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Volumn 16, Issue 6, 2015, Pages 609-617

Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8 + T cells

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; DIPHTHERIA TOXIN; ENHANCED GREEN FLUORESCENT PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; CHEMOTACTIC FACTOR;

EID: 84929965822     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3159     Document Type: Article
Times cited : (387)

References (48)
  • 2
    • 84871482550 scopus 로고    scopus 로고
    • Eosinophils: Changing perspectives in health and disease
    • Rosenberg, H. F. , Dyer, K. D. & Foster, P. S. Eosinophils: changing perspectives in health and disease. Nat. Rev. Immunol. 13, 9-22 (2013).
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 9-22
    • Rosenberg, H.F.1    Dyer, K.D.2    Foster, P.S.3
  • 3
    • 79959353756 scopus 로고    scopus 로고
    • Eosinophils: Multifaceted biological properties and roles in health and disease
    • Kita, H. Eosinophils: multifaceted biological properties and roles in health and disease. Immunol. Rev. 242, 161-177 (2011).
    • (2011) Immunol. Rev. , vol.242 , pp. 161-177
    • Kita, H.1
  • 4
    • 84873702479 scopus 로고    scopus 로고
    • Eosinophil-derived cytokines in health and disease: Unraveling novel mechanisms of selective secretion
    • Melo, R. C. , Liu, L. , Xenakis, J. J. & Spencer, L. A. Eosinophil-derived cytokines in health and disease: unraveling novel mechanisms of selective secretion. Allergy 68, 274-284 (2013).
    • (2013) Allergy , vol.68 , pp. 274-284
    • Melo, R.C.1    Liu, L.2    Xenakis, J.J.3    Spencer, L.A.4
  • 5
    • 0042784917 scopus 로고
    • Ueber das Verhalten der Leukocyten bei malignen Tumoren
    • Reinbach, G. Ueber das Verhalten der Leukocyten bei malignen Tumoren. Arch. Klin. Chir 46, 486-562 (1893).
    • (1893) Arch. Klin. Chir , vol.46 , pp. 486-562
    • Reinbach, G.1
  • 6
    • 33947689316 scopus 로고    scopus 로고
    • Regulation of carcinogenesis by IL-5 and CCL11: A potential role for eosinophils in tumor immune surveillance
    • Simson, L. et al. Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. J. Immunol. 178, 4222-4229 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 4222-4229
    • Simson, L.1
  • 7
    • 33746931253 scopus 로고    scopus 로고
    • Pivotal advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response
    • Cormier, S. A. et al. Pivotal advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response. J. Leukoc. Biol. 79, 1131-1139 (2006).
    • (2006) J. Leukoc. Biol. , vol.79 , pp. 1131-1139
    • Cormier, S.A.1
  • 8
    • 77954105187 scopus 로고    scopus 로고
    • Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells
    • Lotfi, R. et al. Eosinophils oxidize damage-associated molecular pattern molecules derived from stressed cells. J. Immunol. 183, 5023-5031 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 5023-5031
    • Lotfi, R.1
  • 9
    • 33845966763 scopus 로고    scopus 로고
    • Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): Role in the inflammatory response within tumors
    • Lotfi, R. , Lee, J. J. & Lotze, M. T. Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): role in the inflammatory response within tumors. J. Immunother. 30, 16-28 (2007).
    • (2007) J. Immunother. , vol.30 , pp. 16-28
    • Lotfi, R.1    Lee, J.J.2    Lotze, M.T.3
  • 13
    • 0026331269 scopus 로고
    • Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4
    • Golumbek, P. T. et al. Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science 254, 713-716 (1991).
