메뉴 건너뛰기




Volumn 9, Issue 4, 2016, Pages 184-190

Current status and future prospects of chemotherapy for advanced hepatocellular carcinoma

Author keywords

Chemotherapy; Hepatic arterial infusion chemotherapy; Hepatocellular carcinoma; Immune checkpoint inhibitor; Molecular targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT; BRIVANIB; CABOZANTINIB; DOXORUBICIN; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; IMMUNE CHECKPOINT INHIBITOR; LENVATINIB; LINIFANIB; NIVOLUMAB; OXALIPLATIN; RAMUCIRUMAB; REGORAFENIB; SORAFENIB; SUNITINIB; TIVANTINIB; TS 1; UNCLASSIFIED DRUG; CARBANILAMIDE DERIVATIVE; NICOTINAMIDE;

EID: 84978096991     PISSN: 18657257     EISSN: 18657265     Source Type: Journal    
DOI: 10.1007/s12328-016-0670-7     Document Type: Review
Times cited : (31)

References (48)
  • 2
    • 84910627830 scopus 로고    scopus 로고
    • JSH consensus-based clinical practice guidelines for the management of hepatocellular carcinoma: 2014 update by the Liver Cancer Study Group of Japan
    • Kudo M, Matsui O, Izumi N, Liver Cancer Study Group of Japan, et al. JSH consensus-based clinical practice guidelines for the management of hepatocellular carcinoma: 2014 update by the Liver Cancer Study Group of Japan. Liver Cancer. 2014;2014(3):458–68.
    • (2014) Liver Cancer , vol.2014 , Issue.3 , pp. 458-468
    • Kudo, M.1    Matsui, O.2    Izumi, N.3    Liver Cancer Study Group of Japan4
  • 3
    • 84874365037 scopus 로고    scopus 로고
    • Liver resection and transplantation in hepatocellular carcinoma
    • COI: 1:STN:280:DC%2BC2cfltlGhtA%3D%3D, PID: 24159575
    • Belghiti J, Fuks D. Liver resection and transplantation in hepatocellular carcinoma. Liver Cancer. 2012;1:71–82.
    • (2012) Liver Cancer , vol.1 , pp. 71-82
    • Belghiti, J.1    Fuks, D.2
  • 4
    • 0036189111 scopus 로고    scopus 로고
    • Prognostic prediction and treatment strategy in hepatocellular carcinoma
    • PID: 11870363
    • Bruix J, Llovet JM. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology. 2002;35:519–24.
    • (2002) Hepatology , vol.35 , pp. 519-524
    • Bruix, J.1    Llovet, J.M.2
  • 5
    • 0037129704 scopus 로고    scopus 로고
    • Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial
    • PID: 12049862
    • Llovet JM, Real MI, Montaña X, Barcelona Liver Cancer Group, et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet. 2002;359:1734–9.
    • (2002) Lancet , vol.359 , pp. 1734-1739
    • Llovet, J.M.1    Real, M.I.2    Montaña, X.3    Barcelona Liver Cancer Group4
  • 6
    • 84858702846 scopus 로고    scopus 로고
    • Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines
    • PID: 22173160
    • Takayasu K, Arii S, Kudo M, et al. Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines. J Hepatol. 2012;56:886–92.
    • (2012) J Hepatol , vol.56 , pp. 886-892
    • Takayasu, K.1    Arii, S.2    Kudo, M.3
  • 7
    • 84875243085 scopus 로고    scopus 로고
    • Prospective study of transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: an Asian cooperative study between Japan and Korea
    • PID: 23466316
    • Ikeda M, Arai Y, Park SJ, Japan Interventional Radiology in Oncology Study Group (JIVROSG), Korea Interventional Radiology in Oncology Study Group (KIVROSG), et al. Prospective study of transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: an Asian cooperative study between Japan and Korea. J Vasc Interv Radiol. 2013;24:490–500.
