메뉴 건너뛰기




Volumn 130, Issue 1, 2018, Pages 72-82

SGLT2 inhibitors: are they safe?

Author keywords

adverse effects; amputation; cancer; electrolytes; kidney; SGLT2 inhibitors

Indexed keywords

CANAGLIFLOZIN; DAPAGLIFLOZIN; EMPAGLIFLOZIN; FIBROBLAST GROWTH FACTOR; FUROSEMIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROCORTISONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MAGNESIUM; METFORMIN; PARATHYROID HORMONE; POTASSIUM; ANTIDIABETIC AGENT; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 85032500907     PISSN: 00325481     EISSN: 19419260     Source Type: Journal    
DOI: 10.1080/00325481.2018.1394152     Document Type: Review
Times cited : (60)

References (127)
  • 1
    • 85021389331 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes: synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes
    • Chamberlain JJ, Herman WH, Leal S, et al. Pharmacologic therapy for type 2 diabetes: synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes. Ann Intern Med. 2017;166:572–578.
    • (2017) Ann Intern Med , vol.166 , pp. 572-578
    • Chamberlain, J.J.1    Herman, W.H.2    Leal, S.3
  • 3
    • 84891793029 scopus 로고    scopus 로고
    • Does combination therapy with statins and fibrates prevent cardiovascular disease in diabetic patients with atherogenic mixed dyslipidemia?
    • Agouridis AP, Rizos CV, Elisaf MS, et al. Does combination therapy with statins and fibrates prevent cardiovascular disease in diabetic patients with atherogenic mixed dyslipidemia? Rev Diabet Stud. 2013;10:171–190.
    • (2013) Rev Diabet Stud , vol.10 , pp. 171-190
    • Agouridis, A.P.1    Rizos, C.V.2    Elisaf, M.S.3
  • 4
    • 84961626019 scopus 로고    scopus 로고
    • Pitavastatin and carbohydrate metabolism: what is the evidence?
    • Filippatos TD, Elisaf MS., Pitavastatin and carbohydrate metabolism: what is the evidence? Expert Rev Clin Pharmacol. 2016;9:955–960.
    • (2016) Expert Rev Clin Pharmacol , vol.9 , pp. 955-960
    • Filippatos, T.D.1    Elisaf, M.S.2
  • 5
    • 79960441327 scopus 로고    scopus 로고
    • Fenofibrate plus simvastatin (fixed-dose combination) for the treatment of dyslipidaemia
    • Filippatos TD, Elisaf MS., Fenofibrate plus simvastatin (fixed-dose combination) for the treatment of dyslipidaemia. Expert Opin Pharmacother. 2011;12:1945–1958.
    • (2011) Expert Opin Pharmacother , vol.12 , pp. 1945-1958
    • Filippatos, T.D.1    Elisaf, M.S.2
  • 6
    • 85038841578 scopus 로고    scopus 로고
    • Effects of PCSK9 inhibitors on other than low-density lipoprotein cholesterol lipid variables
    • Epub ahead of print
    • Filippatos TD, Kei A, Rizos CV, et al. Effects of PCSK9 inhibitors on other than low-density lipoprotein cholesterol lipid variables. J Cardiovasc Pharmacol Ther. 2017; Epub ahead of print. DOI: 1074248417724868.
    • (2017) J Cardiovasc Pharmacol Ther
    • Filippatos, T.D.1    Kei, A.2    Rizos, C.V.3
  • 8
    • 85014236276 scopus 로고    scopus 로고
    • Mediterranean diet and 10-year (2002–2012) incidence of diabetes and cardiovascular disease in participants with prediabetes: the ATTICA study
    • Filippatos TD, Panagiotakos DB, Georgousopoulou EN, et al. Mediterranean diet and 10-year (2002–2012) incidence of diabetes and cardiovascular disease in participants with prediabetes: the ATTICA study. Rev Diabet Stud. 2016;13:226–235.
    • (2016) Rev Diabet Stud , vol.13 , pp. 226-235
    • Filippatos, T.D.1    Panagiotakos, D.B.2    Georgousopoulou, E.N.3
  • 9
    • 84978653504 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein inhibitors: challenges and perspectives
    • Filippatos TD, Klouras E, Barkas F, et al. Cholesteryl ester transfer protein inhibitors: challenges and perspectives. Expert Rev Cardiovasc Ther. 2016;14:953–962.
    • (2016) Expert Rev Cardiovasc Ther , vol.14 , pp. 953-962
    • Filippatos, T.D.1    Klouras, E.2    Barkas, F.3
  • 10
    • 84948740668 scopus 로고    scopus 로고
    • Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
    • Pfeffer MA, Claggett B, Diaz R, et al. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med. 2015;373:2247–2257.
    • (2015) N Engl J Med , vol.373 , pp. 2247-2257
    • Pfeffer, M.A.1    Claggett, B.2    Diaz, R.3
  • 11
    • 84937053742 scopus 로고    scopus 로고
    • Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
    • Green JB, Bethel MA, Armstrong PW, et al. Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2015;373:232–242.
    • (2015) N Engl J Med , vol.373 , pp. 232-242
    • Green, J.B.1    Bethel, M.A.2    Armstrong, P.W.3
  • 12
    • 84883745765 scopus 로고    scopus 로고
    • Alogliptin after acute coronary syndrome in patients with type 2 diabetes
    • White WB, Cannon CP, Heller SR, et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med. 2013;369:1327–1335.
    • (2013) N Engl J Med , vol.369 , pp. 1327-1335
    • White, W.B.1    Cannon, C.P.2    Heller, S.R.3
  • 13
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med. 2013;369:1317–1326.
    • (2013) N Engl J Med , vol.369 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 14
    • 84978839381 scopus 로고    scopus 로고
    • Liraglutide and cardiovascular outcomes in type 2 diabetes
    • Marso SP, Daniels GH, Brown-Frandsen K, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375:311–322.
    • (2016) N Engl J Med , vol.375 , pp. 311-322
    • Marso, S.P.1    Daniels, G.H.2    Brown-Frandsen, K.3
  • 16
    • 84900988588 scopus 로고    scopus 로고
    • The pharmacokinetic considerations and adverse effects of DPP-4 inhibitors
    • Filippatos TD, Athyros VG, Elisaf MS, et al. The pharmacokinetic considerations and adverse effects of DPP-4 inhibitors. Expert Opin Drug Metab Toxicol. 2014;10:787–812.
    • (2014) Expert Opin Drug Metab Toxicol , vol.10 , pp. 787-812
    • Filippatos, T.D.1    Athyros, V.G.2    Elisaf, M.S.3
  • 17
    • 84892743922 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on renal function
    • Filippatos TD, Elisaf MS. Effects of glucagon-like peptide-1 receptor agonists on renal function. World J Diabetes. 2013;4:190–201.
    • (2013) World J Diabetes , vol.4 , pp. 190-201
    • Filippatos, T.D.1    Elisaf, M.S.2
  • 18
    • 84994813253 scopus 로고    scopus 로고
    • Semaglutide and cardiovascular outcomes in patients with type 2 diabetes
    • Marso SP, Bain SC, Consoli A, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016;375:1834–1844.