    • (1991) Science , vol.254 , pp. 713-716
    • Golumbek, P.T.1
  • 14
    • 0031930938 scopus 로고    scopus 로고
    • Neutrophils but not eosinophils are involved in growth suppression of IL-4-secreting tumors
    • Noffz, G. , Qin, Z. , Kopf, M. & Blankenstein, T. Neutrophils but not eosinophils are involved in growth suppression of IL-4-secreting tumors. J. Immunol. 160, 345-350 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 345-350
    • Noffz, G.1    Qin, Z.2    Kopf, M.3    Blankenstein, T.4
  • 15
    • 0037415596 scopus 로고    scopus 로고
    • Immunotherapy of cytotoxic T cell-resistant tumors by Thelper 2 cells: An eotaxin and STAT6-dependent process
    • Mattes, J. et al. Immunotherapy of cytotoxic T cell-resistant tumors by Thelper 2 cells: an eotaxin and STAT6-dependent process. J. Exp. Med. 197, 387-393 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 387-393
    • Mattes, J.1
  • 16
    • 3242807263 scopus 로고    scopus 로고
    • Increased blood clotting, microvascular density, and inflammation in eotaxin-secreting tumors implanted into mice
    • Samoszuk, M. et al. Increased blood clotting, microvascular density, and inflammation in eotaxin-secreting tumors implanted into mice. Am. J. Pathol. 165, 449-456 (2004).
    • (2004) Am. J. Pathol. , vol.165 , pp. 449-456
    • Samoszuk, M.1
  • 17
    • 0027520859 scopus 로고
    • Eosinophils infiltrating interleukin-5 gene-transfected tumors do not suppress tumor growth
    • Krüger-Krasagakes, S. , Li, W. , Richter, G. , Diamantstein, T. & Blankenstein, T. Eosinophils infiltrating interleukin-5 gene-transfected tumors do not suppress tumor growth. Eur. J. Immunol. 23, 992-995 (1993).
    • (1993) Eur. J. Immunol. , vol.23 , pp. 992-995
    • Krüger-Krasagakes, S.1    Li, W.2    Richter, G.3    Diamantstein, T.4    Blankenstein, T.5
  • 18
    • 0026663801 scopus 로고
    • Tumor-associated eosinophilia in interleukin-2-treated patients: Evidence of toxic eosinophil degranulation on bladder cancer cells
    • Huland, E. & Huland, H. Tumor-associated eosinophilia in interleukin-2-treated patients: Evidence of toxic eosinophil degranulation on bladder cancer cells. J. Cancer Res. Clin. Oncol. 118, 463-467 (1992).
    • (1992) J. Cancer Res. Clin. Oncol. , vol.118 , pp. 463-467
    • Huland, E.1    Huland, H.2
  • 19
    • 0029162057 scopus 로고
    • Evidence for eosinophil activation in cancer patients receiving recombinant interleukin-4: Effects of interleukin-4 alone and following interleukin-2 administration
    • Sosman, J. A. et al. Evidence for eosinophil activation in cancer patients receiving recombinant interleukin-4: Effects of interleukin-4 alone and following interleukin-2 administration. Clin. Cancer Res. 1, 805-812 (1995).
    • (1995) Clin. Cancer Res. , vol.1 , pp. 805-812
    • Sosman, J.A.1
  • 20
    • 84884151496 scopus 로고    scopus 로고
    • Tumor associated macrophages and neutrophils in cancer
    • Galdiero, M. R. et al. Tumor associated macrophages and neutrophils in cancer. Immunobiology 218, 1402-1410 (2013).
    • (2013) Immunobiology , vol.218 , pp. 1402-1410
    • Galdiero, M.R.1
  • 21
    • 78649557780 scopus 로고    scopus 로고
    • Efficient Treg depletion induces T-cell infiltration and rejection of large tumors
    • Li, X. , Kostareli, E. , Suffner, J. , Garbi, N. & Hammerling, G. J. Efficient Treg depletion induces T-cell infiltration and rejection of large tumors. Eur. J. Immunol. 40, 3325-3335 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 3325-3335
    • Li, X.1    Kostareli, E.2    Suffner, J.3    Garbi, N.4    Hammerling, G.J.5
  • 22
    • 49249130983 scopus 로고    scopus 로고
    • Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils
    • Zimmermann, N. et al. Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils. Allergy 63, 1156-1163 (2008).
