Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

Nature Communications

Volumn 8, Issue 1, 2017, Pages

  Hu, Dan ^a   Notarbartolo, Samuele ^b   Croonenborghs, Tom ^a,c,d   Patel, Bonny ^a   Cialic, Ron ^a   Yang, Tun Hsiang ^a   Aschenbrenner, Dominik ^b,h   Andersson, Karin M ^e   Gattorno, Marco ^f   Pham, Minh ^a   Kivisakk, Pia ^a   Pierre, Isabelle V ^a   Lee, Youjin ^a   Kiani, Karun ^a   Bokarewa, Maria ^e   Tjon, Emily ^a   Pochet, Nathalie ^a   Sallusto, Federica ^b,g   Kuchroo, Vijay K ^a   Weiner, Howard L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^f G GASLINI INSTITUTE   (Italy)

^g ETH ZURICH   (Switzerland)

^h UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR 1; GRANZYME B; INTERLEUKIN 10; INTERLEUKIN 17; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MESSENGER RNA; STAT3 PROTEIN; STAT5A PROTEIN;

BLOOD; CELLS AND CELL COMPONENTS; DISEASE INCIDENCE; DISEASE TREATMENT; GENE; GENE EXPRESSION; PATHOGEN;

ADAPTIVE IMMUNITY; ADULT; ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; EX VIVO STUDY; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INNATE IMMUNITY; MALE; MULTIPLE SCLEROSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; UPREGULATION; ANIMAL; CELL CULTURE; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; MIDDLE AGED; MOUSE;

ANIMALIA; MURINAE;

ADULT; ANIMALS; CELLS, CULTURED; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; MALE; MICE; MIDDLE AGED; MULTIPLE SCLEROSIS; TH1 CELLS; TH17 CELLS;

EID: 85034584181     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-01571-8     Document Type: Article

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