Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3

Cancer Science

Volumn 108, Issue 11, 2017, Pages 2187-2194

  Shintoku, Ryosuke ^a,b   Takigawa, Yuta ^a   Yamada, Keiichi ^c   Kubota, Chisato ^a   Yoshimoto, Yuhei ^b   Takeuchi, Toshiyuki ^a   Koshiishi, Ichiro ^a   Torii, Seiji ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

^c Division of Electronics and Informatics Faculty of Science and Technology   (Japan)

Author keywords

Cell death; glutathione peroxidase; iron; Ras; reactive oxygen species

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ALOX15 PROTEIN; CAFFEIC ACID; ERASTIN; LIPID HYDROPEROXIDE; LIPID PEROXIDE; LIPOXYGENASE; PROTEIN; RAS PROTEIN; RSL3 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ALOX15 PROTEIN, HUMAN; ARACHIDONATE 15 LIPOXYGENASE; CARBOLINE DERIVATIVE; PIPERAZINE DERIVATIVE; RSL3 COMPOUND;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL; CELL DEATH; CELL LYSATE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVITY; FERROPTOSIS; FLUORESCENCE MICROSCOPY; HT-1080 CELL LINE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; LIPID MEMBRANE; LIPID PEROXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; DRUG EFFECTS; FIBROSARCOMA; GENE EXPRESSION REGULATION; GENETICS; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE;

ARACHIDONATE 15-LIPOXYGENASE; CARBOLINES; CELL DEATH; CELL LINE, TUMOR; FIBROSARCOMA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIPID PEROXIDATION; PANCREATIC NEOPLASMS; PIPERAZINES; RNA, SMALL INTERFERING;

EID: 85029457962     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.13380     Document Type: Article

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