    • (2016) N Engl J Med , vol.375 , pp. 1834-1844
    • Marso, S.P.1    Bain, S.C.2    Consoli, A.3
  • 19
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373:2117–2128.
    • (2015) N Engl J Med , vol.373 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3
  • 20
    • 84994180780 scopus 로고    scopus 로고
    • Empagliflozin and progression of kidney disease in type 2 diabetes
    • Wanner C, Inzucchi SE, Lachin JM, et al. Empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med. 2016;375:323–334.
    • (2016) N Engl J Med , vol.375 , pp. 323-334
    • Wanner, C.1    Inzucchi, S.E.2    Lachin, J.M.3
  • 21
    • 85034774651 scopus 로고    scopus 로고
    • Canagliflozin and cardiovascular and renal events in type 2 diabetes
    • Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med. 2017.
    • (2017) N Engl J Med
    • Neal, B.1    Perkovic, V.2    Mahaffey, K.W.3
  • 22
    • 84962613532 scopus 로고    scopus 로고
    • Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
    • Wu JH, Foote C, Blomster J, et al. Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2016;4:411–419.
    • (2016) Lancet Diabetes Endocrinol , vol.4 , pp. 411-419
    • Wu, J.H.1    Foote, C.2    Blomster, J.3
  • 23
    • 85011060833 scopus 로고    scopus 로고
    • Renoprotective effects of SGLT2 inhibitors: beyond glucose reabsorption inhibition
    • Tsimihodimos V, Filippatos TD, Filippas-Ntekouan S, et al. Renoprotective effects of SGLT2 inhibitors: beyond glucose reabsorption inhibition. Curr Vasc Pharmacol. 2017;15:96–102.
    • (2017) Curr Vasc Pharmacol , vol.15 , pp. 96-102
    • Tsimihodimos, V.1    Filippatos, T.D.2    Filippas-Ntekouan, S.3
  • 24
    • 85015866863 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 inhibitors on metabolism: unanswered questions and controversies
    • Tsimihodimos V, Filippatos TD, Elisaf MS. Effects of sodium-glucose co-transporter 2 inhibitors on metabolism: unanswered questions and controversies. Expert Opin Drug Metab Toxicol. 2017;13:399–408.
    • (2017) Expert Opin Drug Metab Toxicol , vol.13 , pp. 399-408
    • Tsimihodimos, V.1    Filippatos, T.D.2    Elisaf, M.S.3
  • 25
    • 84976292796 scopus 로고    scopus 로고
    • Mechanisms of blood pressure reduction with sodium-glucose co-transporter 2 (SGLT2) inhibitors
    • Filippatos TD, Tsimihodimos V, Elisaf MS. Mechanisms of blood pressure reduction with sodium-glucose co-transporter 2 (SGLT2) inhibitors. Expert Opin Pharmacother. 2016;17:1581–1583.
    • (2016) Expert Opin Pharmacother , vol.17 , pp. 1581-1583
    • Filippatos, T.D.1    Tsimihodimos, V.2    Elisaf, M.S.3
  • 28
    • 85016038057 scopus 로고    scopus 로고
    • Cancer risk is higher in years before and shortly after type 2 diabetes diagnosis, study shows
    • Mayor S. Cancer risk is higher in years before and shortly after type 2 diabetes diagnosis, study shows. BMJ. 2016;354:i3832.
    • (2016) BMJ , vol.354 , pp. i3832
    • Mayor, S.1
  • 29
    • 84912042480 scopus 로고    scopus 로고
    • Antihyperglycaemic therapies and cancer risk
    • Lutz SZ, Staiger H, Fritsche A, et al. Antihyperglycaemic therapies and cancer risk. Diab Vasc Dis Res. 2014;11:371–389.
    • (2014) Diab Vasc Dis Res , vol.11 , pp. 371-389
    • Lutz, S.Z.1    Staiger, H.2    Fritsche, A.3
  • 31
    • 84962052919 scopus 로고    scopus 로고
    • Pioglitazone use and risk of bladder cancer: population based cohort study
    • Tuccori M, Filion KB, Yin H, et al. Pioglitazone use and risk of bladder cancer: population based cohort study. BMJ. 2016;352:i1541.
    • (2016) BMJ , vol.352 , pp. i1541
    • Tuccori, M.1    Filion, K.B.2    Yin, H.3
  • 32
    • 84966668415 scopus 로고    scopus 로고
    • The current role of thiazolidinediones in diabetes management
    • Rizos CV, Kei A, Elisaf MS. The current role of thiazolidinediones in diabetes management. Arch Toxicol. 2016;90:1861–1881.
    • (2016) Arch Toxicol , vol.90 , pp. 1861-1881
    • Rizos, C.V.1    Kei, A.2    Elisaf, M.S.3
  • 35
    • 84942312400 scopus 로고    scopus 로고
    • Assessing bladder cancer risk in type 2 diabetes clinical trials: the dapagliflozin drug development program as a ‘case study’
    • Ptaszynska A, Cohen SM, Messing EM, et al. Assessing bladder cancer risk in type 2 diabetes clinical trials: the dapagliflozin drug development program as a ‘case study’. Diabetes Ther. 2015;6:357–375.
    • (2015) Diabetes Ther , vol.6 , pp. 357-375
    • Ptaszynska, A.1    Cohen, S.M.2    Messing, E.M.3
  • 36
    • 84898954869 scopus 로고    scopus 로고
    • Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus
    • Reilly TP, Graziano MJ, Janovitz EB, et al. Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus. Diabetes Ther. 2014;5:73–96.
    • (2014) Diabetes Ther , vol.5 , pp. 73-96
    • Reilly, T.P.1    Graziano, M.J.2    Janovitz, E.B.3
  • 37
    • 84921480876 scopus 로고    scopus 로고
    • A review on the relationship between SGLT2 inhibitors and cancer
    • Lin HW, Tseng CH. A review on the relationship between SGLT2 inhibitors and cancer. Int J Endocrinol. 2014;2014:719578.
    • (2014) Int J Endocrinol , vol.2014 , pp. 719578
    • Lin, H.W.1    Tseng, C.H.2
  • 38
    • 85025110453 scopus 로고    scopus 로고
    • SGLT2 inhibitors and risk of cancer in type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials
    • Tang H, Dai Q, Shi W, et al. SGLT2 inhibitors and risk of cancer in type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials. Diabetologia. 2017.
    • (2017) Diabetologia
    • Tang, H.1    Dai, Q.2    Shi, W.3
  • 39
    • 84938152222 scopus 로고    scopus 로고
    • Functional expression of sodium-glucose transporters in cancer
    • Scafoglio C, Hirayama BA, Kepe V, et al. Functional expression of sodium-glucose transporters in cancer. Proc Natl Acad Sci USA. 2015;112:E4111–9.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. E4111-E4119
    • Scafoglio, C.1    Hirayama, B.A.2    Kepe, V.3
  • 40
    • 84883550975 scopus 로고    scopus 로고
    • The kidney as a new target for antidiabetic drugs: SGLT2 inhibitors
    • Cangoz S, Chang YY, Chempakaseril SJ, et al. The kidney as a new target for antidiabetic drugs: SGLT2 inhibitors. J Clin Pharm Ther. 2013;38:350–359.
