Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer

Medicine and Science in Sports and Exercise

Volumn 41, Issue 8, 2009, Pages 1597-1605

  Colbert, Lisa H ^a,h   Westerlind, Kim C ^b   Perkins, Susan N ^c   Haines, Diana C ^d   Berrigan, David ^e   Donehower, Lawrence A ^f   Fuchs Young, Robin ^g   Hursting, Stephen D ^c,g  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^d SAIC FREDERICK INC   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

^g UNIVERSITY OF TEXAS   (United States)

^h Department of Kinesiology ^*  (United States)

Author keywords

Body composition; IGF 1; Mammary; Physical activity

Indexed keywords

BIOLOGICAL MARKER; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY FAT; BODY WEIGHT; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER INCIDENCE; CONTROLLED STUDY; ENERGY BALANCE; EXERCISE; FEMALE; MOUSE; NONHUMAN; ONCOGENE; P53 GENE; PHYSICAL ACTIVITY; RISK REDUCTION; RUNNING; SURVIVAL TIME; TRANSGENIC MOUSE; TREADMILL EXERCISE;

ANIMALS; BODY COMPOSITION; BREAST NEOPLASMS; CARCINOGENICITY TESTS; FEMALE; INSULIN-LIKE GROWTH FACTOR I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; SURVIVAL ANALYSIS;

EID: 68449096247     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e31819f1f05     Document Type: Article

References (41)