    • (2013) J Vasc Interv Radiol , vol.24 , pp. 490-500
    • Ikeda, M.1    Arai, Y.2    Park, S.J.3
  • 8
    • 77949264899 scopus 로고    scopus 로고
    • Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISIONV study
    • Lammer J, Malagari K, Vogl T, PRECISIONV Investigators, et al. Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISIONV study. Cardiovasc Interv Radiol. 2010;33:41–52.
    • (2010) Cardiovasc Interv Radiol , vol.33 , pp. 41-52
    • Lammer, J.1    Malagari, K.2    Vogl, T.3    PRECISIONV Investigators4
  • 9
    • 84904557662 scopus 로고    scopus 로고
    • Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC2cXhtVagsbnF, PID: 24937669
    • Golfieri R, Giampalma E, Renzulli M, PRECISION ITALIA STUDY GROUP, et al. Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinoma. Br J Cancer. 2014;111:255–64.
    • (2014) Br J Cancer , vol.111 , pp. 255-264
    • Golfieri, R.1    Giampalma, E.2    Renzulli, M.3    PRECISION ITALIA STUDY GROUP4
  • 11
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BD1cXhsFChtbnM, PID: 19095497
    • Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10:25–34.
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 12
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • COI: 1:CAS:528:DC%2BD2cXotFalsbk%3D, PID: 15466206
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099–109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 13
    • 33847118123 scopus 로고    scopus 로고
    • Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models
    • COI: 1:CAS:528:DC%2BD2sXhvVeiuro%3D, PID: 17160391
    • Chang YS, Adnane J, Trail PA, et al. Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models. Cancer Chemother Pharmacol. 2007;59:561–74.
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 561-574
    • Chang, Y.S.1    Adnane, J.2    Trail, P.A.3
  • 14
    • 84859726758 scopus 로고    scopus 로고
    • Relationship between baseline hepatic status and outcome, and effect of sorafenib on liver function: SHARP trial subanalyses
    • COI: 1:CAS:528:DC%2BC38XlvFGgtL8%3D, PID: 22245896
    • Raoul JL, Bruix J, Greten TF, et al. Relationship between baseline hepatic status and outcome, and effect of sorafenib on liver function: SHARP trial subanalyses. J Hepatol. 2012;56:1080–8.
    • (2012) J Hepatol , vol.56 , pp. 1080-1088
    • Raoul, J.L.1    Bruix, J.2    Greten, T.F.3
  • 15
    • 84953865606 scopus 로고    scopus 로고
    • Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BC2MXhsFSit7nL, PID: 26361969
    • Bruix J, Takayama T, Mazzaferro V, STORM Investigators, et al. Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2015;16:1344–54.
    • (2015) Lancet Oncol , vol.16 , pp. 1344-1354
    • Bruix, J.1    Takayama, T.2    Mazzaferro, V.3    STORM Investigators4
  • 16
    • 84957619381 scopus 로고    scopus 로고
    • Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: the SPACE trial
    • COI: 1:CAS:528:DC%2BC28Xit12ks78%3D, PID: 26809111
    • Lencioni R, Llovet JM, Han G, et al. Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: the SPACE trial. J Hepatol. 2016;64:1090–8.
    • (2016) J Hepatol , vol.64 , pp. 1090-1098
    • Lencioni, R.1    Llovet, J.M.2    Han, G.3
  • 17
    • 79960805810 scopus 로고    scopus 로고
    • Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3MXhtFKit77O, PID: 21664811
    • Kudo M, Imanaka K, Chida N, et al. Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma. Eur J Cancer. 2011;47:2117–27.
    • (2011) Eur J Cancer , vol.47 , pp. 2117-2127
    • Kudo, M.1    Imanaka, K.2    Chida, N.3
  • 18
    • 84922391871 scopus 로고    scopus 로고
    • Efficacy of sorafenib in intermediate-stage hepatocellular carcinoma patients refractory to transarterial chemoembolization
    • COI: 1:CAS:528:DC%2BC2cXitVGmsbfI, PID: 25227534
    • Ogasawara S, Chiba T, Ooka Y, et al. Efficacy of sorafenib in intermediate-stage hepatocellular carcinoma patients refractory to transarterial chemoembolization. Oncology. 2014;87:330–41.
