메뉴 건너뛰기




Volumn 96, Issue , 2015, Pages 1463-1477

Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation

(17)  El Far, Mohamed a,b   Ancuta, Petronela a,b   Routy, Jean Pierre c   Zhang, Yuwei a,b,d   Bakeman, Wendy d   Bordi, Rebeka a,d   DaFonseca, Sandrina a,b,d   Said, Elias A a,b   Gosselin, Annie a   Tep, Tévy Suzy a,b   Eichbaum, Quentin e   van Grevenynghe, Julien a,b,d   Schwartz, Olivier f   Freeman, Gordon J g   Haddad, Elias K a,d   Chomont, Nicolas a,b,d   Sékaly, Rafick Pierre a,b,d,h  


Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; NEF PROTEIN; VIRUS DNA; NEF PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84937622269     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.000065     Document Type: Article
Times cited : (16)

References (52)
  • 1
    • 0028180868 scopus 로고
    • Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
    • Aiken, C., Konner, J., Landau, N. R., Lenburg, M. E. & Trono, D. (1994). Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76, 853-864.
    • (1994) Cell , vol.76 , pp. 853-864
    • Aiken, C.1    Konner, J.2    Landau, N.R.3    Lenburg, M.E.4    Trono, D.5
  • 2
    • 0035368515 scopus 로고    scopus 로고
    • Dynamic Nef and Nef dynamics: How structure could explain the complex activities of this small HIV protein
    • Arold, S. T. & Baur, A. S. (2001). Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein. Trends Biochem Sci 26, 356-363.
    • (2001) Trends Biochem Sci , vol.26 , pp. 356-363
    • Arold, S.T.1    Baur, A.S.2
  • 3
    • 0027511603 scopus 로고
    • Functional expression of B7/BB1 on activated T lymphocytes
    • Azuma, M., Yssel, H., Phillips, J. H., Spits, H. & Lanier, L. L. (1993). Functional expression of B7/BB1 on activated T lymphocytes. J Exp Med 177, 845-850.
    • (1993) J Exp Med , vol.177 , pp. 845-850
    • Azuma, M.1    Yssel, H.2    Phillips, J.H.3    Spits, H.4    Lanier, L.L.5
  • 4
    • 0027158904 scopus 로고
    • Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection
    • Benson, R. E., Sanfridson, A., Ottinger, J. S., Doyle, C. & Cullen, B. R. (1993). Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. J Exp Med 177, 1561-1566.
    • (1993) J Exp Med , vol.177 , pp. 1561-1566
    • Benson, R.E.1    Sanfridson, A.2    Ottinger, J.S.3    Doyle, C.4    Cullen, B.R.5
  • 5
    • 33645924682 scopus 로고    scopus 로고
    • HIV disease: Fallout from a mucosal catastrophe?
    • Brenchley, J. M., Price, D. A. & Douek, D. C. (2006). HIV disease: fallout from a mucosal catastrophe? Nat Immunol 7, 235-239.
    • (2006) Nat Immunol , vol.7 , pp. 235-239
    • Brenchley, J.M.1    Price, D.A.2    Douek, D.C.3
  • 6
    • 0141457701 scopus 로고    scopus 로고
    • Analysis of early human immunodeficiency virus type 1 DNA synthesis by use of a new sensitive assay for quantifying integrated provirus
    • Brussel, A. & Sonigo, P. (2003). Analysis of early human immunodeficiency virus type 1 DNA synthesis by use of a new sensitive assay for quantifying integrated provirus. J Virol 77, 10119-10124.
    • (2003) J Virol , vol.77 , pp. 10119-10124
    • Brussel, A.1    Sonigo, P.2
  • 7
    • 45949087129 scopus 로고    scopus 로고
    • Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection
    • Cecchinato, V., Tryniszewska, E., Ma, Z. M., Vaccari, M., Boasso, A., Tsai, W. P., Petrovas, C., Fuchs, D., Heraud, J. M. & other authors (2008). Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection. J Immunol 180, 5439-5447.
