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Volumn 39, Issue 6, 2015, Pages 518-527

Metformin promotes apoptosis but suppresses autophagy in glucose-deprived H4IIE hepatocellular carcinoma cells

Author keywords

Apoptosis; Autophagy; H4IIE hepatocellular carcinoma cells; Metformin

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; BECLIN 1; CASPASE 3; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

EID: 84951916498     PISSN: 22336079     EISSN: 22336087     Source Type: Journal    
DOI: 10.4093/dmj.2015.39.6.518     Document Type: Article
Times cited : (21)

References (39)
  • 1
    • 84866322945 scopus 로고    scopus 로고
    • Investigating metformin for cancer prevention and treatment: the end of the beginning
    • Pollak MN. Investigating metformin for cancer prevention and treatment: the end of the beginning. Cancer Discov 2012;2: 778-90.
    • (2012) Cancer Discov , vol.2 , pp. 778-790
    • Pollak, M.N.1
  • 2
    • 84877794387 scopus 로고    scopus 로고
    • Metformin and cancer in type 2 diabetes
    • Park HK. Metformin and cancer in type 2 diabetes. Diabetes Metab J 2013;37:113-6.
    • (2013) Diabetes Metab J , vol.37 , pp. 113-116
    • Park, H.K.1
  • 6
    • 70749106139 scopus 로고    scopus 로고
    • Metformin is a potent inhibitor of endometrial cancer cell proliferation: implications for a novel treatment strategy
    • Cantrell LA, Zhou C, Mendivil A, Malloy KM, Gehrig PA, Bae-Jump VL. Metformin is a potent inhibitor of endometrial cancer cell proliferation: implications for a novel treatment strategy. Gynecol Oncol 2010;116:92-8.
    • (2010) Gynecol Oncol , vol.116 , pp. 92-98
    • Cantrell, L.A.1    Zhou, C.2    Mendivil, A.3    Malloy, K.M.4    Gehrig, P.A.5    Bae-Jump, V.L.6
  • 7
    • 84902328519 scopus 로고    scopus 로고
    • Metformin inhibits histone H2B monoubiquitination and downstream gene transcription in human breast cancer cells
    • Du Y, Zheng H, Wang J, Ren Y, Li M, Gong C, Xu F, Yang C. Metformin inhibits histone H2B monoubiquitination and downstream gene transcription in human breast cancer cells. Oncol Lett 2014;8:809-12.
    • (2014) Oncol Lett , vol.8 , pp. 809-812
    • Du, Y.1    Zheng, H.2    Wang, J.3    Ren, Y.4    Li, M.5    Gong, C.6    Xu, F.7    Yang, C.8
  • 9
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: a nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012;13:251-62.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 10
    • 84888439282 scopus 로고    scopus 로고
    • Metabolic roles of AMPK and metformin in cancer cells
    • Choi YK, Park KG. Metabolic roles of AMPK and metformin in cancer cells. Mol Cells 2013;36:279-87.
    • (2013) Mol Cells , vol.36 , pp. 279-287
    • Choi, Y.K.1    Park, K.G.2
  • 11
    • 84873412963 scopus 로고    scopus 로고
    • Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects
    • Emami Riedmaier A, Fisel P, Nies AT, Schaeffeler E, Schwab M. Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects. Trends Pharmacol Sci 2013; 34:126-35.
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 126-135
    • Emami Riedmaier, A.1    Fisel, P.2    Nies, A.T.3    Schaeffeler, E.4    Schwab, M.5
  • 12
    • 84907061966 scopus 로고    scopus 로고
    • Role of autophagy in the control of body metabolism
    • Quan W, Lee MS. Role of autophagy in the control of body metabolism. Endocrinol Metab (Seoul) 2013;28:6-11.
    • (2013) Endocrinol Metab (Seoul) , vol.28 , pp. 6-11
    • Quan, W.1    Lee, M.S.2
  • 14
    • 84902940561 scopus 로고    scopus 로고
    • Metformin induces apoptosis in hepatocellular carcinoma Huh-7 cells in vitro and its mechanism
    • Lin F, Yan W, Wen T, Wu GY. Metformin induces apoptosis in hepatocellular carcinoma Huh-7 cells in vitro and its mechanism. Zhonghua Zhong Liu Za Zhi 2013;35:742-6.
    • (2013) Zhonghua Zhong Liu Za Zhi , vol.35 , pp. 742-746
    • Lin, F.1    Yan, W.2    Wen, T.3    Wu, G.Y.4
  • 16
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 17
    • 84896731193 scopus 로고    scopus 로고
    • Metformin plays a dual role in MIN6 pancreatic beta cell function through AMPK-dependent autophagy
    • Jiang Y, Huang W, Wang J, Xu Z, He J, Lin X, Zhou Z, Zhang J. Metformin plays a dual role in MIN6 pancreatic beta cell function through AMPK-dependent autophagy. Int J Biol Sci 2014; 10:268-77.
