Epothilone B induces extrinsic pathway of apoptosis in human SKOV-3 ovarian cancer cells

Toxicology in Vitro

Volumn 28, Issue 4, 2014, Pages 675-683

  Rogalska, Aneta ^a   Gajek, Arkadiusz ^a   Marczak, Agnieszka ^a  

^a UNIVERSITY OF LODZ   (Poland)

Author keywords

Apoptosis; Caspases; Epothilone B; Paclitaxel; PARP; TUNEL

Indexed keywords

CALCIUM; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DNA; EPOTHILONE B; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; ANTINEOPLASTIC AGENT; CASPASE; EDETIC ACID; EPOTHILONE DERIVATIVE; PARP1 PROTEIN, HUMAN; TRYPSIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CYTOSOL; DNA FRAGMENTATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; IC 50; LYMPHOCYTE; OVARY CANCER; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; DNA DAMAGE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OVARY TUMOR; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CASPASES; CELL LINE, TUMOR; CYTOCHROMES C; DNA DAMAGE; EDETIC ACID; EPOTHILONES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; OVARIAN NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; TRYPSIN;

EID: 84896057815     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.02.007     Document Type: Article

References (34)

1. Barbetti V., Tusa I., Cipolleschi M.G., Rovida E., Dello Sbarba P. AML1/ETO sensitizes via TRAIL acute myeloid leukemia cells to the pro-apoptotic effects of hypoxia. Cell Death Dis. 2013, 4:e536.
2. Bilski A., Pasz-Walczak G., Kubiak R., Sek P., Chalubinska J., Fendler W., Wronski K., Piekarska A., Pluta P., Potemski P., Jeziorski A., Piekarski J. TRAIL protein expression in breast cancer cells correlates with nuclear grade. Arch. Med. Sci. 2010, 6:545-551.
3. Boucher D., Blais V., Drag M., Denault J.B. Molecular determinants involved in activation of caspase 7. Biosci. Rep. 2011, 31:283-294.
4. Carrara L., Guzzo F., Roque D.M., Bellone S., Emiliano C., Sartori E., Pecorelli S., Schwartz P.E., Rutherford T.J., Santin A.D. Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. Gynecol. Oncol. 2012, 125:231-236.
5. Chaitanya G.V., Steven A.J., Babu P.P. PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Commun. Signal 2010, 8:31.
6. Cheng A.C., Lee M.F., Tsai M.L., Lai C.S., Lee J.H., Ho C.T., Pan M.H. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Food Chem. Toxicol.: Int. J. Br. Ind. Biol. Res. Assoc. 2011, 49:485-493.
7. D'Amours D., Sallmann F.R., Dixit V.M., Poirier G.G. Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis. J. Cell Sci. 2001, 114:3771-3778.
8. Edelman M.J., Shvartsbeyn M. Epothilones in development for non-small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin. Lung Cancer 2012, 13:171-180.
9. Fauzee N.J., Wang Y.L., Dong Z., Li Q.G., Wang T., Mandarry M.T., Xu L., Pan J. Novel hydrophilic docetaxel (CQMU-0519) analogue inhibits proliferation and induces apoptosis in human A549 lung, SKVO3 ovarian and MCF7 breast carcinoma cell lines. Cell Prolif. 2012, 45:352-364.
10. Giorgi C., Baldassari F., Bononi A., Bonora M., De Marchi E., Marchi S., Missiroli S., Patergnani S., Rimessi A., Suski J.M., Wieckowski M.R., Pinton P. Mitochondrial Ca(2+) and apoptosis. Cell Calcium 2012, 52:36-43.
11. Griffin D., Wittmann S., Guo F., Nimmanapalli R., Bali P., Wang H.G., Bhalla K. Molecular determinants of epothilone B derivative (BMS 247550) and Apo-2L/TRAIL-induced apoptosis of human ovarian cancer cells. Gynecol. Oncol. 2003, 89:37-47.
12. Guarneri V., Piacentini F., Barbieri E., Conte P.F. Achievements and unmet needs in the management of advanced ovarian cancer. Gynecol. Oncol. 2010, 117:152-158.
13. Guo F., Nimmanapalli R., Paranawithana S., Wittman S., Griffin D., Bali P., O'Bryan E., Fumero C., Wang H.G., Bhalla K. Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis. Blood 2002, 99:3419-3426.