    • (2013) J Clin Pharm Ther , vol.38 , pp. 350-359
    • Cangoz, S.1    Chang, Y.Y.2    Chempakaseril, S.J.3
  • 41
    • 33845474117 scopus 로고    scopus 로고
    • Hyperglycemic crises in adult patients with diabetes: a consensus statement from the American Diabetes Association
    • Kitabchi AE, Umpierrez GE, Murphy MB, et al. Hyperglycemic crises in adult patients with diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 2006;29:2739–2748.
    • (2006) Diabetes Care , vol.29 , pp. 2739-2748
    • Kitabchi, A.E.1    Umpierrez, G.E.2    Murphy, M.B.3
  • 42
    • 49649099820 scopus 로고    scopus 로고
    • Ketoacidosis occurs in both type 1 and type 2 diabetes–a population-based study from Northern Sweden
    • Wang ZH, Kihl-Selstam E, Eriksson JW. Ketoacidosis occurs in both type 1 and type 2 diabetes–a population-based study from Northern Sweden. Diabet Med. 2008;25:867–870.
    • (2008) Diabet Med , vol.25 , pp. 867-870
    • Wang, Z.H.1    Kihl-Selstam, E.2    Eriksson, J.W.3
  • 43
    • 0037387745 scopus 로고    scopus 로고
    • Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state
    • Chiasson JL, Aris-Jilwan N, Belanger R, et al. Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state. CMAJ. 2003;168:859–866.
    • (2003) CMAJ , vol.168 , pp. 859-866
    • Chiasson, J.L.1    Aris-Jilwan, N.2    Belanger, R.3
  • 44
    • 85016258517 scopus 로고    scopus 로고
    • Canagliflozin-induced diabetic ketoacidosis: case report and review of the literature
    • Turner J, Begum T, Smalligan RD. Canagliflozin-induced diabetic ketoacidosis: case report and review of the literature. J Investig Med High Impact Case Rep. 2016;4:2324709616663231.
    • (2016) J Investig Med High Impact Case Rep , vol.4
    • Turner, J.1    Begum, T.2    Smalligan, R.D.3
  • 45
    • 84988005882 scopus 로고    scopus 로고
    • Euglycemic diabetic ketoacidosis with canagliflozin: not-so-sweet but avoidable complication of sodium-glucose cotransporter-2 inhibitor use
    • Clement M, Senior P. Euglycemic diabetic ketoacidosis with canagliflozin: not-so-sweet but avoidable complication of sodium-glucose cotransporter-2 inhibitor use. Can Fam Physician. 2016;62:725–728.
    • (2016) Can Fam Physician , vol.62 , pp. 725-728
    • Clement, M.1    Senior, P.2
  • 47
    • 84948403433 scopus 로고    scopus 로고
    • Renal sodium-glucose cotransporter inhibition in the management of type 2 diabetes mellitus
    • Abdul-Ghani MA, Norton L, DeFronzo RA. Renal sodium-glucose cotransporter inhibition in the management of type 2 diabetes mellitus. Am J Physiol Renal Physiol. 2015;309:F889–900.
    • (2015) Am J Physiol Renal Physiol , vol.309 , pp. F889-F900
    • Abdul-Ghani, M.A.1    Norton, L.2    DeFronzo, R.A.3
  • 48
    • 84961591798 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibitors: possible anti-atherosclerotic effects beyond glucose lowering
    • Yanai H, Katsuyama H, Hamasaki H, et al. Sodium-glucose cotransporter 2 inhibitors: possible anti-atherosclerotic effects beyond glucose lowering. J Clin Med Res. 2016;8:10–14.
    • (2016) J Clin Med Res , vol.8 , pp. 10-14
    • Yanai, H.1    Katsuyama, H.2    Hamasaki, H.3
  • 49
    • 84937763347 scopus 로고    scopus 로고
    • Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
    • Bonner C, Kerr-Conte J, Gmyr V, et al. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat Med. 2015;21:512–517.
    • (2015) Nat Med , vol.21 , pp. 512-517
    • Bonner, C.1    Kerr-Conte, J.2    Gmyr, V.3
  • 50
    • 84893827104 scopus 로고    scopus 로고
    • Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
    • Merovci A, Solis-Herrera C, Daniele G, et al. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest. 2014;124:509–514.
    • (2014) J Clin Invest , vol.124 , pp. 509-514
    • Merovci, A.1    Solis-Herrera, C.2    Daniele, G.3
  • 51
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
    • Ferrannini E, Muscelli E, Frascerra S, et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest. 2014;124:499–508.
    • (2014) J Clin Invest , vol.124 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3
  • 52
    • 84942258219 scopus 로고    scopus 로고
    • Empagliflozin as adjunct to insulin in patients with type 1 diabetes: a 4-week, randomized, placebo-controlled trial (EASE-1)
    • Pieber TR, Famulla S, Eilbracht J, et al. Empagliflozin as adjunct to insulin in patients with type 1 diabetes: a 4-week, randomized, placebo-controlled trial (EASE-1). Diabetes Obes Metab. 2015;17:928–935.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 928-935
    • Pieber, T.R.1    Famulla, S.2    Eilbracht, J.3
  • 53
    • 84964608804 scopus 로고    scopus 로고
    • Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes
    • Ferrannini E, Baldi S, Frascerra S, et al. Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes. Diabetes. 2016;65:1190–1195.
    • (2016) Diabetes , vol.65 , pp. 1190-1195
    • Ferrannini, E.1    Baldi, S.2    Frascerra, S.3
  • 54
    • 85029522523 scopus 로고    scopus 로고
    • Acid-base and electrolyte disorders associated with the use of antidiabetic drugs
    • 16:121-1132
    • Filippatos T, Tzavella E, Rizos C. Acid-base and electrolyte disorders associated with the use of antidiabetic drugs. Expert Opin Drug Saf. 2017:16:121-1132.
    • (2017) Expert Opin Drug Saf
    • Filippatos, T.1    Tzavella, E.2    Rizos, C.3
  • 55
    • 85019269077 scopus 로고    scopus 로고
    • SGLT2 inhibitors and diabetic ketoacidosis: data from the FDA Adverse Event Reporting System
    • Fadini GP, Bonora BM, Avogaro A. SGLT2 inhibitors and diabetic ketoacidosis: data from the FDA Adverse Event Reporting System. Diabetologia. 2017;60:1385–1389.
    • (2017) Diabetologia , vol.60 , pp. 1385-1389
    • Fadini, G.P.1    Bonora, B.M.2    Avogaro, A.3
  • 56
    • 84962439093 scopus 로고    scopus 로고
    • Euglycemic diabetic ketoacidosis: a predictable, detectable, and preventable safety concern with SGLT2 inhibitors
    • Rosenstock J, Ferrannini E. Euglycemic diabetic ketoacidosis: a predictable, detectable, and preventable safety concern with SGLT2 inhibitors. Diabetes Care. 2015;38:1638–1642.
