메뉴 건너뛰기




Volumn 27, Issue 1, 2018, Pages 10-21

Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment

Author keywords

biomarkers; cancer; cancer therapy; cancer related depression; epinephrine; exercise training; immune surveillance; physical activity; tumor; tumor microenvironment

Indexed keywords

INTRINSIC FACTOR;

EID: 85031826765     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2017.09.015     Document Type: Review
Times cited : (369)

References (109)
  • 3
    • 84876946818 scopus 로고    scopus 로고
    • A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise
    • Aoi, W., Naito, Y., Takagi, T., Tanimura, Y., Takanami, Y., Kawai, Y., Sakuma, K., Hang, L.P., Mizushima, K., Hirai, Y., et al. A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise. Gut 62 (2013), 882–889.
    • (2013) Gut , vol.62 , pp. 882-889
    • Aoi, W.1    Naito, Y.2    Takagi, T.3    Tanimura, Y.4    Takanami, Y.5    Kawai, Y.6    Sakuma, K.7    Hang, L.P.8    Mizushima, K.9    Hirai, Y.10
  • 4
    • 85019384935 scopus 로고    scopus 로고
    • Physical activity and telomere length: impact of aging and potential mechanisms of action
    • Arsenis, N.C., You, T., Ogawa, E.F., Tinsley, G.M., Zuo, L., Physical activity and telomere length: impact of aging and potential mechanisms of action. Oncotarget 8 (2017), 45008–45019.
    • (2017) Oncotarget , vol.8 , pp. 45008-45019
    • Arsenis, N.C.1    You, T.2    Ogawa, E.F.3    Tinsley, G.M.4    Zuo, L.5
  • 5
    • 84978531218 scopus 로고    scopus 로고
    • Efficacy and mechanisms of aerobic exercise on cancer initiation, progression, and metastasis: a critical systematic review of in vivo preclinical data
    • Ashcraft, K.A., Peace, R.M., Betof, A.S., Dewhirst, M.W., Jones, L.W., Efficacy and mechanisms of aerobic exercise on cancer initiation, progression, and metastasis: a critical systematic review of in vivo preclinical data. Cancer Res. 76 (2016), 4032–4050.
    • (2016) Cancer Res. , vol.76 , pp. 4032-4050
    • Ashcraft, K.A.1    Peace, R.M.2    Betof, A.S.3    Dewhirst, M.W.4    Jones, L.W.5
  • 6
    • 18144386162 scopus 로고    scopus 로고
    • Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation
    • Atherton, P.J., Babraj, J., Smith, K., Singh, J., Rennie, M.J., Wackerhage, H., Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation. FASEB J. 19 (2005), 786–788.
    • (2005) FASEB J. , vol.19 , pp. 786-788
    • Atherton, P.J.1    Babraj, J.2    Smith, K.3    Singh, J.4    Rennie, M.J.5    Wackerhage, H.6
  • 7
    • 84931577546 scopus 로고    scopus 로고
    • Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice
    • Aveseh, M., Nikooie, R., Aminaie, M., Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice. J. Physiol. 593 (2015), 2635–2648.
    • (2015) J. Physiol. , vol.593 , pp. 2635-2648
    • Aveseh, M.1    Nikooie, R.2    Aminaie, M.3
  • 9
    • 84923184975 scopus 로고    scopus 로고
    • Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation
    • Benatti, F.B., Pedersen, B.K., Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation. Nat. Rev. Rheumatol. 11 (2015), 86–97.
    • (2015) Nat. Rev. Rheumatol. , vol.11 , pp. 86-97
    • Benatti, F.B.1    Pedersen, B.K.2
  • 11
    • 85013052814 scopus 로고    scopus 로고
    • Depressive spectrum disorders in cancer: prevalence, risk factors and screening for depression: a critical review
    • Caruso, R., Nanni, M.G., Riba, M., Sabato, S., Mitchell, A.J., Croce, E., Grassi, L., Depressive spectrum disorders in cancer: prevalence, risk factors and screening for depression: a critical review. Acta Oncol. 56 (2017), 146–155.
    • (2017) Acta Oncol. , vol.56 , pp. 146-155
    • Caruso, R.1    Nanni, M.G.2    Riba, M.3    Sabato, S.4    Mitchell, A.J.5    Croce, E.6    Grassi, L.7
  • 12
    • 85041723303 scopus 로고    scopus 로고
    • Preoperative exercise training for patients with non-small cell lung cancer
    • Cavalheri V, Granger C. Preoperative exercise training for patients with non-small cell lung cancer. Cochrane Database of Systematic Reviews 2017(6),2017,CD012020.
