Therapeutics of Ebola hemorrhagic fever: Whole-genome transcriptional analysis of successful disease mitigation

Journal of Infectious Diseases

Volumn 204, Issue SUPPL. 3, 2011, Pages

  Yen, Judy Y ^a   Garamszegi, Sara ^b   Geisbert, Joan B ^c   Rubins, Kathleen H ^d   Geisbert, Thomas W ^c   Honko, Anna ^e   Xia, Yu ^b,f,g   Connor, John H ^a,b   Hensley, Lisa E ^e  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^d NASA HEADQUARTERS   (United States)

^e UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^f Boston University   (United States)

^g Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCYTE CHEMOTACTIC PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD CLOTTING; CLUSTER ANALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; DNA MICROARRAY; EBOLA HEMORRHAGIC FEVER; EBOLA VIRUS; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOME ANALYSIS; IMMUNE RESPONSE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; PROTEIN TARGETING; SURVIVAL; TREATMENT RESPONSE; VIRAL GENETICS; VIRUS GENE; VIRUS GENOME;

ANIMALS; BLOOD COAGULATION; BLOOD COAGULATION FACTOR INHIBITORS; EBOLAVIRUS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, VIRAL; GENETIC PREDISPOSITION TO DISEASE; GENOME; HEMORRHAGIC FEVER, EBOLA; LYMPHOCYTE ACTIVATION; MACACA MULATTA; MULTIGENE FAMILY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TRANSCRIPTION, GENETIC;

EID: 80054744851     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir345     Document Type: Conference Paper

References (37)

1. Feldmann H, Geisbert TW, Jahrling PB, et al. Filoviridae. In Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA eds: Virus taxonomy: VIIIth report of the International Committee on Taxonomy of Viruses. London: Elsevier Academic Press, 2005: 645-53.
2. Pratt WD, Wang D, Nichols DK, et al. Protection of nonhuman primates against two species of Ebola virus infection with a single complex adenovirus vector. Clin Vaccine Immunol 2010; 17:572-81.
3. Stroher U, Feldmann H. Progress towards the treatment of Ebola haemorrhagic fever. Expert Opin Investig Drugs 2006; 15:1523-35. (Pubitemid 44848976)
4. Hensley LE, Jones SM, Feldmann H, Jahrling PB, Geisbert TW. Ebola and Marburg viruses: pathogenesis and development of countermeasures. Curr Mol Med 2005; 5:761-72. (Pubitemid 43009516)
5. Feldmann H, Jones SM, Schnittler HJ, Geisbert T. Therapy and prophylaxis of Ebola virus infections. Curr Opin Investig Drugs 2005; 6:823-30. (Pubitemid 41103043)
6. Feldmann H, Jones SM, Daddario-DiCaprio KM, et al. Effective postexposure treatment of Ebola infection. PLoS Pathog 2007; 3:e2.
7. Wolf MC, Freiberg AN, Zhang T, et al. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A 2010; 107:3157-62.
8. Geisbert TW, Lee AC, Robbins M, et al. Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study. Lancet 2010; 375:1896-05.
9. Halfmann P, Ebihara H, Marzi A, et al. Replication-deficient ebolavirus as a vaccine candidate Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses. J Virol 2009; 83:3810-5.
10. Geisbert TW, Geisbert JB, Leung A, et al. Single-injection vaccine protects nonhuman primates against infection with marburg virus and three species of ebola virus protection of nonhuman primates against two species of Ebola virus infection with a single complex adenovirus vector. J Virol 2009; 83:7296-304.
11. Aman MJ, Kinch MS, Warfield K, et al. Development of a broadspectrum antiviral with activity against Ebola virus. Antiviral Res 2009; 83:245-51.
12. Geisbert TW, Daddario-Dicaprio KM, Geisbert JB, et al. Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses. Vaccine 2008; 26:6894-900.
13. Sanchez A, Kahn AS, ZS R, Nabel GL, Ksiazek TG, Peters CJ. Filoviridae. In Knipe DM, Howley PM eds: Fields virology. Philadelphia: Lippincott, Williams & Wilkins, 2001: 1279-304.
14. Villinger F, Rollin PE, Brar SS, et al. Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. J Infect Dis 1999; 179:S188-91. (Pubitemid 29091401)
15. Gupta M, Mahanty S, Ahmed R, Rollin PE. Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly- IC-induced IFN-alpha in vitro. Virology 2001; 284:20-5. (Pubitemid 32476692)
16. Geisbert TW, Young HA, Jahrling PB, Davis KJ, Kagan E, Hensley LE. Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primatemonocytes/macrophages is a key event. J Infect Dis 2003; 188:1618-29. Epub 2003 Nov 14. (Pubitemid 38010671)
17. Geisbert TW, Young HA, Jahrling PB, et al. Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells. Am J Pathol 2003; 163:2371-82. (Pubitemid 37474154)
18. Geisbert TW, Hensley LE, Larsen T, et al. Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection. Am J Pathol 2003; 163:2347-70. (Pubitemid 37466478)
19. Peters CJ. Emerging infections-Ebola and other filoviruses. West J Med 1996; 164:36-8.
20. Bray M, Mahanty S. Ebola hemorrhagic fever and septic shock. J Infect Dis 2003; 188:1613-7. Epub 2003 Nov 14. (Pubitemid 38010670)
21. Geisbert TW, Hensley LE, Jahrling PB, et al. Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys. Lancet 2003; 362:1953-8. (Pubitemid 37548417)
22. Hensley LE, Stevens EL, Yan SB, et al. Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever. J Infect Dis 2007; 196(Suppl 2):S390-9. (Pubitemid 351417286)
23. Wang E, Miller LD, Ohnmacht GA, Liu ET, Marincola FM. High-fidelity mRNA amplification for gene profiling. Nat Biotechnol 2000; 18:457-9. (Pubitemid 30217539)
24. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403:503-11. (Pubitemid 30082188)
25. Boldrick JC, Alizadeh AA, Diehn M, et al. Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Proc Natl Acad Sci U S A 2002; 99:972-7. (Pubitemid 34106620)
26. GenePix Pro Microarray Acquisition & Analysis Software. Computer software. Vers. 6.0.Molecular Devices Products/Software/GenePix-Pro.html. Accessed 21 May 2001.
27. Hubble J, Demeter J, Jin H, et al. Implementation of GenePattern within the Stanford microarray database. Nucleic Acids Res 2009; 37:D898-901.
28. Edgar R, Domrachev M, Lash AE. Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002; 30:207-10. (Pubitemid 34679544)
29. Ritchie ME, Silver J, Oshlack A, et al. A comparison of background correction methods for two-colour microarrays. Bioinformatics 2007; 23:2700-7. (Pubitemid 350048334)
30. Smyth GK, Speed T. Normalization of cDNA microarray data. Methods 2003; 31:265-73. (Pubitemid 37338763)
31. R Development Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2010.
32. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 1998; 95:14863-8. (Pubitemid 29003722)
33. Saldanha AJ. Java Treeview-extensible visualization of microarray data. Bioinformatics 2004; 20:3246-8. (Pubitemid 39619217)
34. Dennis G Jr, Sherman BT, Hosack DA, et al. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol 2003; 4:P3.
35. Rubins KH, Hensley LE, Wahl-Jensen V, et al. The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever. Genome Biol 2007; 8:R174.
36. Cilloniz C, Shinya K, Peng X, et al. Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes. PLoS Pathog 2009; 5:e1000604.
37. Taub DD, Proost P, Murphy WJ, et al. Monocyte chemotactic protein- 1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes. J Clin Invest 1995; 95:1370-6.