    • (2008) J Immunol , vol.180 , pp. 5439-5447
    • Cecchinato, V.1    Tryniszewska, E.2    Ma, Z.M.3    Vaccari, M.4    Boasso, A.5    Tsai, W.P.6    Petrovas, C.7    Fuchs, D.8    Heraud, J.M.9
  • 8
    • 0029793620 scopus 로고    scopus 로고
    • CD4 downmodulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef
    • Chen, B. K., Gandhi, R. T. & Baltimore, D. (1996). CD4 downmodulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef. J Virol 70, 6044-6053.
    • (1996) J Virol , vol.70 , pp. 6044-6053
    • Chen, B.K.1    Gandhi, R.T.2    Baltimore, D.3
  • 10
    • 0033151621 scopus 로고    scopus 로고
    • The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    • Cohen, G. B., Gandhi, R. T., Davis, D. M., Mandelboim, O., Chen, B. K., Strominger, J. L. & Baltimore, D. (1999). The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity 10, 661-671.
    • (1999) Immunity , vol.10 , pp. 661-671
    • Cohen, G.B.1    Gandhi, R.T.2    Davis, D.M.3    Mandelboim, O.4    Chen, B.K.5    Strominger, J.L.6    Baltimore, D.7
  • 11
    • 0032556872 scopus 로고    scopus 로고
    • HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
    • Collins, K. L., Chen, B. K., Kalams, S. A., Walker, B. D. & Baltimore, D. (1998). HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391, 397-401.
    • (1998) Nature , vol.391 , pp. 397-401
    • Collins, K.L.1    Chen, B.K.2    Kalams, S.A.3    Walker, B.D.4    Baltimore, D.5
  • 16
    • 33644779729 scopus 로고    scopus 로고
    • Immunosurveillance and immunoregulation by gammadelta T cells
    • Girardi, M. (2006). Immunosurveillance and immunoregulation by gammadelta T cells. J Invest Dermatol 126, 25-31.
    • (2006) J Invest Dermatol , vol.126 , pp. 25-31
    • Girardi, M.1
  • 17
    • 33644822414 scopus 로고    scopus 로고
    • Pathogenesis of HIV infection: What the virus spares is as important as what it destroys
    • Grossman, Z., Meier-Schellersheim, M., Paul, W. E. & Picker, L. J. (2006). Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nat Med 12, 289-295.
    • (2006) Nat Med , vol.12 , pp. 289-295
    • Grossman, Z.1    Meier-Schellersheim, M.2    Paul, W.E.3    Picker, L.J.4
  • 18
    • 0036569236 scopus 로고    scopus 로고
    • CTLA-4 suppresses proximal TCR signaling in resting human CD4+T cells by inhibiting ZAP-70 Tyr319phosphorylation: A potential role for tyrosine phosphatases
    • Guntermann, C. & Alexander, D. R. (2002). CTLA-4 suppresses proximal TCR signaling in resting human CD4+T cells by inhibiting ZAP-70 Tyr319phosphorylation: a potential role for tyrosine phosphatases. J Immunol 168, 4420-4429.
    • (2002) J Immunol , vol.168 , pp. 4420-4429
    • Guntermann, C.1    Alexander, D.R.2
  • 20
    • 0029991350 scopus 로고    scopus 로고
    • Transfecting mammalian cells: Optimization of critical parameters affecting calcium-phosphate precipitate formation
    • Jordan, M., Schallhorn, A. & Wurm, F. M. (1996). Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res 24, 596-601.
    • (1996) Nucleic Acids Res , vol.24 , pp. 596-601
    • Jordan, M.1    Schallhorn, A.2    Wurm, F.M.3
  • 21
    • 35348873159 scopus 로고    scopus 로고
    • Productive human immunodeficiency virus type 1 infection in peripheral blood predominantly takes place in CD4/ CD8 double-negative T lymphocytes
    • Kaiser, P., Joos, B., Niederöst, B., Weber, R., Günthard, H. F. & Fischer, M. (2007). Productive human immunodeficiency virus type 1 infection in peripheral blood predominantly takes place in CD4/ CD8 double-negative T lymphocytes. J Virol 81, 9693-9706.