    • (2014) Int J Biol Sci , vol.10 , pp. 268-277
    • Jiang, Y.1    Huang, W.2    Wang, J.3    Xu, Z.4    He, J.5    Lin, X.6    Zhou, Z.7    Zhang, J.8
  • 18
    • 84896334276 scopus 로고    scopus 로고
    • Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy
    • Jiang T, Yu JT, Zhu XC, Wang HF, Tan MS, Cao L, Zhang QQ, Gao L, Shi JQ, Zhang YD, Tan L. Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy. Br J Pharmacol 2014;171:3146-57.
    • (2014) Br J Pharmacol , vol.171 , pp. 3146-3157
    • Jiang, T.1    Yu, J.T.2    Zhu, X.C.3    Wang, H.F.4    Tan, M.S.5    Cao, L.6    Zhang, Q.Q.7    Gao, L.8    Shi, J.Q.9    Zhang, Y.D.10    Tan, L.11
  • 19
    • 84875450015 scopus 로고    scopus 로고
    • Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes
    • He C, Zhu H, Li H, Zou MH, Xie Z. Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes. Diabetes 2013;62:1270-81.
    • (2013) Diabetes , vol.62 , pp. 1270-1281
    • He, C.1    Zhu, H.2    Li, H.3    Zou, M.H.4    Xie, Z.5
  • 20
    • 79955839356 scopus 로고    scopus 로고
    • IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway
    • Duan X, Ponomareva L, Veeranki S, Choubey D. IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PLoS One 2011;6:e19532.
    • (2011) PLoS One , vol.6
    • Duan, X.1    Ponomareva, L.2    Veeranki, S.3    Choubey, D.4
  • 22
    • 84942503512 scopus 로고    scopus 로고
    • Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis
    • Carroll B, Korolchuk VI, Sarkar S. Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis. Amino Acids 2015;47:2065-88.
    • (2015) Amino Acids , vol.47 , pp. 2065-2088
    • Carroll, B.1    Korolchuk, V.I.2    Sarkar, S.3
  • 24
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • Currie CJ, Poole CD, Gale EA. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 2009;52:1766-77.
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.3
  • 25
    • 84856283179 scopus 로고    scopus 로고
    • Cancer research. Cancer prevention with a diabetes pill?
    • Taubes G. Cancer research. Cancer prevention with a diabetes pill? Science 2012;335:29.
    • (2012) Science , vol.335 , pp. 29
    • Taubes, G.1
  • 26
    • 84877839664 scopus 로고    scopus 로고
    • The relationship between metformin and cancer in patients with type 2 diabetes
    • Chung HH, Moon JS, Yoon JS, Lee HW, Won KC. The relationship between metformin and cancer in patients with type 2 diabetes. Diabetes Metab J 2013;37:125-31.
    • (2013) Diabetes Metab J , vol.37 , pp. 125-131
    • Chung, H.H.1    Moon, J.S.2    Yoon, J.S.3    Lee, H.W.4    Won, K.C.5
  • 27
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 28
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    • El-Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M, Leverve X. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 2000;275:223-8.
    • (2000) J Biol Chem , vol.275 , pp. 223-228
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3    Averet, N.4    Rigoulet, M.5    Leverve, X.6
  • 29
    • 33645976877 scopus 로고    scopus 로고
    • AMP-activated protein kinase and type 2 diabetes
    • Musi N. AMP-activated protein kinase and type 2 diabetes. Curr Med Chem 2006;13:583-9.
    • (2006) Curr Med Chem , vol.13 , pp. 583-589
    • Musi, N.1
  • 32
    • 84880054521 scopus 로고    scopus 로고
    • Metformin increases mitochondrial energy formation in L6 muscle cell cultures
    • Vytla VS, Ochs RS. Metformin increases mitochondrial energy formation in L6 muscle cell cultures. J Biol Chem 2013;288: 20369-77.
    • (2013) J Biol Chem , vol.288 , pp. 20369-20377
    • Vytla, V.S.1    Ochs, R.S.2
  • 39
    • 84888037538 scopus 로고    scopus 로고
    • The activation of p38 and JNK by ROS, contribute to OLO-2-mediated intrinsic apoptosis in human hepatocellular carcinoma cells
    • Zhang Z, Zhang C, Ding Y, Zhao Q, Yang L, Ling J, Liu L, Ji H, Zhang Y. The activation of p38 and JNK by ROS, contribute to OLO-2-mediated intrinsic apoptosis in human hepatocellular carcinoma cells. Food Chem Toxicol 2014;63:38-47.
    • (2014) Food Chem Toxicol , vol.63 , pp. 38-47
    • Zhang, Z.1    Zhang, C.2    Ding, Y.3    Zhao, Q.4    Yang, L.5    Ling, J.6    Liu, L.7    Ji, H.8    Zhang, Y.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.