    • (2017) Cochrane Database of Systematic Reviews , vol.2017 , Issue.6 , pp. CD012020
    • Cavalheri, V.1    Granger, C.2
  • 13
    • 85028744851 scopus 로고    scopus 로고
    • Improving radiotherapy in cancer treatment: Promises and challenges
    • Chen, H.H.W., Kuo, M.T., Improving radiotherapy in cancer treatment: Promises and challenges. Oncotarget 8 (2017), 62742–62758.
    • (2017) Oncotarget , vol.8 , pp. 62742-62758
    • Chen, H.H.W.1    Kuo, M.T.2
  • 17
    • 84920577302 scopus 로고    scopus 로고
    • Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer
    • Conlon, K.C., Lugli, E., Welles, H.C., Rosenberg, S.A., Fojo, A.T., Morris, J.C., Fleisher, T.A., Dubois, S.P., Perera, L.P., Stewart, D.M., et al. Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J. Clin. Oncol. 33 (2015), 74–82.
    • (2015) J. Clin. Oncol. , vol.33 , pp. 74-82
    • Conlon, K.C.1    Lugli, E.2    Welles, H.C.3    Rosenberg, S.A.4    Fojo, A.T.5    Morris, J.C.6    Fleisher, T.A.7    Dubois, S.P.8    Perera, L.P.9    Stewart, D.M.10
  • 19
    • 85029290103 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumour angiogenesis
    • De Palma, M., Biziato, D., Petrova, T.V., Microenvironmental regulation of tumour angiogenesis. Nat. Rev. Cancer 17 (2017), 457–474.
    • (2017) Nat. Rev. Cancer , vol.17 , pp. 457-474
    • De Palma, M.1    Biziato, D.2    Petrova, T.V.3
  • 20
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis, R.J., Lum, J.J., Hatzivassiliou, G., Thompson, C.B., The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7 (2008), 11–20.
    • (2008) Cell Metab. , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 21
    • 84859633923 scopus 로고    scopus 로고
    • Weight management and its role in breast cancer rehabilitation
    • Demark-Wahnefried, W., Campbell, K.L., Hayes, S.C., Weight management and its role in breast cancer rehabilitation. Cancer 118:8 Suppl (2012), 2277–2287.
    • (2012) Cancer , vol.118 , Issue.8 , pp. 2277-2287
    • Demark-Wahnefried, W.1    Campbell, K.L.2    Hayes, S.C.3
  • 23
    • 85031405447 scopus 로고    scopus 로고
    • Exercise-induced catecholamines activate the hippo tumor suppressor pathway to reduce risks of breast cancer development
    • Dethlefsen, C., Hansen, L.S., Lillelund, C., Andersen, C., Gehl, J., Christensen, J.F., Pedersen, B.K., Hojman, P., Exercise-induced catecholamines activate the hippo tumor suppressor pathway to reduce risks of breast cancer development. Cancer Res. 77 (2017), 4894–4904.
    • (2017) Cancer Res. , vol.77 , pp. 4894-4904
    • Dethlefsen, C.1    Hansen, L.S.2    Lillelund, C.3    Andersen, C.4    Gehl, J.5    Christensen, J.F.6    Pedersen, B.K.7    Hojman, P.8
  • 24
    • 85010930921 scopus 로고    scopus 로고
    • Every exercise bout matters: linking systemic exercise responses to breast cancer control
    • Dethlefsen, C., Pedersen, K.S., Hojman, P., Every exercise bout matters: linking systemic exercise responses to breast cancer control. Breast Cancer Res. Treat. 162 (2017), 399–408.
    • (2017) Breast Cancer Res. Treat. , vol.162 , pp. 399-408
    • Dethlefsen, C.1    Pedersen, K.S.2    Hojman, P.3
  • 26
    • 84929944191 scopus 로고    scopus 로고
    • Fever and the thermal regulation of immunity: the immune system feels the heat
    • Evans, S.S., Repasky, E.A., Fisher, D.T., Fever and the thermal regulation of immunity: the immune system feels the heat. Nat. Rev. Immunol. 15 (2015), 335–349.