    • (2007) J Virol , vol.81 , pp. 9693-9706
    • Kaiser, P.1    Joos, B.2    Niederöst, B.3    Weber, R.4    Günthard, H.F.5    Fischer, M.6
  • 22
    • 42049111434 scopus 로고    scopus 로고
    • Programmed death-1 as a factor in immune exhaustion and activation in HIV infection
    • Kaufmann, D. E. & Walker, B. D. (2008). Programmed death-1 as a factor in immune exhaustion and activation in HIV infection. Curr Opin HIV AIDS 3, 362-367.
    • (2008) Curr Opin HIV AIDS , vol.3 , pp. 362-367
    • Kaufmann, D.E.1    Walker, B.D.2
  • 23
    • 34548680261 scopus 로고    scopus 로고
    • Upregulation of CTLA-4 by HIV-specific CD4+T cells correlates with disease progression and defines a reversible immune dysfunction
    • Kaufmann, D. E., Kavanagh, D. G., Pereyra, F., Zaunders, J. J., Mackey, E. W., Miura, T., Palmer, S., Brockman, M., Rathod, A. & other authors (2007). Upregulation of CTLA-4 by HIV-specific CD4+T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol 8, 1246-1254.
    • (2007) Nat Immunol , vol.8 , pp. 1246-1254
    • Kaufmann, D.E.1    Kavanagh, D.G.2    Pereyra, F.3    Zaunders, J.J.4    Mackey, E.W.5    Miura, T.6    Palmer, S.7    Brockman, M.8    Rathod, A.9
  • 24
    • 79952705605 scopus 로고    scopus 로고
    • Revisiting immune exhaustion during HIV infection
    • Khaitan, A. & Unutmaz, D. (2011). Revisiting immune exhaustion during HIV infection. Curr HIV/AIDS Rep 8, 4-11.
    • (2011) Curr HIV/AIDS Rep , vol.8 , pp. 4-11
    • Khaitan, A.1    Unutmaz, D.2
  • 25
    • 2342557037 scopus 로고    scopus 로고
    • Emerging paradigms of T-cell co-stimulation
    • Kroczek, R. A., Mages, H. W. & Hutloff, A. (2004). Emerging paradigms of T-cell co-stimulation. Curr Opin Immunol 16, 321-327.
    • (2004) Curr Opin Immunol , vol.16 , pp. 321-327
    • Kroczek, R.A.1    Mages, H.W.2    Hutloff, A.3
  • 26
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • Krummel, M. F. & Allison, J. P. (1996). CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 183, 2533-2540.
    • (1996) J Exp Med , vol.183 , pp. 2533-2540
    • Krummel, M.F.1    Allison, J.P.2
  • 28
    • 0037040351 scopus 로고    scopus 로고
    • CTLA-4 upregulation during HIV infection: Association with anergy and possible target for therapeutic intervention
    • Leng, Q., Bentwich, Z., Magen, E., Kalinkovich, A. & Borkow, G. (2002). CTLA-4 upregulation during HIV infection: association with anergy and possible target for therapeutic intervention. AIDS 16, 519-529.
    • (2002) AIDS , vol.16 , pp. 519-529
    • Leng, Q.1    Bentwich, Z.2    Magen, E.3    Kalinkovich, A.4    Borkow, G.5
  • 29
    • 38349109364 scopus 로고    scopus 로고
    • A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2
    • Lindwasser, O. W., Smith, W. J., Chaudhuri, R., Yang, P., Hurley, J. H. & Bonifacino, J. S. (2008). A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2. J Virol 82, 1166-1174.
    • (2008) J Virol , vol.82 , pp. 1166-1174
    • Lindwasser, O.W.1    Smith, W.J.2    Chaudhuri, R.3    Yang, P.4    Hurley, J.H.5    Bonifacino, J.S.6
  • 30
    • 0028076866 scopus 로고
    • Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1
    • Little, S. J., Riggs, N. L., Chowers, M. Y., Fitch, N. J., Richman, D. D., Spina, C. A. & Guatelli, J. C. (1994). Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1. Virology 205, 578-582.
