Mannose-binding lectin gene polymorphism and resistance to therapy in women with recurrent vulvovaginal candidiasis

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 115, Issue 10, 2008, Pages 1225-1231

  Donders, G G G ^a,b,c,d   Babula, O ^e   Bellen, G ^d   Linhares, I M ^e,f   Witkin, S S ^f  

^a Algemeen Ziekenhuis H Hart Tienen   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d Femicare vzw   (Belgium)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Candida vaginitis; Fluconazole; Innate immunity; Maintenance therapy; Mannose binding lectin; Recurrent infection; Recurrent vulvovaginal candidiasis; Risk factors; Therapy resistance; Vaginal immunity

Indexed keywords

ENDONUCLEASE; FLUCONAZOLE; MANNOSE BINDING LECTIN; SODIUM CHLORIDE;

ALLELE; ANTIFUNGAL RESISTANCE; ARTICLE; CANDIDIASIS; CASE CONTROL STUDY; CHEEK; CODON; CONFIDENCE INTERVAL; CONTROLLED STUDY; DNA EXTRACTION; ENZYME METABOLISM; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; MAINTENANCE THERAPY; PHARMACOGENETICS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT INFECTION; RELAPSE; STATISTICAL SIGNIFICANCE; TREATMENT DURATION; TREATMENT RESPONSE; VAGINA CANDIDIASIS; VAGINAL LAVAGE;

ADULT; ANTIFUNGAL AGENTS; CANDIDIASIS, VULVOVAGINAL; CASE-CONTROL STUDIES; CODON; DRUG RESISTANCE; FEMALE; FLUCONAZOLE; FOLLOW-UP STUDIES; HUMANS; MANNOSE-BINDING LECTIN; POLYMORPHISM, GENETIC; RECURRENCE;

EID: 49649121505     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2008.01830.x     Document Type: Article

References (28)

1. Sobel JD. Epidemiology and pathogenesis of recurrent vulvovaginal candidiasis. Am J Obstet Gynecol 1985 152 : 924 35.
2. Giraldo PC, Babula O, Gonçalves AK, Linhares IM, Amaral RL, Ledger WJ, et al. Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis and bacterial vaginosis. Obstet Gynecol 2007 109 : 1123 8.
3. Babula O, Lazdane G, Kroica J, Ledger WJ, Witkin SS. Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women. Clin Infect Dis 2003 37 : 733 7.
4. Eisen DP, Minchinton RM. Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin Infect Dis 2003 37 : 1496 505.
5. Amsell R, Totten PA, Spiegel CA. Non-specific vaginitis: diagnostic criteria and microbiologic and epidemiologic associations. Am J Med 1983 74 : 14 22.
6. Sobel JD, Ferris D, Schwebke J, Nyirjesy P, Wiesenfeld HC, Peipert J, et al. Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis. Am J Obstet Gynecol 2006 194 : 1283 9.
7. Neth O, Jack DL, Dodds AW, Holzel H, Klein NJ, Turner MW. Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun 2000 68 : 688 93.
8. Ip WK, Lau YL. Role of mannose-binding lectin in the innate defense against Candida albicans: enhancement of complement activation, but lack of opsonic function, in phagocytosis by human dendritic cells. J Infect Dis 2004 190 : 632 40.
9. Pellis V, DeSeta F, Crovella S, Bossi F, Bulla R, Guaschino S, et al. Mannose binding lectin and C3 act as recognition molecules for infectious agents in the vagina. Clin Exp Immunol 2005 139 : 120 6.
10. Lillegard JB, Sim RB, Thorkildson P, Gates MA, Kozel TR. Recognition of Candida albicans by mannan-binding lectin in vitro and in vivo. J Infect Dis 2006 193 : 1589 97.
11. Babovic-Vuksanovic D, Snow K, Ten RM. Mannose-binding lectin (MBL) deficiency. Variant alleles in a midwestern population of the United States. Ann Allergy Asthma Immunol 1999 82 : 134 43.
12. Lipscombe RJ, Sumiya M, Summerfield JA, Turner MW. Distinct physiochemical characteristics of human mannose binding protein expression by individuals of differing genotype. Immunology 1995 85 : 660 7.
13. Donders GGG, Bellen G, Byttebier G, Verguts L, Hinoul P, Walckiers R, et al. Degressive maintenance regimen using fluconazole for recurrent vulvo-vaginal candidiasis. Am J Obstet Gynaecol (in press).
14. Donders GGG. Definition and classification of abnormal vaginal flora. Best Pract Res Clin Obstet Gynaecol 2007 21 : 355 73.
15. Donders GGG, Vereecken A, Bosmans E, Dekeersmaecker A, Salembier G, Spitz B. Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis. BJOG 2002 109 : 1 10.
16. Madsen HO, Garred P, Kurtzhals JAL, Lamm LU, Ryder LP, Thiel S, et al. A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics 1994 40 : 37 44.
17. Babula O, Danielsson I, Sjoberg I, Ledger WJ, Witkin SS. Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome. Am J Obstet Gynecol 2004 191 : 762 6.
18. Irving G, Miller D, Robinson A, Reynolds S, Copas AJ. Psychological factors associated with recurrent vaginal candidiasis: a preliminary study. Sex Transm Infect 1998 74 : 334 8.
19. Sobel JD, Wiesenfeld HC, Martens M, Danna P, Hooton TM, Rompalo A, et al. Maintenance fluconazole therapy for recurrent vulvovaginal candidiasis. N Engl J Med 2004 351 : 876 83.
20. Calderon L, Williams R, Martinez M, Clemons KV, Stevens DA. Genetic susceptibility to vaginal candidiasis. Med Mycol 2003 41 : 143 7.
21. Witkin SS, Linhares I, Giraldo P, Jeremias J, Ledger WJ. Individual immunity and susceptibility to female genital tract infection. Am J Obstet Gynecol 2000 183 : 252 6.
22. Donders GGG, Prenen H, Verbeke G, Reybrouck R. Impaired tolerance for glucose in women with recurrent vaginal candidiasis. Am J Obstet Gynecol 2002 187 : 989 93.
23. Neves NA, Carvalho LP, De Oliveira MA, Giraldo PC, Bacellar O, Cruz AA, et al. Association between atopy and recurrent vaginal candidiasis. Clin Exp Immunol 2005 142 : 167 71.
24. Fidel PL Jr., Sobel JD. Immunopathogenesis of recurrent vulvovaginal candidiasis. Clin Microbiol Rev 1996 9 : 335 48.
25. Babula O, Lazdane G, Kroica J, Linhares IM, Ledger WJ, Witkin SS. Frequency of interleukin-4 (IL-4) - 589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis. Clin Infect Dis 2005 40 : 1258 62.
26. Cardenas-Freytag L, Steele C, Wormley FL Jr., Cheng E, Clements JD, Fidel PL Jr. Partial protection against experimental vaginal candidiasis after mucosal vaccination with heat-killed Candida albicans and the mucosal adjuvant LT(R192G). Med Mycol 2002 40 : 291 9.
27. Han Y, Morrison RP, Cutler JE. A vaccine and monoclonal antibodies that enhance mouse resistance to Candida albicans vaginal infection. Infect Immun 1998 66 : 5771 6.
28. Jensenius JC, Jensen PH, McGuire K, Larsen JL, Thiel S. Recombinant mannan-binding lectin (MBL) for therapy. Biochem Soc Trans 2003 31 : 763 7.