CD8-mediated protection against ebola virus infection is perforin dependent

Journal of Immunology

Volumn 174, Issue 7, 2005, Pages 4198-4202

  Gupta, Manisha ^a,c   Greer, Patricia ^a   Mahanty, Siddhartha ^a,d   Shieh, Wun Ju ^a   Zaki, Sherif R ^a   Ahmed, Rafi ^b   Rollin, Pierre E ^a  

^a NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PERFORIN;

ARTICLE; EBOLA VIRUS; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; SURVIVAL; T CELL DEPLETION; T LYMPHOCYTE; VIRUS INFECTION;

EID: 15444362018     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.7.4198     Document Type: Article

References (24)

1. + T cell effector mechanisms in resistance to infection. Annu. Rev. Immunol. 18:275.
2. Kagi, D., B. Ledermann, K. Burki, R. M. Zinkernagel, and H. Hengartner. 1996. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu. Rev. Immunol. 14:207.
3. Binder, G. K., and D. E. Griffin. 2001. Interferon-γ-mediated site-specific clearance of alphavirus from CNS neurons. Science 293:303.
4. Bartholdy, C., J. P. Christensen, D. Wodarz, and A. R. Thomsen. 2000. Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in γ interferon-deficient mice infected with lymphocytic choriomeningitis virus. J. Virol. 74:10304.
5. Matloubian, M., M. Suresh, A. Glass, M. Galvan, K. Chow, J. K. Whitmire, C. M. Walsh, W. R. Clark, and R. Ahmed. 1999. A role for perforin in downregulating T-cell responses during chronic viral infection. J. Virol. 73:2527.
6. Kagi, D., P. Seiler, J. Pavlovic, B. Ledermann, K. Burki, R. M. Zinkernagel, and H. Hengartner. 1995. The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur. J. Immunol. 25:3256.
7. Mahanty, S., and M. Bray. 2004. Pathogenesis of filoviral haemorrhagic fevers. Lancet Infect. Dis. 4:487.
8. Wilson, J. A., and M. K. Hart. 2001. Protection from Ebola virus mediated by cytotoxic T lymphocytes specific for the viral nucleoprotein. J. Virol. 75:2660.
9. Gupta, M., S. Mahanty, P. Greer, J. S. Towner, W. J. Shieh, S. R. Zaki, R. Ahmed, and P. E. Rollin. 2004. Persistent infection with Ebola virus under conditions of partial immunity. J. Virol. 78:958.
10. Bray, M., K. Davis, T. Geisbert, C. Schmaljohn, and J. Huggins. 1998. A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J. Infect. Dis. 178:651.
11. Gupta, M., S. Mahanty, M. Bray, R. Ahmed, and P. E. Rollin. 2001. Passive transfer of antibodies protects immunocompetent and imunodeficient mice against lethal Ebola virus infection without complete inhibition of viral replication. J. Virol. 75:4649.
12. Simmons, G., A. Lee, A. J. Rennekamp, X. Fan, P. Bates, and H. Shen. 2004. Identification of murine T-cell epitopes in Ebola virus nucleoprotein. Virology 318:224.
13. Zaki, S. R., W. J. Shieh, P. W. Greer, C. S. Goldsmith, T. Ferebee, J. Katshitshi, F. K. Tshioko, M. A. Bwaka, R. Swanepoel, P. Calain, et al. 1999. A novel immunohistochemical assay for the detection of Ebola virus in skin: implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever: Commission de Lutte contre les Epidemies a Kikwit. J. Infect. Dis. 179(Suppl. 1):S36.
14. Dutia, B. M., C. J. Clarke, D. J. Allen, and A. A. Nash. 1997. Pathological changes in the spleens of γ interferon receptor-deficient mice infected with murine gammaherpesvirus: a role for CD8 T cells. J. Virol. 71:4278.
15. Sarawar, S. R., R. D. Cardin, J. W. Brooks, M. Mehrpooya, A. M. Hamilton-Easton, X. Y. Mo, and P. C. Doherty. 1997. γ interferon is not essential for recovery from acute infection with murine gammaherpesvirus 68. J. Virol. 71:3916.
16. Guidotti, L. G., K. Ando, M. V. Hobbs, T. Ishikawa, L. Runkel, R. D. Schreiber, and F. V. Chisari. 1994. Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc. Natl. Acad. Sci. USA 91:3764.
17. + T-cell immunity to murine rotavirus in the absence of perforin, fas, and γ interferon. J. Virol. 71:479.
18. Usherwood, E. J., J. W. Brooks, S. R. Sarawar, R. D. Cardin, W. D. Young, D. J. Allen, P. C. Doherty, and A. A. Nash. 1997. Immunological control of murine gammaherpesvirus infection is independent of perforin. J. Gen. Virol. 78(Pt. 8):2025.
19. '19. Riera, L., M. Gariglio, G. Valente, A. Mullbacher, C. Museteanu, S. Landolfo, and M. M. Simon. 2000. Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection. Eur. J. Immunol. 30:1350.
20. Mullbacher, A., R. T. Hla, C. Museteanu, and M. M. Simon. 1999. Perform is essential for control of ectromelia virus but not related poxviruses in mice. J. Virol. 73:1665.
21. Rossi, C. P., A. McAllister, M. Tanguy, D. Kagi, and M. Brahic. 1998. Theiler's virus infection of perforin-deficient mice. J. Virol. 72:4515.
22. Aung, S., J. A. Rutigliano, and B. S. Graham. 2001. Alternative mechanisms of respiratory syncytial virus clearance in perforin knockout mice lead to enhanced disease. J. Virol. 75:9918.
23. + T cells clear influenza virus by perforin or Fas-dependent processes. J. Immunol. 159:5197.
24. Steinhoff, U., U. Muller, A. Schertler, H. Hengartner, M. Aguet, and R. M. Zinkernagel. 1995. Antiviral protection by vesicular stomatitis virus-specific antibodies in α/β interferon receptor-deficient mice. J. Virol. 69:2153.