메뉴 건너뛰기




Volumn 5, Issue 3, 2017, Pages

Host transcriptional response to Ebola virus infection

Author keywords

Ebola virus disease; Host response; Immune response; Microarray; RNA Seq; Transcriptomic

Indexed keywords

CELLULAR STRESS RESPONSE; EBOLA HEMORRHAGIC FEVER; GENETIC TRANSCRIPTION; HUMAN; IMMORTALIZED CELL LINE; IMMUNE RESPONSE; MICROARRAY ANALYSIS; NEXT GENERATION SEQUENCING; NONHUMAN; REVIEW; RNA SEQUENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS;

EID: 85031094295     PISSN: None     EISSN: 2076393X     Source Type: Journal    
DOI: 10.3390/vaccines5030030     Document Type: Review
Times cited : (21)

References (93)
  • 3
    • 84912014036 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. Available online:, accessed on 1 June 2017
    • CDC. 2014 Ebola Outbreak in West Africa: Case Counts. Centers for Disease Control and Prevention. Available online: http://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/case-counts.html (accessed on 1 June 2017).
    • (2014) Ebola Outbreak in West Africa: Case Counts
  • 7
    • 0347122085 scopus 로고    scopus 로고
    • Ebola and Marburg Viruses Replicate in Monocyte-Derived Dendritic Cells without Inducing the Production of Cytokines and Full Maturation
    • Bosio, C.M.; Aman, M.J.; Grogan, C.; Hogan, R.; Ruthel, G.; Negley, D.; Mohamadzadeh, M.; Bavari, S.; Schmaljohn, A. Ebola and Marburg Viruses Replicate in Monocyte-Derived Dendritic Cells without Inducing the Production of Cytokines and Full Maturation. J. Infect. Dis. 2003, 188, 1630-1638.
    • (2003) J. Infect. Dis. , vol.188 , pp. 1630-1638
    • Bosio, C.M.1    Aman, M.J.2    Grogan, C.3    Hogan, R.4    Ruthel, G.5    Negley, D.6    Mohamadzadeh, M.7    Bavari, S.8    Schmaljohn, A.9
  • 8
    • 19344366513 scopus 로고    scopus 로고
    • Ebola virus: The role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever
    • Bray, M.; Geisbert, T.W. Ebola virus: The role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever. Int. J. Biochem. Cell Biol. 2005, 37, 1560-1566.
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 1560-1566
    • Bray, M.1    Geisbert, T.W.2
  • 11
    • 4544293451 scopus 로고    scopus 로고
    • Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic Fever in cynomolgus macaques
    • Reed, D.S.; Hensley, L.E.; Geisbert, J.B.; Jahrling, P.B.; Geisbert, T.W. Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic Fever in cynomolgus macaques. Viral Immunol. 2004, 17, 390-400.
    • (2004) Viral Immunol. , vol.17 , pp. 390-400
    • Reed, D.S.1    Hensley, L.E.2    Geisbert, J.B.3    Jahrling, P.B.4    Geisbert, T.W.5
  • 14
    • 84945335362 scopus 로고    scopus 로고
    • The Role of Cytokines and Chemokines in Filovirus Infection
    • Bixler, S.L.; Goff, A.J. The Role of Cytokines and Chemokines in Filovirus Infection. Viruses 2015, 7, 5489-5507.
    • (2015) Viruses , vol.7 , pp. 5489-5507
    • Bixler, S.L.1    Goff, A.J.2
  • 15
    • 78449261317 scopus 로고    scopus 로고
    • Human Fatal Zaire Ebola Virus Infection Is Associated with an Aberrant Innate Immunity and with Massive Lymphocyte Apoptosis
    • Wauquier, N.; Becquart, P.; Padilla, C.; Baize, S.; Leroy, E.M. Human Fatal Zaire Ebola Virus Infection Is Associated with an Aberrant Innate Immunity and with Massive Lymphocyte Apoptosis. PLoS Negl. Trop. Dis. 2010, 4, e837.
