A prospective multicenter study of adrenal function in critically ill children

American Journal of Respiratory and Critical Care Medicine

Volumn 182, Issue 2, 2010, Pages 246-251

  Menon, Kusum ^a,b   Ward, Roxanne E ^b   Lawson, Margaret L ^a,b   Gaboury, Isabelle ^b,e   Hutchison, James S ^c   Hébert, Paul C ^d  

^a UNIVERSITY OF OTTAWA   (Canada)

^b CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^c HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^d OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY OF CALGARY   (Canada)

Author keywords

Adrenal function; Adrenal gland; Adrenocorticotropic hormone

Indexed keywords

CATECHOLAMINE; CORTICOTROPIN; HYDROCORTISONE;

ADOLESCENT; ADRENAL FUNCTION; ADRENAL INSUFFICIENCY; ARTICLE; CHILD; CLINICAL TRIAL; COHORT ANALYSIS; CRITICALLY ILL PATIENT; DRUG MEGADOSE; FEMALE; HORMONE DETERMINATION; HUMAN; INFANT; INTENSIVE CARE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEWBORN; OUTCOME ASSESSMENT; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SENSITIVITY AND SPECIFICITY; VASCULAR ACCESS; AGE; BLOOD; CANADA; CRITICAL ILLNESS; FLUID THERAPY; HEART SURGERY; INJURY; INTENSIVE CARE UNIT; PRESCHOOL CHILD; STATISTICS;

ADOLESCENT; ADRENAL INSUFFICIENCY; ADRENOCORTICOTROPIC HORMONE; AGE FACTORS; CANADA; CARDIAC SURGICAL PROCEDURES; CATECHOLAMINES; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; FEMALE; FLUID THERAPY; HUMANS; HYDROCORTISONE; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; MALE; PREVALENCE; PROSPECTIVE STUDIES; RISK FACTORS; SENSITIVITY AND SPECIFICITY; WOUNDS AND INJURIES;

EID: 77956635004     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200911-1738OC     Document Type: Article

References (43)