    • (2014) Oncology , vol.87 , pp. 330-341
    • Ogasawara, S.1    Chiba, T.2    Ooka, Y.3
  • 19
    • 84992177760 scopus 로고    scopus 로고
    • Effectiveness of sorafenib in patients with transcatheter arterial chemoembolization (TACE) refractory and intermediate-stage hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC2MXhvF2lu7%2FM, PID: 26734579
    • Arizumi T, Ueshima K, Minami T, et al. Effectiveness of sorafenib in patients with transcatheter arterial chemoembolization (TACE) refractory and intermediate-stage hepatocellular carcinoma. Liver Cancer. 2015;4:253–62.
    • (2015) Liver Cancer , vol.4 , pp. 253-262
    • Arizumi, T.1    Ueshima, K.2    Minami, T.3
  • 20
    • 79953325932 scopus 로고    scopus 로고
    • Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3MXktVOisb0%3D, PID: 21349999
    • Park JW, Finn RS, Kim JS, et al. Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Clin Cancer Res. 2011;17:1973–83.
    • (2011) Clin Cancer Res , vol.17 , pp. 1973-1983
    • Park, J.W.1    Finn, R.S.2    Kim, J.S.3
  • 21
    • 84890274647 scopus 로고    scopus 로고
    • Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study
    • COI: 1:CAS:528:DC%2BC3sXhs12mt7%2FN, PID: 23980084
    • Johnson PJ, Qin S, Park JW, et al. Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study. J Clin Oncol. 2013;31:3517–24.
    • (2013) J Clin Oncol , vol.31 , pp. 3517-3524
    • Johnson, P.J.1    Qin, S.2    Park, J.W.3
  • 22
    • 84885587718 scopus 로고    scopus 로고
    • Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study
    • COI: 1:CAS:528:DC%2BC3sXhs12mt77E, PID: 23980090
    • Llovet JM, Decaens T, Raoul JL, et al. Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized phase III BRISK-PS study. J Clin Oncol. 2013;31:3509–16.
    • (2013) J Clin Oncol , vol.31 , pp. 3509-3516
    • Llovet, J.M.1    Decaens, T.2    Raoul, J.L.3
  • 23
    • 84984559340 scopus 로고    scopus 로고
    • Phase 2 trial of linifanib (ABT-869) in patients with unresectable or metastatic hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3sXjs12jtg%3D%3D, PID: 22833179
    • Toh HC, Chen PJ, Carr BI, et al. Phase 2 trial of linifanib (ABT-869) in patients with unresectable or metastatic hepatocellular carcinoma. Cancer. 2013;119:380–7.
    • (2013) Cancer , vol.119 , pp. 380-387
    • Toh, H.C.1    Chen, P.J.2    Carr, B.I.3
  • 24
    • 84920993186 scopus 로고    scopus 로고
    • Linifanib versus sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial
    • COI: 1:CAS:528:DC%2BC2MXit1Chu7c%3D, PID: 25488963
    • Cainap C, Qin S, Huang WT, et al. Linifanib versus sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial. J Clin Oncol. 2015;33:172–9.
    • (2015) J Clin Oncol , vol.33 , pp. 172-179
    • Cainap, C.1    Qin, S.2    Huang, W.T.3
  • 25
    • 84891915708 scopus 로고    scopus 로고
    • Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trial
    • COI: 1:CAS:528:DC%2BC3sXhvFSksrbL, PID: 24081937
    • Cheng AL, Kang YK, Lin DY, et al. Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trial. J Clin Oncol. 2013;31:4067–75.
    • (2013) J Clin Oncol , vol.31 , pp. 4067-4075
    • Cheng, A.L.1    Kang, Y.K.2    Lin, D.Y.3
  • 26
    • 84923144891 scopus 로고    scopus 로고
    • SEARCH: a phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with advanced hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC2MXktlCntrw%3D, PID: 25547503
    • Zhu AX, Rosmorduc O, Evans TR, Ross PJ, Santoro A, Carrilho FJ, et al. SEARCH: a phase III, randomized, double-blind, placebo-controlled trial of sorafenib plus erlotinib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2015;33:559–66.
