IgG Fc engineering to modulate antibody effector functions

Protein and Cell

Volumn 9, Issue 1, 2018, Pages 63-73

  Wang, Xinhua ^a   Mathieu, Mary ^a   Brezski, Randall J ^a  

^a GENENTECH INC   (United States)

Author keywords

antibody dependent cell mediated cytotoxicity; antibody dependent cellular phagocytosis; complement dependent cytotoxicity; Fc engineering; Fc gamma receptor; monoclonal antibody; neonatal Fc receptor

Indexed keywords

IMMUNOGLOBULIN G; MOGAMULIZUMAB; MONOCLONAL ANTIBODY; OFATUMUMAB; PROTEIN TYROSINE PHOSPHATASE; RITUXIMAB; ANTIGEN; COMPLEMENT; FC RECEPTOR;

AMINO ACID SEQUENCE; ANTIBODY ENGINEERING; CRYSTAL STRUCTURE; HUMAN; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; ANIMAL; METABOLISM; PROTEIN ENGINEERING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS; COMPLEMENT SYSTEM PROTEINS; HUMANS; IMMUNOGLOBULIN G; PROTEIN ENGINEERING; RECEPTORS, FC;

EID: 85030698420     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-017-0473-8     Document Type: Review

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