    • (2010) PLoS Negl. Trop. Dis. , vol.4 , pp. e837
    • Wauquier, N.1    Becquart, P.2    Padilla, C.3    Baize, S.4    Leroy, E.M.5
  • 17
    • 84954211517 scopus 로고    scopus 로고
    • The cytokine storm of severe influenza and development of immunomodulatory therapy
    • Liu, Q.; Zhou, Y.; Yang, Z. The cytokine storm of severe influenza and development of immunomodulatory therapy. Cell Mol. Immunol. 2016, 13, 3-10.
    • (2016) Cell Mol. Immunol. , vol.13 , pp. 3-10
    • Liu, Q.1    Zhou, Y.2    Yang, Z.3
  • 20
    • 80053929813 scopus 로고    scopus 로고
    • Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells
    • Leung, L.W.; Park, M.-S.; Martinez, O.; Valmas, C.; López, C.B.; Basler, C.F. Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells. Immunol. Cell Biol. 2011, 89, 792-802.
    • (2011) Immunol. Cell Biol. , vol.89 , pp. 792-802
    • Leung, L.W.1    Park, M.-S.2    Martinez, O.3    Valmas, C.4    López, C.B.5    Basler, C.F.6
  • 21
    • 37149040796 scopus 로고    scopus 로고
    • Ebola Virus VP24 Proteins Inhibit the Interaction of NPI-1 Subfamily Karyopherin Proteins with Activated STAT1
    • Reid, S.P.; Valmas, C.; Martinez, O.; Sanchez, F.M.; Basler, C.F. Ebola Virus VP24 Proteins Inhibit the Interaction of NPI-1 Subfamily Karyopherin Proteins with Activated STAT1. J. Virol. 2007, 81, 13469-13477.
    • (2007) J. Virol. , vol.81 , pp. 13469-13477
    • Reid, S.P.1    Valmas, C.2    Martinez, O.3    Sanchez, F.M.4    Basler, C.F.5
  • 22
    • 84917671407 scopus 로고    scopus 로고
    • Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses
    • Martines, R.B.; Ng, D.L.; Greer, P.W.; Rollin, P.E.; Zaki, S.R. Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses. J. Pathol. 2015, 235, 153-174.
    • (2015) J. Pathol. , vol.235 , pp. 153-174
    • Martines, R.B.1    Ng, D.L.2    Greer, P.W.3    Rollin, P.E.4    Zaki, S.R.5
  • 25
    • 33644777658 scopus 로고    scopus 로고
    • Global Suppression of the Host Antiviral Response by Ebola- and Marburgviruses: Increased Antagonism of the Type I Interferon Response Is Associated with Enhanced Virulence
    • Kash, J.C.; Muhlberger, E.; Carter, V.; Grosch, M.; Perwitasari, O.; Proll, S.C.; Thomas, M.J.; Weber, F.; Klenk, H.-D.; Katze, M.G. Global Suppression of the Host Antiviral Response by Ebola- and Marburgviruses: Increased Antagonism of the Type I Interferon Response Is Associated with Enhanced Virulence. J. Virol. 2006, 80, 3009-3020.
    • (2006) J. Virol. , vol.80 , pp. 3009-3020
    • Kash, J.C.1    Muhlberger, E.2    Carter, V.3    Grosch, M.4    Perwitasari, O.5    Proll, S.C.6    Thomas, M.J.7    Weber, F.8    Klenk, H.-D.9    Katze, M.G.10
  • 26
    • 84906346490 scopus 로고    scopus 로고
    • H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice
    • Morrison, J.; Josset, L.; Tchitchek, N.; Chang, J.; Belser, J.A.; Swayne, D.E.; Pantin-Jackwood, M.J.; Tumpey, T.M.; Katze, M.G. H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice. J. Virol. 2014, 88, 10556-10568.
