Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells

Toxicology in Vitro

Volumn 47, Issue , 2018, Pages 48-62

  Rogalska, Aneta ^a   Bukowska, Barbara ^a   Marczak, Agnieszka ^a  

^a UNIVERSITY OF LODZ   (Poland)

Author keywords

Apoptosis; Cell cycle; DNA damage; Epothilone A; Metformin

Indexed keywords

CASPASE 3; EPOTHILONE A; HISTONE H2AX; MESSENGER RNA; METFORMIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; CASP3 PROTEIN, HUMAN; EPOTHILONE DERIVATIVE; H2AFX PROTEIN, HUMAN; HISTONE; PARP1 PROTEIN, HUMAN; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG POTENCY; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENOTOXICITY; HEP-G2 CELL LINE; HUMAN; HUMAN CELL; IC50; LIVER CELL CARCINOMA; MONOTHERAPY; OVARY ADENOCARCINOMA; OXIDATIVE STRESS; SK-OV-3 CELL LINE; UPREGULATION; ADENOCARCINOMA; AGONISTS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; DRUG RESISTANCE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; METABOLISM; OVARY TUMOR; PATHOLOGY; TUMOR CELL LINE;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL LINE, TUMOR; DNA DAMAGE; DRUG RESISTANCE, NEOPLASM; EPOTHILONES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; HUMANS; HYPOGLYCEMIC AGENTS; LIVER NEOPLASMS; METFORMIN; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; OXIDATIVE STRESS; POLY (ADP-RIBOSE) POLYMERASE-1; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 85034093254     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2017.11.001     Document Type: Article

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