Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells

Oncotarget

Volumn 6, Issue 26, 2015, Pages 22624-22640

  Bruno, Silvia ^a   Ledda, Bernardetta ^a   Tenca, Claudya ^a   Ravera, Silvia ^a   Orengo, Anna Maria ^b   Mazzarello, Andrea Nicola ^a,c   Pesenti, Elisa ^a   Casciaro, Salvatore ^a   Racchi, Omar ^d   Ghiotto, Fabio ^a   Marini, Cecilia ^e   Sambuceti, Gianmario ^a,b   DeCensi, Andrea ^f,g   Fais, Franco ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^d VILLA SCASSI HOSPITAL   (Italy)

^e CNR   (Italy)

^f EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^g GALLIERA HOSPITAL   (Italy)

Author keywords

Cancer therapy; Cell activation; Cell proliferation; Chronic lymphocytic leukemia; Metformin

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; CD40 ANTIGEN; CD40 LIGAND; CHEMOKINE RECEPTOR CXCR4; FLUDARABINE; HERMES ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; METFORMIN; PROTEIN KINASE B; PROTEIN MCL 1; STAT3 PROTEIN; ANTIDIABETIC AGENT;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CANCER GROWTH; CELL ACTIVATION; CELL ADHESION; CELL CYCLE PROGRESSION; CELL HOMING; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; CELL CYCLE; DRUG EFFECTS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; METABOLISM; PATHOLOGY;

CELL CYCLE; CELL PROLIFERATION; HUMANS; HYPOGLYCEMIC AGENTS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; METFORMIN; SIGNAL TRANSDUCTION;

EID: 84941204952     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4168     Document Type: Article

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