-
1
-
-
84861316751
-
Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis
-
Macanas, P. P.; Leisewitz, A.; Broekhuizen, R.; Cautivo, K.; Barriga, F. M.; Leisewitz, F.; Gidi, V.; Riquelme, E.; Montecinos, V. P.; Swett, P.; Besa, P.; Ramirez, P.; Ocqueteau, M.; Kalergis, A. M.; Holt, M.; Rettig, M.; DiPersio, J. F.; Nervi, B. Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis. PLoS One 7:e37203; 2012.
-
(2012)
PLoS One
, vol.7
-
-
Macanas, P.P.1
Leisewitz, A.2
Broekhuizen, R.3
Cautivo, K.4
Barriga, F.M.5
Leisewitz, F.6
Gidi, V.7
Riquelme, E.8
Montecinos, V.P.9
Swett, P.10
Besa, P.11
Ramirez, P.12
Ocqueteau, M.13
Kalergis, A.M.14
Holt, M.15
Rettig, M.16
DiPersio, J.F.17
Nervi, B.18
-
2
-
-
79959891134
-
+ progenitor cells against first-generation FLT3 tyrosine kinase inhibitors
-
+ progenitor cells against first-generation FLT3 tyrosine kinase inhibitors. Cancer Res. 71:4696-4706; 2011.
-
(2011)
Cancer Res.
, vol.71
, pp. 4696-4706
-
-
Parmar, A.1
Marz, S.2
Rushton, S.3
Holzwarth, C.4
Lind, K.5
Kayser, S.6
Döhner, K.7
Peschel, C.8
Oostendorp, R.A.9
Götze, K.S.10
-
3
-
-
84929961117
-
Role of microenvironment in resistance of therapy in AML
-
Tabe, Y.; Konopleva, M. Role of microenvironment in resistance of therapy in AML. Curr. Hematol. Malig. Rep. 10:96-103; 2015.
-
(2015)
Curr. Hematol. Malig. Rep.
, vol.10
, pp. 96-103
-
-
Tabe, Y.1
Konopleva, M.2
-
5
-
-
84944630038
-
Kip1 axis
-
Kip1 axis. Mol. Carcinog. 54:1678-1685; 2015.
-
(2015)
Mol. Carcinog.
, vol.54
, pp. 1678-1685
-
-
Chen, P.1
Huang, H.F.2
Wu, J.Y.3
Lu, R.4
Wu, Y.J.5
Jiang, X.6
Yuan, Q.7
Chen, Y.Z.8
-
6
-
-
33847225602
-
Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blast
-
Tazzari, P. L.; Cappellini, A.; Ricci, F.; Evangelisti, C.; Papa, V.; Grafone, T.; Martinelli, G.; Conte, R.; Cocco, L.; McCubrey, J. A.; Martelli, A. M. Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blast. Leukemia 21:427-438; 2007.
-
(2007)
Leukemia
, vol.21
, pp. 427-438
-
-
Tazzari, P.L.1
Cappellini, A.2
Ricci, F.3
Evangelisti, C.4
Papa, V.5
Grafone, T.6
Martinelli, G.7
Conte, R.8
Cocco, L.9
McCubrey, J.A.10
Martelli, A.M.11
-
7
-
-
33744457653
-
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia
-
Martelli, A. M.; Nyakem, M.; Tabellini, G.; Bortul, R.; Tazzari, P. L.; Evangelisti, C.; Cocco, L. Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia 20:911-928; 2006.
-
(2006)
Leukemia
, vol.20
, pp. 911-928
-
-
Martelli, A.M.1
Nyakem, M.2
Tabellini, G.3
Bortul, R.4
Tazzari, P.L.5
Evangelisti, C.6
Cocco, L.7
-
8
-
-
0036968347
-
Activation of the PI3K/Akt pathway and chemotherapeutic resistance
-
West, K. A.; Castillo, S. S.; Dennis, P. A. Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist. Updat. 5:234-248; 2002.