    • (2015) Diabetes Care , vol.38 , pp. 1638-1642
    • Rosenstock, J.1    Ferrannini, E.2
  • 57
    • 85006820094 scopus 로고    scopus 로고
    • SGLT2 inhibitor-associated diabetic ketoacidosis: clinical review and recommendations for prevention and diagnosis
    • Goldenberg RM, Berard LD, Cheng AY, et al. SGLT2 inhibitor-associated diabetic ketoacidosis: clinical review and recommendations for prevention and diagnosis. Clin Ther. 2016;38:2654–64.e1.
    • (2016) Clin Ther , vol.38 , pp. 2654
    • Goldenberg, R.M.1    Berard, L.D.2    Cheng, A.Y.3
  • 58
    • 85018539845 scopus 로고    scopus 로고
    • Incidence of diabetic ketoacidosis among patients with type 2 diabetes mellitus treated with SGLT2 inhibitors and other antihyperglycemic agents
    • Wang Y, Desai M, Ryan PB, et al. Incidence of diabetic ketoacidosis among patients with type 2 diabetes mellitus treated with SGLT2 inhibitors and other antihyperglycemic agents. Diabetes Res Clin Pract. 2017;128:83–90.
    • (2017) Diabetes Res Clin Pract , vol.128 , pp. 83-90
    • Wang, Y.1    Desai, M.2    Ryan, P.B.3
  • 59
    • 84980337086 scopus 로고    scopus 로고
    • Effect of sodium-glucose cotransporter 2 inhibitors on diabetic ketoacidosis among patients with type 2 diabetes: a meta-analysis of randomized controlled trials
    • Tang H, Li D, Wang T, et al. Effect of sodium-glucose cotransporter 2 inhibitors on diabetic ketoacidosis among patients with type 2 diabetes: a meta-analysis of randomized controlled trials. Diabetes Care. 2016;39:e123–4.
    • (2016) Diabetes Care , vol.39 , pp. e123-e124
    • Tang, H.1    Li, D.2    Wang, T.3
  • 60
    • 85019751779 scopus 로고    scopus 로고
    • Effects of SGLT-2 inhibitors on diabetic ketoacidosis: a meta-analysis of randomised controlled trials
    • Monami M, Nreu B, Zannoni S, et al. Effects of SGLT-2 inhibitors on diabetic ketoacidosis: a meta-analysis of randomised controlled trials. Diabetes Res Clin Pract. 2017;130:53–60.
    • (2017) Diabetes Res Clin Pract , vol.130 , pp. 53-60
    • Monami, M.1    Nreu, B.2    Zannoni, S.3
  • 61
    • 84975853831 scopus 로고    scopus 로고
    • CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis
    • Ferrannini E, Mark M, Mayoux E. CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis. Diabetes Care. 2016;39:1108–1114.
    • (2016) Diabetes Care , vol.39 , pp. 1108-1114
    • Ferrannini, E.1    Mark, M.2    Mayoux, E.3
  • 62
    • 84975840750 scopus 로고    scopus 로고
    • Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis
    • Mudaliar S, Alloju S, Henry RR. Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis. Diabetes Care. 2016;39:1115–1122.
    • (2016) Diabetes Care , vol.39 , pp. 1115-1122
    • Mudaliar, S.1    Alloju, S.2    Henry, R.R.3
  • 63
    • 33846842006 scopus 로고    scopus 로고
    • Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome
    • Benfield T, Jensen JS, Nordestgaard BG. Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome. Diabetologia. 2007;50:549–554.
    • (2007) Diabetologia , vol.50 , pp. 549-554
    • Benfield, T.1    Jensen, J.S.2    Nordestgaard, B.G.3
  • 64
    • 0036676813 scopus 로고    scopus 로고
    • Adherence of type 1-fimbriated Escherichia coli to uroepithelial cells: more in diabetic women than in control subjects
    • Geerlings SE, Meiland R, van Lith EC, et al. Adherence of type 1-fimbriated Escherichia coli to uroepithelial cells: more in diabetic women than in control subjects. Diabetes Care. 2002;25:1405–1409.
    • (2002) Diabetes Care , vol.25 , pp. 1405-1409
    • Geerlings, S.E.1    Meiland, R.2    van Lith, E.C.3
  • 65
    • 0032846814 scopus 로고    scopus 로고
    • Effect of glucose and pH on uropathogenic and non-uropathogenic Escherichia coli: studies with urine from diabetic and non-diabetic individuals
    • Geerlings SE, Brouwer EC, Gaastra W, et al. Effect of glucose and pH on uropathogenic and non-uropathogenic Escherichia coli: studies with urine from diabetic and non-diabetic individuals. J Med Microbiol. 1999;48:535–539.
    • (1999) J Med Microbiol , vol.48 , pp. 535-539
    • Geerlings, S.E.1    Brouwer, E.C.2    Gaastra, W.3
  • 66
    • 0031035272 scopus 로고    scopus 로고
    • Impaired leucocyte functions in diabetic patients
    • Delamaire M, Maugendre D, Moreno M, et al. Impaired leucocyte functions in diabetic patients. Diabet Med. 1997;14:29–34.
    • (1997) Diabet Med , vol.14 , pp. 29-34
    • Delamaire, M.1    Maugendre, D.2    Moreno, M.3
  • 67
    • 0034109144 scopus 로고    scopus 로고
    • Estrogen effects on Candida albicans: a potential virulence-regulating mechanism
    • Zhang X, Essmann M, Burt ET, et al. Estrogen effects on Candida albicans: a potential virulence-regulating mechanism. J Infect Dis. 2000;181:1441–1446.
    • (2000) J Infect Dis , vol.181 , pp. 1441-1446
    • Zhang, X.1    Essmann, M.2    Burt, E.T.3
  • 68
    • 49649121505 scopus 로고    scopus 로고
    • Mannose-binding lectin gene polymorphism and resistance to therapy in women with recurrent vulvovaginal candidiasis
    • Donders GG, Babula O, Bellen G, et al. Mannose-binding lectin gene polymorphism and resistance to therapy in women with recurrent vulvovaginal candidiasis. Bjog. 2008;115:1225–1231.
    • (2008) Bjog , vol.115 , pp. 1225-1231
    • Donders, G.G.1    Babula, O.2    Bellen, G.3
  • 69
    • 77950675511 scopus 로고    scopus 로고
    • Candida infections of the genitourinary tract
    • Achkar JM, Fries BC. Candida infections of the genitourinary tract. Clin Microbiol Rev. 2010;23:253–273.
    • (2010) Clin Microbiol Rev , vol.23 , pp. 253-273
    • Achkar, J.M.1    Fries, B.C.2
  • 70
    • 84940056292 scopus 로고    scopus 로고
    • Urinary and genital infections in patients with diabetes: how to diagnose and how to treat
    • Njomnang Soh P, Vidal F, Huyghe E, et al. Urinary and genital infections in patients with diabetes: how to diagnose and how to treat. Diabetes Metab. 2016;42:16–24.