1. Berrigan D, Lavigne JA, Perkins SN, Nagy TR, Barrett JC, Hursting SD. Phenotypic effects of calorie restriction and insulin-like growth factor-1 treatment on body composition and bone mineral density of C57BL/6 mice: implications for cancer prevention. In Vivo. 2005;19:667-74.
2. Blackshear PE, Genetically engineered rodent models of mammary gland carcinogenesis: an overview. Toxicol Pathol. 2001;29:105-16.
3. Bocchinfuso WP, Korach KS. Mammary gland development and tumorigenesis in estrogen receptor knockout mice. J Mammary Gland Biol Neoplasia. 1997;2:323-34.
4. Bravenboer N, Engelbregt MJT, Visser NA, Popp-Snijders C, Lips P. The effect of exercise on systemic and bone concentrations of growth factors in rats. J Orthop Res. 2001;19:945-9.
5. Cohen LA, Choi K, Backlund JY, Harris R, Wang CX. Modulation of N-nitrosomethylurea induced mammary tumorigenesis by dietary fat and voluntary exercise. In Vivo. 1991;5:333-44.
6. Cohen LA, Choi KW, Wang C. Influence of dietary fat, caloric restriction, and voluntary exercise on n-nitrosomethylurea-induced mammary tumorigenesis in rats. Cancer Res. 1988;48:4276-83.
7. Cohen LA, Kendall ME, Meschter C, Epstein MA, Reinhardt J, Zang E. Inhibition of rat mammary tumorigenesis by voluntary exercise. In Vivo. 1993;7:151-8.
8. Colbert LH, Davis JM, Essig DA, Ghaffar A, Mayer EP. Exercise and tumor development in a mouse predisposed to multiple intestinal adenomas. Med Sci Sports Exerc. 2000;32(10): 1704-8.
9. Min mice. Med Sci Sports Exerc. 2003; 35(10):1662-9.
10. Min mice. Carcinogenesis. 2006;27:2103-7.
11. De Bono JP, Adlam D, Paterson DJ, Channon KM. Novel quantitative phenotypes of exercise training in mouse models. Am J Physiol Regul Integr Comp Physiol. 2006;290:R926-34.
12. Donehower LA, Godley LA, Aldaz CM, et al. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev. 1995;9:882-95.
13. Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature. 1992;356:215-21.
14. Friedenreich CM, Cust AE. Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med. 2008;42:636-47.
15. Gillette CA, Zhu Z, Westerlind KC, Melby CL, Wolfe P, Thompson HJ. Energy availability and mammary carcinogenesis: effects of calorie restriction and exercise. Carcinogenesis. 1997;18:1183-8.
16. Hoffman-Goetz L, May KM, Arumugam Y. Exercise training and mouse mammary tumor metastasis. Anticancer Res. 1994;14:2627-32.
17. Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC. Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Annu Rev Med. 2003;54:131-52.
18. Hursting SD, Perkins SN, Colbert LH, et al. Effects of energy balance modulation on spontaneous mammary tumorigenesis in p53-deficient, Wnt-1 transgenic mice. Cancer Epidemiol Biomarkers Prev. 2002;11:1154s.
19. Lane HW, Teer P, Keith RE, White MT, Strahan S. Reduced energy intake and moderate exercise reduce mammary tumor incidence in virgin female BALB/c mice treated with 7,12-dimethylbenz(a)anthracene. J Nutr. 1991;121:1883-8.
20. Lee IM. Physical activity and cancer prevention - data from epi-demiologic studies. Med Sci Sports Exerc. 2003;35(11):1823-7.
21. Li Y, Hively WP, Varmus HE. Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene. 2000;19:1002-9.
22. Lu J, Xie L, Sylvester J, et al. Different gene expression of skin tissues between mice with weight controlled by either calorie restriction or physical exercise. Exp Biol Med. 2007;232:473-80.
23. Min mice through different mechanisms. Cancer Res. 2003;63:1752-5.
24. McTiernan A, Ulrich C, Slate S, Potter J. Physical activity and cancer etiology: associations and mechanisms. Cancer Causes Control. 1998;9:487-509.
25. Min/+ mice. J Appl Physiol. 2005;98:2219-25.
26. National Research Council. Guide for the Care and Use of Laboratory Animals. Washington (DC): National Academy Press; 1996.
27. Orenstein MR, Friedenreich CM. Review of physical activity and the IGF family. J Physical Act Aging. 2004;1:291-320.
28. Patel AC, Nunez NP, Perkins SN, Barrett JC, Hursting SD. Effects of energy balance on cancer in genetically altered mice. J Nutr. 2004;134:3394S-8S.
29. Schefer V, Talan MI. Oxygen consumption in adult and aged C57BL/6J mice during acute treadmill exercise of different intensity. Exp Gerontol. 1996;31:387-92.
30. Shephard RJ. Exercise in the prevention and treatment of cancer. Sports Med. 1993;15:258-80.
31. Thompson HJ, Ronan AM, Ritacco KA, Tagliaferro AR. Effect of type and amount of dietary fat on the enhancement of rat mammary tumorigenesis by exercise. Cancer Res. 1989;49:1904-8.
32. Thompson HJ, Ronan AM, Ritacco KA, Tagliferro AR, Meeker LD. Effect of exercise on the induction of mammary carcinogen-esis. Cancer Res. 1988;48:2720-3.
33. Thompson HJ, Westerlind KC, Snedden J, Briggs S, Singh M. Exercise intensity dependent inhibition of 1-methyl-1-nitrosourea induced mammary carcinogenesis in female F-344 rats. Carcino-genesis. 1995;16:1783-6.
34. Thompson HJ, Westerlind KC, Snedden JR, Briggs S, Singh M. Inhibition of mammary carcinogenesis by treadmill exercise. J Natl Cancer Inst. 1995;87:453-5.
35. Thompson HJ, Zhu Z, Jiang W. Weight control and breast cancer prevention: are the effects of reduced energy intake equivalent to those of increased energy expenditure? J Nutr. 2004;134:3407S-11S.
36. Westerlind KC. Physical activity and cancer prevention - mechanisms. Med Sci Sports Exerc. 2003;35(11):1834-40.
37. Westerlind KC, McCarty HL, Gibson KJ, Strange R. Effect of exercise on the rat mammary gland: implications for carcinogenesis. Acta Physiol Scand. 2002;175:147-56.
38. Westerlind KC, McCarty HL, Schultheiss PC, et al. Moderate exercise training slows mammary tumour growth in adolescent rats. Eur J Cancer Prev. 2003;12:281-7.
39. Whittal KS, Parkhouse WS. Exercise during adolescence and its effects on mammary gland development, proliferation, and nitro-somethylurea (NMU) induced tumorigenesis in rats. Breast Cancer Res Treat. 1996;37:21-7.
40. Whittal-Strange KS, Chadau S, Parkhouse WS. Exercise during puberty and NMU induced mammary tumorigenesis in rats. Breast Cancer Res Treat. 1998;47:1-8.
41. Xie L, Jian Y, Ouyang P, et al. Effects of dietary calorie restriction or exercise on the PI3K and ras signalling pathways in the skin of mice. J Biol Chem. 2007;282:28025-35.