-
(2002)
Drug Resist. Updat.
, vol.5
, pp. 234-248
-
-
West, K.A.1
Castillo, S.S.2
Dennis, P.A.3
-
9
-
-
84981730509
-
-
2nd ed. Beijing, China: The Peoples Medical Publishing House
-
Zhinan, Z.; Yushu, H.; Yong, Q. Z. Hematology, 2nd ed. Beijing, China: The Peoples Medical Publishing House; 2012.
-
(2012)
Hematology
-
-
Zhinan, Z.1
Yushu, H.2
Yong, Q.Z.3
-
10
-
-
13844273087
-
PI3K-Akt pathway: Its functions and alterations in human cancer
-
Osaki, M.; Oshimura, M.; Ito, H. PI3K-Akt pathway: Its functions and alterations in human cancer. Apoptosis 9:667-676; 2004.
-
(2004)
Apoptosis
, vol.9
, pp. 667-676
-
-
Osaki, M.1
Oshimura, M.2
Ito, H.3
-
11
-
-
84954555869
-
Abnormal protein glycosylation and activation PI3K/Akt/mTOR pathway: Role in bladder cancer prognosis and targeted therapeutics
-
Costa, C.; Pereira, S.; Lima, L.; Peixoto, A.; Fernandes, E.; Neves, D.; Neves, M.; Gaiteiro, C.; Tavares, A.; Gil da Costa, R. M.; Cruz, R.; Amaro, T.; Oliveira, P. A.; Ferreira, J. A.; Santos, L. L. Abnormal protein glycosylation and activation PI3K/Akt/mTOR pathway: role in bladder cancer prognosis and targeted therapeutics. PLoS One 10:e0141253; 2015.
-
(2015)
PLoS One
, vol.10
-
-
Costa, C.1
Pereira, S.2
Lima, L.3
Peixoto, A.4
Fernandes, E.5
Neves, D.6
Neves, M.7
Gaiteiro, C.8
Tavares, A.9
Gil Da Costa, R.M.10
Cruz, R.11
Amaro, T.12
Oliveira, P.A.13
Ferreira, J.A.14
Santos, L.L.15
-
12
-
-
84940772550
-
The expression of the PI3K/Akt/mTOR pathway in gastric cancer and its role in gastric cancer prognosis
-
Ying, J.; Xu, Q.; Liu, B.; Zhang, G.; Chen, L.; Pan, H. The expression of the PI3K/Akt/mTOR pathway in gastric cancer and its role in gastric cancer prognosis. Onco. Targets Ther. 8:2427-2433; 2015.
-
(2015)
Onco. Targets Ther.
, vol.8
, pp. 2427-2433
-
-
Ying, J.1
Xu, Q.2
Liu, B.3
Zhang, G.4
Chen, L.5
Pan, H.6
-
13
-
-
84871893381
-
Regulatory mechanism of PI3K/AKT signaling pathway in acute leukemia
-
Wang, W. L.; Zhang, Y. C.; Zeng, H. M.; Hua, C. L.; Wei, W.; Xu, J.; Zhu, X. F.; Cheng, T.; Yuan, W. P. Regulatory mechanism of PI3K/AKT signaling pathway in acute leukemia. J. Exp. Hematol. 20:18-21; 2012.
-
(2012)
J. Exp. Hematol.
, vol.20
, pp. 18-21
-
-
Wang, W.L.1
Zhang, Y.C.2
Zeng, H.M.3
Hua, C.L.4
Wei, W.5
Xu, J.6
Zhu, X.F.7
Cheng, T.8
Yuan, W.P.9
-
14
-
-
35948984135
-
Chemotherapy-resistant human AML stem cells home to and engraft within the bonemarrow endosteal region
-
Ishikawa, F.; Yoshida, S.; Saito, Y.; Hijikata, A.; Kitamura, H.; Tanaka, S.; Nakamura, R.; Tanaka, T.; Tomiyama, H.; Saito, N.; Fukata, M.; Miyamoto, T.; Lyons, B.; Ohshima, K.; Uchida, N.; Taniguchi, S.; Ohara, O.; Akashi, K.; Harada, M.; Shultz, L. D. Chemotherapy-resistant human AML stem cells home to and engraft within the bonemarrow endosteal region. Nat. Biotechnol. 25:1315-1321;2007.
