Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 22, 2015, Pages 7073-7078

  LaFrance, Michelle E ^a   Farrow, Melissa A ^a   Chandrasekaran, Ramyavardhanee ^a   Sheng, Jinsong ^a   Rubin, Donald H ^a,b   Lacy, D Borden ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Nectin 3; PVRL3; Toxin

Indexed keywords

CELL RECEPTOR; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; MONOCLONAL ANTIBODY; MUTANT PROTEIN; POLIOVIRUS RECEPTOR LIKE 3; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VIRULENCE FACTOR; VIRUS RECEPTOR; BACTERIAL PROTEIN; BACTERIAL TOXIN; CELL ADHESION MOLECULE; ENTEROTOXIN; NECTINS; TOXB PROTEIN, CLOSTRIDIUM DIFFICILE;

ANIMAL CELL; ARTICLE; CELL DEATH; CLOSTRIDIUM DIFFICILE INFECTION; COLON MUCOSA; CONTROLLED STUDY; CRISPR CAS SYSTEM; CYTOTOXICITY; EXPLANT; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MUTAGENESIS; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PSEUDOMEMBRANOUS COLITIS; ANALYSIS OF VARIANCE; CACO 2 CELL LINE; CHEMISTRY; COLON; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; IMMUNOLOGY; METABOLISM;

CLOSTRIDIUM DIFFICILE; POLIOVIRUS;

ANALYSIS OF VARIANCE; ANTIBODIES, MONOCLONAL; BACTERIAL PROTEINS; BACTERIAL TOXINS; CACO-2 CELLS; CELL ADHESION MOLECULES; CLOSTRIDIUM DIFFICILE; COLON; ENTEROTOXINS; EPITHELIAL CELLS; GENETIC COMPLEMENTATION TEST; HELA CELLS; HUMANS; MUTAGENESIS, INSERTIONAL;

EID: 84930965989     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1500791112     Document Type: Article

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