    • (2014) J. Virol. , vol.88 , pp. 10556-10568
    • Morrison, J.1    Josset, L.2    Tchitchek, N.3    Chang, J.4    Belser, J.A.5    Swayne, D.E.6    Pantin-Jackwood, M.J.7    Tumpey, T.M.8    Katze, M.G.9
  • 27
    • 0036678864 scopus 로고    scopus 로고
    • Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza
    • Geiss, G.K.; Salvatore, M.; Tumpey, T.M.; Carter, V.S.; Wang, X.; Basler, C.F.; Taubenberger, J.K.; Bumgarner, R.E.; Palese, P.; Katze, M.G.; et al. Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proc. Natl. Acad. Sci. USA 2002, 99, 10736-10741.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10736-10741
    • Geiss, G.K.1    Salvatore, M.2    Tumpey, T.M.3    Carter, V.S.4    Wang, X.5    Basler, C.F.6    Taubenberger, J.K.7    Bumgarner, R.E.8    Palese, P.9    Katze, M.G.10
  • 30
    • 43949091157 scopus 로고    scopus 로고
    • Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein
    • Hartman, A.L.; Ling, L.; Nichol, S.T.; Hibberd, M.L. Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein. J. Virol. 2008, 82, 5348-5358.
    • (2008) J. Virol. , vol.82 , pp. 5348-5358
    • Hartman, A.L.1    Ling, L.2    Nichol, S.T.3    Hibberd, M.L.4
  • 31
    • 33745276555 scopus 로고    scopus 로고
    • Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replication
    • Hartman, A.L.; Dover, J.E.; Towner, J.S.; Nichol, S.T. Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replication. J. Virol. 2006, 80, 6430-6440.
    • (2006) J. Virol. , vol.80 , pp. 6430-6440
    • Hartman, A.L.1    Dover, J.E.2    Towner, J.S.3    Nichol, S.T.4
  • 32
  • 34
    • 0348053693 scopus 로고    scopus 로고
    • Mechanisms Underlying Coagulation Abnormalities in Ebola Hemorrhagic Fever: Overexpression of Tissue Factor in Primate Monocytes/Macrophages Is a Key Event
    • Geisbert, T.W.; Young, H.A.; Jahrling, P.B.; Davis, K.J.; Kagan, E.; Hensley, L.E. Mechanisms Underlying Coagulation Abnormalities in Ebola Hemorrhagic Fever: Overexpression of Tissue Factor in Primate Monocytes/Macrophages Is a Key Event. J. Infect. Dis. 2003, 188, 1618-1629.
    • (2003) J. Infect. Dis. , vol.188 , pp. 1618-1629
    • Geisbert, T.W.1    Young, H.A.2    Jahrling, P.B.3    Davis, K.J.4    Kagan, E.5    Hensley, L.E.6
  • 38
    • 84937685091 scopus 로고    scopus 로고
    • Different Temporal Effects of Ebola Virus VP35 and VP24 Proteins on Global Gene Expression in Human Dendritic Cells
    • Ilinykh, P.A.; Lubaki, N.M.; Widen, S.G.; Renn, L.A.; Theisen, T.C.; Rabin, R.L.; Wood, T.G.; Bukreyev, A. Different Temporal Effects of Ebola Virus VP35 and VP24 Proteins on Global Gene Expression in Human Dendritic Cells. J. Virol. 2015, 89, 7567-7583.
    • (2015) J. Virol. , vol.89 , pp. 7567-7583
    • Ilinykh, P.A.1    Lubaki, N.M.2    Widen, S.G.3    Renn, L.A.4    Theisen, T.C.5    Rabin, R.L.6    Wood, T.G.7    Bukreyev, A.8
  • 41
    • 0031688699 scopus 로고    scopus 로고
    • A Mouse Model for Evaluation of Prophylaxis and Therapy of Ebola Hemorrhagic Fever
    • Bray, M.; Davis, K.; Geisbert, T.; Schmaljohn, C.; Huggins, J. A Mouse Model for Evaluation of Prophylaxis and Therapy of Ebola Hemorrhagic Fever. Source J. Infect. Dis. 1998, 178, 651-661.