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 335-349
    • Evans, S.S.1    Repasky, E.A.2    Fisher, D.T.3
  • 27
    • 84873406669 scopus 로고    scopus 로고
    • Understanding the mechanisms and treatment options in cancer cachexia
    • Fearon, K., Arends, J., Baracos, V., Understanding the mechanisms and treatment options in cancer cachexia. Nat. Rev. Clin. Oncol. 10 (2013), 90–99.
    • (2013) Nat. Rev. Clin. Oncol. , vol.10 , pp. 90-99
    • Fearon, K.1    Arends, J.2    Baracos, V.3
  • 28
    • 77956905415 scopus 로고    scopus 로고
    • Dual roles for immunity in gastrointestinal cancers
    • Ferrone, C., Dranoff, G., Dual roles for immunity in gastrointestinal cancers. J. Clin. Oncol. 28 (2010), 4045–4051.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4045-4051
    • Ferrone, C.1    Dranoff, G.2
  • 31
    • 84957963722 scopus 로고    scopus 로고
    • Inflammatory marker changes in postmenopausal women after a year-long exercise intervention comparing high versus moderate volumes
    • Friedenreich, C.M., O'Reilly, R., Shaw, E., Stanczyk, F.Z., Yasui, Y., Brenner, D.R., Courneya, K.S., Inflammatory marker changes in postmenopausal women after a year-long exercise intervention comparing high versus moderate volumes. Cancer Prev. Res. (Phila.) 9 (2016), 196–203.
    • (2016) Cancer Prev. Res. (Phila.) , vol.9 , pp. 196-203
    • Friedenreich, C.M.1    O'Reilly, R.2    Shaw, E.3    Stanczyk, F.Z.4    Yasui, Y.5    Brenner, D.R.6    Courneya, K.S.7
  • 32
    • 85019007752 scopus 로고    scopus 로고
    • The limits of exercise physiology: from performance to health
    • Gabriel, B.M., Zierath, J.R., The limits of exercise physiology: from performance to health. Cell Metab. 25 (2017), 1000–1011.
    • (2017) Cell Metab. , vol.25 , pp. 1000-1011
    • Gabriel, B.M.1    Zierath, J.R.2
  • 35
    • 74949113994 scopus 로고    scopus 로고
    • Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression therapy for prostate cancer without bone metastases: a randomized controlled trial
    • Galvão, D.A., Taaffe, D.R., Spry, N., Joseph, D., Newton, R.U., Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression therapy for prostate cancer without bone metastases: a randomized controlled trial. J. Clin. Oncol. 28 (2010), 340–347.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 340-347
    • Galvão, D.A.1    Taaffe, D.R.2    Spry, N.3    Joseph, D.4    Newton, R.U.5
  • 36
    • 84918576681 scopus 로고    scopus 로고
    • Effects of the exercise-inducible myokine irisin on malignant and non-malignant breast epithelial cell behavior in vitro
    • Gannon, N.P., Vaughan, R.A., Garcia-Smith, R., Bisoffi, M., Trujillo, K.A., Effects of the exercise-inducible myokine irisin on malignant and non-malignant breast epithelial cell behavior in vitro. Int. J. Cancer 136 (2015), E197–E202.
    • (2015) Int. J. Cancer , vol.136 , pp. E197-E202
    • Gannon, N.P.1    Vaughan, R.A.2    Garcia-Smith, R.3    Bisoffi, M.4    Trujillo, K.A.5
  • 37
    • 84984878746 scopus 로고    scopus 로고
    • Local hyperthermia in head and neck cancer: mechanism, application and advance
    • Gao, S., Zheng, M., Ren, X., Tang, Y., Liang, X., Local hyperthermia in head and neck cancer: mechanism, application and advance. Oncotarget 7 (2016), 57367–57378.
    • (2016) Oncotarget , vol.7 , pp. 57367-57378
    • Gao, S.1    Zheng, M.2    Ren, X.3    Tang, Y.4    Liang, X.5
  • 38
    • 84983752571 scopus 로고    scopus 로고
    • Blood flow responses to mild-intensity exercise in ectopic vs. orthotopic prostate tumors; dependence upon host tissue hemodynamics and vascular reactivity
    • Garcia, E., Becker, V.G., McCullough, D.J., Stabley, J.N., Gittemeier, E.M., Opoku-Acheampong, A.B., Sieman, D.W., Behnke, B.J., Blood flow responses to mild-intensity exercise in ectopic vs. orthotopic prostate tumors; dependence upon host tissue hemodynamics and vascular reactivity. J. Appl. Physiol. 121 (2016), 15–24.