    • (2016) Diabetes Metab , vol.42 , pp. 16-24
    • Njomnang Soh, P.1    Vidal, F.2    Huyghe, E.3
  • 71
    • 84898917720 scopus 로고    scopus 로고
    • Genital and urinary tract infections in diabetes: impact of pharmacologically-induced glucosuria
    • Geerlings S, Fonseca V, Castro-Diaz D, et al. Genital and urinary tract infections in diabetes: impact of pharmacologically-induced glucosuria. Diabetes Res Clin Pract. 2014;103:373–381.
    • (2014) Diabetes Res Clin Pract , vol.103 , pp. 373-381
    • Geerlings, S.1    Fonseca, V.2    Castro-Diaz, D.3
  • 72
    • 0033758731 scopus 로고    scopus 로고
    • Species-specific prevalence of vaginal candidiasis among patients with diabetes mellitus and its relation to their glycaemic status
    • Goswami R, Dadhwal V, Tejaswi S, et al. Species-specific prevalence of vaginal candidiasis among patients with diabetes mellitus and its relation to their glycaemic status. J Infect. 2000;41:162–166.
    • (2000) J Infect , vol.41 , pp. 162-166
    • Goswami, R.1    Dadhwal, V.2    Tejaswi, S.3
  • 73
    • 0344923836 scopus 로고    scopus 로고
    • Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans
    • Fidel PL, Vazquez JA, Sobel JD. Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clinical Microbiology Reviews. 1999;12:80–96.
    • (1999) Clinical Microbiology Reviews , vol.12 , pp. 80-96
    • Fidel, P.L.1    Vazquez, J.A.2    Sobel, J.D.3
  • 74
    • 84896701131 scopus 로고    scopus 로고
    • Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study
    • Jabbour SA, Hardy E, Sugg J, et al. Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study. Diabetes Care. 2014;37:740–750.
    • (2014) Diabetes Care , vol.37 , pp. 740-750
    • Jabbour, S.A.1    Hardy, E.2    Sugg, J.3
  • 75
    • 84964240560 scopus 로고    scopus 로고
    • Long-term efficacy and safety of canagliflozin over 104 weeks in patients aged 55-80 years with type 2 diabetes
    • Bode B, Stenlof K, Harris S, et al. Long-term efficacy and safety of canagliflozin over 104 weeks in patients aged 55-80 years with type 2 diabetes. Diabetes Obes Metab. 2015;17:294–303.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 294-303
    • Bode, B.1    Stenlof, K.2    Harris, S.3
  • 76
    • 84943200890 scopus 로고    scopus 로고
    • Empagliflozin as add-on to metformin plus sulphonylurea in patients with type 2 diabetes
    • Haering HU, Merker L, Christiansen AV, et al. Empagliflozin as add-on to metformin plus sulphonylurea in patients with type 2 diabetes. Diabetes Res Clin Pract. 2015;110:82–90.
    • (2015) Diabetes Res Clin Pract , vol.110 , pp. 82-90
    • Haering, H.U.1    Merker, L.2    Christiansen, A.V.3
  • 77
    • 85020393721 scopus 로고    scopus 로고
    • Safety and efficiency of SGLT2 inhibitor combining with insulin in subjects with diabetes: systematic review and meta-analysis of randomized controlled trials
    • Yang Y, Chen S, Pan H, et al. Safety and efficiency of SGLT2 inhibitor combining with insulin in subjects with diabetes: systematic review and meta-analysis of randomized controlled trials. Medicine (Baltimore). 2017;96:e6944.
    • (2017) Medicine (Baltimore) , vol.96 , pp. e6944
    • Yang, Y.1    Chen, S.2    Pan, H.3
  • 78
    • 84897952259 scopus 로고    scopus 로고
    • The safety of dipeptidyl peptidase-4 (DPP-4) inhibitors or sodium-glucose cotransporter 2 (SGLT-2) inhibitors added to metformin background therapy in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
    • Kawalec P, Mikrut A, Lopuch S. The safety of dipeptidyl peptidase-4 (DPP-4) inhibitors or sodium-glucose cotransporter 2 (SGLT-2) inhibitors added to metformin background therapy in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetes Metab Res Rev. 2014;30:269–283.
    • (2014) Diabetes Metab Res Rev , vol.30 , pp. 269-283
    • Kawalec, P.1    Mikrut, A.2    Lopuch, S.3
  • 79
    • 84882251091 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis
    • Vasilakou D, Karagiannis T, Athanasiadou E, et al. Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis. Ann Intern Med. 2013;159:262–274.
    • (2013) Ann Intern Med , vol.159 , pp. 262-274
    • Vasilakou, D.1    Karagiannis, T.2    Athanasiadou, E.3
  • 80
    • 85020394574 scopus 로고    scopus 로고
    • Effects of SGLT2 inhibitors on UTIs and genital infections in type 2 diabetes mellitus: a systematic review and meta-analysis
    • Liu J, Li L, Li S. Effects of SGLT2 inhibitors on UTIs and genital infections in type 2 diabetes mellitus: a systematic review and meta-analysis. Sci Rep. 2017;7:2824.
    • (2017) Sci Rep , vol.7 , pp. 2824
    • Liu, J.1    Li, L.2    Li, S.3
  • 81
    • 84969915634 scopus 로고    scopus 로고
    • Efficacy and safety of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes mellitus: systematic review and network meta-analysis
    • Zaccardi F, Webb DR, Htike ZZ, et al. Efficacy and safety of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes mellitus: systematic review and network meta-analysis. Diabetes Obes Metab. 2016;18:783–794.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 783-794
    • Zaccardi, F.1    Webb, D.R.2    Htike, Z.Z.3
  • 82
    • 85007022677 scopus 로고    scopus 로고
    • Urinary tract and genital infections in patients with type 2 diabetes treated with sodium-glucose co-transporter 2 inhibitors: a meta-analysis of randomized controlled trials
    • Li D, Wang T, Shen S, et al. Urinary tract and genital infections in patients with type 2 diabetes treated with sodium-glucose co-transporter 2 inhibitors: a meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2017;19:348–355.
    • (2017) Diabetes Obes Metab , vol.19 , pp. 348-355
    • Li, D.1    Wang, T.2    Shen, S.3
  • 83
    • 85021379472 scopus 로고    scopus 로고
    • Clinical risk factors predicting genital fungal infections with sodium-glucose cotransporter 2 inhibitor treatment: the ABCD nationwide dapagliflozin audit
    • Epub ahead of print
    • Thong KY, Yadagiri M, Barnes DJ, et al. Clinical risk factors predicting genital fungal infections with sodium-glucose cotransporter 2 inhibitor treatment: the ABCD nationwide dapagliflozin audit. Prim Care Diabetes. 2017; Epub ahead of print. DOI: 10.1016/j.pcd.2017.06.004
    • (2017) Prim Care Diabetes
    • Thong, K.Y.1    Yadagiri, M.2    Barnes, D.J.3
  • 84
    • 85038815455 scopus 로고    scopus 로고
    • A case of septic shock due to Serratia marcescens pyelonephritis and bacteremia in a patient receiving empagliflozin
    • Kufel WD, Scrimenti A, Steele JM. A case of septic shock due to Serratia marcescens pyelonephritis and bacteremia in a patient receiving empagliflozin. J Pharm Pract. 2016.
