The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Cell

Volumn 171, Issue 5, 2017, Pages 1110-1124.e18

  Gaidt, Moritz M ^a   Ebert, Thomas S ^a   Chauhan, Dhruv ^a   Ramshorn, Katharina ^a   Pinci, Francesca ^a   Zuber, Sarah ^a   O'Duill, Fionan ^a   Schmid Burgk, Jonathan L ^a   Hoss, Florian ^b   Buhmann, Raymund ^c   Wittmann, Georg ^c   Latz, Eicke ^b,d   Subklewe, Marion ^a,c   Hornung, Veit ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

AIM2; Caspase 1; cGAS; DNA; IL 1 ; inflammasome; lysosomal cell death; NLRP3; STING

Indexed keywords

CELL DNA; CRYOPYRIN; INFLAMMASOME; DNA; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NLRP3 PROTEIN, HUMAN;

ARTICLE; BONE MARROW CELL; CELL ACTIVATION; CELL DEATH; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC SCREENING; HEK293 CELL LINE; HUMAN; HUMAN CELL; LYSOSOME; MONOCYTE; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; UPREGULATION; CYTOLOGY; METABOLISM;

CELL DEATH; DNA; HUMANS; INFLAMMASOMES; MEMBRANE PROTEINS; MONOCYTES; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; SIGNAL TRANSDUCTION;

EID: 85031298583     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.09.039     Document Type: Article

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