    • (2016) J. Appl. Physiol. , vol.121 , pp. 15-24
    • Garcia, E.1    Becker, V.G.2    McCullough, D.J.3    Stabley, J.N.4    Gittemeier, E.M.5    Opoku-Acheampong, A.B.6    Sieman, D.W.7    Behnke, B.J.8
  • 39
    • 84857571701 scopus 로고    scopus 로고
    • Human thermoregulation and the cardiovascular system
    • González-Alonso, J., Human thermoregulation and the cardiovascular system. Exp. Physiol. 97 (2012), 340–346.
    • (2012) Exp. Physiol. , vol.97 , pp. 340-346
    • González-Alonso, J.1
  • 40
    • 84889056274 scopus 로고    scopus 로고
    • Cancer immunosurveillance and immunoediting by natural killer cells
    • Gross, E., Sunwoo, J.B., Bui, J.D., Cancer immunosurveillance and immunoediting by natural killer cells. Cancer J. 19 (2013), 483–489.
    • (2013) Cancer J. , vol.19 , pp. 483-489
    • Gross, E.1    Sunwoo, J.B.2    Bui, J.D.3
  • 44
    • 84925026377 scopus 로고    scopus 로고
    • Exercise-induced lung cancer regression: mechanistic findings from a mouse model
    • Higgins, K.A., Park, D., Lee, G.Y., Curran, W.J., Deng, X., Exercise-induced lung cancer regression: mechanistic findings from a mouse model. Cancer 120 (2014), 3302–3310.
    • (2014) Cancer , vol.120 , pp. 3302-3310
    • Higgins, K.A.1    Park, D.2    Lee, G.Y.3    Curran, W.J.4    Deng, X.5
  • 47
    • 18944367562 scopus 로고    scopus 로고
    • Physical activity and survival after breast cancer diagnosis
    • Holmes, M.D., Chen, W.Y., Feskanich, D., Kroenke, C.H., Colditz, G.A., Physical activity and survival after breast cancer diagnosis. JAMA 293 (2005), 2479–2486.
    • (2005) JAMA , vol.293 , pp. 2479-2486
    • Holmes, M.D.1    Chen, W.Y.2    Feskanich, D.3    Kroenke, C.H.4    Colditz, G.A.5
  • 48
    • 84925966184 scopus 로고    scopus 로고
    • Exploiting the critical perioperative period to improve long-term cancer outcomes
    • Horowitz, M., Neeman, E., Sharon, E., Ben-Eliyahu, S., Exploiting the critical perioperative period to improve long-term cancer outcomes. Nat. Rev. Clin. Oncol. 12 (2015), 213–226.
    • (2015) Nat. Rev. Clin. Oncol. , vol.12 , pp. 213-226
    • Horowitz, M.1    Neeman, E.2    Sharon, E.3    Ben-Eliyahu, S.4
  • 50
    • 84973866719 scopus 로고    scopus 로고
    • Exercise-dependent regulation of NK cells in cancer protection
    • Idorn, M., Hojman, P., Exercise-dependent regulation of NK cells in cancer protection. Trends Mol. Med. 22 (2016), 565–577.
    • (2016) Trends Mol. Med. , vol.22 , pp. 565-577
    • Idorn, M.1    Hojman, P.2
  • 51
    • 84860522779 scopus 로고    scopus 로고
    • Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial
    • Imayama, I., Ulrich, C.M., Alfano, C.M., Wang, C., Xiao, L., Wener, M.H., Campbell, K.L., Duggan, C., Foster-Schubert, K.E., Kong, A., et al. Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial. Cancer Res. 72 (2012), 2314–2326.
    • (2012) Cancer Res. , vol.72 , pp. 2314-2326
    • Imayama, I.1    Ulrich, C.M.2    Alfano, C.M.3    Wang, C.4    Xiao, L.5    Wener, M.H.6    Campbell, K.L.7    Duggan, C.8    Foster-Schubert, K.E.9    Kong, A.10
  • 52
    • 84873536110 scopus 로고    scopus 로고
    • Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas
    • Jiang, W., Zhu, Z., Thompson, H.J., Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas. Carcinogenesis 34 (2013), 378–387.
