Reduced Levels of Protein Tyrosine Phosphatase CD45 Protect Mice from the Lethal Effects of Ebola Virus Infection

Cell Host and Microbe

Volumn 6, Issue 2, 2009, Pages 162-173

  Panchal, Rekha G ^a   Bradfute, Steven B ^a   Peyser, Brian D ^a   Warfield, Kelly L ^a   Ruthel, Gordon ^a   Lane, Douglas ^b   Kenny, Tara A ^b   Anderson, Arthur O ^a   Raschke, William C ^c,d   Bavari, Sina ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b SAIC FREDERICK INC   (United States)

^c SIDNEY KIMMEL CANCER CENTER   (United States)

^d Virogenics Inc   (United States)

Author keywords

MICROBIO

Indexed keywords

GAMMA INTERFERON; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE CD45; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; EBOLA VIRUS; FEMALE; GENE EXPRESSION REGULATION; HOST SUSCEPTIBILITY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTECTION; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; RNA VIRUS INFECTION; SPLEEN CELL; WILD TYPE;

ANIMALS; ANTIGENS, CD45; CD8-POSITIVE T-LYMPHOCYTES; DISEASE SUSCEPTIBILITY; EBOLAVIRUS; GENE EXPRESSION PROFILING; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERON-GAMMA; LYMPH NODES; MACROPHAGES, PERITONEAL; MICE; MODELS, BIOLOGICAL; SPLEEN; SURVIVAL ANALYSIS;

EBOLA VIRUS; MURINAE; MUS; RODENTIA;

EID: 68349133176     PISSN: 19313128     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chom.2009.07.003     Document Type: Article

References (45)