    • (2015) J Clin Oncol , vol.33 , pp. 559-566
    • Zhu, A.X.1    Rosmorduc, O.2    Evans, T.R.3    Ross, P.J.4    Santoro, A.5    Carrilho, F.J.6
  • 27
    • 84868328046 scopus 로고    scopus 로고
    • Ikeda K, Kumada H, Kudo M, et al. Phase I/II trial of lenvatinib (E7080), a multi-targeted tyrosine kinase inhibitor, in patients (pts) with advanced hepatocellular carcinoma (HCC). ;23(Suppl 9; abstr 737P)
    • Ikeda K, Kumada H, Kudo M, et al. Phase I/II trial of lenvatinib (E7080), a multi-targeted tyrosine kinase inhibitor, in patients (pts) with advanced hepatocellular carcinoma (HCC). Ann Oncol. 2012;23(Suppl 9; abstr 737P).
    • (2012) Ann Oncol.
  • 28
    • 84903593280 scopus 로고    scopus 로고
    • Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial
    • PID: 25058218
    • Zhu AX, Kudo M, Assenat E, et al. Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial. JAMA. 2014;312:57–67.
    • (2014) JAMA , vol.312 , pp. 57-67
    • Zhu, A.X.1    Kudo, M.2    Assenat, E.3
  • 29
    • 84923850547 scopus 로고    scopus 로고
    • Verslype C, Cohn AL, Kelley RK, et al. Activity of cabozantinib (XL184) in hepatocellular carcinoma: Results from a phase II randomized discontinuation trial (RDT). ;30(Suppl; abstr 4007)
    • Verslype C, Cohn AL, Kelley RK, et al. Activity of cabozantinib (XL184) in hepatocellular carcinoma: Results from a phase II randomized discontinuation trial (RDT). J Clin Oncol. 2012;30(Suppl; abstr 4007).
    • (2012) J Clin Oncol.
  • 30
    • 84937523736 scopus 로고    scopus 로고
    • Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial
    • COI: 1:CAS:528:DC%2BC2MXhtVKhtbzJ, PID: 26095784
    • Zhu AX, Park JO, Ryoo BY, REACH Trial Investigators, et al. Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial. Lancet Oncol. 2015;16:859–70.
    • (2015) Lancet Oncol , vol.16 , pp. 859-870
    • Zhu, A.X.1    Park, J.O.2    Ryoo, B.Y.3    REACH Trial Investigators4
  • 31
    • 84871721240 scopus 로고    scopus 로고
    • Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase2 study
    • COI: 1:CAS:528:DC%2BC3sXhsV2nug%3D%3D, PID: 23182627
    • Santoro A, Rimassa L, Borbath I, et al. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase2 study. Lancet Oncol. 2013;14:55–63.
    • (2013) Lancet Oncol , vol.14 , pp. 55-63
    • Santoro, A.1    Rimassa, L.2    Borbath, I.3
  • 32
    • 84885173677 scopus 로고    scopus 로고
    • Regorafenib as second-line therapy for intermediate or advanced hepatocellular carcinoma: multicentre, open-label, phase II safety study
    • COI: 1:CAS:528:DC%2BC3sXhtVKrtb7E, PID: 23809766
    • Bruix J, Tak WY, Gasbarrini A, et al. Regorafenib as second-line therapy for intermediate or advanced hepatocellular carcinoma: multicentre, open-label, phase II safety study. Eur J Cancer. 2013;49:3412–9.