    • (2013) Carcinogenesis , vol.34 , pp. 378-387
    • Jiang, W.1    Zhu, Z.2    Thompson, H.J.3
  • 53
    • 84874501476 scopus 로고    scopus 로고
    • Effect of exercise on markers of inflammation in breast cancer survivors: the Yale exercise and survivorship study
    • Jones, S.B., Thomas, G.A., Hesselsweet, S.D., Alvarez-Reeves, M., Yu, H., Irwin, M.L., Effect of exercise on markers of inflammation in breast cancer survivors: the Yale exercise and survivorship study. Cancer Prev. Res. (Phila.) 6 (2013), 109–118.
    • (2013) Cancer Prev. Res. (Phila.) , vol.6 , pp. 109-118
    • Jones, S.B.1    Thomas, G.A.2    Hesselsweet, S.D.3    Alvarez-Reeves, M.4    Yu, H.5    Irwin, M.L.6
  • 55
    • 79952087043 scopus 로고    scopus 로고
    • Physical activity and survival after prostate cancer diagnosis in the health professionals follow-up study
    • Kenfield, S.A., Stampfer, M.J., Giovannucci, E., Chan, J.M., Physical activity and survival after prostate cancer diagnosis in the health professionals follow-up study. J. Clin. Oncol. 29 (2011), 726–732.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 726-732
    • Kenfield, S.A.1    Stampfer, M.J.2    Giovannucci, E.3    Chan, J.M.4
  • 56
    • 84931037860 scopus 로고    scopus 로고
    • Inflammation-induced activation of the indoleamine 2,3-dioxygenase pathway: relevance to cancer-related fatigue
    • Kim, S., Miller, B.J., Stefanek, M.E., Miller, A.H., Inflammation-induced activation of the indoleamine 2,3-dioxygenase pathway: relevance to cancer-related fatigue. Cancer 121 (2015), 2129–2136.
    • (2015) Cancer , vol.121 , pp. 2129-2136
    • Kim, S.1    Miller, B.J.2    Stefanek, M.E.3    Miller, A.H.4
  • 57
    • 84906934662 scopus 로고    scopus 로고
    • Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
    • Kir, S., White, J.P., Kleiner, S., Kazak, L., Cohen, P., Baracos, V.E., Spiegelman, B.M., Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature 513 (2014), 100–104.
    • (2014) Nature , vol.513 , pp. 100-104
    • Kir, S.1    White, J.P.2    Kleiner, S.3    Kazak, L.4    Cohen, P.5    Baracos, V.E.6    Spiegelman, B.M.7
  • 59
    • 84981163280 scopus 로고    scopus 로고
    • Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing?
    • Klil-Drori, A.J., Azoulay, L., Pollak, M.N., Cancer, obesity, diabetes, and antidiabetic drugs: is the fog clearing?. Nat. Rev. Clin. Oncol. 14 (2017), 85–99.
    • (2017) Nat. Rev. Clin. Oncol. , vol.14 , pp. 85-99
    • Klil-Drori, A.J.1    Azoulay, L.2    Pollak, M.N.3
  • 60
    • 85019131066 scopus 로고    scopus 로고
    • Inhibition of human lung cancer cell proliferation and survival by post-exercise serum is associated with the inhibition of Akt, mTOR, p70 S6K, and Erk1/2
    • Kurgan, N., Tsakiridis, E., Kouvelioti, R., Moore, J., Klentrou, P., Tsiani, E., Inhibition of human lung cancer cell proliferation and survival by post-exercise serum is associated with the inhibition of Akt, mTOR, p70 S6K, and Erk1/2. Cancers (Basel), 9, 2017, E46.
    • (2017) Cancers (Basel) , vol.9 , pp. E46
    • Kurgan, N.1    Tsakiridis, E.2    Kouvelioti, R.3    Moore, J.4    Klentrou, P.5    Tsiani, E.6
  • 61
    • 76749169812 scopus 로고    scopus 로고
    • Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index
    • Lee, C., Safdie, F.M., Raffaghello, L., Wei, M., Madia, F., Parrella, E., Hwang, D., Cohen, P., Bianchi, G., Longo, V.D., Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 70 (2010), 1564–1572.