    • (1998) Source J. Infect. Dis. , vol.178 , pp. 651-661
    • Bray, M.1    Davis, K.2    Geisbert, T.3    Schmaljohn, C.4    Huggins, J.5
  • 46
    • 84885405310 scopus 로고    scopus 로고
    • Animal models for Ebola and Marburg virus infections
    • Nakayama, E.; Saijo, M. Animal models for Ebola and Marburg virus infections. Front. Microbiol. 2013.
    • (2013) Front. Microbiol.
    • Nakayama, E.1    Saijo, M.2
  • 49
    • 4544228226 scopus 로고    scopus 로고
    • Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: Cellular responses, virus load, and nitric oxide levels
    • Sanchez, A.; Lukwiya, M.; Bausch, D.; Mahanty, S.; Sanchez, A.J.; Wagoner, K.D.; Rollin, P.E. Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: Cellular responses, virus load, and nitric oxide levels. J. Virol. 2004, 78, 10370-10377.
    • (2004) J. Virol. , vol.78 , pp. 10370-10377
    • Sanchez, A.1    Lukwiya, M.2    Bausch, D.3    Mahanty, S.4    Sanchez, A.J.5    Wagoner, K.D.6    Rollin, P.E.7
  • 50
    • 0021038540 scopus 로고
    • Haematological and biochemical monitoring of ebola infection in rhesus monkeys: Implications for patient management
    • Fisher-Hoch, S.P.; Lloyd, G.; Platt, G.S.; Simpson, D.I.H.; Neild, G.H.; Barrett, A.J. Haematological and biochemical monitoring of ebola infection in rhesus monkeys: implications for patient management. Lancet 1983, 322, 1055-1058.
    • (1983) Lancet , vol.322 , pp. 1055-1058
    • Fisher-Hoch, S.P.1    Lloyd, G.2    Platt, G.S.3    Simpson, D.I.H.4    Neild, G.H.5    Barrett, A.J.6
  • 53
    • 80052295571 scopus 로고    scopus 로고
    • Functional genomics reveals the induction of inflammatory response and metalloproteinase gene expression during lethal Ebola virus infection
    • Cilloniz, C.; Ebihara, H.; Ni, C.; Neumann, G.; Korth, M.J.; Kelly, S.M.; Kawaoka, Y.; Feldmann, H.; Katze, M.G. Functional genomics reveals the induction of inflammatory response and metalloproteinase gene expression during lethal Ebola virus infection. J. Virol. 2011, 85, 9060-9068.
    • (2011) J. Virol. , vol.85 , pp. 9060-9068
    • Cilloniz, C.1    Ebihara, H.2    Ni, C.3    Neumann, G.4    Korth, M.J.5    Kelly, S.M.6    Kawaoka, Y.7    Feldmann, H.8    Katze, M.G.9
  • 55
    • 84866985444 scopus 로고    scopus 로고
    • Mouse models for filovirus infections
    • Bradfute, S.B.; Warfield, K.L.; Bray, M. Mouse models for filovirus infections. Viruses 2012, 4, 1477-1508.
    • (2012) Viruses , vol.4 , pp. 1477-1508
    • Bradfute, S.B.1    Warfield, K.L.2    Bray, M.3
  • 61
    • 84978114927 scopus 로고    scopus 로고
    • Neurological Complications of Ebola Virus Infection
    • Billioux, B.J.; Smith, B.; Nath, A. Neurological Complications of Ebola Virus Infection. Neurotherapeutics 2016, 13, 461-470.
