CTLA-4+PD-1− Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques

Immunity

Volumn 47, Issue 4, 2017, Pages 776-788.e5

  McGary, Colleen S ^a   Deleage, Claire ^b   Harper, Justin ^a   Micci, Luca ^a   Ribeiro, Susan P ^c   Paganini, Sara ^a   Kuri Cervantes, Leticia ^c   Benne, Clarisse ^c   Ryan, Emily S ^a   Balderas, Robert ^d   Jean, Sherrie ^a   Easley, Kirk ^e   Marconi, Vincent ^a,f   Silvestri, Guido ^a,f   Estes, Jacob D ^b   Sekaly, Rafick Pierre ^c   Paiardini, Mirko ^a,f  

^a EMORY UNIVERSITY   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BD Technologies   (United States)

^e EMORY UNIVERSITY   (United States)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

animal models; co inhibitory receptors; CTLA 4; HIV; latent viral reservoir; PD 1; regulatory T cells; SIV; T follicular helper cells

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DARUNAVIR; EMTRICITABINE; MARAVIROC; PROGRAMMED DEATH 1 RECEPTOR; RALTEGRAVIR; RITONAVIR; STAT5 PROTEIN; TENOFOVIR; VIRUS DNA; ANTIRETROVIRUS AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIRETROVIRAL THERAPY; ARTICLE; CD4+ T LYMPHOCYTE; CELL SURVIVAL; CONTROLLED STUDY; DNA CONTENT; FEMALE; LYMPH FOLLICLE; LYMPH NODE BIOPSY; MEMORY T LYMPHOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; RHESUS MONKEY; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; T1 CELL LINE; TFH CELL; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; CONFOCAL MICROSCOPY; DRUG EFFECTS; HELPER CELL; HIV INFECTIONS; HOST PATHOGEN INTERACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IN SITU HYBRIDIZATION; LYMPH NODE; METABOLISM; PHYSIOLOGY; VIROLOGY;

ANIMALS; ANTI-RETROVIRAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CTLA-4 ANTIGEN; HIV INFECTIONS; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOLOGIC MEMORY; IN SITU HYBRIDIZATION; LYMPH NODES; MACACA MULATTA; MICROSCOPY, CONFOCAL; PROGRAMMED CELL DEATH 1 RECEPTOR; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

EID: 85032836283     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.09.018     Document Type: Article

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