TRIM4 modulates type i interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination

Journal of Molecular Cell Biology

Volumn 6, Issue 2, 2014, Pages 154-163

  Yan, Jie ^a   Li, Qi ^a   Mao, Ai Ping ^a   Hu, Ming Ming ^a   Shu, Hong Bing ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

antiviral response; RIG I; TRIM4; type I interferon; ubiquitination

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; REGULATOR PROTEIN; RETINOIC ACID INDUCIBLE PROTEIN I; TRIM4 PROTEIN; UNCLASSIFIED DRUG; BETA INTERFERON; CARRIER PROTEIN; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; LYSINE; POLYUBIQUITIN; PROTEIN BINDING; TRANSCRIPTION FACTOR; TRIM25 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL LYSATE; CONTROLLED STUDY; GENE INTERACTION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; INNATE IMMUNITY; INTERFERON INDUCTION; MUTANT; NONHUMAN; PROTEIN DEGRADATION; TRANSIENT TRANSFECTION; UBIQUITINATION; VIRUS ACTIVATION; CELL LINE; DRUG EFFECTS; HEK293 CELL LINE; METABOLISM; PHYSIOLOGY; SENDAI VIRUS; SIGNAL TRANSDUCTION;

CARRIER PROTEINS; CELL LINE; DEAD-BOX RNA HELICASES; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; INTERFERON-BETA; LYSINE; POLYUBIQUITIN; PROTEIN BINDING; SENDAI VIRUS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84899698672     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mju005     Document Type: Article

References (29)

1. Akira, S., Uematsu, S., andTakeuchi, O. (2006). Pathogenrecognition and innate immunity. Cell 124, 783-801.
2. Andrejeva, J., Childs, K.S., Young, D.F., et al. (2004). The V proteins of para-myxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc. Natl Acad. Sci. USA 101, 17264-17269.
3. Arimoto, K., Takahashi, H., Hishiki, T., et al. (2007). Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proc. Natl Acad. Sci. USA 104, 7500-7505.
4. Barbalat, R., Ewald, S.E., Mouchess, M.L., et al. (2011). Nucleic acid recognition by the innate immune system. Annu. Rev. Immunol. 29, 185-214.
5. Fitzgerald, K.A., McWhirter, S.M., Faia, K.L., et al. (2003). IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491-496.
6. Friedman, C.S., O'Donnell, M.A., Legarda-Addison, D., et al. (2008). The tumour suppressor CYLD isa negative regulatorof RIG-I-mediated antiviral response. EMBO Rep. 9, 930-936.
7. Gack, M.U. (2007). TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446, 916-920.
8. Gao, D., Yang, Y.K., Wang, R.P., et al. (2009). REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I. PLoS One 4, e5760.
9. Gitlin, L., Barchet, W., Gilfillan, S., et al. (2006). Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyo-carditis picornavirus. Proc. Natl Acad. Sci. USA 103, 8459-8464.
10. Hiscott, J. (2007). Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response. Cytokine Growth Factor Rev. 18, 483-490.
11. Honda, K., Takaoka, A., and Taniguchi, T. (2006). Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity 25, 349-360.
12. Kato, H., Sato, S., Yoneyama, M., et al. (2005). Cell type-specific involvement of RIG-I in antiviral response. Immunity 23, 19-28.
13. Kato, H., Takeuchi, O., Sato, S., et al. (2006). Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441, 101-105.
14. Kato, H., Takeuchi, O., Mikamo-Satoh, E., et al. (2008). Length-dependent recog-nitionofdouble-strandedribonucleicacidsbyretinoicacid-induciblegene-Iand melanoma differentiation-associated gene 5. J. Exp. Med. 205, 1601-1610.
15. Kawai, T., Takahashi, K., Sato, S., et al. (2005). IPS-1, an adaptor triggering RIG-I-and Mda5-mediated type I interferon induction. Nat. Immunol. 6, 981-988.
16. Li, Q., Yan, J., Mao, A.P., et al. (2011). Tripartite motif 8 (TRIM8) modulates TNFalpha-and IL-1beta-triggered NF-kappaB activation by targeting TAK1 for K63-linked polyubiquitination. Proc. Natl Acad. Sci. USA 108, 19341-19346.
17. Li, Y., Chen, R., Zhou, Q., et al. (2012). LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc. Natl Acad. Sci. USA 109, 11770-11775.
18. McNab, F.W., Rajsbaum, R., Stoye, J.P., et al. (2011). Tripartite-motif proteins and innate immune regulation. Curr. Opin. Immunol. 23, 46-56.
19. Meylan, E., Curran, J., Hofmann, K., et al. (2005). Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437, 1167-1172.
20. Oshiumi, H., Matsumoto, M., Hatakeyama, S., et al. (2009). Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-b induction during the early phase of viral infection. J. Biol. Chem. 284, 807-817.
21. Ronald, P.C., and Beutler, B. (2010). Plant and animal sensors of conserved mi-crobial signatures. Science 330, 1061-1064.
22. Seth, R.B., Sun, L., Ea, C.K., et al. (2005). Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669-682.
23. Takeuchi, O., and Akira, S. (2010). Pattern recognition receptors and inflammation. Cell 140, 805-820.
24. Wang, Y.Y., Liu, L.J., Zhong, B., et al. (2010). WDR5isessentialforassemblyofthe VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Proc. Natl Acad. Sci. USA 107, 815-820.
25. Xu, L.G., Wang, Y.Y., Han, K.J., et al. (2005). VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell 19, 727-740.
26. Yang, K., Shi, H.X., Liu, X.Y., et al. (2009). TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response. J. Immunol. 182, 3782-3792.
27. Yoneyama, M., Kikuchi, M., Natsukawa, T., et al. (2004). The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5, 730-737.
28. Zhang, M., Wu, X., Lee, A.J., et al. (2008). Regulation of IkappaB kinase-related kinases and antiviral responsesbytumor suppressorCYLD.J.Biol. Chem. 283, 18621-18626.
29. Zhong, B., Yang, Y., Li, S., et al. (2008). The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29, 538-550.