Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants

Journal of Biological Chemistry

Volumn 292, Issue 42, 2017, Pages 17290-17301

  Gupta, Pulkit ^a   Zhang, Zhifen ^b,c   Sugiman Marangos, Seiji N ^b   Tam, John ^b   Raman, Swetha ^b   Julien, Jean Phillipe ^b,c   Kroh, Heather K ^d   Lacy, D Borden ^d   Murgolo, Nicholas ^a   Bekkari, Kavitha ^a   Therien, Alex G ^a   Hernandez, Lorraine D ^a   Melnyk, Roman A ^b,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CLOSTRIDIUM; CROPS; CYTOLOGY; MOLECULAR BIOLOGY;

C-TERMINAL TRUNCATION; CELL SURFACE RECEPTORS; CLOSTRIDIUM DIFFICILE; FUNCTIONAL DEFECTS; GLUCOSYLTRANSFERASES; MULTIDOMAIN PROTEINS; NOSOCOMIAL PATHOGENS; RECEPTOR-MEDIATED ENDOCYTOSIS;

BINDING SITES;

BACTERIAL TOXIN; BEZLOTOXUMAB; CELL SURFACE RECEPTOR; CSPG4 RECEPTOR; TCDB TOXIN; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CSPG4 PROTEIN, HUMAN; GLUCOSYLTRANSFERASE; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PROTEIN BINDING; PROTEOCHONDROITIN SULFATE; TOXB PROTEIN, CLOSTRIDIUM DIFFICILE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL VIRULENCE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CROP DOMAIN; CYTOTOXICITY; HYDROPHOBICITY; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR BINDING; SEQUENCE ALIGNMENT; ANIMAL; ANTAGONISTS AND INHIBITORS; CACO-2 CELL LINE; CHEMISTRY; CHLOROCEBUS AETHIOPS; CHO CELL LINE; CRICETULUS; ENZYMOLOGY; GENETICS; HAMSTER; HEK293 CELL LINE; HUMAN; METABOLISM; PATHOGENICITY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; BACTERIAL PROTEINS; BACTERIAL TOXINS; CACO-2 CELLS; CERCOPITHECUS AETHIOPS; CHO CELLS; CHONDROITIN SULFATE PROTEOGLYCANS; CLOSTRIDIUM DIFFICILE; CRICETINAE; CRICETULUS; GLUCOSYLTRANSFERASES; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; PROTEIN BINDING; PROTEIN DOMAINS;

EID: 85032027927     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M117.806687     Document Type: Article

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