    • (1994) Virology , vol.205 , pp. 578-582
    • Little, S.J.1    Riggs, N.L.2    Chowers, M.Y.3    Fitch, N.J.4    Richman, D.D.5    Spina, C.A.6    Guatelli, J.C.7
  • 31
    • 34548510349 scopus 로고    scopus 로고
    • HIV-1 Nef-induced downregulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2
    • Lubben, N. B., Sahlender, D. A., Motley, A. M., Lehner, P. J., Benaroch, P. & Robinson, M. S. (2007). HIV-1 Nef-induced downregulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2. Mol Biol Cell 18, 3351-3365.
    • (2007) Mol Biol Cell , vol.18 , pp. 3351-3365
    • Lubben, N.B.1    Sahlender, D.A.2    Motley, A.M.3    Lehner, P.J.4    Benaroch, P.5    Robinson, M.S.6
  • 32
    • 84876129831 scopus 로고    scopus 로고
    • HIV-1 Nef and T-cell activation: A history of contradictions
    • Markle, T. J., Mwimanzi, P. & Brockman, M. A. (2013). HIV-1 Nef and T-cell activation: a history of contradictions. Future Virol 8, 391-404.
    • (2013) Future Virol , vol.8 , pp. 391-404
    • Markle, T.J.1    Mwimanzi, P.2    Brockman, M.A.3
  • 34
    • 0033780046 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding
    • O'Doherty, U., Swiggard, W. J. & Malim, M. H. (2000). Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding. J Virol 74, 10074-10080.
    • (2000) J Virol , vol.74 , pp. 10074-10080
    • O'Doherty, U.1    Swiggard, W.J.2    Malim, M.H.3
  • 35
    • 79961104556 scopus 로고    scopus 로고
    • Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2
    • Olivieri, K. C., Mukerji, J. & Gabuzda, D. (2011). Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2. Retrovirology 8, 64.
    • (2011) Retrovirology , vol.8 , pp. 64
    • Olivieri, K.C.1    Mukerji, J.2    Gabuzda, D.3
  • 36
    • 84856077084 scopus 로고    scopus 로고
    • HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling
    • Pan, X., Rudolph, J. M., Abraham, L., Habermann, A., Haller, C., Krijnse-Locker, J. & Fackler, O. T. (2012). HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling. Blood 119, 786-797.
    • (2012) Blood , vol.119 , pp. 786-797
    • Pan, X.1    Rudolph, J.M.2    Abraham, L.3    Habermann, A.4    Haller, C.5    Krijnse-Locker, J.6    Fackler, O.T.7
  • 38
    • 0033515427 scopus 로고    scopus 로고
    • Nef-induced CD4 degradation: A diacidicbased motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes
    • Piguet, V., Gu, F., Foti, M., Demaurex, N., Gruenberg, J., Carpentier, J. L. & Trono, D. (1999). Nef-induced CD4 degradation: a diacidicbased motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. Cell 97, 63-73.
    • (1999) Cell , vol.97 , pp. 63-73
    • Piguet, V.1    Gu, F.2    Foti, M.3    Demaurex, N.4    Gruenberg, J.5    Carpentier, J.L.6    Trono, D.7
  • 39
    • 60549110302 scopus 로고    scopus 로고
    • Cross-linking of CD80 on CD4+T cells activates a calcium-dependent signaling pathway
    • Podojil, J. R. & Miller, S. D. (2009). Cross-linking of CD80 on CD4+T cells activates a calcium-dependent signaling pathway. J Immunol 182, 766-773.
    • (2009) J Immunol , vol.182 , pp. 766-773
    • Podojil, J.R.1    Miller, S.D.2
  • 40
    • 33846410668 scopus 로고    scopus 로고
    • Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+central memory T cells
    • Riou, C., Yassine-Diab, B., Van Grevenynghe, J., Somogyi, R., Greller, L. D., Gagnon, D., Gimmig, S., Wilkinson, P., Shi, Y. & other authors (2007). Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+central memory T cells. J Exp Med 204, 79-91.
