Effects of metformin on proliferation and apoptosis of human megakaryoblastic Dami and MEG-01 cells

Journal of Pharmacological Sciences

Volumn 135, Issue 1, 2017, Pages 14-21

  Liang, Xue ^a   Kong, Peiyan ^b   Wang, Jin ^a   Xu, Yulin ^a   Gao, Chunfang ^a   Guo, Guozhen ^c  

^a Institute of Anal Colorectal Surgery   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Acute megakaryoblastic leukemia; Apoptosis; Dami; MEG 01; Metformin

Indexed keywords

CASPASE 3; CASPASE 9; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; P21 ACTIVATED KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; ANTIDIABETIC AGENT; STRESS ACTIVATED PROTEIN KINASE;

ACUTE MEGAKARYOCYTIC LEUKEMIA; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DAMI CELL LINE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEG-01 CELL LINE; MEGAKARYOBLAST; UPREGULATION; WESTERN BLOTTING; CELL CULTURE; CELL LINE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; MAPK SIGNALING; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPOGLYCEMIC AGENTS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKEMIA, MEGAKARYOBLASTIC, ACUTE; MAP KINASE SIGNALING SYSTEM; MEGAKARYOCYTE PROGENITOR CELLS; METFORMIN; MOLECULAR TARGETED THERAPY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; SIGNAL TRANSDUCTION;

EID: 85029469959     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2017.08.003     Document Type: Article

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