1. Alexander D.R. The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function. Semin. Immunol. 12 (2000) 349-359
2. Alici E., Konstantinidis K.V., Sutlu T., Aints A., Gahrton G., Ljunggren H.G., and Dilber M.S. Anti-myeloma activity of endogenous and adoptively transferred activated natural killer cells in experimental multiple myeloma model. Exp. Hematol. 35 (2007) 1839-1846
3. Alonso A., Sasin J., Bottini N., Friedberg I., Friedberg I., Osterman A., Godzik A., Hunter T., Dixon J., and Mustelin T. Protein tyrosine phosphatases in the human genome. Cell 117 (2004) 699-711
4. Bowen E.T., Platt G.S., Simpson D.I., McArdell L.B., and Raymond R.T. Ebola haemorrhagic fever: experimental infection of monkeys. Trans. R. Soc. Trop. Med. Hyg. 72 (1978) 188-191
5. Bradfute S.B., Braun D.R., Shamblin J.D., Geisbert J.B., Paragas J., Garrison A., Hensley L.E., and Geisbert T.W. Lymphocyte death in a mouse model of Ebola virus infection. J. Infect. Dis. 196 Suppl 2 (2007) S296-S304
6. Bradfute S.B., Warfield K.L., and Bavari S. Functional CD8+ T Cell Responses in Lethal Ebola Virus Infection. J. Immunol. 180 (2008) 4058-4066
7. Bray M., Davis K., Geisbert T., Schmaljohn C., and Huggins J. A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J. Infect. Dis. 178 (1998) 651-661
8. Byth K.F., Conroy L.A., Howlett S., Smith A.J., May J., Alexander D.R., and Holmes N. CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J. Exp. Med. 183 (1996) 1707-1718
9. Connolly B.M., Steele K.E., Davis K.J., Geisbert T.W., Kell W.M., Jaax N.K., and Jahrling P.B. Pathogenesis of experimental Ebola virus infection in guinea pigs. J. Infect. Dis. 179 Suppl 1 (1999) S203-S217
10. Couper K.N., Blount D.G., and Riley E.M. IL-10: the master regulator of immunity to infection. J. Immunol. 180 (2008) 5771-5777
11. Desai D.M., Sap J., Silvennoinen O., Schlessinger J., and Weiss A. The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation. EMBO J. 13 (1994) 4002-4010
12. Falcon S., and Gentleman R. Using GOstats to test gene lists for GO term association. Bioinformatics 23 (2007) 257-258
13. Gentleman R.C., Carey V.J., Bates D.M., Bolstad B., Dettling M., Dudoit S., Ellis B., Gautier L., Ge Y., Gentry J., et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5 (2004) R80
14. Gibb T.R., Bray M., Geisbert T.W., Steele K.E., Kell W.M., Davis K.J., and Jaax N.K. Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice. J. Comp. Pathol. 125 (2001) 233-242
15. Hermiston M.L., Xu Z., and Weiss A. CD45: a critical regulator of signaling thresholds in immune cells. Annu. Rev. Immunol. 21 (2003) 107-137
16. Hoenen T., Groseth A., Falzarano D., and Feldmann H. Ebola virus: unravelling pathogenesis to combat a deadly disease. Trends Mol. Med. 12 (2006) 206-215
17. Hutchinson K.L., and Rollin P.E. Cytokine and chemokine expression in humans infected with Sudan Ebola virus. J. Infect. Dis. 196 Suppl 2 (2007) S357-S363
18. Irie-Sasaki J., Sasaki T., Matsumoto W., Opavsky A., Cheng M., Welstead G., Griffiths E., Krawczyk C., Richardson C.D., Aitken K., et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature 409 (2001) 349-354
19. Kendziorski C.M., Newton M.A., Lan H., and Gould M.N. On parametric empirical Bayes methods for comparing multiple groups using replicated gene expression profiles. Stat. Med. 22 (2003) 3899-3914
20. Kim M.O., Suh H.S., Si Q., Terman B.I., and Lee S.C. Anti-CD45RO Suppresses Human Immunodeficiency Virus Type 1 Replication in Microglia: Role of Hck Tyrosine Kinase and Implications for AIDS Dementia. J. Virol. 80 (2006) 62-72
21. King S.B., Knorn A.M., Ohnmacht C., and Voehringer D. Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6. J. Immunol. 180 (2008) 754-763
22. McNeill L., Salmond R.J., Cooper J.C., Carret C.K., Cassady-Cain R.L., Roche-Molina M., Tandon P., Holmes N., and Alexander D.R. The Differential Regulation of Lck Kinase Phosphorylation Sites by CD45 Is Critical for T Cell Receptor Signaling Responses. Immunity 27 (2007) 425-437
23. Moe J.B., Lambert R.D., and Lupton H.W. Plaque assay for Ebola virus. J. Clin. Microbiol. 13 (1981) 791-793
24. Mohamadzadeh M. Potential Factors Induced by Filoviruses that Lead to Immune Supression. Curr. Mol. Med. 9 (2009) 174-185
25. Mohamadzadeh M., Chen L., Olinger G.G., Pratt W.D., and Schmaljohn A.L. Filoviruses and the balance of innate, adaptive, and inflammatory responses. Viral Immunol. 19 (2006) 602-612
26. Mohamadzadeh M., Chen L., and Schmaljohn A.L. How Ebola and Marburg viruses battle the immune system. Nat. Rev. Immunol. 7 (2007) 556-567
27. Panchal R.G., Ulrich R.L., Bradfute S.B., Lane D., Ruthel G., Kenny T.A., Iversen P.L., Anderson A.O., Gussio R., Raschke W.C., et al. Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis. J. Biol. Chem. 284 (2009) 12874-12885
28. Roach T., Slater S., Koval M., White L., Cahir McFarland E.D., Okumura M., Thomas M., and Brown E. CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr. Biol. 7 (1997) 408-417
29. Ryabchikova E., Kolesnikova L., Smolina M., Tkachev V., Pereboeva L., Baranova S., Grazhdantseva A., and Rassadkin Y. Ebola virus infection in guinea pigs: presumable role of granulomatous inflammation in pathogenesis. Arch. Virol. 141 (1996) 909-921
30. Thomas M.L. The leukocyte common antigen family. Annu. Rev. Immunol. 7 (1989) 339-369
31. Thomas M.L., and Brown E.J. Positive and negative regulation of Src-family membrane kinases by CD45. Immunol. Today 20 (1999) 406-411
32. Thomsen A.R., Nansen A., Madsen A.N., Bartholdy C., and Christensen J.P. Regulation of T cell migration during viral infection: role of adhesion molecules and chemokines. Immunol. Lett. 85 (2003) 119-127
33. Towner J.S., Sealy T.K., Khristova M.L., Albarino C.G., Conlan S., Reeder S.A., Quan P.L., Lipkin W.I., Downing R., Tappero J.W., et al. Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda. PLoS Pathog. 4 (2008) e1000212
34. Villinger F., Rollin P.E., Brar S.S., Chikkala N.F., Winter J., Sundstrom J.B., Zaki S.R., Swanepoel R., Ansari A.A., and Peters C.J. Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. J. Infect. Dis. 179 Suppl 1 (1999) S188-S191
35. Virts E.L., Diago O., and Raschke W.C. A CD45 minigene restores regulated isoform expression and immune function in CD45-deficient mice: therapeutic implications for human CD45-null severe combined immunodeficiency. Blood 101 (2003) 849-855
36. Virts E.L., and Raschke W.C. The role of intron sequences in high level expression from CD45 cDNA constructs. J. Biol. Chem. 276 (2001) 19913-19920
37. Wallace V.A., Penninger J.M., Kishihara K., Timms E., Shahinian A., Pircher H., Kundig T.M., Ohashi P.S., and Mak T.W. Alterations in the level of CD45 surface expression affect the outcome of thymic selection. J. Immunol. 158 (1997) 3205-3214
38. Wang G., Tschoi M., Spolski R., Lou Y., Ozaki K., Feng C., Kim G., Leonard W.J., and Hwu P. In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res. 63 (2003) 9016-9022
39. Warfield K.L., Deal E.M., and Bavari S. Filovirus infections. J. Am. Vet. Med. Assoc. 234 (2009) 1130-1139
40. Warfield K.L., Olinger G., Deal E.M., Swenson D.L., Bailey M., Negley D.L., Hart M.K., and Bavari S. Induction of humoral and CD8+ T cell responses are required for protection against lethal Ebola virus infection. J. Immunol. 175 (2005) 1184-1191
41. Warfield K.L., Swenson D.L., Olinger G.G., Nichols D.K., Pratt W.D., Blouch R., Stein D.A., Aman M.J., Iversen P.L., and Bavari S. Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers. PLoS Pathog. 2 (2006) e1
42. Wu Z., Irizarry R.A., Gentleman R.C., Martinez-Murillo F., and Spencer F. A model-based background adjustment for oligonucleotide expression Arrays. J. Am. Stat. Assoc. 99 (2004) 909-917
43. Yang Z., Day Y.J., Toufektsian M.C., Xu Y., Ramos S.I., Marshall M.A., French B.A., and Linden J. Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes. Circulation 114 (2006) 2056-2064
44. Zamoyska R. Why is there so much CD45 on T cells?. Immunity 27 (2007) 421-423
45. Zhong W., Roberts A.D., and Woodland D.L. Antibody-independent antiviral function of memory CD4+ T cells in vivo requires regulatory signals from CD8+ effector T cells. J. Immunol. 167 (2001) 1379-1386