Centipedegrass extract induces apoptosis through the activation of caspases and the downregulation of PI3K/AKT and MAPK phosphorylation in leukemia cells

International Journal of Molecular Medicine

Volumn 35, Issue 2, 2015, Pages 511-518

  Bai, Hyoung Woo ^a   Badaboina, Srilatha ^a   Park, Chul Hong ^a,b   Choi, Bo Yun ^a   Na, Yun Hee ^a,b   Chung, Byung Yeoup ^a  

^a Korea Atomic Energy Research Institute   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Acute lymphoblastic leukemia; Apoptosis; Caspase; CEM CM3 cells; Centipedegrass extract; Jurkat; Mitogen activated protein kinase; Phosphatidylinositol 3 kinase AKT

Indexed keywords

BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 3; CASPASE 7; CASPASE 9; CASPASE INHIBITOR; CENTIPEDEGRASS EXTRACT; CYTOCHROME C; DIMETHYL SULFOXIDE; EFFECTOR CASPASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; CASP3 PROTEIN, HUMAN; CASP7 PROTEIN, HUMAN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL SURVIVAL; CELL VIABILITY; CENTIPEDEGRASS; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY ASSAY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC50; IMMUNOBLOTTING; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; POACEAE; PROTEIN PHOSPHORYLATION; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; JURKAT CELL LINE; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

APOPTOSIS; CASPASE 3; CASPASE 7; DOWN-REGULATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; JURKAT CELLS; MAP KINASE SIGNALING SYSTEM; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PLANT EXTRACTS; POACEAE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84919628841     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.2012     Document Type: Article

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