Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B

Cell Research

Volumn 25, Issue 2, 2015, Pages 157-168

  Yuan, Pengfei ^a   Zhang, Hongmin ^a   Cai, Changzu ^a   Zhu, Shiyou ^a   Zhou, Yuexin ^a   Yang, Xiaozhou ^a   He, Ruina ^a   Li, Chan ^a   Guo, Shengjie ^a   Li, Shan ^b   Huang, Tuxiong ^c   Perez Cordon, Gregorio ^c   Feng, Hanping ^c   Wei, Wensheng ^a  

^a PEKING UNIVERSITY   (China)

^b SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^c UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

Author keywords

Clostridium difficile; CROPs; CSPG4; receptor; TcdB; toxin

Indexed keywords

ANIMALIA; BACILLUS (BACTERIUM); BACTERIA (MICROORGANISMS); CLOSTRIDIUM DIFFICILE; MUS; POSIBACTERIA;

ANTIGEN; BACTERIAL PROTEIN; BACTERIAL TOXIN; CHONDROITIN SULFATE PROTEOGLYCAN 4; INTERLEUKIN 8; PROTEIN BINDING; PROTEOGLYCAN; SMALL INTERFERING RNA; TOXB PROTEIN, CLOSTRIDIUM DIFFICILE;

ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CHEMISTRY; CLOSTRIDIUM INFECTION; CYTOSKELETON; ENDOCYTOSIS; GENE INACTIVATION; HEK293 CELL LINE; HELA CELL LINE; HT-29 CELL LINE; HUMAN; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; MOUSE; NUCLEOTIDE SEQUENCE; PATHOLOGY; PEPTOCLOSTRIDIUM DIFFICILE; PROTEIN TERTIARY STRUCTURE;

ANIMALS; ANTIGENS; BACTERIAL PROTEINS; BACTERIAL TOXINS; BASE SEQUENCE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; CYTOSKELETON; ENDOCYTOSIS; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HELA CELLS; HT29 CELLS; HUMANS; INTERLEUKIN-8; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEOGLYCANS; RNA, SMALL INTERFERING;

EID: 84922252575     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2014.169     Document Type: Article

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