    • (2010) Cancer Res. , vol.70 , pp. 1564-1572
    • Lee, C.1    Safdie, F.M.2    Raffaghello, L.3    Wei, M.4    Madia, F.5    Parrella, E.6    Hwang, D.7    Cohen, P.8    Bianchi, G.9    Longo, V.D.10
  • 62
    • 85020134977 scopus 로고    scopus 로고
    • Breast cancer oral anti-cancer medication adherence: a systematic review of psychosocial motivators and barriers
    • Lin, C., Clark, R., Tu, P., Bosworth, H.B., Zullig, L.L., Breast cancer oral anti-cancer medication adherence: a systematic review of psychosocial motivators and barriers. Breast Cancer Res. Treat. 165 (2017), 247–260.
    • (2017) Breast Cancer Res. Treat. , vol.165 , pp. 247-260
    • Lin, C.1    Clark, R.2    Tu, P.3    Bosworth, H.B.4    Zullig, L.L.5
  • 63
    • 33750842264 scopus 로고    scopus 로고
    • Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice
    • Lu, Y.P., Lou, Y.R., Nolan, B., Peng, Q.Y., Xie, J.G., Wagner, G.C., Conney, A.H., Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice. Proc. Natl. Acad. Sci. USA 103 (2006), 16301–16306.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 16301-16306
    • Lu, Y.P.1    Lou, Y.R.2    Nolan, B.3    Peng, Q.Y.4    Xie, J.G.5    Wagner, G.C.6    Conney, A.H.7
  • 66
    • 84891273535 scopus 로고    scopus 로고
    • Effects of exercise training on tumor hypoxia and vascular function in the rodent preclinical orthotopic prostate cancer model
    • McCullough, D.J., Nguyen, L.M., Siemann, D.W., Behnke, B.J., Effects of exercise training on tumor hypoxia and vascular function in the rodent preclinical orthotopic prostate cancer model. J. Appl. Physiol. 115 (2013), 1846–1854.
    • (2013) J. Appl. Physiol. , vol.115 , pp. 1846-1854
    • McCullough, D.J.1    Nguyen, L.M.2    Siemann, D.W.3    Behnke, B.J.4
  • 67
    • 84898926809 scopus 로고    scopus 로고
    • Modulation of blood flow, hypoxia, and vascular function in orthotopic prostate tumors during exercise
    • McCullough, D.J., Stabley, J.N., Siemann, D.W., Behnke, B.J., Modulation of blood flow, hypoxia, and vascular function in orthotopic prostate tumors during exercise. J. Natl. Cancer Inst., 106, 2014, dju036.
    • (2014) J. Natl. Cancer Inst. , vol.106 , pp. dju036
    • McCullough, D.J.1    Stabley, J.N.2    Siemann, D.W.3    Behnke, B.J.4
  • 68
    • 39749104209 scopus 로고    scopus 로고
    • Mechanisms linking physical activity with cancer
    • McTiernan, A., Mechanisms linking physical activity with cancer. Nat. Rev. Cancer 8 (2008), 205–211.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 205-211
    • McTiernan, A.1
  • 71
    • 84867908861 scopus 로고    scopus 로고
    • Mishra, S.I., Scherer, R.W., Snyder, C., Geigle, P.M., Berlanstein, D.R., Topaloglu, O., Exercise interventions on health-related quality of life for people with cancer during active treatment. Cochrane Database Syst. Rev., 2012, 10.1002/14651858.CD008465.pub2.
    • Mishra, S.I., Scherer, R.W., Snyder, C., Geigle, P.M., Berlanstein, D.R., Topaloglu, O., Exercise interventions on health-related quality of life for people with cancer during active treatment. Cochrane Database Syst. Rev., 2012, 10.1002/14651858.CD008465.pub2.
  • 74
    • 79955369630 scopus 로고    scopus 로고
    • Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer
    • Morikawa, T., Kuchiba, A., Yamauchi, M., Meyerhardt, J.A., Shima, K., Nosho, K., Chan, A.T., Giovannucci, E., Fuchs, C.S., Ogino, S., Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer. JAMA 305 (2011), 1685–1694.
    • (2011) JAMA , vol.305 , pp. 1685-1694
    • Morikawa, T.1    Kuchiba, A.2    Yamauchi, M.3    Meyerhardt, J.A.4    Shima, K.5    Nosho, K.6    Chan, A.T.7    Giovannucci, E.8    Fuchs, C.S.9    Ogino, S.10
  • 75
    • 85017110803 scopus 로고    scopus 로고
    • Type I interferons and natural killer cell regulation in cancer
    • Müller, L., Aigner, P., Stoiber, D., Type I interferons and natural killer cell regulation in cancer. Front. Immunol., 8, 2017, 304.