    • (2016) J Pharm Pract
    • Kufel, W.D.1    Scrimenti, A.2    Steele, J.M.3
  • 85
    • 85019705024 scopus 로고    scopus 로고
    • Caution advised with dapagliflozin in the setting of male urinary tract outlet obstruction
    • Hall V, Kwong J, Johnson D, et al. Caution advised with dapagliflozin in the setting of male urinary tract outlet obstruction. BMJ Case Rep. 2017;2017. DOI:10.1136/bcr-2017-219335
    • (2017) BMJ Case Rep , vol.2017
    • Hall, V.1    Kwong, J.2    Johnson, D.3
  • 86
    • 85021054097 scopus 로고    scopus 로고
    • Safety and tolerability of empagliflozin in patients with type 2 diabetes: pooled analysis of phase I-III clinical trials
    • Kohler S, Zeller C, Iliev H, et al. Safety and tolerability of empagliflozin in patients with type 2 diabetes: pooled analysis of phase I-III clinical trials. Adv Ther. 2017;34:1707–1726.
    • (2017) Adv Ther , vol.34 , pp. 1707-1726
    • Kohler, S.1    Zeller, C.2    Iliev, H.3
  • 87
    • 84992146453 scopus 로고    scopus 로고
    • Toe amputations with SGLT-2 inhibitors: data from randomized clinical trials
    • Monami M, Zannoni S, Nreu B, et al. Toe amputations with SGLT-2 inhibitors: data from randomized clinical trials. Acta Diabetol. 2017;54:411–413.
    • (2017) Acta Diabetol , vol.54 , pp. 411-413
    • Monami, M.1    Zannoni, S.2    Nreu, B.3
  • 88
    • 85024835007 scopus 로고    scopus 로고
    • SGTL2 inhibitors and amputations in the US FDA Adverse Event Reporting System
    • 5:680681
    • Fadini GP, Avogaro A. SGTL2 inhibitors and amputations in the US FDA Adverse Event Reporting System. Lancet Diabetes Endocrinol. 2017;5:680681.
    • (2017) Lancet Diabetes Endocrinol
    • Fadini, G.P.1    Avogaro, A.2
  • 89
    • 84988410173 scopus 로고    scopus 로고
    • Elevated serum magnesium associated with SGLT2 inhibitor use in type 2 diabetes patients: a meta-analysis of randomised controlled trials
    • Tang H, Zhang X, Zhang J, et al. Elevated serum magnesium associated with SGLT2 inhibitor use in type 2 diabetes patients: a meta-analysis of randomised controlled trials. Diabetologia. 2016;59:2546–2551.
    • (2016) Diabetologia , vol.59 , pp. 2546-2551
    • Tang, H.1    Zhang, X.2    Zhang, J.3
  • 90
    • 85016986779 scopus 로고    scopus 로고
    • Effects of canagliflozin on serum magnesium in patients with type 2 diabetes mellitus: a post hoc analysis of randomized controlled trials
    • Gilbert RE, Mende C, Vijapurkar U, et al. Effects of canagliflozin on serum magnesium in patients with type 2 diabetes mellitus: a post hoc analysis of randomized controlled trials. Diabetes Ther. 2017;8:451–458.
    • (2017) Diabetes Ther , vol.8 , pp. 451-458
    • Gilbert, R.E.1    Mende, C.2    Vijapurkar, U.3
  • 91
    • 85027511295 scopus 로고    scopus 로고
    • SGLT2 inhibitors-induced electrolyte abnormalities: an analysis of the associated mechanisms
    • Epub ahead of print
    • Filippatos TD, Tsimihodimos V, Liamis G, et al. SGLT2 inhibitors-induced electrolyte abnormalities: an analysis of the associated mechanisms. Diabetes Metab Syndr. 2017; Epub ahead of print. DOI: 10.1016/j.dsx.2017.08.03
    • (2017) Diabetes Metab Syndr
    • Filippatos, T.D.1    Tsimihodimos, V.2    Liamis, G.3
  • 92
    • 84929377076 scopus 로고    scopus 로고
    • Dapagliflozin lowers plasma glucose concentration and improves beta-cell function
    • Merovci A, Mari A, Solis C, et al. Dapagliflozin lowers plasma glucose concentration and improves beta-cell function. J Clin Endocrinol Metab. 2015;100:1927–1932.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 1927-1932
    • Merovci, A.1    Mari, A.2    Solis, C.3
  • 93
    • 84931068290 scopus 로고    scopus 로고
    • Downregulation of transient receptor potential M6 channels as a cause of hypermagnesiuric hypomagnesemia in obese type 2 diabetic rats
    • Takayanagi K, Shimizu T, Tayama Y, et al. Downregulation of transient receptor potential M6 channels as a cause of hypermagnesiuric hypomagnesemia in obese type 2 diabetic rats. Am J Physiol Renal Physiol. 2015;308:F1386–97.
    • (2015) Am J Physiol Renal Physiol , vol.308 , pp. F1386-F1397
    • Takayanagi, K.1    Shimizu, T.2    Tayama, Y.3
  • 94
    • 84984622380 scopus 로고    scopus 로고
    • Glucagon actions on the kidney revisited: possible role in potassium homeostasis
    • Bankir L, Bouby N, Blondeau B, et al. Glucagon actions on the kidney revisited: possible role in potassium homeostasis. Am J Physiol Renal Physiol. 2016;311:F469–86.
    • (2016) Am J Physiol Renal Physiol , vol.311 , pp. F469-F486
    • Bankir, L.1    Bouby, N.2    Blondeau, B.3
  • 95
    • 84992463370 scopus 로고    scopus 로고
    • Effect of acute hyperinsulinemia on magnesium homeostasis in humans
    • 33:e2844
    • Xu LH, Maalouf NM. Effect of acute hyperinsulinemia on magnesium homeostasis in humans. Diabetes Metab Res Rev. 2017;33:e2844.
    • (2017) Diabetes Metab Res Rev
    • Xu, L.H.1    Maalouf, N.M.2
  • 96
    • 84899961819 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebo-controlled trial
    • Barnett AH, Mithal A, Manassie J, et al. Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2014;2:369–384.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 369-384
    • Barnett, A.H.1    Mithal, A.2    Manassie, J.3
  • 97
    • 84897394040 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
    • Kohan DE, Fioretto P, Tang W, et al. Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int. 2014;85:962–971.
    • (2014) Kidney Int , vol.85 , pp. 962-971
    • Kohan, D.E.1    Fioretto, P.2    Tang, W.3
  • 98
    • 84961827997 scopus 로고    scopus 로고
    • Effect of the SGLT2 inhibitor dapagliflozin on potassium levels in patients with type 2 diabetes mellitus: a pooled analysis
    • Yavin Y, Mansfield TA, Ptaszynska A, et al. Effect of the SGLT2 inhibitor dapagliflozin on potassium levels in patients with type 2 diabetes mellitus: a pooled analysis. Diabetes Ther. 2016;7:125–137.