1. Bouachour G, Tirot P, Varache N, Gouello JP, Harry P, Alquier P. Hemodynamic changes in acute adrenal insufficiency. Intensive Care Med 1994;20:138-141.
2. Hinshaw LB, Beller BK, Chang AC,Murray CK, Flournoy DJ, Passey RB, Archer LT. Corticosteroid/antibiotic treatment of adrenalectomized dogs challenged with lethal E. coli. Circ Shock 1985;16:265-277.
3. Ledingham IM, Watt I. Influence of sedation on mortality in critically ill multiple trauma patients. Lancet 1983;1:1270.
4. Prakanrattana U, Valairucha S, Sriyoschati S, Pornvilawan S, Phanchaipetch T.Early extubation following open heart surgery inpediatric patients with congenital heart diseases. J Med Assoc Thai 1997;80:87-95.
5. Huang CJ, Lin HC. Association between adrenal insufficiency and ventilator weaning. Am J Respir Crit Care Med 2006;173:276-280.
6. Beishuizen A, Thijs LG. Relative adrenal failure in intensive care: an identifiable problem requiring treatment? Best Pract Res Clin Endocrinol Metab 2001;15:513-531.
7. Cooper MS, Stewart PM. Corticosteroid insufficiency in acutely ill patients. N Engl J Med 2003;348:727-734.
8. Cronin L, Cook DJ, Carlet J, Heyland DK, King D, Lansang MA, Fisher CJ Jr. Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Crit Care Med 1995;23:1430-1439.
9. Marik PE, Zaloga GP. Adrenal insufficiency in the critically ill: a new look at an old problem. Chest 2002;122:1784-1796.
10. Lefering R, Neugebauer EA. Steroid controversy in sepsis and septic shock: a meta-analysis. Crit Care Med 1995;23:1294-1303.
11. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ 2004;329:480.
12. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008;358:111-124.
13. Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288:862-871.
14. Hebbar K, Rigby MR, Felner EI, Easley KA, Fortenberry JD. Neuroendocrine dysfunction in pediatric critical illness. Pediatr Crit Care Med 2009;10:35-40.
15. Ando M, Park IS, Wada N, Takahashi Y. Steroid supplementation: a legitimate pharmacotherapy after neonatal open heart surgery. Ann Thorac Surg 2005;80:1672-1678.
16. Bone M, Diver M, Selby A, Sharples A, Addison M, Clayton P. Assessment of adrenal function in the initial phase of meningococcal disease. Pediatrics 2002;110:563-569.
17. Casartelli CH, Garcia PC, Branco RG, Piva JP, Einloft PR, Tasker RC. Adrenal response in children with septic shock. Intensive Care Med 2007;33:1609-1613.
18. Menon K, Clarson C. Adrenal function in pediatric critical illness. Pediatr Crit Care Med 2002;3:112-116.
19. Pizarro CF, Troster EJ, Damiani D, Carcillo JA. Absolute and relative adrenal insufficiency in children with septic shock. Crit Care Med 2005;33:855-859.
20. Sarthi M, Lodha R, Vivekanandhan S, Arora NK. 2006. Adrenal status in children with septic shock using low-dose stimulation test. Pediatr Crit Care Med 2007;8:23-28.
21. Samransamruajkit R, Jitchaiwat S, Deerojanawong J, Sritippayawan S, Praphal N. Adrenal insufficiency in early phase of pediatric acute lung injury/acute respiratory distress syndrome. J Crit Care 2007;22:314-318.
22. Riordan FA, Thomson AP, Ratcliffe JM, Sills JA, Diver MJ, Hart CA. Admission cortisol and adrenocorticotrophic hormone levels in children with meningococcal disease: evidence of adrenal insufficiency? Crit Care Med 1999;27:2257-2261.
23. Hatherill M, Tibby SM, Hilliard T, Turner C, Murdoch IA. Adrenal insufficiency in septic shock. Arch Dis Child 1999;80:51-55.
24. Gajarski RJ, Stefanelli CB, Graziano JN, Kaciroti N, Charpie JR, Vazquez D. Adrenocortical response in infants undergoing cardiac surgery with cardiopulmonary bypass and circulatory arrest. Pediatr Crit Care Med 2010;11:44-51.
25. Menon K, Lawson M. Identification of adrenal insufficiency in pediatric critical illness. Pediatr Crit Care Med 2007;8:276-278.
26. Brierley J, Carcillo JA, Choong K, Cornell T, Decaen A, Deymann A, Doctor A, Davis A, Duff J, Dugas MA, et al. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med 2009;37:666-688.
27. Tabarki B, Coffinieres A, Van Den BP, Huault G, Landrieu P, Sebire G. Critical illness neuromuscular disease: clinical, electrophysiological, and prognostic aspects. Arch Dis Child 2002;86:103-107.
28. Markovitz BP, Goodman DM, Watson RS, Bertoch D, Zimmerman J. A retrospective cohort study of prognostic factors associated with outcome in pediatric severe sepsis: what is the role of steroids? Pediatr Crit Care Med 2005;6:270-274.
29. Menon K. Final results of the adrenal insufficiency study in pediatric critical illness. Presented at the Canadian Critical Care Forum.October 25, 2009. Toronto, Canada.
30. Rose SR, Lustig RH, Burstein S, Pitukcheewanont P, Broome DC, Burghen GA. Diagnosis of ACTH deficiency. Comparison of over-night metyrapone test to either low-dose or high-dose ACTH test. Horm Res 1999;52:73-79.
31. Marik PE, Kiminyo K, Zaloga GP. Adrenal insufficiency in critically ill patients with human immunodeficiency virus. Crit Care Med 2002;30:1267-1273.
32. Marik PE, Zaloga GP. Adrenal insufficiency during septic shock. Crit Care Med 2003;31:141-145.
33. Park YJ, Park KS, Kim JH, Shin CS, Kim SY, Lee HK. Reproducibility of the cortisol response to stimulation with the low dose (1 microg) of ACTH. Clin Endocrinol (Oxf) 1999;51:153-158.
34. Huang TS, Jiang YD. Repetitive graded ACTH stimulation test for adrenal insufficiency. J Endocrinol Invest 2000;23:163-169.
35. Crowley S, Hindmarsh PC, Honour JW, Brook CG. Reproducibility of the cortisol response to stimulation with a low dose of ACTH(1-24): the effect of basal cortisol levels and comparison of low-dose with high-dose secretory dynamics. J Endocrinol 1993;136:167-172.
36. Pollack MM, Patel KM, Ruttimann UE. PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med 1996;24:743-752.
37. Leteurtre S, Martinot A, Duhamel A, Proulx F, Grandbastien B, Cotting J, Gottesman R, Joffe A, Pfenninger J, Hubert P, et al. Validation of the Paediatric Logistic Organ Dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet 2003;362:192-197.
38. Newcombe RG. Two-sided confidence intervals for the single proportion: comparison of seven methods. Stat Med 1998;17:857-872.
39. Cooper MS, Stewart PM. Adrenal insufficiency in critical illness. J Intensive Care Med 2007;22:348-362.
40. Sainsbury JR, Stoddart JC, Watson MJ. Plasma cortisol levels. A comparison between sick patients and volunteers given intravenous cortisol. Anaesthesia 1981;36:16-21.
41. Dimopoulou I, Ilias I, Roussou P, Gavala A, Malefaki A, Milou E, Pitaridis M, Roussos C. Adrenal function in non-septic long-stay critically ill patients: evaluation with the low-dose (1 μg) corticotropin stimulation test. Intensive Care Med 2002;28:1168-1171.
42. Hamrahian AH, Oseni TS, Arafah BM. Measurements of serum free cortisol in critically ill patients. N Engl J Med 2004;350:1629-1638.
43. Poomthavorn P, Lertbunrian R, Preutthipan A, Sriphrapradang A, Khlairit P, Mahachoklertwattana P. Serum free cortisol index, free cortisol, and total cortisol in critically ill children. Intensive Care Med 2009;35:1281-1285.