    • (2008) Allergy , vol.63 , pp. 1156-1163
    • Zimmermann, N.1
  • 23
    • 78751627318 scopus 로고    scopus 로고
    • Eosinophils are required for the maintenance of plasma cells in the bone marrow
    • Chu, V. T. et al. Eosinophils are required for the maintenance of plasma cells in the bone marrow. Nat. Immunol. 12, 151-159 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 151-159
    • Chu, V.T.1
  • 24
    • 43749112760 scopus 로고    scopus 로고
    • Vascular normalization in Rgs5-deficient tumours promotes immune destruction
    • Hamzah, J. et al. Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 453, 410-414 (2008).
    • (2008) Nature , vol.453 , pp. 410-414
    • Hamzah, J.1
  • 25
    • 1542405217 scopus 로고    scopus 로고
    • Eosinophils: 'New' roles for 'old' cells
    • Munitz, A. & Levi-Schaffer, F. Eosinophils: 'new' roles for 'old' cells. Allergy 59, 268-275 (2004).
    • (2004) Allergy , vol.59 , pp. 268-275
    • Munitz, A.1    Levi-Schaffer, F.2
  • 26
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: Harnessing the T cell response
    • Restifo, N. P. , Dudley, M. E. & Rosenberg, S. A. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat. Rev. Immunol. 12, 269-281 (2012).
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 27
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain, R. K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307, 58-62 (2005).
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 28
    • 0027400726 scopus 로고
    • Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    • Dalton, D. K. et al. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 259, 1739-1742 (1993).
    • (1993) Science , vol.259 , pp. 1739-1742
    • Dalton, D.K.1
  • 29
    • 57649112725 scopus 로고    scopus 로고
    • Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
    • Stockmann, C. et al. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 456, 814-818 (2008).
    • (2008) Nature , vol.456 , pp. 814-818
    • Stockmann, C.1
  • 30
    • 84900991885 scopus 로고    scopus 로고
    • The impact of the immune system on tumor: Angiogenesis and vascular remodeling
    • Stockmann, C. , Schadendorf, D. , Klose, R. & Helfrich, I. The impact of the immune system on tumor: angiogenesis and vascular remodeling. Front. Oncol. 4, 69 (2014).
    • (2014) Front. Oncol. , vol.4 , pp. 69
    • Stockmann, C.1    Schadendorf, D.2    Klose, R.3    Helfrich, I.4
  • 31
    • 84877870613 scopus 로고    scopus 로고
    • Vascular normalization as an emerging strategy to enhance cancer immunotherapy
    • Huang, Y. , Goel, S. , Duda, D. G. , Fukumura, D. & Jain, R. K. Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Res. 73, 2943-2948 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 2943-2948
    • Huang, Y.1    Goel, S.2    Duda, D.G.3    Fukumura, D.4    Jain, R.K.5
  • 32
    • 0036494443 scopus 로고    scopus 로고
    • Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication
    • Ganss, R. , Ryschich, E. , Klar, E. , Arnold, B. & Hammerling, G. J. Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication. Cancer Res. 62, 1462-1470 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 1462-1470
    • Ganss, R.1    Ryschich, E.2    Klar, E.3    Arnold, B.4    Hammerling, G.J.5
  • 33
    • 0037138426 scopus 로고    scopus 로고
    • Transformation of the microvascular system during multistage tumorigenesis
    • Ryschich, E. , Schmidt, J. , Hammerling, G. J. , Klar, E. & Ganss, R. Transformation of the microvascular system during multistage tumorigenesis. Int. J. Cancer 97, 719-725 (2002).
    • (2002) Int. J. Cancer , vol.97 , pp. 719-725
    • Ryschich, E.1    Schmidt, J.2    Hammerling, G.J.3    Klar, E.4    Ganss, R.5
  • 34
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
    • Facciabene, A. et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells. Nature 475, 226-230 (2011).