    • (2016) Diabetes Ther , vol.7 , pp. 125-137
    • Yavin, Y.1    Mansfield, T.A.2    Ptaszynska, A.3
  • 99
    • 84906837116 scopus 로고    scopus 로고
    • Effect of canagliflozin on serum electrolytes in patients with type 2 diabetes in relation to estimated glomerular filtration rate (eGFR)
    • Weir MR, Kline I, Xie J, et al. Effect of canagliflozin on serum electrolytes in patients with type 2 diabetes in relation to estimated glomerular filtration rate (eGFR). Curr Med Res Opin. 2014;30:1759–1768.
    • (2014) Curr Med Res Opin , vol.30 , pp. 1759-1768
    • Weir, M.R.1    Kline, I.2    Xie, J.3
  • 100
    • 84960259844 scopus 로고    scopus 로고
    • Importance of inhibiting sodium-glucose cotransporter and its compelling indication in type 2 diabetes: pathophysiological hypothesis
    • Kimura G. Importance of inhibiting sodium-glucose cotransporter and its compelling indication in type 2 diabetes: pathophysiological hypothesis. J Am Soc Hypertens. 2016;10:271–278.
    • (2016) J Am Soc Hypertens , vol.10 , pp. 271-278
    • Kimura, G.1
  • 102
    • 84954514891 scopus 로고    scopus 로고
    • Effects of canagliflozin on fracture risk in patients with type 2 diabetes mellitus
    • Watts NB, Bilezikian JP, Usiskin K, et al. Effects of canagliflozin on fracture risk in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2016;101:157–166.
    • (2016) J Clin Endocrinol Metab , vol.101 , pp. 157-166
    • Watts, N.B.1    Bilezikian, J.P.2    Usiskin, K.3
  • 103
    • 84994383020 scopus 로고    scopus 로고
    • Lack of evidence for a harmful effect of sodium-glucose co-transporter 2 (SGLT2) inhibitors on fracture risk among type 2 diabetes patients: a network and cumulative meta-analysis of randomized controlled trials
    • Tang HL, Li DD, Zhang JJ, et al. Lack of evidence for a harmful effect of sodium-glucose co-transporter 2 (SGLT2) inhibitors on fracture risk among type 2 diabetes patients: a network and cumulative meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2016;18:1199–1206.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 1199-1206
    • Tang, H.L.1    Li, D.D.2    Zhang, J.J.3
  • 104
    • 85029158143 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 (SGLT2) inhibitors and fracture risk in patients with type 2 diabetes mellitus: a meta-analysis
    • Ruanpeng D, Ungprasert P, Sangtian J, et al. Sodium-glucose cotransporter 2 (SGLT2) inhibitors and fracture risk in patients with type 2 diabetes mellitus: a meta-analysis. Diabetes Metab Res Rev. 2017;33:e2903.
    • (2017) Diabetes Metab Res Rev
    • Ruanpeng, D.1    Ungprasert, P.2    Sangtian, J.3
  • 105
    • 84954564720 scopus 로고    scopus 로고
    • Evaluation of bone mineral density and bone biomarkers in patients with type 2 diabetes treated with canagliflozin
    • Bilezikian JP, Watts NB, Usiskin K, et al. Evaluation of bone mineral density and bone biomarkers in patients with type 2 diabetes treated with canagliflozin. J Clin Endocrinol Metab. 2016;101:44–51.
    • (2016) J Clin Endocrinol Metab , vol.101 , pp. 44-51
    • Bilezikian, J.P.1    Watts, N.B.2    Usiskin, K.3
  • 106
    • 84867142771 scopus 로고    scopus 로고
    • Dapagliflozin has no effect on markers of bone formation and resorption or bone mineral density in patients with inadequately controlled type 2 diabetes mellitus on metformin
    • Ljunggren O, Bolinder J, Johansson L, et al. Dapagliflozin has no effect on markers of bone formation and resorption or bone mineral density in patients with inadequately controlled type 2 diabetes mellitus on metformin. Diabetes Obes Metab. 2012;14:990–999.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 990-999
    • Ljunggren, O.1    Bolinder, J.2    Johansson, L.3
  • 107
    • 84948567431 scopus 로고    scopus 로고
    • Effects of baseline blood pressure and low-density lipoprotein cholesterol on safety and efficacy of canagliflozin in Japanese patients with type 2 diabetes mellitus
    • Inagaki N, Goda M, Yokota S, et al. Effects of baseline blood pressure and low-density lipoprotein cholesterol on safety and efficacy of canagliflozin in Japanese patients with type 2 diabetes mellitus. Adv Ther. 2015;32:1085–1103.
    • (2015) Adv Ther , vol.32 , pp. 1085-1103
    • Inagaki, N.1    Goda, M.2    Yokota, S.3
  • 108
    • 84912533839 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin for type 2 diabetes: a systematic review and meta-analysis
    • Liakos A, Karagiannis T, Athanasiadou E, et al. Efficacy and safety of empagliflozin for type 2 diabetes: a systematic review and meta-analysis. Diabetes Obes Metab. 2014;16:984–993.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 984-993
    • Liakos, A.1    Karagiannis, T.2    Athanasiadou, E.3
  • 109
    • 84860183617 scopus 로고    scopus 로고
    • A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials
    • Musso G, Gambino R, Cassader M, et al. A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials. Ann Med. 2012;44:375–393.
    • (2012) Ann Med , vol.44 , pp. 375-393
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 110
    • 85010202013 scopus 로고    scopus 로고
    • Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin
    • Hayashi T, Fukui T, Nakanishi N, et al. Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin. Cardiovasc Diabetol. 2017;16:8.
    • (2017) Cardiovasc Diabetol , vol.16 , pp. 8
    • Hayashi, T.1    Fukui, T.2    Nakanishi, N.3
  • 111
    • 85018513669 scopus 로고    scopus 로고
    • A comparison of effects of DPP-4 inhibitor and SGLT2 inhibitor on lipid profile in patients with type 2 diabetes
    • Cha SA, Park YM, Yun JS, et al. A comparison of effects of DPP-4 inhibitor and SGLT2 inhibitor on lipid profile in patients with type 2 diabetes. Lipids Health Dis. 2017;16:58.
    • (2017) Lipids Health Dis , vol.16 , pp. 58
    • Cha, S.A.1    Park, Y.M.2    Yun, J.S.3
  • 112
    • 85016992878 scopus 로고    scopus 로고
    • Effects of the SGLT2 inhibitor dapagliflozin on HDL cholesterol, particle size, and cholesterol efflux capacity in patients with type 2 diabetes: a randomized placebo-controlled trial
    • Fadini GP, Bonora BM, Zatti G, et al. Effects of the SGLT2 inhibitor dapagliflozin on HDL cholesterol, particle size, and cholesterol efflux capacity in patients with type 2 diabetes: a randomized placebo-controlled trial. Cardiovasc Diabetol. 2017;16:42.
