 2001.
11. Piemonti, L.; Leone, B. E.; Nano, R.; Saccani, A.; Monti, P.; Maffi, P.; Bianchi, G.; Sica, A.; Peri, G.; Melzi, R.; Aldrighetti, L.; Secchi, A.; Di Carlo, V.; Allavena, P.; Bertuzzi, F. Human pancreatic islets produce and secrete MCP-1/CCL2: Relevance in human islet transplantation. Diabetes 51:55-65; 2002.
12. Pratschke, J.; Wilhelm, M. J.; Kusaka, M.; Beato, F.; Milford, E. L.; Hancock, W. W.; Tilney, N. L. Accelerated rejection of renal allografts from brain-dead donors. Ann. Surg. 232:263-271; 2000.
13. Sandler, S.; Andersson, A.; Hellerstrom, C. Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets. Endocrinology 121:1424-1431; 1987.
14. Shapiro, A. M.; Ryan, E. A.; Lakey, J. R. Pancreatic islet transplantation in the treatment of diabetes mellitus. Best Pract. Res. Clin. Endocrinol. Metab. 15:241-264, 2001.
15. Takada, M.; Nadeau, K. C.; Hancock, W. W.; Mackenzie, H. S.; Shaw, G. D.; Waaga, A. M.; Chandraker, A.; Sayegh, M. H.; Tilney, N. L. Effects of explosive brain death on cytokine activation of peripheral organs in the rat. Transplantation 65:1533-1542; 1998.
16. van der Hoeven, J. A.; Ploeg, R. J.; Postema, F.; Molema, G.; de Vos, P.; Girbes, A. R.; van Suylichem, P. T.; Ter Horst, G. J. Induction of organ dysfunction and activation of inflammatory markers in donor liver and kidney during hypotensive brain death. Transplant. Proc. 31:1006-1007; 1999.
17. Vargas, F.; Vives-Pi, M.; Somoza, N.; Armengol, P.; Alcalde, L.; Marti, M.; Costa, M.; Serradell, L.; Dominguez, O.; Fernandez-Llamazares, J.; Julian, J. F.; Sanmarti, A.; Pujol-Borrell, R. Endotoxin contamination may be responsible for the unexplained failure of human pancreatic islet transplantation. Transplantation 65:722-727; 1998.
18. Wilhelm, M. J.; Pratschke, J.; Beato, F.; Taal, M.; Kusaka, M.; Hancock, W. W.; Tilney, N. L. Activation of the heart by donor brain death accelerates acute rejection after transplantation. Circulation 102:2426-2433; 2000.
19. Zhai, Q. H.; Futrell, N.; Chen, F. J. Gene expression of IL-10 in relationship to TNF-alpha, IL-1beta and IL-2 in the rat brain following middle cerebral artery occlusion. J. Neurol. Sci. 152:119-124; 1997.