TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses

PLoS Pathogens

Volumn 13, Issue 9, 2017, Pages

  Yang, Qing ^a   Liu, Tian Tian ^b   Lin, Heng ^b   Zhang, Man ^b   Wei, Jin ^b   Luo, Wei Wei ^b   Hu, Yun Hong ^b   Zhong, Bo ^a   Hu, Ming Ming ^b   Shu, Hong Bing ^a,b  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; PROTEIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRIPARTITE MOTIF CONTAINING PROTEIN E3; TRIPARTITE MOTIF PROTEIN; UNCLASSIFIED DRUG; CYTOKINE; LIPOPOLYSACCHARIDE; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TAX1BP1 PROTEIN, HUMAN; TICAM1 PROTEIN, HUMAN; TLR3 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRIM32 PROTEIN, HUMAN; TUMOR PROTEIN; UBIQUITIN PROTEIN LIGASE; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BONE MARROW DERIVED MACROPHAGE; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENOTYPING TECHNIQUE; HUMAN ALPHAHERPESVIRUS 1; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INNATE IMMUNITY; LUCIFERASE ASSAY; LUNG FIBROBLAST; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN DEGRADATION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SALMONELLOSIS; SIGNAL TRANSDUCTION; UBIQUITINATION; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; MACROPHAGE; METABOLISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; AUTOPHAGY; CYTOKINES; HUMANS; IMMUNITY, INNATE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGES; NEOPLASM PROTEINS; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION FACTORS; TRIPARTITE MOTIF PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 85030461542     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006600     Document Type: Article

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