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 1315-1321
-
-
Ishikawa, F.1
Yoshida, S.2
Saito, Y.3
Hijikata, A.4
Kitamura, H.5
Tanaka, S.6
Nakamura, R.7
Tanaka, T.8
Tomiyama, H.9
Saito, N.10
Fukata, M.11
Miyamoto, T.12
Lyons, B.13
Ohshima, K.14
Uchida, N.15
Taniguchi, S.16
Ohara, O.17
Akashi, K.18
Harada, M.19
Shultz, L.D.20
more..
-
15
-
-
84920973657
-
Expression of three different ATP-binding cassette transporters and correlation to chemoresistance in acute myeloid leukemia
-
Palaiologou, D.; Panayiotidis, P.; Papanikolaou, G.; Georgiou, G.; Boutsikas, G.; Hatzinicolaou, S. L.; Pangalis, G. A.; Sakellaropoulos, N.; Vassilakopoulos, T. P.; Angelopoulou, M. K. Expression of three different ATP-binding cassette transporters and correlation to chemoresistance in acute myeloid leukemia. Int. J. Lab. Hematol. 37:e7-e10; 2015.
-
(2015)
Int. J. Lab. Hematol.
, vol.37
, pp. e7-e10
-
-
Palaiologou, D.1
Panayiotidis, P.2
Papanikolaou, G.3
Georgiou, G.4
Boutsikas, G.5
Hatzinicolaou, S.L.6
Pangalis, G.A.7
Sakellaropoulos, N.8
Vassilakopoulos, T.P.9
Angelopoulou, M.K.10
-
16
-
-
84892740116
-
Reduced ABCG2 and increased SLC22A1 mRNA expression are associated with imatinib response in chronic myeloid leukemia
-
de Lima, L. T.; Vivona, D.; Bueno, C. T.; Hirata, M. H.; Luchessi, A. D.; de Castro, F. A.; de Lourdes, F.; Chauffaille, M.; Zanichelli, M. A.; Chiattone, C. S.; Hungria, V. T.; Guerra-Shinohara, E. M. Reduced ABCG2 and increased SLC22A1 mRNA expression are associated with imatinib response in chronic myeloid leukemia. Med. Oncol. 31:851; 2014.
-
(2014)
Med. Oncol.
, vol.31
, pp. 851
-
-
De Lima, L.T.1
Vivona, D.2
Bueno, C.T.3
Hirata, M.H.4
Luchessi, A.D.5
De Castro, F.A.6
De Lourdes, F.7
Chauffaille, M.8
Zanichelli, M.A.9
Chiattone, C.S.10
Hungria, V.T.11
Guerra-Shinohara, E.M.12
-
17
-
-
84869804156
-
Drug efflux transporters and multidrug resistance in acute leukemia: Therapeutic impact and novel approaches to mediation
-
Xia, C. Q.; Smith, P. G. Drug efflux transporters and multidrug resistance in acute leukemia: therapeutic impact and novel approaches to mediation. Mol. Pharmacol. 82(6):1008-1021; 2012.
-
(2012)
Mol. Pharmacol.
, vol.82
, Issue.6
, pp. 1008-1021
-
-
Xia, C.Q.1
Smith, P.G.2
-
18
-
-
77955101301
-
Adhesion-induced drug resistance in leukemia stem cells
-
Funayama, K.; Murai, F.; Shimane, M.; Nomura, H.; Asano, S. Adhesion-induced drug resistance in leukemia stem cells. Pharmacology 86(2):79-84; 2010.