    • (2013) Eur J Cancer , vol.49 , pp. 3412-3419
    • Bruix, J.1    Tak, W.Y.2    Gasbarrini, A.3
  • 33
    • 84891587587 scopus 로고    scopus 로고
    • Randomized, multicenter, open-label study of oxaliplatin plus fluorouracil/leucovorin versus doxorubicin as palliative chemotherapy in patients with advanced hepatocellular carcinoma from Asia
    • COI: 1:CAS:528:DC%2BC3sXhs12mt77K, PID: 23980077
    • Qin S, Bai Y, Lim HY, et al. Randomized, multicenter, open-label study of oxaliplatin plus fluorouracil/leucovorin versus doxorubicin as palliative chemotherapy in patients with advanced hepatocellular carcinoma from Asia. J Clin Oncol. 2013;31:3501–8.
    • (2013) J Clin Oncol , vol.31 , pp. 3501-3508
    • Qin, S.1    Bai, Y.2    Lim, H.Y.3
  • 34
    • 84940447290 scopus 로고    scopus 로고
    • Kudo M, Moriguchi M, Numata K, et al. A randomized, double-blind, placebo-controlled phase III study of S-1 in patients with sorafenib-refractory advanced hepatocellular carcinoma (S-CUBE). ; 33(Suppl; abstr 4018)
    • Kudo M, Moriguchi M, Numata K, et al. A randomized, double-blind, placebo-controlled phase III study of S-1 in patients with sorafenib-refractory advanced hepatocellular carcinoma (S-CUBE). J Clin Oncol. 2015; 33(Suppl; abstr 4018).
    • (2015) J Clin Oncol.
  • 35
    • 84976462971 scopus 로고    scopus 로고
    • Kudo M, Okusaka T, Kaneko S, et al. Identification of a high-response patient population to S-1 via predictive enrichment strategy analysis of the S-CUBE phase III trial. ; 34(Suppl 4S; abstr 229)
    • Kudo M, Okusaka T, Kaneko S, et al. Identification of a high-response patient population to S-1 via predictive enrichment strategy analysis of the S-CUBE phase III trial. J Clin Oncol. 2016; 34(Suppl 4S; abstr 229).
    • (2016) J Clin Oncol.
  • 36
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • COI: 1:CAS:528:DC%2BC38XhtV2rs7fN, PID: 22658127
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443–54.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 37
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • PID: 26027431
    • Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 2015;373:23–34.
    • (2015) N Engl J Med , vol.373 , pp. 23-34
    • Larkin, J.1    Chiarion-Sileni, V.2    Gonzalez, R.3
  • 38
    • 84944937210 scopus 로고    scopus 로고
    • nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC28XjsFyitL0%3D, PID: 26412456
    • Borghaei H, Paz-Ares L, Horn L, et al. nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015;373:1627–39.
    • (2015) N Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3
  • 39
    • 61549122071 scopus 로고    scopus 로고
    • Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD1MXht1Ontr8%3D, PID: 19188168
    • Gao Q, Wang XY, Qiu SJ, et al. Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin Cancer Res. 2009;15:971–9.
    • (2009) Clin Cancer Res , vol.15 , pp. 971-979
    • Gao, Q.1    Wang, X.Y.2    Qiu, S.J.3
  • 40
    • 84976622250 scopus 로고    scopus 로고
    • Intratumoral CD3 and CD8 T-cell densities associated with relapse-free survival in HCC
    • COI: 1:CAS:528:DC%2BC28XntlOktr8%3D, PID: 26968206
    • Gabrielson A, Wu Y, Wang H, et al. Intratumoral CD3 and CD8 T-cell densities associated with relapse-free survival in HCC. Cancer Immunol Res. 2016;4:419–30.
    • (2016) Cancer Immunol Res , vol.4 , pp. 419-430
    • Gabrielson, A.1    Wu, Y.2    Wang, H.3
  • 41
    • 84940447290 scopus 로고    scopus 로고
    • El-Khoueiry AB, Melero I, Crocenzi TS, et al. Phase I/II safety and antitumor activity of nivolumab in patients with advanced hepatocellular carcinoma (HCC): CA209-040. ; 33(Suppl; abstr LBA101)
    • El-Khoueiry AB, Melero I, Crocenzi TS, et al. Phase I/II safety and antitumor activity of nivolumab in patients with advanced hepatocellular carcinoma (HCC): CA209-040. J Clin Oncol. 2015; 33(Suppl; abstr LBA101).