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1
  • 36
    • 84887561907 scopus 로고    scopus 로고
    • Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapy
    • Klug, F. et al. Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 24, 589-602 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 589-602
    • Klug, F.1
  • 37
    • 2442452552 scopus 로고    scopus 로고
    • CpG motifs as proinflammatory factors render autochthonous tumors permissive for infiltration and destruction
    • Garbi, N. , Arnold, B. , Gordon, S. , Hammerling, G. J. & Ganss, R. CpG motifs as proinflammatory factors render autochthonous tumors permissive for infiltration and destruction. J. Immunol. 172, 5861-5869 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 5861-5869
    • Garbi, N.1    Arnold, B.2    Gordon, S.3    Hammerling, G.J.4    Ganss, R.5
  • 38
    • 84871861969 scopus 로고    scopus 로고
    • PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
    • Finlay, D. K. et al. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J. Exp. Med. 209, 2441-2453 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 2441-2453
    • Finlay, D.K.1
  • 39
    • 84879058083 scopus 로고    scopus 로고
    • Combining antiangiogenic therapy with adoptive cell immunotherapy exerts better antitumor effects in non-small cell lung cancer models
    • Shi, S. et al. Combining antiangiogenic therapy with adoptive cell immunotherapy exerts better antitumor effects in non-small cell lung cancer models. PLoS ONE 8, e65757 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e65757
    • Shi, S.1
  • 40
    • 84867902940 scopus 로고    scopus 로고
    • Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
    • Huang, Y. et al. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc. Natl. Acad. Sci. USA 109, 17561-17566 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 17561-17566
    • Huang, Y.1
  • 41
    • 41149083753 scopus 로고    scopus 로고
    • Generation of Th1 and Th2 chemokines by human eosinophils: Evidence for a critical role of TNF
    • Liu, L. Y. et al. Generation of Th1 and Th2 chemokines by human eosinophils: Evidence for a critical role of TNF. J. Immunol. 179, 4840-4848 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 4840-4848
    • Liu, L.Y.1
  • 42
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • Wu, D. et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332, 243-247 (2011).
    • (2011) Science , vol.332 , pp. 243-247
    • Wu, D.1
  • 43
    • 84878432797 scopus 로고    scopus 로고
    • Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: An early increase in lymphocyte and eosinophil counts is associated with improved survival
    • Delyon, J. et al. Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival. Ann. Oncol. 24, 1697-1703 (2013).
    • (2013) Ann. Oncol. , vol.24 , pp. 1697-1703
    • Delyon, J.1
  • 44
    • 84880757177 scopus 로고    scopus 로고
    • Deciphering and reversing tumor immune suppression
    • Motz, G. T. & Coukos, G. Deciphering and reversing tumor immune suppression. Immunity 39, 61-73 (2013).
    • (2013) Immunity , vol.39 , pp. 61-73
    • Motz, G.T.1    Coukos, G.2
  • 45
    • 80052206084 scopus 로고    scopus 로고
    • Prognostic and predictive impact of intra-and peritumoral immune infiltrates
    • Fridman, W. H. et al. Prognostic and predictive impact of intra-and peritumoral immune infiltrates. Cancer Res. 71, 5601-5605 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 5601-5605
    • Fridman, W.H.1
  • 46
    • 77949900562 scopus 로고    scopus 로고
    • Dendritic cells support homeostatic expansion of Foxp3+ regulatory T cells in Foxp3. LuciDTR mice
    • Suffner, J. et al. Dendritic cells support homeostatic expansion of Foxp3+ regulatory T cells in Foxp3. LuciDTR mice. J. Immunol. 184, 1810-1820 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 1810-1820
    • Suffner, J.1
  • 47
    • 68049142434 scopus 로고    scopus 로고
    • Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy
    • Kohlmeyer, J. et al. Complete regression of advanced primary and metastatic mouse melanomas following combination chemoimmunotherapy. Cancer Res. 69, 6265-6274 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 6265-6274
    • Kohlmeyer, J.1
  • 48
    • 70350543807 scopus 로고    scopus 로고
    • Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis
    • Domschke, C. et al. Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis. Cancer Res. 69, 8420-8428 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 8420-8428
    • Domschke, C.1


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