-
(2010)
Pharmacology
, vol.86
, Issue.2
, pp. 79-84
-
-
Funayama, K.1
Murai, F.2
Shimane, M.3
Nomura, H.4
Asano, S.5
-
19
-
-
4344653856
-
Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: Direct evidence of PI3K activation
-
Kubota, Y.; Ohnishi, H.; Kitanaka, A.; Ishida, T.; Tanaka, T. Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation. Leukemia 18:1438-1440; 2004.
-
(2004)
Leukemia
, vol.18
, pp. 1438-1440
-
-
Kubota, Y.1
Ohnishi, H.2
Kitanaka, A.3
Ishida, T.4
Tanaka, T.5
-
20
-
-
0042744837
-
Survival of acute myeloid leukemia cells requires PI3 kinase activation
-
Xu, Q.; Simpson, S. E.; Scialla, T. J.; Bagg, A.; Carroll, M. Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 102:972-980; 2003.
-
(2003)
Blood
, vol.102
, pp. 972-980
-
-
Xu, Q.1
Simpson, S.E.2
Scialla, T.J.3
Bagg, A.4
Carroll, M.5
-
21
-
-
18544374589
-
Pharmacologic inhibition of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathion depletion and increased peroxide accumulation in myeloid leukemia cells
-
Ramos, A. M.; Fernandez, C.; Amran, D.; Sancho, P.; de Blas, E.; Aller, P. Pharmacologic inhibition of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathion depletion and increased peroxide accumulation in myeloid leukemia cells. Blood 105:4013-4020; 2005.
-
(2005)
Blood
, vol.105
, pp. 4013-4020
-
-
Ramos, A.M.1
Fernandez, C.2
Amran, D.3
Sancho, P.4
De Blas, E.5
Aller, P.6
-
22
-
-
0030837555
-
PTEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
-
Myers, M. P.; Stolarov, J. P.; Eng, C.; Li, J.; Wang, S. I.; Wigler, M. H.; Parsons, R.; Tonks, N. K. PTEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci. USA 94:9052-9057; 1997.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 9052-9057
-
-
Myers, M.P.1
Stolarov, J.P.2
Eng, C.3
Li, J.4
Wang, S.I.5
Wigler, M.H.6
Parsons, R.7
Tonks, N.K.8
-
23
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
-
Tamura, M.; Gu, J.; Matsumoto, K.; Aota, S.;Parsons, R.; Yamada, M. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280:1614-1617; 1998.
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
Aota, S.4
Parsons, R.5
Yamada, M.6
-
24
-
-
11144354308
-
Loss of heterozygosity on 10q and mutational status of PTEN and BMPR1 A in colorectal primary tumors and metastases
-
Karoui, M.; Tresallet, C.; Julie, C.; Zimmermann, U.; Staroz, F.; Brams, A.; Muti, C.; Boulard, C.; Robreau, A. M.; Puy, M.; Malafosse, R.; Penna, C.; Pruvot, F. R.; Thiery, J. P.; Boileau, C.; Rougier, P.; Nordlinger, B.; Radvanyi, F.; Franc, B.; Hofmann-Radvanyi, H. Loss of heterozygosity on 10q and mutational status of PTEN and BMPR1 A in colorectal primary tumors and metastases. Br. J. Cancer 90:1230-1234; 2004.
-
(2004)
Br. J. Cancer
, vol.90
, pp. 1230-1234
-
-
Karoui, M.1
Tresallet, C.2
Julie, C.3
Zimmermann, U.4
Staroz, F.5
Brams, A.6
Muti, C.7
Boulard, C.8
Robreau, A.M.9
Puy, M.10
Malafosse, R.11
Penna, C.12
Pruvot, F.R.13
Thiery, J.P.14
Boileau, C.15
Rougier, P.16
Nordlinger, B.17
Radvanyi, F.18
Franc, B.19
Hofmann-Radvanyi, H.20
more..
