Evaluation of early corticosteroid therapy in management of pediatric septic shock in pediatric intensive care patients: A randomized clinical study

Pediatric Infectious Disease Journal

Volumn 36, Issue 2, 2017, Pages 155-159

  El Nawawy, Ahmed ^a   Khater, Doaa ^a,b   Omar, Heba ^c   Wali, Yasser ^a,b  

^a ALEXANDRIA UNIVERSITY   (Egypt)

^b SULTAN QABOOS UNIVERSITY HOSPITAL   (Oman)

^c CAIRO UNIVERSITY   (Egypt)

Author keywords

Corticosteroids; Septic shock; Shock reversal; Superinfection

Indexed keywords

CORTICOSTEROID; CORTICOTROPIN; HYDROCORTISONE; STEROID;

ACUTE KIDNEY FAILURE; ACUTE LIVER FAILURE; ADRENAL GLAND; ADRENAL INSUFFICIENCY; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CHILD; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN TEST; DISSEMINATED INTRAVASCULAR CLOTTING; FLUID THERAPY; HUMAN; HYDROCORTISONE BLOOD LEVEL; INTENSIVE CARE; INTERVENTION STUDY; LENGTH OF STAY; MAJOR CLINICAL STUDY; PRACTICE GUIDELINE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEPTIC SHOCK; TIME TO TREATMENT; BLOOD; INFANT; KAPLAN MEIER METHOD; PEDIATRIC INTENSIVE CARE UNIT;

ADRENAL CORTEX HORMONES; ADRENOCORTICOTROPIC HORMONE; CHILD, PRESCHOOL; HUMANS; HYDROCORTISONE; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; KAPLAN-MEIER ESTIMATE; PROSPECTIVE STUDIES; SHOCK, SEPTIC;

EID: 84992748423     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0000000000001380     Document Type: Article

References (27)

1. Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6:2-8.
2. Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41:580-637.
3. Wolfler A, Silvani P, Musicco M, et al; Italian Pediatric Sepsis Study (SISPe) group. Incidence of and mortality due to sepsis, severe sepsis and septic shock in Italian Pediatric Intensive Care Units: a prospective national survey. Intensive Care Med. 2008;34:1690-1697.
4. de Oliveira CF, de Oliveira DS, Gottschald AF, et al. ACCM/PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation. Intensive Care Med. 2008;34:1065-1075.
5. Carcillo JA, Kuch BA, Han YY, et al. Mortality and functional morbidity after use of PALS/APLS by community physicians. Pediatrics. 2009;124:500-508.
6. Zimmerman JJ. A history of adjunctive glucocorticoid treatment for pediatric sepsis: moving beyond steroid pulp fiction toward evidence-based medicine. Pediatr Crit Care Med. 2007;8:530-539.
7. Benken ST, Hutson TK, Gardiner RL, et al. A single-center review of Prescribing trends and outcomes of corticosteroid replacement therapy in critically ill children with septic shock. Open Crit Care Med J. 2010;3:51-56.
8. Menon K, Lawson M. Identification of adrenal insufficiency in pediatric critical illness. Pediatr Crit Care Med. 2007;8:276-278.
9. Hildebrandt T, Mansour M, Al Samsam R. The use of steroids in children with septicemia: review of the literature and assessment of current practice in PICUs in the UK. Paediatr Anaesth. 2005;15:358-365.
10. Markovitz BP, Goodman DM, Watson RS, et al. A retrospective cohort study of prognostic factors associated with outcome in pediatric severe sepsis: what is the role of steroids? Pediatr Crit Care Med. 2005;6:270-274.
11. Kim J, Shin W. How to do random allocation (randomization). Clin Orthop Surg. 2014;6:103-109.
12. Slater A, Shann F, Pearson G; Paediatric Index of Mortality (PIM) Study Group. PIM2: a revised version of the Paediatric Index of Mortality. Intensive Care Med. 2003;29:278-285.
13. Leteurtre S, Duhamel A, Grandbastien B, et al. Paediatric Logistic Organ Dysfunction (PELOD) score. Lancet. 2006;367:897; author reply 900-897; author reply 902.
14. Sevketoglu E, Anil A, Kazanci S, et al. Is an inotrope score a predictor of mortality and morbidity in children with septic shock? Crit Care. 2015;19:147.
15. Weiss SL, Pomerantz WJ. Septic shock: rapid recognition and initial resuscitation in children. Up To Date. 2013:1-19. Available at http://www.uptodate. com/contents/septic-shock-rapid-recognition-and-initial-resuscitation-inchildren? topicKey=EM%2F85767.
16. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36:309-332.
17. Pizarro CF, Troster EJ, Damiani D, et al. Absolute and relative adrenal insufficiency in children with septic shock. Crit Care Med. 2005;33:855-859.
18. Riordan FA, Thomson AP, Ratcliffe JM, et al. Admission cortisol and adrenocorticotrophic hormone levels in children with meningococcal disease: evidence of adrenal insufficiency? Crit Care Med. 1999;27:2257-2261.
19. Annane D. Corticosteroids for severe sepsis: an evidence-based guide for physician. Ann Intensive Care. 2011;1:7.
20. Bendel S, Karlsson S, Pettilä V, et al; Finnsepsis Study Group. Free cortisol in sepsis and septic shock. Anesth Analg. 2008;106:1813-1819.
21. Hebbar K, Rigby MR, Felner EI, et al. Neuroendocrine dysfunction in pediatric critical illness. Pediatr Crit Care Med. 2009;10:35-40.
22. Carcillo JA, Fields AI; American College of Critical Care Medicine Task Force Committee Members. Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock. Crit Care Med. 2002;30:1365-1378.
23. Sprung CL, Annane D, Keh D, et al; CORTICUS Study Group. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358:111-124.
24. Annane D, Bellissant E, Bollaert PE, et al. Corticosteroids for treating sepsis. Cochrane Database Syst Rev. 2015:CD002243.
25. Hatherill M, Tibby SM, Hilliard T, et al. Adrenal insufficiency in septic shock. Arch Dis Child. 1999; 80:51-55.
26. Sarthi M, Lodha R, Vivekanandhan S, et al. Adrenal status in children with septic shock using low-dose stimulation test. Pediatr Crit Care Med. 2007;8:23-28.
27. El-Wiher N, Cornell TT, Kissoon N, et al. Management and treatment guidelines for sepsis in pediatric patients. Open Inflamm J. 2011;4 (suppl 1-M11):101-109.