    • (2016) Neurotherapeutics , vol.13 , pp. 461-470
    • Billioux, B.J.1    Smith, B.2    Nath, A.3
  • 67
    • 85018188050 scopus 로고    scopus 로고
    • Transcriptomic analysis reveals a previously unknown role for CD8(+) T-cells in rVSV-EBOV mediated protection
    • Menicucci, A.R.; Sureshchandra, S.; Marzi, A.; Feldmann, H.; Messaoudi, I. Transcriptomic analysis reveals a previously unknown role for CD8(+) T-cells in rVSV-EBOV mediated protection. Sci. Rep. 2017, 7, 919.
    • (2017) Sci. Rep. , vol.7 , pp. 919
    • Menicucci, A.R.1    Sureshchandra, S.2    Marzi, A.3    Feldmann, H.4    Messaoudi, I.5
  • 71
    • 84920771962 scopus 로고    scopus 로고
    • Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection
    • Caballero, I.S.; Yen, J.Y.; Hensley, L.E.; Honko, A.N.; Goff, A.J.; Connor, J.H. Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection. BMC Genom. 2014, 15, 1-12.
    • (2014) BMC Genom. , vol.15 , pp. 1-12
    • Caballero, I.S.1    Yen, J.Y.2    Hensley, L.E.3    Honko, A.N.4    Goff, A.J.5    Connor, J.H.6
  • 78
    • 80054741833 scopus 로고    scopus 로고
    • Recombinant vesicular stomatitis virus-based vaccines against Ebola and Marburg virus infections
    • Geisbert, T.W.; Feldmann, H. Recombinant vesicular stomatitis virus-based vaccines against Ebola and Marburg virus infections. J. Infect. Dis. 2011, 204, S1075-S1081.
    • (2011) J. Infect. Dis. , vol.204 , pp. S1075-S1081
    • Geisbert, T.W.1    Feldmann, H.2
  • 79
    • 84870601170 scopus 로고    scopus 로고
    • Vesicular Stomatitis Virus-Based Vaccines for Prophylaxis and Treatment of Filovirus Infections
    • Marzi, A.; Feldmann, H.; Geisbert, T.W.; Falzarano, D. Vesicular Stomatitis Virus-Based Vaccines for Prophylaxis and Treatment of Filovirus Infections. J. Bioterror. Biodef. 2011.
    • (2011) J. Bioterror. Biodef.
    • Marzi, A.1    Feldmann, H.2    Geisbert, T.W.3    Falzarano, D.4
  • 80
    • 85010755634 scopus 로고    scopus 로고
    • Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: Final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)
    • Henao-Restrepo, A.M.; Camacho, A.; Longini, I.M.; Watson, C.H.; Edmunds, W.J.; Egger, M.; Carroll, M.W.; Dean, N.E.; Diatta, I.; Doumbia, M.; et al. Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!). Lancet 2017, 389, 505-518.
    • (2017) Lancet , vol.389 , pp. 505-518
    • Henao-Restrepo, A.M.1    Camacho, A.2    Longini, I.M.3    Watson, C.H.4    Edmunds, W.J.5    Egger, M.6    Carroll, M.W.7    Dean, N.E.8    Diatta, I.9    Doumbia, M.10
  • 87
    • 85013391410 scopus 로고    scopus 로고
    • Interferon β-1a for the treatment of Ebola virus disease: A historically controlled, single-arm proof-of-concept trial
    • Konde, M.K.; Baker, D.P.; Traore, F.A.; Sow, M.S.; Camara, A.; Barry, A.A.; Mara, D.; Barry, A.; Cone, M.; Kaba, I.; et al. Interferon β-1a for the treatment of Ebola virus disease: A historically controlled, single-arm proof-of-concept trial. PLoS ONE 2017, 12, e0169255.
    • (2017) PLoS ONE , vol.12 , pp. e0169255
    • Konde, M.K.1    Baker, D.P.2    Traore, F.A.3    Sow, M.S.4    Camara, A.5    Barry, A.A.6    Mara, D.7    Barry, A.8    Cone, M.9    Kaba, I.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.