-
25
-
-
1842853656
-
Study of the mutation and expression of PTEN gene in endometrial carcinoma and epithelial ovarian cancer
-
Che, Y. C.; Yao, Q.; Dai, S. Z.; Luo, B.; Wang, Y. Study of the mutation and expression of PTEN gene in endometrial carcinoma and epithelial ovarian cancer. Chin. J. Obstet. Gynecol. 37:608-611; 2002.
-
(2002)
Chin. J. Obstet. Gynecol.
, vol.37
, pp. 608-611
-
-
Che, Y.C.1
Yao, Q.2
Dai, S.Z.3
Luo, B.4
Wang, Y.5
-
26
-
-
44349111717
-
Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: Is PTEN loss predictor of local recurrence?
-
Colakoglu, T.; Yildirim, S.; Kayaseleuk, F.; Nursal, T. Z.; Ezer, A.; Noyan, T.; Karakayali, H.; Haberal, M. Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence? Am. J. Surg. 195:719-725; 2008.
-
(2008)
Am. J. Surg.
, vol.195
, pp. 719-725
-
-
Colakoglu, T.1
Yildirim, S.2
Kayaseleuk, F.3
Nursal, T.Z.4
Ezer, A.5
Noyan, T.6
Karakayali, H.7
Haberal, M.8
-
27
-
-
79960635820
-
Role of Pten in leukemia stem cells
-
Peng, C.; Chen, Y.; Li, D.; Li, S. Role of Pten in leukemia stem cells. Oncotarget 1:156-160; 2010.
-
(2010)
Oncotarget
, vol.1
, pp. 156-160
-
-
Peng, C.1
Chen, Y.2
Li, D.3
Li, S.4
-
28
-
-
44349088690
-
Multi-genetic events collaboratively contribute to Pten-null leukemia stem-cell formation
-
Guo, W.; Lasky, J. L.; Chang, C. J.; Mosessian, S.; Lewis, X.; Xiao, Y.; Yeh, J. E.; Chen, J. Y.; Iruela-Arispe, M. L.; Varella-Garcia, M.; Wu, H. Multi-genetic events collaboratively contribute to Pten-null leukemia stem-cell formation. Nature 453:529-533; 2008.
-
(2008)
Nature
, vol.453
, pp. 529-533
-
-
Guo, W.1
Lasky, J.L.2
Chang, C.J.3
Mosessian, S.4
Lewis, X.5
Xiao, Y.6
Yeh, J.E.7
Chen, J.Y.8
Iruela-Arispe, M.L.9
Varella-Garcia, M.10
Wu, H.11
-
29
-
-
33646376411
-
Pten dependence distinguish haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz, O. H.; Valdez, R.; Theisen, B. K.; Guo, W.; Ferguson, D. O.; Wu, H.; Morrison, S. J. Pten dependence distinguish haematopoietic stem cells from leukaemia-initiating cells. Nature 441:475-482; 2006.
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
30
-
-
4043093341
-
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
-
Hemando, E.; Nahle, Z.; Juan, G.; Diaz-Rodriguez, E.; Alaminos, M.; Hemann, M.; Michel, L.; Mittal, V.; Gerald, W.; Benezra, R.; Lowe, S. W.; Cordon-Card, C. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature 430:797-802; 2004.
-
(2004)
Nature
, vol.430
, pp. 797-802
-
-
Hemando, E.1
Nahle, Z.2
Juan, G.3
Diaz-Rodriguez, E.4
Alaminos, M.5
Hemann, M.6
Michel, L.7
Mittal, V.8
Gerald, W.9
Benezra, R.10
Lowe, S.W.11
Cordon-Card, C.12
-
31
-
-
33846483151
-
Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: Impact on in vivo tumor growth
-
Ramasamy, R.; Lam, E. W.; Soeiro, I.; Tisato, V.; Bonnet, D.; Dazzi, F. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. Leukemia 21(2):304-310; 2007.
-
(2007)
Leukemia
, vol.21
, Issue.2
, pp. 304-310
-
-
Ramasamy, R.1
Lam, E.W.2
Soeiro, I.3
Tisato, V.4
Bonnet, D.5
Dazzi, F.6
|