    • (2017) Front. Immunol. , vol.8 , pp. 304
    • Müller, L.1    Aigner, P.2    Stoiber, D.3
  • 76
    • 84861917512 scopus 로고    scopus 로고
    • Autophagy and cardiovascular aging: lesson learned from rapamycin
    • Nair, S., Ren, J., Autophagy and cardiovascular aging: lesson learned from rapamycin. Cell Cycle 11 (2012), 2092–2099.
    • (2012) Cell Cycle , vol.11 , pp. 2092-2099
    • Nair, S.1    Ren, J.2
  • 77
    • 41149148789 scopus 로고    scopus 로고
    • The impact of T-cell immunity on ovarian cancer outcomes
    • Nelson, B.H., The impact of T-cell immunity on ovarian cancer outcomes. Immunol. Rev. 222 (2008), 101–116.
    • (2008) Immunol. Rev. , vol.222 , pp. 101-116
    • Nelson, B.H.1
  • 79
    • 84955671824 scopus 로고    scopus 로고
    • Interventions that may reduce depressive symptoms among prostate cancer patients: a systematic review and meta-analysis
    • Newby, T.A., Graff, J.N., Ganzini, L.K., McDonagh, M.S., Interventions that may reduce depressive symptoms among prostate cancer patients: a systematic review and meta-analysis. Psychooncology 24 (2015), 1686–1693.
    • (2015) Psychooncology , vol.24 , pp. 1686-1693
    • Newby, T.A.1    Graff, J.N.2    Ganzini, L.K.3    McDonagh, M.S.4
  • 82
    • 84904722547 scopus 로고    scopus 로고
    • Obesity and cancer–mechanisms underlying tumour progression and recurrence
    • Park, J., Morley, T.S., Kim, M., Clegg, D.J., Scherer, P.E., Obesity and cancer–mechanisms underlying tumour progression and recurrence. Nat. Rev. Endocrinol. 10 (2014), 455–465.
    • (2014) Nat. Rev. Endocrinol. , vol.10 , pp. 455-465
    • Park, J.1    Morley, T.S.2    Kim, M.3    Clegg, D.J.4    Scherer, P.E.5
  • 83
    • 55949119252 scopus 로고    scopus 로고
    • Muscle as an endocrine organ: focus on muscle-derived interleukin-6
    • Pedersen, B.K., Febbraio, M.A., Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol. Rev. 88 (2008), 1379–1406.
    • (2008) Physiol. Rev. , vol.88 , pp. 1379-1406
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 84
    • 84864283300 scopus 로고    scopus 로고
    • Muscles, exercise and obesity: skeletal muscle as a secretory organ
    • Pedersen, B.K., Febbraio, M.A., Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 8 (2012), 457–465.
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 457-465
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 85
    • 84947907977 scopus 로고    scopus 로고
    • Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases
    • Pedersen, B.K., Saltin, B., Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand. J. Med. Sci. Sports 25:Suppl 3 (2015), 1–72.
    • (2015) Scand. J. Med. Sci. Sports , vol.25 , pp. 1-72
    • Pedersen, B.K.1    Saltin, B.2
  • 86
    • 84926640947 scopus 로고    scopus 로고
    • Effects of exercise on tumor physiology and metabolism
    • Pedersen, L., Christensen, J.F., Hojman, P., Effects of exercise on tumor physiology and metabolism. Cancer J. 21 (2015), 111–116.
    • (2015) Cancer J. , vol.21 , pp. 111-116
    • Pedersen, L.1    Christensen, J.F.2    Hojman, P.3
  • 88
    • 84929606030 scopus 로고    scopus 로고
    • Regular exercise decreases liver tumors development in hepatocyte-specific PTEN-deficient mice independently of steatosis
    • Piguet, A.C., Saran, U., Simillion, C., Keller, I., Terracciano, L., Reeves, H.L., Dufour, J.F., Regular exercise decreases liver tumors development in hepatocyte-specific PTEN-deficient mice independently of steatosis. J. Hepatol. 62 (2015), 1296–1303.
