Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017

Intensive Care Medicine

Volumn 43, Issue 12, 2017, Pages 1751-1763

  Annane, Djillali ^a   Pastores, Stephen M ^b   Rochwerg, Bram ^c   Arlt, Wiebke ^d   Balk, Robert A ^e   Beishuizen, Albertus ^f   Briegel, Josef ^g   Carcillo, Joseph ^h   Christ Crain, Mirjam ⁱ   Cooper, Mark S ^j   Marik, Paul E ^k   Umberto Meduri, Gianfranco ^l   Olsen, Keith M ^m   Rodgers, Sophia ⁿ   Russell, James A ^o   Van den Berghe, Greet ^p  

^a LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c MCMASTER UNIVERSITY   (Canada)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

^f MEDISCH SPECTRUM TWENTE   (Netherlands)

^g LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^h UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY HOSPITAL BASEL   (Switzerland)

^j UNIVERSITY OF SYDNEY   (Australia)

^k EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^l VETERANS AFFAIRS MEDICAL CENTER   (United States)

^m UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

ⁿ UNIVERSITY OF NEW MEXICO   (United States)

^o UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^p UNIVERSITY OF LEUVEN   (Belgium)

more..

Author keywords

Acute respiratory distress syndrome; Corticosteroids; Critical illness; Glucocorticoids; Major trauma; Sepsis; Septic shock

Indexed keywords

CORTICOSTEROID; CORTICOTROPIN; HYDROCORTISONE; HYPERTENSIVE AGENT; METHYLPREDNISOLONE; TETRACOSACTIDE; ANTIINFLAMMATORY AGENT; HORMONE;

ADRENAL INSUFFICIENCY; ADULT RESPIRATORY DISTRESS SYNDROME; BLOOD LEVEL; CLINICAL ASSESSMENT; CLINICAL OUTCOME; CONFERENCE PAPER; CORTICOSTEROID THERAPY; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN TEST; CRITICAL ILLNESS; CRITICAL ILLNESS RELATED CORTICOSTEROID INSUFFICIENCY; CRITICALLY ILL PATIENT; DISEASE SEVERITY; DRUG MEGADOSE; EVIDENCE BASED PRACTICE; HEALTH CARE POLICY; HEMODYNAMICS; HUMAN; HYDROCORTISONE BLOOD LEVEL; INJURY; INTENSIVE CARE; PEER REVIEW; PRACTICE GUIDELINE; SEPTIC SHOCK; ADULT; ADVISORY COMMITTEE; BLOOD; COMPLICATION; CONSENSUS DEVELOPMENT; DEFICIENCY; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; EVIDENCE BASED MEDICINE; HYPOPHYSIS ADRENAL SYSTEM; INTRAVENOUS DRUG ADMINISTRATION; PATHOPHYSIOLOGY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ADRENAL CORTEX HORMONES; ADRENAL INSUFFICIENCY; ADRENOCORTICOTROPIC HORMONE; ADULT; ADVISORY COMMITTEES; ANTI-INFLAMMATORY AGENTS; COSYNTROPIN; CRITICAL CARE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EVIDENCE-BASED MEDICINE; HORMONES; HUMANS; HYDROCORTISONE; INFUSIONS, INTRAVENOUS; METHYLPREDNISOLONE; PITUITARY-ADRENAL SYSTEM; RESPIRATORY DISTRESS SYNDROME, ADULT; SHOCK, SEPTIC; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 85029760772     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-017-4919-5     Document Type: Conference Paper

References (66)

1. Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arlt W, Keh D, Briegel J, Beishuizen A, Dimopoulou I, Tsagarakis S, Singer M, Chrousos GP, Zaloga G, Bokhari F, Vogeser M, American College of Critical Care Medicine (2008) Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 36(6):1937–1949
2. Cochrane Collaboration (2012) Cochrane: review manager. Edition 5.2. Edited by Centre TNC. Cochrane Collaboration, Copenhagen
3. Shea BJ, Grimshaw JM, Wells GA et al (2007) Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 7:10
4. Higgins JP, Altman DG, Gøtzsche PC, Cochrane Bias Methods Group; Cochrane Statistical Methods Group et al (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928
5. Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwel P (2016) The Newcastle--Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available at: www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 21 Nov 2016
6. Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J (2003) The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 3:25
7. Kavanagh BP (2009) The GRADE system for rating clinical guidelines. PLoS Med 6(9):e1000094
8. Andrews JC, Schunemann HJ, Oxman AD et al (2013) GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation’s direction and strength. J Clin Epidemiol 66(7):726–735
9. Rhodes A, Evans LE, Alhazzani W et al (2016) Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock. Intensive Care Med 43(3):304–377
10. Bornstein SR, Allolio B, Arlt W et al (2016) Diagnosis and treatment of primary adrenal insufficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 101(2):364–389
11. Marik PE, Zaloga GP (2003) Adrenal insufficiency during septic shock. Crit Care Med 31(1):141–145
12. de Jong MF, Molenaar N, Beishuizen A, Groeneveld AB (2015) Diminished adrenal sensitivity to endogenous and exogenous adrenocorticotropic hormone in critical illness: a prospective cohort study. Crit Care 19:1. Erratum in: Crit Care. 2015;19:313
13. Yang Y, Liu L, Jiang D, Wang J, Ye Z, Ye J, Chao J, Zhao M, Ao D, Qiu H (2014) Critical illness-related corticosteroid insufficiency after multiple traumas: a multicenter, prospective cohort study. J Trauma Acute Care Surg 76(6):1390–1396
14. Menon K, Ward RE, Lawson ML, Gaboury I, Hutchison JS, Hebert PC, Canadian Critical Care Trials Group (2010) A prospective multicenter study of adrenal function in critically ill children. Am J Respir Crit Care Med 182(2):246–251
15. Hamrahian AH, Oseni TS, Arafah BM (2004) Measurements of serum free cortisol in critically ill patients. N Engl J Med 350:1629–1638
16. Molenaar N, Groeneveld ABJ, Dijstelbloem HM et al (2011) Assessing adrenal insufficiency of corticosteroid secretion using free versus total cortisol levels in critical illness. Intensive Care Med 37:1986–1993
17. Tarjanyi Z, Montsko G, Kenyeres P et al (2014) Free and total cortisol levels are useful prognostic markers in critically ill patients: a prospective observational study. Eur J Endocrinol 171:751–759
18. Jessop DS, Turner-Cobb JM (2008) Measurement and meaning of salivary cortisol: a focus on health and disease in children. Stress 11(1):1–14
19. Galbois A, Obadia E, Chalumeau-Lemoine L, Chelha R (2016) Using serum total cortisol assays overstates the adrenal insufficiency prevalence in cirrhotic patients. Eur Rev Med Pharmacol Sci 20(18):3730–3731
20. Galbois A, Rudler M, Massard J et al (2010) Assessment of adrenal function in cirrhotic patients: salivary cortisol should be preferred. J Hepatol 52(6):839–845
21. Estrada-Y-Martin RM, Orlander PR (2011) Salivary cortisol can replace free serum cortisol measurements in patients with septic shock. Chest 140(5):1216–1222
22. Coolens JL, Van Baelen H, Heyns W (1987) Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin. J Steroid Biochem 26(2):197–202
23. Ho JT, Al-Musalhi H, Chapman MJ et al (2006) Septic shock and sepsis: a comparison of total and free plasma cortisol levels. J Clin Endocrinol Metab 91(1):105–114
24. Ospina NS, Al Nofal A, Bancos I et al (2016) ACTH stimulation tests for the diagnosis of adrenal insufficiency: systematic review and meta-analysis. J Clin Endocrinol Metab 101(2):427–434
25. Moraes RB, Friedman G, Tonietto T, Saltz H, Czepielewski M (2012) Comparison of low and high dose cosyntropin stimulation tests in the diagnosis of adrenal insufficiency in septic shock patients. Horm Metab Res 44(4):296–301
26. Schneider AJ, Voerman HJ (1991) Abrupt hemodynamic improvement in late septic shock with physiological doses of glucocorticoids. Intensive Care Med 17:436–437
27. Baldwin WA, Allo M (1993) Occult hypoadrenalism in critically ill patients. Arch Surg 128:673–676
28. Annane D, Bellissant E, Sébille V et al (1998) Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve. Br J Clin Pharmacol 46:589–597
29. Marik PE, Zaloga GP (2003) Adrenal insufficiency during septic shock. Crit Care Med 31:141–145
30. Annane D, Sebille V, Charpentier C et al (2002) Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288:862–871
31. Arabi YM, Aljumah A, Dabbagh O et al (2010) Low-dose hydrocortisone in patients with cirrhosis and septic shock: a randomized controlled trial. CMAJ 182:1971–1977
32. Sprung CL, Annane D, Keh D et al (2008) Hydrocortisone therapy for patients with septic shock. N Engl J Med 358:111–124
33. Keh D, Trips E, Marx G et al (2016) Effect of hydrocortisone on development of shock among patients with severe sepsis: the HYPRESS randomized clinical trial. JAMA 316:1775–1785
34. Wira CR, Dodge K, Sather J, Dziura J (2014) Meta-analysis of protocolized goal-directed hemodynamic optimization for the management of severe sepsis and septic shock in the Emergency Department. West J Emerg Med 15:51–59
35. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y (2015) Corticosteroids for treating sepsis. Cochrane Database Syst Rev 12:CD002243
36. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29(7):1303–1310
37. Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348(16):1546–1554
38. Torio CM, Andrews RM (2011) National Inpatient Hospital Costs: the most expensive conditions by Payer, 2011: Statistical Brief #160. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2006 Feb–2013 Aug
39. Fleischmann C, Thomas-Rueddel DO, Hartmann M et al (2016) Hospital incidence and mortality rates of sepsis. Dtsch Arztebl Int 113(10):159–166
40. Annane D, Bellisant E, Cavaillon JM (2005) Septic shock. Lancet 365(9453):63–78
41. Prigent H, Maxime V, Annane D (2004) Clinical review: corticotherapy in sepsis. Crit Care 8(2):122–129
42. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y (2015) Corticosteroids for treating sepsis. Cochrane Database Syst Rev. 12:CD002243
43. Gibbison B, López-López JA, Higgins JP, Miller T, Angelini GD, Lightman SL, Annane D (2017) Corticosteroids in septic shock: a systematic review and network meta-analysis. Crit Care 21(1):78
44. O’Hearn K, McNally D, Choong k, On behalf of the Canadian Critical Care Trials Group et al (2016) Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial. Trials 17:238
45. Menon K, McNally D, O’Hearn K, Canadian Critical Care Trials Group et al (2017) A randomized controlled trial of corticosteroids in pediatric septic shock: a pilot feasibility study. Pediatr Crit Care Med 18(6):505–512
46. Tongyoo S, Permpikul C, Mongkolpun W, Vattanavanit V, Udompanturak S, Kocak M, Meduri GU (2016) Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial. Crit Care 20(1):329
47. El-Nawawy A, Khater D, Omar H, Wali Y (2017) Evaluation of early corticosteroid therapy in management of pediatric septic shock in pediatric intensive care patients: a randomized clinical study. Pediatr Infect Dis J 36(2):155–159
48. Annane D, Brun Buisson C, Cariou A, The APROCCHSS Investigators for the TRIGGERSEP Network et al (2016) Design and conduct of the activated protein C and corticosteroids for human septic shock (APROCCHSS) trial. Ann Intensive Care 6:43
49. Ranieri VM, Thompson BT, Barie PS et al (2013) Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 366(22):2055–2064
50. Venkatesh B, Myburgh J, Finfer S et al (2013) The ADRENAL study protocol: adjunctive corticosteroid treatment in critically ill patients with septic shock. Crit Care Resusc 15(2):83–88
51. Bellani G, Laffey JG, Pham T, LUNG SAFE Investigators; ESICM Trials Group et al (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315(8):788–800
52. Angus DC, Clermont G, Linde-Zwirble WT, Musthafa AA, Dremsizov TT, Lidicker J, Lave JR, NO-06 Investigators (2006) Healthcare costs and long-term outcomes after acute respiratory distress syndrome: a phase III trial of inhaled nitric oxide. Crit Care Med 34(12):2883–2890
53. Hill AD, Fowler RA, Burns KE et al (2017) Long-term outcomes and health care utilization after prolonged mechanical ventilation. Ann Am Thorac Soc 14(3):355–362
54. Herridge MS, Chu LM, Matte A, RECOVER Program Investigators (Phase 1: towards RECOVER); Canadian Critical Care Trials Group et al (2016) The RECOVER program: disability risk groups and 1-year outcome after 7 or more days of mechanical ventilation. Am J Respir Crit Care Med 194(7):831–844
55. Meduri GU, Headley AS, Golden E et al (1998) Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial. JAMA 280:159–165
56. Steinberg KP, Hudson LD, Goodman RB, Hough CL, Lanken PN, Hyzy R, Thompson BT, Ancukiewicz M, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network (2006) Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 354(16):1671–1684
57. Meduri GU, Golden E, Freire AX, Taylor E, Zaman M, Carson SJ, Gibson M, Umberger R (2007) Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest 131(4):954–963
58. Rezk NA, Ibrahim AM (2013) Effects of methylprednisolone in early ARDS. Egypt J Chest Dis Tuberc 6291:167–172
59. Confalonieri M, Urbino R, Potena A, Piattella M, Parigi P, Puccio G, Della Porta R, Giorgio C, Blasi F, Umberger R, Meduri GU (2005) Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med 171(3):242–248
60. Annane D, Sébille V, Bellissant E, Ger-Inf-05 Study Group (2006) Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome. Crit Care Med 34(1):22–30
61. Meduri GU, Bridges L, Shin MC et al (2016) Prolonged glucocorticoid treatment is associated with improved ARDS outcomes: analysis of individual patients’ data from four randomized trials and trial-level meta-analysis of the updated literature. Intensive Care Med 42(5):829–840
62. Meduri GU, Eltorky MA (2015) Understanding ARDS-associated fibroproliferation. Intensive Care Med 41(3):517–520
63. Greos LS, Vichyanond P, Bloedow DC, Irvin CG, Larsen GL, Szefler SJ, Hill MR (1991) Methylprednisolone achieves greater concentrations in the lung than prednisolone. A pharmacokinetic analysis. Am Rev Respir Dis 144(3):586–592
64. Hoen S, Asehnoune K, Brailly-Tabard S et al (2002) Cortisol response to corticotropin stimulation in trauma patients: influence of hemorrhagic shock. Anesthesiology 97(4):807–813
65. Roquilly A, Mahe PJ, Seguin P et al (2011) Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study. JAMA 305(12):1201–1209
66. Asehnoune K, Seguin P, Allary J, Corti-TC Study Group et al (2014) Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial. Lancet Respir Med 2(9):706–716