14. Hsu J.L., Leong P.K., Ho Y.F., Hsu L.C., Lu P.H., Chen C.S., Guh J.H. Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair. Cancer Lett. 2012, 319:214-222.
15. Hu Y., Benedict M.A., Wu D., Inohara N., Nunez G. Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc. Natl. Acad. Sci. USA 1998, 95:4386-4391.
16. Huber V., Fais S., Iero M., Lugini L., Canese P., Squarcina P., Zaccheddu A., Colone M., Arancia G., Gentile M., Seregni E., Valenti R., Ballabio G., Belli F., Leo E., Parmiani G., Rivoltini L. Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape. Gastroenterology 2005, 128:1796-1804.
17. Janssen K., Pohlmann S., Janicke R.U., Schulze-Osthoff K., Fischer U. Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment. Blood 2007, 110:3662-3672.
18. Kim S.J., Chung M.J., Kim J.S., Kim B., Park W.H., Kim S.H., Kim S.Z., Lee J.S., Kim S.M. Deciphering the role of paclitaxel in the SKGT4 human esophageal adenocarcinoma cell line. Int. J. Oncol. 2011, 39:1587-1591.
19. Liu J.R., Opipari A.W., Tan L., Jiang Y., Zhang Y., Tang H., Nunez G. Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance. Cancer Res. 2002, 62:924-931.
20. Margolin N., Raybuck S.A., Wilson K.P., Chen W., Fox T., Gu Y., Livingston D.J. Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases. J. Biol. Chem. 1997, 272:7223-7228.
21. Mughal W., Dhingra R., Kirshenbaum L.A. Striking a balance: autophagy, apoptosis, and necrosis in a normal and failing heart. Curr. Hypertens. Rep. 2012, 9:8.
22. Park S.J., Wu C.H., Gordon J.D., Zhong X., Emami A., Safa A.R. Taxol induces caspase-10-dependent apoptosis. J. Biol. Chem. 2004, 279:51057-51067.
23. Park S.J., Kim M.J., Kim H.B., Sohn H.Y., Bae J.H., Kang C.D., Kim S.H. Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway. Biochem. Pharmacol. 2009, 77:1328-1336.
24. Parkash J., Asotra K. Calcium wave signaling in cancer cells. Life Sci. 2010, 87:587-595.
25. Peters K.N., Dhariwala M.O., Hughes Hanks J.M., Brown C.R., Anderson D.M. Early apoptosis of macrophages modulated by injection of Yersinia pestis YopK promotes progression of primary pneumonic plague. PLoS Pathog. 2013, 9:e1003324.
26. Rogalska A., Marczak A., Gajek A., Szwed M., Sliwinska A., Drzewoski J., Jozwiak Z. Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B. Toxicol. In Vitro 2013, 27:239-249.
27. Shiraki K., Yamanaka T., Inoue H., Kawakita T., Enokimura N., Okano H., Sugimoto K., Murata K., Nakano T. Expression of TNF-related apoptosis-inducing ligand in human hepatocellular carcinoma. Int. J. Oncol. 2005, 26:1273-1281.
28. Siddiqui-Jain A., Bliesath J., Macalino D., Omori M., Huser N., Streiner N., Ho C.B., Anderes K., Proffitt C., O'Brien S.E., Lim J.K., Von Hoff D.D., Ryckman D.M., Rice W.G., Drygin D. CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy. Mol. Cancer Ther. 2012, 11:994-1005.
29. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
30. Tan D.S., Miller R.E., Kaye S.B. New perspectives on molecular targeted therapy in ovarian clear cell carcinoma. Br. J. Cancer 2013, 108:1553-1559.
31. Valenzuela M.T., Guerrero R., Nunez M.I., Ruiz De Almodovar J.M., Sarker M., de Murcia G., Oliver F.J. PARP-1 modifies the effectiveness of p53-mediated DNA damage response. Oncogene 2002, 21:1108-1116.
32. Wennerberg E., Sarhan D., Carlsten M., Kaminskyy V.O., D'Arcy P., Zhivotovsky B., Childs R., Lundqvist A. Doxorubicin sensitizes human tumor cells to NK cell- and T-cell-mediated killing by augmented TRAIL receptor signaling. Int. J. Cancer 2013.
33. Wiltshire T., Senft J., Wang Y., Konat G.W., Wenger S.L., Reed E., Wang W. BRCA1 contributes to cell cycle arrest and chemoresistance in response to the anticancer agent irofulven. Mol. Pharmacol. 2007, 71:1051-1060.
34. Xu J., Zhou J.Y., Wei W.Z., Wu G.S. Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells. PLoS One 2010, 5:e10226.