    • (2015) J. Hepatol. , vol.62 , pp. 1296-1303
    • Piguet, A.C.1    Saran, U.2    Simillion, C.3    Keller, I.4    Terracciano, L.5    Reeves, H.L.6    Dufour, J.F.7
  • 91
    • 77149155687 scopus 로고    scopus 로고
    • IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors
    • Satoh-Takayama, N., Lesjean-Pottier, S., Vieira, P., Sawa, S., Eberl, G., Vosshenrich, C.A., Di Santo, J.P., IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors. J. Exp. Med. 207 (2010), 273–280.
    • (2010) J. Exp. Med. , vol.207 , pp. 273-280
    • Satoh-Takayama, N.1    Lesjean-Pottier, S.2    Vieira, P.3    Sawa, S.4    Eberl, G.5    Vosshenrich, C.A.6    Di Santo, J.P.7
  • 93
    • 84882733761 scopus 로고    scopus 로고
    • Mechanisms regulating skeletal muscle growth and atrophy
    • Schiaffino, S., Dyar, K.A., Ciciliot, S., Blaauw, B., Sandri, M., Mechanisms regulating skeletal muscle growth and atrophy. FEBS J. 280 (2013), 4294–4314.
    • (2013) FEBS J. , vol.280 , pp. 4294-4314
    • Schiaffino, S.1    Dyar, K.A.2    Ciciliot, S.3    Blaauw, B.4    Sandri, M.5
  • 97
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
    • Sharma, P., Allison, J.P., Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161 (2015), 205–214.
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 98
    • 84878849527 scopus 로고    scopus 로고
    • A systematic review of pre-surgical exercise intervention studies with cancer patients
    • Singh, F., Newton, R.U., Galvão, D.A., Spry, N., Baker, M.K., A systematic review of pre-surgical exercise intervention studies with cancer patients. Surg. Oncol. 22 (2013), 92–104.
    • (2013) Surg. Oncol. , vol.22 , pp. 92-104
    • Singh, F.1    Newton, R.U.2    Galvão, D.A.3    Spry, N.4    Baker, M.K.5
  • 99
    • 77955268790 scopus 로고    scopus 로고
    • Transmission of donor melanoma by organ transplantation
    • Strauss, D.C., Thomas, J.M., Transmission of donor melanoma by organ transplantation. Lancet Oncol. 11 (2010), 790–796.
    • (2010) Lancet Oncol. , vol.11 , pp. 790-796
    • Strauss, D.C.1    Thomas, J.M.2
  • 100
    • 84991809193 scopus 로고    scopus 로고
    • Oncogenic regulation of tumor metabolic reprogramming
    • Tarrado-Castellarnau, M., de Atauri, P., Cascante, M., Oncogenic regulation of tumor metabolic reprogramming. Oncotarget 7 (2016), 62726–62753.
    • (2016) Oncotarget , vol.7 , pp. 62726-62753
    • Tarrado-Castellarnau, M.1    de Atauri, P.2    Cascante, M.3
  • 102
    • 84983759423 scopus 로고    scopus 로고
    • Voluntary physical activity abolishes the proliferative tumor growth microenvironment created by adipose tissue in animals fed a high fat diet
    • Theriau, C.F., Shpilberg, Y., Riddell, M.C., Connor, M.K., Voluntary physical activity abolishes the proliferative tumor growth microenvironment created by adipose tissue in animals fed a high fat diet. J. Appl. Physiol. 121 (2016), 139–153.
    • (2016) J. Appl. Physiol. , vol.121 , pp. 139-153
    • Theriau, C.F.1    Shpilberg, Y.2    Riddell, M.C.3    Connor, M.K.4
  • 103
    • 70350759858 scopus 로고    scopus 로고
    • Candidate mechanisms accounting for effects of physical activity on breast carcinogenesis
    • Thompson, H.J., Jiang, W., Zhu, Z., Candidate mechanisms accounting for effects of physical activity on breast carcinogenesis. IUBMB Life 61 (2009), 895–901.
    • (2009) IUBMB Life , vol.61 , pp. 895-901
    • Thompson, H.J.1    Jiang, W.2    Zhu, Z.3
  • 107
    • 84989271246 scopus 로고    scopus 로고
    • The ever-expanding myokinome: discovery challenges and therapeutic implications
    • Whitham, M., Febbraio, M.A., The ever-expanding myokinome: discovery challenges and therapeutic implications. Nat. Rev. Drug Discov. 15 (2016), 719–729.
    • (2016) Nat. Rev. Drug Discov. , vol.15 , pp. 719-729
    • Whitham, M.1    Febbraio, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.