    • (2007) J Exp Med , vol.204 , pp. 79-91
    • Riou, C.1    Yassine-Diab, B.2    Van Grevenynghe, J.3    Somogyi, R.4    Greller, L.D.5    Gagnon, D.6    Gimmig, S.7    Wilkinson, P.8    Shi, Y.9
  • 41
    • 53049101894 scopus 로고    scopus 로고
    • Compensation in flow cytometry
    • Roederer, M. (2002). Compensation in flow cytometry. Curr Protoc Cytom 22, 1.14.1-1.14.20.
    • (2002) Curr Protoc Cytom , vol.22 , pp. 1.14.1-1.14.20
    • Roederer, M.1
  • 42
    • 84856016549 scopus 로고    scopus 로고
    • HIV-induced T-cell activation/exhaustion in rectal mucosa is controlled only partially by antiretroviral treatment
    • Rueda, C. M., Velilla, P. A., Chougnet, C. A., Montoya, C. J. & Rugeles, M. T. (2012). HIV-induced T-cell activation/exhaustion in rectal mucosa is controlled only partially by antiretroviral treatment. PLoS One 7, e30307.
    • (2012) PLoS One , vol.7
    • Rueda, C.M.1    Velilla, P.A.2    Chougnet, C.A.3    Montoya, C.J.4    Rugeles, M.T.5
  • 43
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto, F., Lenig, D., Förster, R., Lipp, M. & Lanzavecchia, A. (1999). Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712.
    • (1999) Nature , vol.401 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Förster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 44
    • 17444413400 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism
    • Schindler, M., Münch, J. & Kirchhoff, F. (2005). Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism. J Virol 79, 5489-5498.
    • (2005) J Virol , vol.79 , pp. 5489-5498
    • Schindler, M.1    Münch, J.2    Kirchhoff, F.3
  • 47
    • 0033529258 scopus 로고    scopus 로고
    • HIV-1 Nef increases T cell activation in a stimulus-dependent manner
    • Schrager, J. A. & Marsh, J. W. (1999). HIV-1 Nef increases T cell activation in a stimulus-dependent manner. Proc Natl Acad Sci U S A 96, 8167-8172.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8167-8172
    • Schrager, J.A.1    Marsh, J.W.2
  • 48
    • 0029875421 scopus 로고    scopus 로고
    • Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
    • Schwartz, O., Maréchal, V., Le Gall, S., Lemonnier, F. & Heard, J. M. (1996). Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat Med 2, 338-342.
    • (1996) Nat Med , vol.2 , pp. 338-342
    • Schwartz, O.1    Maréchal, V.2    Le Gall, S.3    Lemonnier, F.4    Heard, J.M.5
  • 49
    • 33646552033 scopus 로고    scopus 로고
    • Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse
    • Thoulouze, M. I., Sol-Foulon, N., Blanchet, F., Dautry-Varsat, A., Schwartz, O. & Alcover, A. (2006). Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse. Immunity 24, 547-561.
    • (2006) Immunity , vol.24 , pp. 547-561
    • Thoulouze, M.I.1    Sol-Foulon, N.2    Blanchet, F.3    Dautry-Varsat, A.4    Schwartz, O.5    Alcover, A.6
  • 51
    • 0036889125 scopus 로고    scopus 로고
    • Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking
    • Williams, M., Roeth, J. F., Kasper, M. R., Fleis, R. I., Przybycin, C. G. & Collins, K. L. (2002). Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking. J Virol 76, 12173-12184.
    • (2002) J Virol , vol.76 , pp. 12173-12184
    • Williams, M.1    Roeth, J.F.2    Kasper, M.R.3    Fleis, R.I.4    Przybycin, C.G.5    Collins, K.L.6
  • 52
    • 0035943355 scopus 로고    scopus 로고
    • Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA
    • Wu, Y. & Marsh, J. W. (2001). Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA. Science 293, 1503-1506.
    • (2001) Science , vol.293 , pp. 1503-1506
    • Wu, Y.1    Marsh, J.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.