    • (2015) J Clin Oncol.
  • 42
    • 42649086177 scopus 로고    scopus 로고
    • Phase II study of hepatic arterial infusion of a fine-powder formulation of cisplatin for advanced hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD1cXptlajsLw%3D, PID: 18430093
    • Yoshikawa M, Ono N, Yodono H, Ichida T, Nakamura H. Phase II study of hepatic arterial infusion of a fine-powder formulation of cisplatin for advanced hepatocellular carcinoma. Hepatol Res. 2008;38:474–83.
    • (2008) Hepatol Res , vol.38 , pp. 474-483
    • Yoshikawa, M.1    Ono, N.2    Yodono, H.3    Ichida, T.4    Nakamura, H.5
  • 43
    • 0036682065 scopus 로고    scopus 로고
    • Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: analysis of 48 cases
    • PID: 12209752
    • Ando E, Tanaka M, Yamashita F, et al. Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: analysis of 48 cases. Cancer. 2002;95:588–95.
    • (2002) Cancer , vol.95 , pp. 588-595
    • Ando, E.1    Tanaka, M.2    Yamashita, F.3
  • 44
    • 77954487817 scopus 로고    scopus 로고
    • Hepatic arterial infusion chemotherapy using low-dose 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3cXos1Wlt78%3D, PID: 20616598
    • Ueshima K, Kudo M, Takita M, et al. Hepatic arterial infusion chemotherapy using low-dose 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma. Oncology. 2010;78:148–53.
    • (2010) Oncology , vol.78 , pp. 148-153
    • Ueshima, K.1    Kudo, M.2    Takita, M.3
  • 45
    • 82355184589 scopus 로고    scopus 로고
    • Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC38Xis1eksbg%3D, PID: 22133996
    • Yamashita T, Arai K, Sunagozaka H, et al. Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellular carcinoma. Oncology. 2011;81:281–90.
    • (2011) Oncology , vol.81 , pp. 281-290
    • Yamashita, T.1    Arai, K.2    Sunagozaka, H.3
  • 46
    • 33646383886 scopus 로고    scopus 로고
    • Combination therapy of intraarterial 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma with portal venous invasion
    • COI: 1:CAS:528:DC%2BD28XkvFGhs7s%3D, PID: 16565970
    • Obi S, Yoshida H, Toune R, et al. Combination therapy of intraarterial 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma with portal venous invasion. Cancer. 2006;106:1990–7.
    • (2006) Cancer , vol.106 , pp. 1990-1997
    • Obi, S.1    Yoshida, H.2    Toune, R.3
  • 47
    • 84940447290 scopus 로고    scopus 로고
    • Ikeda M, Shimizu S, Sato T, et al. Sorafenib plus intra-arterial cisplatin versus sorafenib alone in patients with advanced hepatocellular carcinoma: a randomized phase II trial. ; 33(Suppl; abstr 4076)
    • Ikeda M, Shimizu S, Sato T, et al. Sorafenib plus intra-arterial cisplatin versus sorafenib alone in patients with advanced hepatocellular carcinoma: a randomized phase II trial. J Clin Oncol. 2015; 33(Suppl; abstr 4076).
    • (2015) J Clin Oncol.
  • 48
    • 85012893080 scopus 로고    scopus 로고
    • Kudo M, Ueshima K, Yokosuka O, et al. Prospective randomized controlled phase III trial comparing the efficacy of sorafenib versus sorafenib in combination with low-dose cisplatin/fluorouracil hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma. ;64(Suppl 2; abstr LB04)
    • Kudo M, Ueshima K, Yokosuka O, et al. Prospective randomized controlled phase III trial comparing the efficacy of sorafenib versus sorafenib in combination with low-dose cisplatin/fluorouracil hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma. J Hepatol. 2016;64(Suppl 2; abstr LB04).
    • (2016) J Hepatol.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.