    • (2017) Cardiovasc Diabetol , vol.16 , pp. 42
    • Fadini, G.P.1    Bonora, B.M.2    Zatti, G.3
  • 113
    • 84975789692 scopus 로고    scopus 로고
    • Empagliflozin, via switching metabolism toward lipid utilization, moderately increases LDL cholesterol levels through reduced LDL catabolism
    • Briand F, Mayoux E, Brousseau E, et al. Empagliflozin, via switching metabolism toward lipid utilization, moderately increases LDL cholesterol levels through reduced LDL catabolism. Diabetes. 2016;65:2032–2038.
    • (2016) Diabetes , vol.65 , pp. 2032-2038
    • Briand, F.1    Mayoux, E.2    Brousseau, E.3
  • 114
    • 84923196210 scopus 로고    scopus 로고
    • Are lower levels of LDL-cholesterol really better? Looking at the results of IMPROVE-IT: opinions of three experts - III
    • Filippatos TD, Elisaf MS. Are lower levels of LDL-cholesterol really better? Looking at the results of IMPROVE-IT: opinions of three experts - III. Hellenic J Cardiol. 2015;56:7–9.
    • (2015) Hellenic J Cardiol , vol.56 , pp. 7-9
    • Filippatos, T.D.1    Elisaf, M.S.2
  • 115
    • 84994296486 scopus 로고    scopus 로고
    • 2016 ESC/EAS guidelines for the management of dyslipidaemias
    • Catapano AL, Graham I, De Backer G, et al. 2016 ESC/EAS guidelines for the management of dyslipidaemias. Eur Heart J. 2016;37:2999–3058.
    • (2016) Eur Heart J , vol.37 , pp. 2999-3058
    • Catapano, A.L.1    Graham, I.2    De Backer, G.3
  • 116
    • 85023777061 scopus 로고    scopus 로고
    • Canagliflozin and cardiovascular and renal events in type 2 diabetes
    • Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med. 2017;377:644–657.
    • (2017) N Engl J Med , vol.377 , pp. 644-657
    • Neal, B.1    Perkovic, V.2    Mahaffey, K.W.3
  • 118
    • 85018324492 scopus 로고    scopus 로고
    • ACE and SGLT2 inhibitors: the future for non-diabetic and diabetic proteinuric renal disease
    • Perico N, Ruggenenti P, Remuzzi G. ACE and SGLT2 inhibitors: the future for non-diabetic and diabetic proteinuric renal disease. Curr Opin Pharmacol. 2017;33:34–40.
    • (2017) Curr Opin Pharmacol , vol.33 , pp. 34-40
    • Perico, N.1    Ruggenenti, P.2    Remuzzi, G.3
  • 119
    • 84994731812 scopus 로고    scopus 로고
    • Benefits and harms of sodium-glucose co-transporter 2 inhibitors in patients with type 2 diabetes: a systematic review and meta-analysis
    • Storgaard H, Gluud LL, Bennett C, et al. Benefits and harms of sodium-glucose co-transporter 2 inhibitors in patients with type 2 diabetes: a systematic review and meta-analysis. PLoS One. 2016;11:e0166125.
    • (2016) PLoS One , vol.11
    • Storgaard, H.1    Gluud, L.L.2    Bennett, C.3
  • 120
    • 84947998361 scopus 로고    scopus 로고
    • Effect of canagliflozin on liver function tests in patients with type 2 diabetes
    • Leiter LA, Forst T, Polidori D, et al. Effect of canagliflozin on liver function tests in patients with type 2 diabetes. Diabetes Metab. 2016;42:25–32.
    • (2016) Diabetes Metab , vol.42 , pp. 25-32
    • Leiter, L.A.1    Forst, T.2    Polidori, D.3
  • 121
    • 84929584388 scopus 로고    scopus 로고
    • Short-term impacts of sodium/glucose co-transporter 2 inhibitors in Japanese clinical practice: considerations for their appropriate use to avoid serious adverse events
    • Yabe D, Nishikino R, Kaneko M, et al. Short-term impacts of sodium/glucose co-transporter 2 inhibitors in Japanese clinical practice: considerations for their appropriate use to avoid serious adverse events. Expert Opin Drug Saf. 2015;14:795–800.
    • (2015) Expert Opin Drug Saf , vol.14 , pp. 795-800
    • Yabe, D.1    Nishikino, R.2    Kaneko, M.3
  • 122
    • 85019367291 scopus 로고    scopus 로고
    • Increased hematocrit during sodium-glucose cotransporter 2 inhibitor therapy indicates recovery of tubulointerstitial function in diabetic kidneys
    • Sano M, Takei M, Shiraishi Y, et al. Increased hematocrit during sodium-glucose cotransporter 2 inhibitor therapy indicates recovery of tubulointerstitial function in diabetic kidneys. J Clin Med Res. 2016;8:844–847.
    • (2016) J Clin Med Res , vol.8 , pp. 844-847
    • Sano, M.1    Takei, M.2    Shiraishi, Y.3
  • 123
    • 85005950931 scopus 로고    scopus 로고
    • Stroke paradox with SGLT-2 inhibitors: a play of chance or a viscosity-mediated reality?
    • Imprialos KP, Boutari C, Stavropoulos K, et al. Stroke paradox with SGLT-2 inhibitors: a play of chance or a viscosity-mediated reality? J Neurol Neurosurg Psychiatry. 2017;88:249–253.
    • (2017) J Neurol Neurosurg Psychiatry , vol.88 , pp. 249-253
    • Imprialos, K.P.1    Boutari, C.2    Stavropoulos, K.3
  • 125
    • 84958548824 scopus 로고    scopus 로고
    • Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis
    • Sonesson C, Johansson PA, Johnsson E, et al. Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis. Cardiovasc Diabetol. 2016;15:37.
    • (2016) Cardiovasc Diabetol , vol.15 , pp. 37
    • Sonesson, C.1    Johansson, P.A.2    Johnsson, E.3
  • 126
    • 85018712189 scopus 로고    scopus 로고
    • Empagliflozin and cerebrovascular events in patients with type 2 diabetes mellitus at high cardiovascular risk
    • Zinman B, Inzucchi SE, Lachin JM, et al. Empagliflozin and cerebrovascular events in patients with type 2 diabetes mellitus at high cardiovascular risk. Stroke. 2017;48:1218–1225.
    • (2017) Stroke , vol.48 , pp. 1218-1225
    • Zinman, B.1    Inzucchi, S.E.2    Lachin, J.M.3
  • 127
    • 84982113684 scopus 로고    scopus 로고
    • 2016 European guidelines on cardiovascular disease prevention in clinical practice: the Sixth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of 10 societies and by invited experts)developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)
    • Piepoli MF, Hoes AW, Agewall S, et al. 2016 European guidelines on cardiovascular disease prevention in clinical practice: the Sixth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of 10 societies and by invited experts)developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J. 2016;37:2315–2381.
    • (2016) Eur Heart J , vol.37 , pp. 2315-2381
    • Piepoli, M.F.1    Hoes, A.W.2    Agewall, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.